OBJECTIVE: To observe the effects of Xingnaojing Injection on the function of cranial nerves and the level of ET-1,hs-CRP and TNF-α in elderly patients with acute cerebral infarction. METHODS: A total of 86 elderly p...OBJECTIVE: To observe the effects of Xingnaojing Injection on the function of cranial nerves and the level of ET-1,hs-CRP and TNF-α in elderly patients with acute cerebral infarction. METHODS: A total of 86 elderly patients with acute cerebral infarction were randomly divided into observation group and control group. The 43 cases in the control group were treated by conventional Western medicine, and 43 cases in the observation group were treated by Xingnaojing injection on the basis of the treatment in control group. After 2 weeks' treatment in Xuancheng People's Hospital of Anhui Province, the neurological function(NIHSS score and MMSE score), daily living ability(BI Index score and ADL score),laboratory indicators(hs-CRP, ET-1, TNF-α) of the 2 groups before and after the treatment were observed and compared,the total clinical effectiveness of the 2 groups were compared. RESULTS: The total effective rate was 88.4% in the observation group, which was signi?cantly higher than that in the control group(62.8%)(P < 0.05). The NIHSS scores in the 2 groups were both signi?cantly increased after the treatment(P < 0.05) while the MMSE scores were signi?cantly decreased(P < 0.05) in the 2 groups, and the scores' improvement in the observation group was signi?cantly higher than that in the control group(P < 0.05). The BI score and ADL score were significantly increased in the 2 groups after the treatment(P < 0.05), and the improvements were obvious in the observation group. The levels of ET-1, hs-CRP and TNF-αin the 2 groups were signi?cantly decreased after the treatment(P < 0.05), and the indexes in the observation group were signi?cantly lower than that in the control group(P < 0.05). CONLUSIONS: Xingnaojing injection can reduce the levels of serum ET-1, hs-CRP and TNF-α, as well as the degree of neurological de?cit in the treatment of elderly patients with acute cerebral infarction. It is also helpful for the prognosis and outcomes of patients with cerebral infarction.展开更多
目的观察金芪降糖片对糖尿病大血管并发症患者血管内皮细胞及炎症因子的影响。方法将40例2型糖尿病合并大血管并发症患者随机分为2组。对照组20例,采用西药常规治疗;中药组20例,在西药常规治疗基础上加金芪降糖片8片,每日3次。治疗周期...目的观察金芪降糖片对糖尿病大血管并发症患者血管内皮细胞及炎症因子的影响。方法将40例2型糖尿病合并大血管并发症患者随机分为2组。对照组20例,采用西药常规治疗;中药组20例,在西药常规治疗基础上加金芪降糖片8片,每日3次。治疗周期3个月。观察治疗前后患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、血脂、糖化血红蛋白(HbA1c)、内皮素-1(ET-1)、细胞间黏附分子-1(ICAM-1)、肿瘤坏死因子-α(TNF-α)、P-选择素水平。结果 2组治疗后FBG、2 h PG、HbA1c均明显下降(P<0.05),组间HbA1c差异有统计学意义(P<0.05)。中药组治疗后三酰甘油、低密度脂蛋白胆固醇明显下降,高密度脂蛋白胆固醇明显上升,与对照组比较差异有统计学意义(P<0.05)。中药组治疗后ET-1、ICAM-1、TNF-α、P-选择素水平明显下降,较对照组差异有统计学意义(P<0.01)。结论金芪降糖片具有显著的降糖作用,改善糖尿病的脂代谢紊乱,可以减轻血管内皮细胞的损伤和抑制炎症因子水平。展开更多
文摘OBJECTIVE: To observe the effects of Xingnaojing Injection on the function of cranial nerves and the level of ET-1,hs-CRP and TNF-α in elderly patients with acute cerebral infarction. METHODS: A total of 86 elderly patients with acute cerebral infarction were randomly divided into observation group and control group. The 43 cases in the control group were treated by conventional Western medicine, and 43 cases in the observation group were treated by Xingnaojing injection on the basis of the treatment in control group. After 2 weeks' treatment in Xuancheng People's Hospital of Anhui Province, the neurological function(NIHSS score and MMSE score), daily living ability(BI Index score and ADL score),laboratory indicators(hs-CRP, ET-1, TNF-α) of the 2 groups before and after the treatment were observed and compared,the total clinical effectiveness of the 2 groups were compared. RESULTS: The total effective rate was 88.4% in the observation group, which was signi?cantly higher than that in the control group(62.8%)(P < 0.05). The NIHSS scores in the 2 groups were both signi?cantly increased after the treatment(P < 0.05) while the MMSE scores were signi?cantly decreased(P < 0.05) in the 2 groups, and the scores' improvement in the observation group was signi?cantly higher than that in the control group(P < 0.05). The BI score and ADL score were significantly increased in the 2 groups after the treatment(P < 0.05), and the improvements were obvious in the observation group. The levels of ET-1, hs-CRP and TNF-αin the 2 groups were signi?cantly decreased after the treatment(P < 0.05), and the indexes in the observation group were signi?cantly lower than that in the control group(P < 0.05). CONLUSIONS: Xingnaojing injection can reduce the levels of serum ET-1, hs-CRP and TNF-α, as well as the degree of neurological de?cit in the treatment of elderly patients with acute cerebral infarction. It is also helpful for the prognosis and outcomes of patients with cerebral infarction.
文摘目的观察金芪降糖片对糖尿病大血管并发症患者血管内皮细胞及炎症因子的影响。方法将40例2型糖尿病合并大血管并发症患者随机分为2组。对照组20例,采用西药常规治疗;中药组20例,在西药常规治疗基础上加金芪降糖片8片,每日3次。治疗周期3个月。观察治疗前后患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、血脂、糖化血红蛋白(HbA1c)、内皮素-1(ET-1)、细胞间黏附分子-1(ICAM-1)、肿瘤坏死因子-α(TNF-α)、P-选择素水平。结果 2组治疗后FBG、2 h PG、HbA1c均明显下降(P<0.05),组间HbA1c差异有统计学意义(P<0.05)。中药组治疗后三酰甘油、低密度脂蛋白胆固醇明显下降,高密度脂蛋白胆固醇明显上升,与对照组比较差异有统计学意义(P<0.05)。中药组治疗后ET-1、ICAM-1、TNF-α、P-选择素水平明显下降,较对照组差异有统计学意义(P<0.01)。结论金芪降糖片具有显著的降糖作用,改善糖尿病的脂代谢紊乱,可以减轻血管内皮细胞的损伤和抑制炎症因子水平。
