Introduction: Studies showed a high prevalence of metabolic abnormalities including dyslipidemia, type 2 diabetes in cases of low testosterone in men and which are associated with increased cardiovascular risk. Hypogo...Introduction: Studies showed a high prevalence of metabolic abnormalities including dyslipidemia, type 2 diabetes in cases of low testosterone in men and which are associated with increased cardiovascular risk. Hypogonadism represents the second cause of endocrine osteoporosis. Objectives: The objectives of our work were: to determine the main causes of hypogonadism in women and men;to assess the frequency of metabolic and osteosdensitometric abnormalities in the hypogonadal population. Patients and methods: A retrospective descriptive study was carried out over 7 years on 120 patients, hospitalized in the Endocrinology department of the Hassan II University Hospital of Fez-Morocco for hypogonadism. The patients selected were those who had symptoms of hypogonadism confirmed in men by: low total testosterone for Tanner stage in adolescents, ng/ml or lower limit of normal for adults;in women, hypoestrogenia 30 pg/l. Gonadotropin dosage, karyotype, pelvic or testicular ultrasound and pituitary MRI, for etiological diagnosis, were performed. Bone densitometry was performed for bone impact and lipid profile for metabolic profile. Results: Out of 120 patients, there were 77 women and 43 men. The average age was 31.51 years. In men, the main causes were central hypogonadism in 67.4% and primary testicular failure in 32.6%. In women, central hypogonadism was also the most common cause noted in 63.7% and premature ovarian failure was observed in 36.4%. HypoHDL was significantly more frequent p (0.005) in women, osteopenia and osteoporosis were significantly more frequent in women than in men p (0.046). Conclusion: Central causes represent the most common etiology of hypogonadism in both sexes;abnormalities of bone mineralization and metabolic disorders were predominant in women.展开更多
Tannery wastewater causes serious ecological and sanitary damage. Chemical analysis of water from Binlamdoune River of the medina of Fez was conducted and the results revealed the presence of toxic elements from tanne...Tannery wastewater causes serious ecological and sanitary damage. Chemical analysis of water from Binlamdoune River of the medina of Fez was conducted and the results revealed the presence of toxic elements from tanneries and other industrial activities, which strongly affected water quality. To determine the effectiveness of bioremediation for depollution, we studied the abundance and diversity of bacteria residing in these polluted environments. Conducting denaturing gradient gel electrophoresis （PCR-DGGE） of the 16S rDNA area using primers related to bacteria showed a bacterial community belonging to eubacterial groups, that is, Epsilonproteobacteria, Clostridia, Lactobacillales, Bacteroidetes, Gammaproteobacteria, and Alphaproteobacteria. In addition, cloning displayed the presence of clones belonging to the Firmicutes group. Moreover, scanning electron microscopy revealed a significant heterogeneity of microorganism forms and structures. These endogenous microbes could have a significant role in the purification of Binlamdoune River and Fez tannery wastewater.展开更多
Objective:To evaluate the larvicidal activity of essential oil of Origanum mtijoruna(Lamiaceae)cultivated in Morocco against Culex pipiens(Diptera:Culicidae).Methods:The analysis and the identification of the various ...Objective:To evaluate the larvicidal activity of essential oil of Origanum mtijoruna(Lamiaceae)cultivated in Morocco against Culex pipiens(Diptera:Culicidae).Methods:The analysis and the identification of the various constituents of essential oil were carried out by gas chromatography coupled with mass spectrometry.Biological test was performed according to a standard methodology inspired by the World Health Organization protocol with slight modification.Results:This oil mainly consisted of monoterpene and sesquiterpenes.The majority compounds are 4-terpinene(28.96%),y-terpinene(18.57%),α-terpinene(12.72%) and sabinene(8.02%).The lethal concentrations(LC_(50) and LC_(90)) measured for the essential oil Origanum majorana,were respectively of the order of 258.71 mg/L and 580.49 mg/L.Conclusions:The results could be useful in search for newer,safer,and more effective natural larvicidal agents.展开更多
