An unusual diterpenoid excoagallochaol A （1）, together with epi-β-amyrin （2）, epitaraxerol （3）, epi-a-amyrin （4）, epilupeol （5）, betulin （6）, betulinic acid （7）, lupenone （8）, betulone （9）, betuloni...An unusual diterpenoid excoagallochaol A （1）, together with epi-β-amyrin （2）, epitaraxerol （3）, epi-a-amyrin （4）, epilupeol （5）, betulin （6）, betulinic acid （7）, lupenone （8）, betulone （9）, betulonic acid （10）, （9Z,12Z,15Z）-2,3-dihydroxypropyl octadecatrienoate （11）, and （9Z,12Z）-2,3-dihydroxypropyl octadecadienoate （12）were isolated from the stems of Excoecaria agallocha L. Their structures were elucidated by spectroscopic analyses, and the absolute stereochemistry of 1 was assigned using Mosher method. Compounds 4, 8, 10-12 were isolated from the genus Excoecaria for the first time.展开更多
A new ent-isopimarane diterpenoid,Agallochaone A（1）,together with the known 8,13-epoxy-14-labden-3-one（2）and Excoecarin B（3）were isolated from the whole plant of mangrove Excoecaria agallocha L.and identified on...A new ent-isopimarane diterpenoid,Agallochaone A（1）,together with the known 8,13-epoxy-14-labden-3-one（2）and Excoecarin B（3）were isolated from the whole plant of mangrove Excoecaria agallocha L.and identified on the basis of a detailed spectral analysis,including 2D NMR spectrometry and HRESI-MS.展开更多
[Objectives]To study the anti-inflammatory effects of water extract and ethanol extract from Excoecaria cochinchinensis Lour.[Methods]The acute and chronic inflammation models of mouse paw edema induced by cotton ball...[Objectives]To study the anti-inflammatory effects of water extract and ethanol extract from Excoecaria cochinchinensis Lour.[Methods]The acute and chronic inflammation models of mouse paw edema induced by cotton ball granuloma and carrageenan were established respectively,and the anti-inflammatory effects of water and ethanol extract from E.cochinchinensis Lour.on acute and chronic inflammation in mice were evaluated.The experimental mice were equally divided into three groups of high,medium and low dose of E.cochinchinensis Lour.(60,40 and 20 g/kg),dexamethasone(0.006 g/kg)group and blank group(distilled water).In the cotton ball granuloma test in mice,the mice were given intragastric administration continuously for 7 d after cotton ball implantation.In the experiment of inflammation induced by carrageenan,the mice in each group were given intragastric administration once a day for 7 d,and the inflammatory model was made after the last administration.[Results]The granuloma inhibition rates of mice in the high,medium and low dose groups of water extract and ethanol extract from E.cochinchinensis Lour were significantly lower than those in the blank group(P<0.05).The degree of paw edema in each dose group of water and ethanol extract from E.cochinchinensis Lour.was significantly lower than that in the blank group(P<0.05).[Conclusions]The water and ethanol extracts from E.cochinchinensis Lour.had significant anti-inflammatory effects.展开更多
We evaluated the effects of Ralstonia solanacearum (Rs) induced biotic stress in three mangroves, viz., Avicennia officinalis, Derris trifoliata and Excoecaria agallocha. These plants were grown in pots as well as hyd...We evaluated the effects of Ralstonia solanacearum (Rs) induced biotic stress in three mangroves, viz., Avicennia officinalis, Derris trifoliata and Excoecaria agallocha. These plants were grown in pots as well as hydroponic systems with sufficient controls, and about 8 × 104 colony forming units of Rs suspension was injected into the healthy test plants (saplings). The plants were subjected to biochemical and isozyme analyses. Upon induction of Rs stress, highly significant (p 0.01) biochemical changes (%) were noticed in respect to controls: carbohydrate