AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolis...AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively analyzed.Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for ferroportin.As a control,normal liver tissue was obtained from 18 living donors of liver transplantation.Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.RESULTS:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in vivo.Conversely,iron administration suppresses HCV replication in vitro.Therefore,the association between HCV infection and iron metabolism remains unclear.Compared with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and hepcidin.When the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and ferroportin.Expression of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected liver.BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group.HCV infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in hepatocytes.CONCLUSION:Decreased expression of hepcidin and ferroportin in SV展开更多
Le projet ferroviaire entrepris par China Railway Signal and Communication Corp.International(CRSC)promet de stimuler l’économie du Malawi en générant des centaines d'emplois.
The study by the author of magnetic scattering neutrons in the structures of ferrimagnets, as well as his experiments with the separation of magnetic charges in dipole pairs ±g in magnetic field, showed that fund...The study by the author of magnetic scattering neutrons in the structures of ferrimagnets, as well as his experiments with the separation of magnetic charges in dipole pairs ±g in magnetic field, showed that fundamental magnetic particles (magnetic charges) are real structural components of atoms and substance. It is the magnetic poles, and not the moving electric charges are the direct sources of all magnetic fields and magnetic manifestations in Nature. Basic reasons of ignoring the magnetic fundamental particles by world physical theory, for almost 150 years, are the ultra-harsh confinement of these particles in substance which radically is different from the confinement electrons, as well as the vicious concept of the electric magnetism Maxwell. Rotating magnetic dipoles in conductors which are untwisted by electric current, are direct sources of the vortex magnetic field rot<em><strong>H</strong></em>. One should also expect the formation of a vortex electric field rot<em><strong>E </strong></em>forming by rotating electric dipoles which are untwisted by the current of magnetic charges. This article provides an experimental answer to the question: what field is formed around a conductor if joint direct currents of electric<em> <strong style="white-space:normal;"><em>J</em></strong></em><sub>e</sub> and magnetic<strong><em> J</em></strong><sub>g</sub> charges are passed through it? The author’s experiments have shown that in this case the vortex electromagnetic current is realized which manifests itself as the vortex electromagnetic (gravitational) field. It is possible to implement such a process, according to the results of the author’s research, exclusively in superconductors. The vector character of the gravitational field is in many respects similar to the vortex magnetic field which makes it possible to introduce such it states as paragravitation and ferrogravitation into representations. To create joint currents of electric and magnetic charges, the author used the inertial forces of these particl展开更多
Microwave is an electromagnetic wave and consists of the electric and the magnetic fields.The microwave electric field interacts with dielectric materials and heat is generated due to the dielectric loss,which is a ma...Microwave is an electromagnetic wave and consists of the electric and the magnetic fields.The microwave electric field interacts with dielectric materials and heat is generated due to the dielectric loss,which is a major mechanism of microwave heating of water.Microwave magnetic field interaction with materials has to be discussed in terms of two different mechanisms.The first class is the induction current generation in(mainly)metallic materials, which gives rise the Joule heat,although the penetration distance into metals are limited within a microns or less.In this article,a characteristic application of microwave induction heating of metal thin film is presented.The second class is the microwave interaction with the ferro(or ferri)magnetic materials.Effect of ferromagnetic resonance(FMR)is taken into consideration as the fundamental heating mechanism of the ferro-magnetic materials.The FMR heating behavior of Fe_3O_4 is presented.Discussion is made for the phenomena observed in the experiments.展开更多