In order to develop an urban GIS of Fez, we began with the scoping and feasibility study of the system. This strategic review has identified the characteristics of the urban areas, their problems, needs and existing p...In order to develop an urban GIS of Fez, we began with the scoping and feasibility study of the system. This strategic review has identified the characteristics of the urban areas, their problems, needs and existing potential, both in terms of data, equipment or personnel. This contribution focuses on a conceptual modeling of the geospatial database, the proposed template for the system and the quality assurance plan for the project. According to the feasibility study conducted during the first phase, the system must have an architecture respecting the intervention of actors in the city. Therefore, the implementation of the system requires an adequate hardware and software platform for optimum operation of the proposed urban GIS. After identifying technical choices, the financing plan of this scenario has been proposed. This arrangement is structured in three parts: Hardware, Software and Development/Training.展开更多
Fasciculation and elongation zeta/zygin(FEZ) proteins are a family of hub proteins and share many characteristics like high connectivity in interaction networks, they are involved in several cellular processes, evolve...Fasciculation and elongation zeta/zygin(FEZ) proteins are a family of hub proteins and share many characteristics like high connectivity in interaction networks, they are involved in several cellular processes, evolve slowly and in general have intrinsically disordered regions. In 1985, unc-76 gene was firstly described and involved in axonal growth in C. elegans, and in 1997 Bloom and Horvitz enrolled also the human homologues genes, FEZ1 and FEZ2, in this process. While nematodes possess one gene(unc-76), mammalians have one more copy(FEZ1 and FEZ2). Several animal models have been used to study FEZ family functions like: C. elegans, D. melanogaster, R. novergicus and human cells.Complementation assays were performed and demonstrated the function conservation between paralogues. Human FEZ1 protein is more studied followed by UNC-76 and FEZ2 proteins, respectively. While FEZ1 and UNC-76 shared interaction partners, FEZ2 evolved and increased the number of protein-protein interactions(PPI) with cytoplasmatic partners. FEZ proteins are implicated in intracellular transport, acting as bivalent cargo transport adaptors in kinesinmediated movement. Especially in light of this cellular function, this family of proteins has been involved in several processes like neuronal development,neurological disorders, viral infection and autophagy. However, nuclear functions of FEZ proteins have been explored as well, due to high content of PPI with nuclear proteins, correlating FEZ1 expression to Sox2 and Hoxb4 gene regulation and retinoic acid signaling. These recent findings open new avenue to study FEZ proteins functions and its involvement in already described processes.This review intends to reunite aspects of evolution, structure, interaction partners and function of FEZ proteins and correlate them to physiological and pathological processes.展开更多
AIM: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer.METHODS: To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of ...AIM: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer.METHODS: To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma.RESULTS: Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively.CONCLUSION: A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.展开更多
越来越多的证据表明,长非编码RNA在肿瘤发生发展中起着关键作用。FEZ家族锌指1反义RNA 1(FEZF1-AS1)是一种与肿瘤密切相关的长非编码RNA,对多种类型的恶性肿瘤产生致病作用,并与肿瘤患者的预后不良及化疗耐药性有关。因此,FEZF1-AS1有...越来越多的证据表明,长非编码RNA在肿瘤发生发展中起着关键作用。FEZ家族锌指1反义RNA 1(FEZF1-AS1)是一种与肿瘤密切相关的长非编码RNA,对多种类型的恶性肿瘤产生致病作用,并与肿瘤患者的预后不良及化疗耐药性有关。因此,FEZF1-AS1有可能成为一种新型的癌症临床诊断和预后生物标志物,为肿瘤治疗提供新的分子靶点。本研究利用中国知网和PubMed数据库,在中国知网中以“FEZF1-AS1”“癌症或肿瘤”为关键词,在PubMed中以“FEZF1-AS1”“cancer or tumor”为关键词,分别检索2012-01-01-2023-12-01相关文献。纳入标准:(1)FEZF1-AS1与癌症诊断与治疗;(2)FEZF1-AS1与癌症的发生发展;(3)FEZF1-AS1与癌症的耐药性。剔除标准:重复,及其发表时间较早的综述文章。最终纳入分析文献65篇。研究发现,FEZF1-AS1不仅可以通过海绵化miRNA、引发染色质表观遗传、与蛋白质相互作用、调节信号通路、与mRNA形成双链等5种机制,在胰腺癌、结直肠癌、肝癌、非小细胞肺癌、胃癌、胶质母细胞瘤、宫颈癌、卵巢癌、口腔鳞状细胞癌、喉鳞状细胞癌、视网膜母细胞瘤、骨髓瘤、骨肉瘤、乳腺癌、鼻咽癌、前列腺癌和膀胱癌等17种肿瘤的发生发展中起致病作用,而且与癌症的化疗耐药密切相关。提示FEZF1-AS1具有极好的潜力,有可能成为癌症早期诊断、治疗和改善人类癌症整体预后的重要分子标志物。展开更多
