Ferumoxytol, an iron replacement product, is a new type of superparamagnetic iron oxide ap- proved by the US Food and Drug Administration. Herein, we assessed the feasibility of tracking transplanted human adipose-der...Ferumoxytol, an iron replacement product, is a new type of superparamagnetic iron oxide ap- proved by the US Food and Drug Administration. Herein, we assessed the feasibility of tracking transplanted human adipose-derived stem cells labeled with ferumoxytol in middle cerebral artery occlusion-injured rats by 3.0 T MRI in vivo. 1 × 104 human adipose-derived stem cells labeled with ferumoxytol-heparin-protamine were transplanted into the brains of rats with middle cerebral artery occlusion. Neurologic impairment was scored at 1, 7, 14, and 28 days after transplantation. T2-weighted imaging and enhanced susceptibility-weighted angiography were used to observe transplanted cells. Results of imaging tests were compared with results of Prussian blue staining. The modified neurologic impairment scores were significantly lower in rats transplanted with cells at all time points except I day post-transplantation compared with rats without transplantation. Regions with hypointense signals on T2-weighted and enhanced susceptibility-weighted angiography images corresponded with areas stained by Prussian blue, suggesting the presence of superparamagnetic iron oxide particles within the engrafted cells. Enhanced susceptibility-weighted angiography image exhibited better sensitivity and contrast in tracing ferumoxytol-heparin-protamine-labeled human adipose-derived stem ceils compared with T2-weighted imaging in routine MRI.展开更多
This study describes a novel model of cancer. Cancer is caused, according to this model, by two toxic molecules, COF2 (carbonyl fluoride) and CS2 (carbon disulfide). COF2 acts as a catalyst and produces CS2. CS2 acts ...This study describes a novel model of cancer. Cancer is caused, according to this model, by two toxic molecules, COF2 (carbonyl fluoride) and CS2 (carbon disulfide). COF2 acts as a catalyst and produces CS2. CS2 acts as a catalyst and produces COF2. Hence, the molecules COF2 and CS2 have the ability to reproduce each other, i.e. to create a chain reaction where COF2 and CS2 are multiplied. COF2 and CS2 are toxic. It is proposed that long-term cell exposure to COF2 and CS2 may disturb cell apoptosis and cause uncontrolled cell growth, i.e. cancer. Consequently, cancer is caused by a disease causing mechanism or agent and not by a pathogen. However, cancer can be initiated by e.g. a bacteria or virus that contains the molecules COF2 and CS2, wherein these molecules start a chain reaction producing COF2 and CS2 in the infected area and where the result can be cancer. The study describes why Fe2O3 (iron (III) oxide) may have a therapeutic effect on cancer.展开更多
One of the major elements contributing to anemia in Chronic Kidney Disease (CKD) patients is iron deficiency. Iron supplementation in oral form is often not tolerated and ineffectively absorbed. Intravenous (IV) infus...One of the major elements contributing to anemia in Chronic Kidney Disease (CKD) patients is iron deficiency. Iron supplementation in oral form is often not tolerated and ineffectively absorbed. Intravenous (IV) infusion is time consuming and is inconvenient in Peritoneal Dialysis (PD) patients self-treating at home. A new preparation of iron, ferumoxytol, is a carbohydrate-coated, paramagnetic iron oxide nanoparticle, which can be administered as a bolus intravenous injection, allowing the PD patient to more easily comply with current IV iron dosing regimens. Few studies have been done to evaluate the efficacy of ferumoxytol in PD population. We retrospectively reviewed the medical records of peritoneal dialysis patients who received at least one dose of ferumoxytol between January 2010 and August 2010 and observed that 17 patients showed an improvement in hemoglobin (Hb) to 1 gm/dl within a month of treatment along with a decrease in epoetin dosage in subsequent weeks.展开更多
基金supported by the Science and Technology Plan Project of Dalian City in China,No.2014E14SF186
文摘Ferumoxytol, an iron replacement product, is a new type of superparamagnetic iron oxide ap- proved by the US Food and Drug Administration. Herein, we assessed the feasibility of tracking transplanted human adipose-derived stem cells labeled with ferumoxytol in middle cerebral artery occlusion-injured rats by 3.0 T MRI in vivo. 1 × 104 human adipose-derived stem cells labeled with ferumoxytol-heparin-protamine were transplanted into the brains of rats with middle cerebral artery occlusion. Neurologic impairment was scored at 1, 7, 14, and 28 days after transplantation. T2-weighted imaging and enhanced susceptibility-weighted angiography were used to observe transplanted cells. Results of imaging tests were compared with results of Prussian blue staining. The modified neurologic impairment scores were significantly lower in rats transplanted with cells at all time points except I day post-transplantation compared with rats without transplantation. Regions with hypointense signals on T2-weighted and enhanced susceptibility-weighted angiography images corresponded with areas stained by Prussian blue, suggesting the presence of superparamagnetic iron oxide particles within the engrafted cells. Enhanced susceptibility-weighted angiography image exhibited better sensitivity and contrast in tracing ferumoxytol-heparin-protamine-labeled human adipose-derived stem ceils compared with T2-weighted imaging in routine MRI.
文摘This study describes a novel model of cancer. Cancer is caused, according to this model, by two toxic molecules, COF2 (carbonyl fluoride) and CS2 (carbon disulfide). COF2 acts as a catalyst and produces CS2. CS2 acts as a catalyst and produces COF2. Hence, the molecules COF2 and CS2 have the ability to reproduce each other, i.e. to create a chain reaction where COF2 and CS2 are multiplied. COF2 and CS2 are toxic. It is proposed that long-term cell exposure to COF2 and CS2 may disturb cell apoptosis and cause uncontrolled cell growth, i.e. cancer. Consequently, cancer is caused by a disease causing mechanism or agent and not by a pathogen. However, cancer can be initiated by e.g. a bacteria or virus that contains the molecules COF2 and CS2, wherein these molecules start a chain reaction producing COF2 and CS2 in the infected area and where the result can be cancer. The study describes why Fe2O3 (iron (III) oxide) may have a therapeutic effect on cancer.
文摘One of the major elements contributing to anemia in Chronic Kidney Disease (CKD) patients is iron deficiency. Iron supplementation in oral form is often not tolerated and ineffectively absorbed. Intravenous (IV) infusion is time consuming and is inconvenient in Peritoneal Dialysis (PD) patients self-treating at home. A new preparation of iron, ferumoxytol, is a carbohydrate-coated, paramagnetic iron oxide nanoparticle, which can be administered as a bolus intravenous injection, allowing the PD patient to more easily comply with current IV iron dosing regimens. Few studies have been done to evaluate the efficacy of ferumoxytol in PD population. We retrospectively reviewed the medical records of peritoneal dialysis patients who received at least one dose of ferumoxytol between January 2010 and August 2010 and observed that 17 patients showed an improvement in hemoglobin (Hb) to 1 gm/dl within a month of treatment along with a decrease in epoetin dosage in subsequent weeks.
