目的探讨TOF-PET(time of flight-positron emission tomography)对于评价小肿瘤病灶(病灶最长径<2cm)的临床应用价值。方法临床明确诊断肿瘤患者28例,共58个小病灶。PET-CT检查使用联影u MI S-96R进行全身扫描,扫描结束后使用UIdea...目的探讨TOF-PET(time of flight-positron emission tomography)对于评价小肿瘤病灶(病灶最长径<2cm)的临床应用价值。方法临床明确诊断肿瘤患者28例,共58个小病灶。PET-CT检查使用联影u MI S-96R进行全身扫描,扫描结束后使用UIdeal工作站进行图像重建,分别选用TOF和非TOF重建,均采用点扩展函数(point spread function,PSF)、最大期望值算法(ordered subsets expectation maximization,OSEM)、半高宽(full width at half maximum,FWHM)4.0。测量58个病灶的18F-FDG摄取,分别测量TOF与非TOF图像病灶的18F-FDG标准摄取率平均值(standard uptake value mean,SUVmean)、肝脏SUVmean和肝脏SD值,并计算图像的信噪比(signal-to-noise ratio,SNR)。应用SPSS 21统计软件包对数据进行统计学分析,采用配对t检验比较TOF-PET与非TOF-PET图像的测量值差异。结果 28例患者TOF-PET和非TOF-PET图像肝脏的SUVmean值无显著性差异(P>0.05)。FDG摄取增高的58个病灶,TOF-PET与非TOF-PET图像的SUVmean、SNR值均有显著性差异(P<0.01),TOF-PET图像测量值显著增高,SUVmean、SNR分别提高10.26%、11.96%。结论 TOF-PET技术较非TOF-PET技术可以明显提高小肿瘤病灶的SUVmean、SNR值,有助于提高临床小病灶的诊断能力。展开更多
Objective：To evaluate the clinical value with positron emission tomography/computerized tomography（PET/CT） imaging for the detection of vulnerable plaque in atherosclerotic lesions. Methods：Sixty people with a age...Objective：To evaluate the clinical value with positron emission tomography/computerized tomography（PET/CT） imaging for the detection of vulnerable plaque in atherosclerotic lesions. Methods：Sixty people with a age of over 60[mean age （69.2 ± 7.1）years] underwent three dimension（3D） whole-body fluorine-18-2-fluoro-2-deoxy-D-glucose（^18F-FDG） PET/CT imaging and were evaluated retrospectively, including 6 cases assessed as normal and 54 cases with active atherosclerotic plaque. Fifty-four cases with SUVs and CT values in the aortic wall of high-FDG-uptake were measured retrospectively. These high-FDG-uptake cases in the aortic wall were divided into three groups according their CT value. Cases in group 1 had high uptake in atherosclerotic lesions of the aortic wall with CT value of less than 60 Hu（soft plaque）. Cases in group 2 had high uptake with CT value between 60-100 Hu （intermediate plaque）, Cases in group 3 had high uptake with CT value more than 100 Hu（calcified plaque）, Group 4 was normal. Results： In group 1, there were 42 high-FDG-uptake sites （average SUV 1.553 ± 0.486）. In group 2, there were 30 high-FDG-uptake sites（average SUV 1.393 ± 0.296）. In group 3, there were 36 high-FDG-uptake sites（average SUV 1.354 ± 0.189）. In group 4, there were 33 normal-FDG-uptake sites （average SUV was 1.102 ± 0.141）, The SUVs showed significant difference among the four groups（F = 678.909, P = 0.000）. There were also significant difference found between the normal-FDG-uptake group and the high-FDG-uptake groups（P = 0.000, 0.000, 0.001, respectively）. Conclusion：Different degrees of ^18F-FDG uptake in active large atherosclerotic plaque were shown in different stages of atherosclerotic plaque formation. The soft plaque had the highest FDG uptake in this study. This suggested that ^18F- FDG PET/CT imaging may be of great potential value in early diagnosis and monitoring of vulnerable soft plaque in atherosclerotic lesions.展开更多
文摘Objective：To evaluate the clinical value with positron emission tomography/computerized tomography（PET/CT） imaging for the detection of vulnerable plaque in atherosclerotic lesions. Methods：Sixty people with a age of over 60[mean age （69.2 ± 7.1）years] underwent three dimension（3D） whole-body fluorine-18-2-fluoro-2-deoxy-D-glucose（^18F-FDG） PET/CT imaging and were evaluated retrospectively, including 6 cases assessed as normal and 54 cases with active atherosclerotic plaque. Fifty-four cases with SUVs and CT values in the aortic wall of high-FDG-uptake were measured retrospectively. These high-FDG-uptake cases in the aortic wall were divided into three groups according their CT value. Cases in group 1 had high uptake in atherosclerotic lesions of the aortic wall with CT value of less than 60 Hu（soft plaque）. Cases in group 2 had high uptake with CT value between 60-100 Hu （intermediate plaque）, Cases in group 3 had high uptake with CT value more than 100 Hu（calcified plaque）, Group 4 was normal. Results： In group 1, there were 42 high-FDG-uptake sites （average SUV 1.553 ± 0.486）. In group 2, there were 30 high-FDG-uptake sites（average SUV 1.393 ± 0.296）. In group 3, there were 36 high-FDG-uptake sites（average SUV 1.354 ± 0.189）. In group 4, there were 33 normal-FDG-uptake sites （average SUV was 1.102 ± 0.141）, The SUVs showed significant difference among the four groups（F = 678.909, P = 0.000）. There were also significant difference found between the normal-FDG-uptake group and the high-FDG-uptake groups（P = 0.000, 0.000, 0.001, respectively）. Conclusion：Different degrees of ^18F-FDG uptake in active large atherosclerotic plaque were shown in different stages of atherosclerotic plaque formation. The soft plaque had the highest FDG uptake in this study. This suggested that ^18F- FDG PET/CT imaging may be of great potential value in early diagnosis and monitoring of vulnerable soft plaque in atherosclerotic lesions.
