Inflammatory bowel diseases(IBD), including ulcerative colitis and Crohn's disease are chronic, life-long, and relapsing diseases of the gastrointestinal tract. Currently, there are no complete cure possibilities,...Inflammatory bowel diseases(IBD), including ulcerative colitis and Crohn's disease are chronic, life-long, and relapsing diseases of the gastrointestinal tract. Currently, there are no complete cure possibilities, but combined pharmacological and nutritional therapy may induce remission of the disease. Malnutrition and specific nutritional deficiencies are frequent among IBD patients, so the majority of them need nutritional treatment, which not only improves the state of nutrition of the patients but has strong anti-inflammatory activity as well. Moreover, some nutrients, from early stages of life are suspected as triggering factors in the etiopathogenesis of IBD. Both parenteral and enteral nutrition is used in IBD therapy, but their practical utility in different populations and in different countries is not clearly established, and there are sometimes conflicting theories concerning the role of nutrition in IBD. This review presents the actual data from research studies on the influence of nutrition on the etiopathogenesis of IBD and the latest findings regarding its mechanisms of action. The use of both parenteral and enteral nutrition as therapeutic methods in induction and maintenance therapy in IBD treatment is also extensively discussed. Comparison of the latest research data, scientific theories concerning the role of nutrition in IBD, and different opinions about them are also presented and discussed. Additionally, some potential future perspectives for nutritional therapy are highlighted.展开更多
Exclusive enteral nutrition(EEN)is well-established as a first line therapy instead of corticosteroid(CS)therapy to treat active Crohn’s disease(CD)in children.It also has been shown to have benefits over and above i...Exclusive enteral nutrition(EEN)is well-established as a first line therapy instead of corticosteroid(CS)therapy to treat active Crohn’s disease(CD)in children.It also has been shown to have benefits over and above induction of disease remission in paediatric populations.However,other than in Japanese populations,this intervention is not routinely utilised in adults.To investigate potential reasons for variation in response between adult studies of EEN and CS therapy.The Ovid database was searched over a 6-mo period.Articles directly comparing EEN and CS therapy in adults were included.Eleven articles were identified.EEN therapy remission rates varied considerably.Poor compliance with EEN therapy due to unpalatable formula was an issue in half of the studies.Remission rates of studies that only included patients with previously untreated/new CD were higher than studies including patients with both existing and new disease.There was limited evidence to determine if disease location,duration of disease or age of diagnosis affected EEN therapy outcomes.There is some evidence to support the use of EEN as a treatment option for a select group of adults,namely those motivated to adhere to an EEN regimen and possibly those newly diagnosed with CD.In addition,the use of more palatable formulas could improve treatment compliance.展开更多
目的系统分析克罗恩病患儿经全肠内营养诱导缓解后进行食物重新引入的相关研究,识别食物重新引入的具体内容和结局指标,为医护人员开展相关研究或干预提供参考。方法采用范围综述方法,系统检索中国生物医学文献数据库、中国知网、万方...目的系统分析克罗恩病患儿经全肠内营养诱导缓解后进行食物重新引入的相关研究,识别食物重新引入的具体内容和结局指标,为医护人员开展相关研究或干预提供参考。方法采用范围综述方法,系统检索中国生物医学文献数据库、中国知网、万方数据库、维普数据库、JBI循证卫生保健中心数据库、Cochrane Library、BMJ Best Practice、Web of Science、PubMed、Embase、CINAHL Complete等国内外数据库,检索时限为建库至2022年11月。对纳入文献进行筛选、汇总和分析。结果最终纳入21篇文献,从食物重新引入方法(开始时间、维持时间、饮食类型、速度和频率、肠内营养停止情况)和结局评价(评价指标和评价时间)两大方面进行了归纳。结论克罗恩病患儿食物重新引入方案存在较大差异,未来研究应注重探究最佳的食物重新引入策略,制订规范的评价标准,为克罗恩病患儿制订科学和有效的食物重新引入方案。展开更多
文摘Inflammatory bowel diseases(IBD), including ulcerative colitis and Crohn's disease are chronic, life-long, and relapsing diseases of the gastrointestinal tract. Currently, there are no complete cure possibilities, but combined pharmacological and nutritional therapy may induce remission of the disease. Malnutrition and specific nutritional deficiencies are frequent among IBD patients, so the majority of them need nutritional treatment, which not only improves the state of nutrition of the patients but has strong anti-inflammatory activity as well. Moreover, some nutrients, from early stages of life are suspected as triggering factors in the etiopathogenesis of IBD. Both parenteral and enteral nutrition is used in IBD therapy, but their practical utility in different populations and in different countries is not clearly established, and there are sometimes conflicting theories concerning the role of nutrition in IBD. This review presents the actual data from research studies on the influence of nutrition on the etiopathogenesis of IBD and the latest findings regarding its mechanisms of action. The use of both parenteral and enteral nutrition as therapeutic methods in induction and maintenance therapy in IBD treatment is also extensively discussed. Comparison of the latest research data, scientific theories concerning the role of nutrition in IBD, and different opinions about them are also presented and discussed. Additionally, some potential future perspectives for nutritional therapy are highlighted.
文摘Exclusive enteral nutrition(EEN)is well-established as a first line therapy instead of corticosteroid(CS)therapy to treat active Crohn’s disease(CD)in children.It also has been shown to have benefits over and above induction of disease remission in paediatric populations.However,other than in Japanese populations,this intervention is not routinely utilised in adults.To investigate potential reasons for variation in response between adult studies of EEN and CS therapy.The Ovid database was searched over a 6-mo period.Articles directly comparing EEN and CS therapy in adults were included.Eleven articles were identified.EEN therapy remission rates varied considerably.Poor compliance with EEN therapy due to unpalatable formula was an issue in half of the studies.Remission rates of studies that only included patients with previously untreated/new CD were higher than studies including patients with both existing and new disease.There was limited evidence to determine if disease location,duration of disease or age of diagnosis affected EEN therapy outcomes.There is some evidence to support the use of EEN as a treatment option for a select group of adults,namely those motivated to adhere to an EEN regimen and possibly those newly diagnosed with CD.In addition,the use of more palatable formulas could improve treatment compliance.
文摘目的系统分析克罗恩病患儿经全肠内营养诱导缓解后进行食物重新引入的相关研究,识别食物重新引入的具体内容和结局指标,为医护人员开展相关研究或干预提供参考。方法采用范围综述方法,系统检索中国生物医学文献数据库、中国知网、万方数据库、维普数据库、JBI循证卫生保健中心数据库、Cochrane Library、BMJ Best Practice、Web of Science、PubMed、Embase、CINAHL Complete等国内外数据库,检索时限为建库至2022年11月。对纳入文献进行筛选、汇总和分析。结果最终纳入21篇文献,从食物重新引入方法(开始时间、维持时间、饮食类型、速度和频率、肠内营养停止情况)和结局评价(评价指标和评价时间)两大方面进行了归纳。结论克罗恩病患儿食物重新引入方案存在较大差异,未来研究应注重探究最佳的食物重新引入策略,制订规范的评价标准,为克罗恩病患儿制订科学和有效的食物重新引入方案。