Redox mechanism of ferrocene, acetylferrocene, ferrocenyl cinnamenyl ketone at a platinum electrode was studied with cyclic voltammetry (CV) and in-situ Fourier transform infrared (FTIR) spectroelectrochemistry. The ...Redox mechanism of ferrocene, acetylferrocene, ferrocenyl cinnamenyl ketone at a platinum electrode was studied with cyclic voltammetry (CV) and in-situ Fourier transform infrared (FTIR) spectroelectrochemistry. The IR bands in the range of 2000-1000 cm-1 attributed to the stretching and ring vibrations of these materials show the main spectral changes in the processes.展开更多
The experimental results of the redox of manganese and ferro ions by manganese bacteria are described. Under the aerobic conditions, the manganese bacteria can oxidate Mn2+ into Mn4+. In the course of the manganese ba...The experimental results of the redox of manganese and ferro ions by manganese bacteria are described. Under the aerobic conditions, the manganese bacteria can oxidate Mn2+ into Mn4+. In the course of the manganese bacteria multiplication, the continual increaes of environmental pH is advantageous to the oxidation of manganese and the rise of environmental temperature helps the bacteria to speed the oxidation of manganese ions. The manganese bacteria can fastly oxidate Fe2+ in the culture containing low vaient ferro into Fe3+, its oxidation speed being faster than that of manganese oxide. Under the anaerobic conditions,the manganese bacteria can reduce high valent ferro in solutioninto low valent ferro and distinctly lower the environmental pH.展开更多
The ferro resonance caused by an electromagnetic potential transformer is a frequently occurring internal overvoltage in the power distribution network, and it threatens the safe operation of the network. Fast and acc...The ferro resonance caused by an electromagnetic potential transformer is a frequently occurring internal overvoltage in the power distribution network, and it threatens the safe operation of the network. Fast and accurate detection is the prerequisite for suppression and elimination of ferro resonance. Wavelet transform provides a powerful tool for analysis of nonstationary signals. This paper applies wavelet transform to detect ferro resonance. Analysis results show that it makes extraction of failure information accurate, and fast algorithm makes detection real time.展开更多
Experimental and theoretical studies of the author (period: 1968-present) have shown that true sources of </span><span style="font-family:"">the </span><span style="font-family...Experimental and theoretical studies of the author (period: 1968-present) have shown that true sources of </span><span style="font-family:"">the </span><span style="font-family:"">magnetic field are magnetic fundamental particles (magnetic charges), and not moving electrons. The main reason for <span>ignoring real magnetic charges, as well as true antielectrons in physical</span> science is the hard conditions for confinement of these particles in atoms and substance</span><span style="font-family:"">s</span><span style="font-family:"">, which </span><span style="font-family:"">is </span><span style="font-family:"">radically different from the confinement of electrons. Magnetic charges together with electric charges form the shells atoms which are <span>electromagnetic, and not electronic. Namely</span></span><span style="font-family:"">,</span><span style="font-family:""> electromagnetic shells are</span><span style="font-family:""> sources of gravitational field which is </span><span style="font-family:"">a </span><span style="font-family:"">vortex electromagnetic field and de<span>scribed by the vortex</span></span><span style="font-family:""> rot [<i>E</i> - <i>H</i>]</span><span style="font-family:"">. Depending on the state polarization o</span><span style="font-family:"">f vortex vectors </span><span style="font-family:"">rot [<i>E</i> - <i>H</i>]</span><span style="font-family:""> in compositions of atomic gravitational fields it </span><span style="font-family:"">is </span><span style="font-family:"">subdivided into paragravitational (PGF) and ferrogravitational fields </span><span style="font-family:"">(FGF). The overwhelming number of atoms emits PGF. Between the masses (bodies, atoms, nucleons and others) emitting PGF areas of negative gravitational “Dark Energy” are realized the forces of which press the masses towards each other. Namely</span><span style="font-family:"">,</span><span style="font-family:""> the compression of atoms by the forces of paragravitational “Dark Energy” underlies th展开更多
On February 27,the China’s stock index dropped sharply by 9% from the day before,triggering a worldwide slide.Some media called it China Stock Woes.We do notknow if the foreign hot money will stay in Chinese stock no...On February 27,the China’s stock index dropped sharply by 9% from the day before,triggering a worldwide slide.Some media called it China Stock Woes.We do notknow if the foreign hot money will stay in Chinese stock now.Some experts thoughtthe woes were caused by high growth in 2006.In a word,as discussed in CCR’sFebruary 6th issue,China’s stock market is linked with stocks worldwide more展开更多
