A biofilm refers to a group of organized bacteria attached to the surface of living or inanimate objects and surrounded by some macromolecules. It is rich in organic components such as polysaccharides,peptides and pho...A biofilm refers to a group of organized bacteria attached to the surface of living or inanimate objects and surrounded by some macromolecules. It is rich in organic components such as polysaccharides,peptides and phospholipids,greatly increases the resistance of bacteria to antibacterial drugs,and can cause infections in humans and animals. At present,the measure to prevent the infections is to prevent microbial colonies from adhering to the surface of the objects,which will help to improve the therapeutic effect of clinically serious infectious diseases. In addition,the identification and inhibition of biofilm formation genes is also an important research direction to control such infections. In this paper,molecular mechanisms of bacterial biofilm resistance to drugs that has caused widespread concern were summarized.展开更多
基金Supported by Natural Science Foundation of Tianjin City(07JCYBJC16000)Project for Key Technology Integration and Enhancement of Students’Comprehensive Ability of Affiliated Animal Hospital of Tianjin Agricultural University(ZH004901)
文摘A biofilm refers to a group of organized bacteria attached to the surface of living or inanimate objects and surrounded by some macromolecules. It is rich in organic components such as polysaccharides,peptides and phospholipids,greatly increases the resistance of bacteria to antibacterial drugs,and can cause infections in humans and animals. At present,the measure to prevent the infections is to prevent microbial colonies from adhering to the surface of the objects,which will help to improve the therapeutic effect of clinically serious infectious diseases. In addition,the identification and inhibition of biofilm formation genes is also an important research direction to control such infections. In this paper,molecular mechanisms of bacterial biofilm resistance to drugs that has caused widespread concern were summarized.