content was generally high (24-36) in all plants;hydroponic mangroves showed higher starch content, mangroves under hydroponic system showed increased reducing sugars (29-46), almost all mangroves showed increased protein content;phenolics showed a swing of decrease or increase between plants grown in pot and hydroponic systems;and all plants in general showed higher proline content. Regarding oxidative stress isozymes (OSE) and superoxide dismutase (EC1.15.1.1), mangroves showed 1 or 2 additional isozymes with comparable relative mobility;similarly 1 or 2 additional peroxidase (EC1.11.1.7) isozymes were found in mangroves grown under hydroponic system. Briefly, Rs induced biotic stress did not cause any wilt symptom in all the 3 mangroves tested, but their normal biochemical and OSE patterns, especially of those grown as hydroponics were elicited to significantly higher levels.展开更多
Chemical examination of a Chinese mangrove plant Excoecaria agallocha L.led to the isolations of a new glucoside named l-（3,5-dimethoxy-4-hydroxybenzyl）-6-O-galloyl-l-O-β-D-glucopyranoside（1）,together with 10 kno...Chemical examination of a Chinese mangrove plant Excoecaria agallocha L.led to the isolations of a new glucoside named l-（3,5-dimethoxy-4-hydroxybenzyl）-6-O-galloyl-l-O-β-D-glucopyranoside（1）,together with 10 known glycosides including 3,5-dimethoxy-4-hydroxybenzyl-l-O-β-D-glucopyranoside（2）,hydrangeifolin I（3）,（2-methoxy-5-hydroxymethyl-phenyl） -l-O-β-D-（6-Ogalloyl） glucopyranoside（4）,（3,5-dimethoxy-4-hydroxyphenyl）-l-O-β-D-（6-O-galloyl） glucopyranoside （5）,3-methoxy-4-hydroxyphenyl l-O-β-D-（6-O-galloyl） glucopyranoside（6）,3,4,5-trimethoxyphenyl-（6-O-galloyl）-O-β-D-glucopyranoside （7）,koaburaside（8）,koaburaside monomethyl ether（9）,cuneatasides D（10）,and（？）-isosyringin（11）.Their structures were determined through the extensive spectroscopic analysis and comparison with the reported data in literature. Compounds 2-6,8-11 were isolated from the genus Excoecaria for the first time.展开更多
文摘An unusual diterpenoid excoagallochaol A （1）, together with epi-β-amyrin （2）, epitaraxerol （3）, epi-a-amyrin （4）, epilupeol （5）, betulin （6）, betulinic acid （7）, lupenone （8）, betulone （9）, betulonic acid （10）, （9Z,12Z,15Z）-2,3-dihydroxypropyl octadecatrienoate （11）, and （9Z,12Z）-2,3-dihydroxypropyl octadecadienoate （12）were isolated from the stems of Excoecaria agallocha L. Their structures were elucidated by spectroscopic analyses, and the absolute stereochemistry of 1 was assigned using Mosher method. Compounds 4, 8, 10-12 were isolated from the genus Excoecaria for the first time.
基金Supported by the Germany Federal Ministry for Education and Research and Technology(Nos.BMBF0312849A,CHN02/323and CHN02/322).
文摘A new ent-isopimarane diterpenoid,Agallochaone A（1）,together with the known 8,13-epoxy-14-labden-3-one（2）and Excoecarin B（3）were isolated from the whole plant of mangrove Excoecaria agallocha L.and identified on the basis of a detailed spectral analysis,including 2D NMR spectrometry and HRESI-MS.
基金Supported by National Natural Science Foundation(81360524)First Scientific Research Project of High-level Talents in the Affiliated Hospital of Youjiang Medical University for Nationalities in 2019(Y20196311)+3 种基金2019 Project of Improving the Basic Scientific Research Ability of Young Teachers in Guangxi Colleges and Universities(2019KY0341)2019 Youth Fund Project of Guangxi University of Chinese Medicine(2019QN036)School-level Scientific Research Project of Youjiang Medical University for Nationalities(YY2018KY018)Laboratory for Chemical and Quality Analysis of Traditional Chinese(Zhuang)Medicine,Third-level Scientific Research Laboratory of the State Administration of Traditional Chinese Medicine(Guo Zhong Yi Yao Fa200921).
