Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. The...Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer＇s disease and Parkinson＇s disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support – mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor – in the survival, proliferation and maturation of affected neurons in Alzheimer＇s disease and Parkinson＇s disease as well as their putative application as new therapeutic approach for these diseases management.展开更多
基金supported by the Brazilian agencies:Conselho Nacional de Desenvolvimento Científico e Tecnologico(CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nível Superior(CAPES)+4 种基金Programa de Apoio aos Nucleos de Excelencia(PRONEX)Fundacao de AmparoaPesquisa do Estado do Rio Grande do Sul(FAPERGS)Fundacao de ApoioàPesquisa do Estado de Santa Catarina(FAPESC)FINEP(Financiadora de Estudos e Projetos)INCT(Instituto Nacional de Ciencia e Tecnologia)
文摘Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer＇s disease and Parkinson＇s disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support – mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor – in the survival, proliferation and maturation of affected neurons in Alzheimer＇s disease and Parkinson＇s disease as well as their putative application as new therapeutic approach for these diseases management.
