The endothelium plays a fundamental role in the blood coagulation cascade and at the site of injury is important in the development, and sequela, of atheroma. It is also now firmly established that endothelial cells c...The endothelium plays a fundamental role in the blood coagulation cascade and at the site of injury is important in the development, and sequela, of atheroma. It is also now firmly established that endothelial cells can produce both vasorelaxant and vasoconstrictor factors and thus directly influence vascular tone and blood flow. Prostacyelin and NO are both potent vasodilators, and endothelin is a highly potent 21 amino acid peptide vasoconstrictor, which have all been shown to be展开更多
基金Supported by a joint Canadian Hypertension Society and Medical Research Council Fellowship award (to GJW)an Alberta Heritage Foundation for Medical Research Fellowship award (to DH) and MRC operating grant support to WCC and CRT.
文摘The endothelium plays a fundamental role in the blood coagulation cascade and at the site of injury is important in the development, and sequela, of atheroma. It is also now firmly established that endothelial cells can produce both vasorelaxant and vasoconstrictor factors and thus directly influence vascular tone and blood flow. Prostacyelin and NO are both potent vasodilators, and endothelin is a highly potent 21 amino acid peptide vasoconstrictor, which have all been shown to be