文摘[Objectives]To study the anti-inflammatory effects of water extract and ethanol extract from Excoecaria cochinchinensis Lour.[Methods]The acute and chronic inflammation models of mouse paw edema induced by cotton ball granuloma and carrageenan were established respectively,and the anti-inflammatory effects of water and ethanol extract from E.cochinchinensis Lour.on acute and chronic inflammation in mice were evaluated.The experimental mice were equally divided into three groups of high,medium and low dose of E.cochinchinensis Lour.(60,40 and 20 g/kg),dexamethasone(0.006 g/kg)group and blank group(distilled water).In the cotton ball granuloma test in mice,the mice were given intragastric administration continuously for 7 d after cotton ball implantation.In the experiment of inflammation induced by carrageenan,the mice in each group were given intragastric administration once a day for 7 d,and the inflammatory model was made after the last administration.[Results]The granuloma inhibition rates of mice in the high,medium and low dose groups of water extract and ethanol extract from E.cochinchinensis Lour were significantly lower than those in the blank group(P<0.05).The degree of paw edema in each dose group of water and ethanol extract from E.cochinchinensis Lour.was significantly lower than that in the blank group(P<0.05).[Conclusions]The water and ethanol extracts from E.cochinchinensis Lour.had significant anti-inflammatory effects.
文摘We evaluated the effects of Ralstonia solanacearum (Rs) induced biotic stress in three mangroves, viz., Avicennia officinalis, Derris trifoliata and Excoecaria agallocha. These plants were grown in pots as well as hydroponic systems with sufficient controls, and about 8 × 104 colony forming units of Rs suspension was injected into the healthy test plants (saplings). The plants were subjected to biochemical and isozyme analyses. Upon induction of Rs stress, highly significant (p 0.01) biochemical changes (%) were noticed in respect to controls: carbohydrate content was generally high (24-36) in all plants;hydroponic mangroves showed higher starch content, mangroves under hydroponic system showed increased reducing sugars (29-46), almost all mangroves showed increased protein content;phenolics showed a swing of decrease or increase between plants grown in pot and hydroponic systems;and all plants in general showed higher proline content. Regarding oxidative stress isozymes (OSE) and superoxide dismutase (EC1.15.1.1), mangroves showed 1 or 2 additional isozymes with comparable relative mobility;similarly 1 or 2 additional peroxidase (EC1.11.1.7) isozymes were found in mangroves grown under hydroponic system. Briefly, Rs induced biotic stress did not cause any wilt symptom in all the 3 mangroves tested, but their normal biochemical and OSE patterns, especially of those grown as hydroponics were elicited to significantly higher levels.
文摘Chemical examination of a Chinese mangrove plant Excoecaria agallocha L.led to the isolations of a new glucoside named l-（3,5-dimethoxy-4-hydroxybenzyl）-6-O-galloyl-l-O-β-D-glucopyranoside（1）,together with 10 known glycosides including 3,5-dimethoxy-4-hydroxybenzyl-l-O-β-D-glucopyranoside（2）,hydrangeifolin I（3）,（2-methoxy-5-hydroxymethyl-phenyl） -l-O-β-D-（6-Ogalloyl） glucopyranoside（4）,（3,5-dimethoxy-4-hydroxyphenyl）-l-O-β-D-（6-O-galloyl） glucopyranoside （5）,3-methoxy-4-hydroxyphenyl l-O-β-D-（6-O-galloyl） glucopyranoside（6）,3,4,5-trimethoxyphenyl-（6-O-galloyl）-O-β-D-glucopyranoside （7）,koaburaside（8）,koaburaside monomethyl ether（9）,cuneatasides D（10）,and（？）-isosyringin（11）.Their structures were determined through the extensive spectroscopic analysis and comparison with the reported data in literature. Compounds 2-6,8-11 were isolated from the genus Excoecaria for the first time.