Affected by the export tax rise, China’s tungsten export price rose by about 40 per cent in the first 10 months of 2006. The average price of Ammonium Paratungstate (APT) was US＄23,000/MT, up by 43.5 per cent year-o...Affected by the export tax rise, China’s tungsten export price rose by about 40 per cent in the first 10 months of 2006. The average price of Ammonium Paratungstate (APT) was US＄23,000/MT, up by 43.5 per cent year-on-year, and that of ferro-tungsten, blue tungsten oxide as well as yellow oxide also increased by 32.4 per cent to US＄24,000/MT, 27.4 per cent to US＄25,000/MT and 42.6 per cent to US＄26,000/MT respectively.展开更多
Since the beginning of this year,China’s exportof ferro-molybdenum has increased by someconsiderable amount,leading to uncontrolledmining of the molybdenum resources. Customsstatistics show that in the first half of ...Since the beginning of this year,China’s exportof ferro-molybdenum has increased by someconsiderable amount,leading to uncontrolledmining of the molybdenum resources. Customsstatistics show that in the first half of this year,along with the price increase of ferro-molybdenum on the international market,China’s export of ferro-molybdenum grew by13.7 per cent year on year to 17,885 tons withthe trade volume reaching US$239,000,000,upby 1.5 times.Among the total export,Liaoningprovince became the largest exporter of ferro-molybdenum with 11,829 tons and a value ofUS$162,000,000, up by 48.7 per cent and 2.展开更多
Some authors have studied a series of (Pd0.9965 Fe0.0035)1-xMnx alloys which exhibit distinctly different magnetic properties depending upon the Mn concentration x. It is attributed to the competing interaction in mag...Some authors have studied a series of (Pd0.9965 Fe0.0035)1-xMnx alloys which exhibit distinctly different magnetic properties depending upon the Mn concentration x. It is attributed to the competing interaction in magnetic systems, In general, for a large number of alloy systems with mixed ferro-antiferromagnetic interactions, the competition leads to a diversity of magnetic struetures and critical phenomena.展开更多
Ferric concretions have been discovered in the surface sediments from the southern part of the Huanghai Sea to the northern part of the East China Sea in June, 1981. Their morphology can be classified into three kinds...Ferric concretions have been discovered in the surface sediments from the southern part of the Huanghai Sea to the northern part of the East China Sea in June, 1981. Their morphology can be classified into three kinds: gelatins, se-展开更多
The single crystal of LiTaO3 is an important ferro-electric crystal, pcssessing comparatively better electro-optic, piezo-electric and thermo-electrio properties. It has been put widely into applications.Using X-ray p...The single crystal of LiTaO3 is an important ferro-electric crystal, pcssessing comparatively better electro-optic, piezo-electric and thermo-electrio properties. It has been put widely into applications.Using X-ray powder diffraction and neutron diffraction methods, Abraham et al.展开更多
China Nonferrous Metal Co.,Ltd.(SZ:000758)announced on August 2nd that the company will form a joint venture named China Nonferrous Metal South Rare Earth(Xinfeng)Co.,Ltd.,partnering
基金Supported by grants from Research Program of Intractable Disease provided by the Ministry of Health,Labor and Welfare of Japan,and a Grant-in-Aid for Clinical Research from the National Hospital Organization of Japan
文摘AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively analyzed.Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for ferroportin.As a control,normal liver tissue was obtained from 18 living donors of liver transplantation.Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.RESULTS:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in vivo.Conversely,iron administration suppresses HCV replication in vitro.Therefore,the association between HCV infection and iron metabolism remains unclear.Compared with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and hepcidin.When the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and ferroportin.Expression of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected liver.BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group.HCV infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in hepatocytes.CONCLUSION:Decreased expression of hepcidin and ferroportin in SV
文摘Le projet ferroviaire entrepris par China Railway Signal and Communication Corp.International(CRSC)promet de stimuler l’économie du Malawi en générant des centaines d'emplois.
