Background:Endolymphatic sac tumor(ELST)is one of neuroectodermal tumor which arising from endolymphatic sac and duct.It is actually quite rare,with less than 200 cases reported.Although ELST presents benign appearanc...Background:Endolymphatic sac tumor(ELST)is one of neuroectodermal tumor which arising from endolymphatic sac and duct.It is actually quite rare,with less than 200 cases reported.Although ELST presents benign appearance in histopathology,it can present aggressive destructive behavior in clinical.The cornerstone of treatment for ELST is complete surgical excision.However,it is almost impossible to completely resect the advanced stage tumor.There is still controversy about other treatments,such as radiotherapy and gamma knife surgery.Case presentation:A 47-year-old man was admitted in The First Affiliated Hospital of Fujian Medical University with a 7-year history of progressive hearing loss and near 6-month repeated attacks of headache.Preoperative CT revealed a massive intracranial lesion and associated hydrocephalus.MR scanning demonstrated a 7.2 cm×4.6 cm×4.2 cm bulky mass located in left-sided posterior cranial fossa and temporo-occipital region which showed hyperintensity on T1-weighted images and mixed signal intensity on T2-weighted images.There was no neither clinical manifestation nor family history of Von Hippel–Lindau syndrome(VHL).Due to the mass that was large and invading the bone of skull base,it was difficult to extirpate surgically,so the ventriculoperitoneal shunt combined with local biopsy was performed.The postoperative pathology and immunohistochemical findings confirmed the lesion was an endolymphatic sac tumor.After operation,the patient regularly received radiotherapy.Conclusion:The widely accepted management of ELST is complete surgical resection.However,it is difficult for surgeons to achieve radical resection with late-stage ELST.Currently,there is much dispute about the role of radiotherapy for the management of ELST in academic circles.In this case where the mass cannot be surgical removed,radiotherapy has the curative effect for ELST in terms of disease control and quality of life.展开更多
In China’s asteroid mission to be launched around 2025,(7968)133 P/Elst-Pizarro(hereafter 133 P)will be the second target,after a visit to asteroid(469219)Kamo’oalewa.This paper describes a simulation of precise orb...In China’s asteroid mission to be launched around 2025,(7968)133 P/Elst-Pizarro(hereafter 133 P)will be the second target,after a visit to asteroid(469219)Kamo’oalewa.This paper describes a simulation of precise orbit determination for the spacecraft around comet 133 P,as well as estimation of its gravitational parameter(GM)value and the solar radiation pressure coefficient Cr for the spacecraft.Different cometocentric distances of 200,150 and 100 km orbits are considered,as well as two tracking modes:exclusive two-way range-rate mode(Earth station to spacecraft)and combinations of two-way range-rate and local spacecraft onboard ranging to the comet.Compared to exclusive two-way range-rate,the introduction of local ranging observables improves the final GM uncertainties by up to one order of magnitude.An ephemeris error in the orbit of 133 P is also considered,and we show that,to obtain a reliable estimate of the GM for 133 P,this error cannot exceed a one km range.展开更多
文摘Background:Endolymphatic sac tumor(ELST)is one of neuroectodermal tumor which arising from endolymphatic sac and duct.It is actually quite rare,with less than 200 cases reported.Although ELST presents benign appearance in histopathology,it can present aggressive destructive behavior in clinical.The cornerstone of treatment for ELST is complete surgical excision.However,it is almost impossible to completely resect the advanced stage tumor.There is still controversy about other treatments,such as radiotherapy and gamma knife surgery.Case presentation:A 47-year-old man was admitted in The First Affiliated Hospital of Fujian Medical University with a 7-year history of progressive hearing loss and near 6-month repeated attacks of headache.Preoperative CT revealed a massive intracranial lesion and associated hydrocephalus.MR scanning demonstrated a 7.2 cm×4.6 cm×4.2 cm bulky mass located in left-sided posterior cranial fossa and temporo-occipital region which showed hyperintensity on T1-weighted images and mixed signal intensity on T2-weighted images.There was no neither clinical manifestation nor family history of Von Hippel–Lindau syndrome(VHL).Due to the mass that was large and invading the bone of skull base,it was difficult to extirpate surgically,so the ventriculoperitoneal shunt combined with local biopsy was performed.The postoperative pathology and immunohistochemical findings confirmed the lesion was an endolymphatic sac tumor.After operation,the patient regularly received radiotherapy.Conclusion:The widely accepted management of ELST is complete surgical resection.However,it is difficult for surgeons to achieve radical resection with late-stage ELST.Currently,there is much dispute about the role of radiotherapy for the management of ELST in academic circles.In this case where the mass cannot be surgical removed,radiotherapy has the curative effect for ELST in terms of disease control and quality of life.
基金the National Natural Science Foundation of China(U1831132 and 41874010)Innovation Group of Natural Fund of Hubei Province(2018CFA087)supported by a DAR fund in planetology from the French Space Agency(CNES)。
文摘In China’s asteroid mission to be launched around 2025,(7968)133 P/Elst-Pizarro(hereafter 133 P)will be the second target,after a visit to asteroid(469219)Kamo’oalewa.This paper describes a simulation of precise orbit determination for the spacecraft around comet 133 P,as well as estimation of its gravitational parameter(GM)value and the solar radiation pressure coefficient Cr for the spacecraft.Different cometocentric distances of 200,150 and 100 km orbits are considered,as well as two tracking modes:exclusive two-way range-rate mode(Earth station to spacecraft)and combinations of two-way range-rate and local spacecraft onboard ranging to the comet.Compared to exclusive two-way range-rate,the introduction of local ranging observables improves the final GM uncertainties by up to one order of magnitude.An ephemeris error in the orbit of 133 P is also considered,and we show that,to obtain a reliable estimate of the GM for 133 P,this error cannot exceed a one km range.