文摘Introduction: Studies showed a high prevalence of metabolic abnormalities including dyslipidemia, type 2 diabetes in cases of low testosterone in men and which are associated with increased cardiovascular risk. Hypogonadism represents the second cause of endocrine osteoporosis. Objectives: The objectives of our work were: to determine the main causes of hypogonadism in women and men;to assess the frequency of metabolic and osteosdensitometric abnormalities in the hypogonadal population. Patients and methods: A retrospective descriptive study was carried out over 7 years on 120 patients, hospitalized in the Endocrinology department of the Hassan II University Hospital of Fez-Morocco for hypogonadism. The patients selected were those who had symptoms of hypogonadism confirmed in men by: low total testosterone for Tanner stage in adolescents, ng/ml or lower limit of normal for adults;in women, hypoestrogenia 30 pg/l. Gonadotropin dosage, karyotype, pelvic or testicular ultrasound and pituitary MRI, for etiological diagnosis, were performed. Bone densitometry was performed for bone impact and lipid profile for metabolic profile. Results: Out of 120 patients, there were 77 women and 43 men. The average age was 31.51 years. In men, the main causes were central hypogonadism in 67.4% and primary testicular failure in 32.6%. In women, central hypogonadism was also the most common cause noted in 63.7% and premature ovarian failure was observed in 36.4%. HypoHDL was significantly more frequent p (0.005) in women, osteopenia and osteoporosis were significantly more frequent in women than in men p (0.046). Conclusion: Central causes represent the most common etiology of hypogonadism in both sexes;abnormalities of bone mineralization and metabolic disorders were predominant in women.
基金supported by the Interuniversity Cooperation ProgramScientific Research between Spain and Morocco. A/5712/06 Project:Study of Bacterial Biodiversity Present in Sebou River Using Classical Microbiology and Molecular (DGGE and FISH) Techniques
文摘Tannery wastewater causes serious ecological and sanitary damage. Chemical analysis of water from Binlamdoune River of the medina of Fez was conducted and the results revealed the presence of toxic elements from tanneries and other industrial activities, which strongly affected water quality. To determine the effectiveness of bioremediation for depollution, we studied the abundance and diversity of bacteria residing in these polluted environments. Conducting denaturing gradient gel electrophoresis （PCR-DGGE） of the 16S rDNA area using primers related to bacteria showed a bacterial community belonging to eubacterial groups, that is, Epsilonproteobacteria, Clostridia, Lactobacillales, Bacteroidetes, Gammaproteobacteria, and Alphaproteobacteria. In addition, cloning displayed the presence of clones belonging to the Firmicutes group. Moreover, scanning electron microscopy revealed a significant heterogeneity of microorganism forms and structures. These endogenous microbes could have a significant role in the purification of Binlamdoune River and Fez tannery wastewater.
文摘Objective:To evaluate the larvicidal activity of essential oil of Origanum mtijoruna(Lamiaceae)cultivated in Morocco against Culex pipiens(Diptera:Culicidae).Methods:The analysis and the identification of the various constituents of essential oil were carried out by gas chromatography coupled with mass spectrometry.Biological test was performed according to a standard methodology inspired by the World Health Organization protocol with slight modification.Results:This oil mainly consisted of monoterpene and sesquiterpenes.The majority compounds are 4-terpinene(28.96%),y-terpinene(18.57%),α-terpinene(12.72%) and sabinene(8.02%).The lethal concentrations(LC_(50) and LC_(90)) measured for the essential oil Origanum majorana,were respectively of the order of 258.71 mg/L and 580.49 mg/L.Conclusions:The results could be useful in search for newer,safer,and more effective natural larvicidal agents.