文摘The study by the author of magnetic scattering neutrons in the structures of ferrimagnets, as well as his experiments with the separation of magnetic charges in dipole pairs ±g in magnetic field, showed that fundamental magnetic particles (magnetic charges) are real structural components of atoms and substance. It is the magnetic poles, and not the moving electric charges are the direct sources of all magnetic fields and magnetic manifestations in Nature. Basic reasons of ignoring the magnetic fundamental particles by world physical theory, for almost 150 years, are the ultra-harsh confinement of these particles in substance which radically is different from the confinement electrons, as well as the vicious concept of the electric magnetism Maxwell. Rotating magnetic dipoles in conductors which are untwisted by electric current, are direct sources of the vortex magnetic field rot<em><strong>H</strong></em>. One should also expect the formation of a vortex electric field rot<em><strong>E </strong></em>forming by rotating electric dipoles which are untwisted by the current of magnetic charges. This article provides an experimental answer to the question: what field is formed around a conductor if joint direct currents of electric<em> <strong style="white-space:normal;"><em>J</em></strong></em><sub>e</sub> and magnetic<strong><em> J</em></strong><sub>g</sub> charges are passed through it? The author’s experiments have shown that in this case the vortex electromagnetic current is realized which manifests itself as the vortex electromagnetic (gravitational) field. It is possible to implement such a process, according to the results of the author’s research, exclusively in superconductors. The vector character of the gravitational field is in many respects similar to the vortex magnetic field which makes it possible to introduce such it states as paragravitation and ferrogravitation into representations. To create joint currents of electric and magnetic charges, the author used the inertial forces of these particl
文摘Microwave is an electromagnetic wave and consists of the electric and the magnetic fields.The microwave electric field interacts with dielectric materials and heat is generated due to the dielectric loss,which is a major mechanism of microwave heating of water.Microwave magnetic field interaction with materials has to be discussed in terms of two different mechanisms.The first class is the induction current generation in(mainly)metallic materials, which gives rise the Joule heat,although the penetration distance into metals are limited within a microns or less.In this article,a characteristic application of microwave induction heating of metal thin film is presented.The second class is the microwave interaction with the ferro(or ferri)magnetic materials.Effect of ferromagnetic resonance(FMR)is taken into consideration as the fundamental heating mechanism of the ferro-magnetic materials.The FMR heating behavior of Fe_3O_4 is presented.Discussion is made for the phenomena observed in the experiments.
文摘Redox mechanism of ferrocene, acetylferrocene, ferrocenyl cinnamenyl ketone at a platinum electrode was studied with cyclic voltammetry (CV) and in-situ Fourier transform infrared (FTIR) spectroelectrochemistry. The IR bands in the range of 2000-1000 cm-1 attributed to the stretching and ring vibrations of these materials show the main spectral changes in the processes.
文摘The experimental results of the redox of manganese and ferro ions by manganese bacteria are described. Under the aerobic conditions, the manganese bacteria can oxidate Mn2+ into Mn4+. In the course of the manganese bacteria multiplication, the continual increaes of environmental pH is advantageous to the oxidation of manganese and the rise of environmental temperature helps the bacteria to speed the oxidation of manganese ions. The manganese bacteria can fastly oxidate Fe2+ in the culture containing low vaient ferro into Fe3+, its oxidation speed being faster than that of manganese oxide. Under the anaerobic conditions,the manganese bacteria can reduce high valent ferro in solutioninto low valent ferro and distinctly lower the environmental pH.
文摘The ferro resonance caused by an electromagnetic potential transformer is a frequently occurring internal overvoltage in the power distribution network, and it threatens the safe operation of the network. Fast and accurate detection is the prerequisite for suppression and elimination of ferro resonance. Wavelet transform provides a powerful tool for analysis of nonstationary signals. This paper applies wavelet transform to detect ferro resonance. Analysis results show that it makes extraction of failure information accurate, and fast algorithm makes detection real time.