文摘In order to develop an urban GIS of Fez, we began with the scoping and feasibility study of the system. This strategic review has identified the characteristics of the urban areas, their problems, needs and existing potential, both in terms of data, equipment or personnel. This contribution focuses on a conceptual modeling of the geospatial database, the proposed template for the system and the quality assurance plan for the project. According to the feasibility study conducted during the first phase, the system must have an architecture respecting the intervention of actors in the city. Therefore, the implementation of the system requires an adequate hardware and software platform for optimum operation of the proposed urban GIS. After identifying technical choices, the financing plan of this scenario has been proposed. This arrangement is structured in three parts: Hardware, Software and Development/Training.
文摘Fasciculation and elongation zeta/zygin(FEZ) proteins are a family of hub proteins and share many characteristics like high connectivity in interaction networks, they are involved in several cellular processes, evolve slowly and in general have intrinsically disordered regions. In 1985, unc-76 gene was firstly described and involved in axonal growth in C. elegans, and in 1997 Bloom and Horvitz enrolled also the human homologues genes, FEZ1 and FEZ2, in this process. While nematodes possess one gene(unc-76), mammalians have one more copy(FEZ1 and FEZ2). Several animal models have been used to study FEZ family functions like: C. elegans, D. melanogaster, R. novergicus and human cells.Complementation assays were performed and demonstrated the function conservation between paralogues. Human FEZ1 protein is more studied followed by UNC-76 and FEZ2 proteins, respectively. While FEZ1 and UNC-76 shared interaction partners, FEZ2 evolved and increased the number of protein-protein interactions(PPI) with cytoplasmatic partners. FEZ proteins are implicated in intracellular transport, acting as bivalent cargo transport adaptors in kinesinmediated movement. Especially in light of this cellular function, this family of proteins has been involved in several processes like neuronal development,neurological disorders, viral infection and autophagy. However, nuclear functions of FEZ proteins have been explored as well, due to high content of PPI with nuclear proteins, correlating FEZ1 expression to Sox2 and Hoxb4 gene regulation and retinoic acid signaling. These recent findings open new avenue to study FEZ proteins functions and its involvement in already described processes.This review intends to reunite aspects of evolution, structure, interaction partners and function of FEZ proteins and correlate them to physiological and pathological processes.
基金Supported by Research Center of Gastric and Liver Disease in Tehran Taleghani hospital
文摘AIM: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer.METHODS: To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma.RESULTS: Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively.CONCLUSION: A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.
文摘越来越多的证据表明,长非编码RNA在肿瘤发生发展中起着关键作用。FEZ家族锌指1反义RNA 1(FEZF1-AS1)是一种与肿瘤密切相关的长非编码RNA,对多种类型的恶性肿瘤产生致病作用,并与肿瘤患者的预后不良及化疗耐药性有关。因此,FEZF1-AS1有可能成为一种新型的癌症临床诊断和预后生物标志物,为肿瘤治疗提供新的分子靶点。本研究利用中国知网和PubMed数据库,在中国知网中以“FEZF1-AS1”“癌症或肿瘤”为关键词,在PubMed中以“FEZF1-AS1”“cancer or tumor”为关键词,分别检索2012-01-01-2023-12-01相关文献。纳入标准:(1)FEZF1-AS1与癌症诊断与治疗;(2)FEZF1-AS1与癌症的发生发展;(3)FEZF1-AS1与癌症的耐药性。剔除标准:重复,及其发表时间较早的综述文章。最终纳入分析文献65篇。研究发现,FEZF1-AS1不仅可以通过海绵化miRNA、引发染色质表观遗传、与蛋白质相互作用、调节信号通路、与mRNA形成双链等5种机制,在胰腺癌、结直肠癌、肝癌、非小细胞肺癌、胃癌、胶质母细胞瘤、宫颈癌、卵巢癌、口腔鳞状细胞癌、喉鳞状细胞癌、视网膜母细胞瘤、骨髓瘤、骨肉瘤、乳腺癌、鼻咽癌、前列腺癌和膀胱癌等17种肿瘤的发生发展中起致病作用,而且与癌症的化疗耐药密切相关。提示FEZF1-AS1具有极好的潜力,有可能成为癌症早期诊断、治疗和改善人类癌症整体预后的重要分子标志物。