文摘Experimental and theoretical studies of the author (period: 1968-present) have shown that true sources of </span><span style="font-family:"">the </span><span style="font-family:"">magnetic field are magnetic fundamental particles (magnetic charges), and not moving electrons. The main reason for <span>ignoring real magnetic charges, as well as true antielectrons in physical</span> science is the hard conditions for confinement of these particles in atoms and substance</span><span style="font-family:"">s</span><span style="font-family:"">, which </span><span style="font-family:"">is </span><span style="font-family:"">radically different from the confinement of electrons. Magnetic charges together with electric charges form the shells atoms which are <span>electromagnetic, and not electronic. Namely</span></span><span style="font-family:"">,</span><span style="font-family:""> electromagnetic shells are</span><span style="font-family:""> sources of gravitational field which is </span><span style="font-family:"">a </span><span style="font-family:"">vortex electromagnetic field and de<span>scribed by the vortex</span></span><span style="font-family:""> rot [<i>E</i> - <i>H</i>]</span><span style="font-family:"">. Depending on the state polarization o</span><span style="font-family:"">f vortex vectors </span><span style="font-family:"">rot [<i>E</i> - <i>H</i>]</span><span style="font-family:""> in compositions of atomic gravitational fields it </span><span style="font-family:"">is </span><span style="font-family:"">subdivided into paragravitational (PGF) and ferrogravitational fields </span><span style="font-family:"">(FGF). The overwhelming number of atoms emits PGF. Between the masses (bodies, atoms, nucleons and others) emitting PGF areas of negative gravitational “Dark Energy” are realized the forces of which press the masses towards each other. Namely</span><span style="font-family:"">,</span><span style="font-family:""> the compression of atoms by the forces of paragravitational “Dark Energy” underlies th
文摘On February 27,the China’s stock index dropped sharply by 9% from the day before,triggering a worldwide slide.Some media called it China Stock Woes.We do notknow if the foreign hot money will stay in Chinese stock now.Some experts thoughtthe woes were caused by high growth in 2006.In a word,as discussed in CCR’sFebruary 6th issue,China’s stock market is linked with stocks worldwide more
文摘Affected by the export tax rise, China’s tungsten export price rose by about 40 per cent in the first 10 months of 2006. The average price of Ammonium Paratungstate (APT) was US＄23,000/MT, up by 43.5 per cent year-on-year, and that of ferro-tungsten, blue tungsten oxide as well as yellow oxide also increased by 32.4 per cent to US＄24,000/MT, 27.4 per cent to US＄25,000/MT and 42.6 per cent to US＄26,000/MT respectively.
文摘Since the beginning of this year,China’s exportof ferro-molybdenum has increased by someconsiderable amount,leading to uncontrolledmining of the molybdenum resources. Customsstatistics show that in the first half of this year,along with the price increase of ferro-molybdenum on the international market,China’s export of ferro-molybdenum grew by13.7 per cent year on year to 17,885 tons withthe trade volume reaching US$239,000,000,upby 1.5 times.Among the total export,Liaoningprovince became the largest exporter of ferro-molybdenum with 11,829 tons and a value ofUS$162,000,000, up by 48.7 per cent and 2.
文摘Some authors have studied a series of (Pd0.9965 Fe0.0035)1-xMnx alloys which exhibit distinctly different magnetic properties depending upon the Mn concentration x. It is attributed to the competing interaction in magnetic systems, In general, for a large number of alloy systems with mixed ferro-antiferromagnetic interactions, the competition leads to a diversity of magnetic struetures and critical phenomena.
文摘Ferric concretions have been discovered in the surface sediments from the southern part of the Huanghai Sea to the northern part of the East China Sea in June, 1981. Their morphology can be classified into three kinds: gelatins, se-
文摘The single crystal of LiTaO3 is an important ferro-electric crystal, pcssessing comparatively better electro-optic, piezo-electric and thermo-electrio properties. It has been put widely into applications.Using X-ray powder diffraction and neutron diffraction methods, Abraham et al.
文摘China Nonferrous Metal Co.,Ltd.(SZ:000758)announced on August 2nd that the company will form a joint venture named China Nonferrous Metal South Rare Earth(Xinfeng)Co.,Ltd.,partnering
