Background: To evaluate bone-mineral-density-BMD determined by dual-energy X-ray absorptiometry-DEXA and bone turnover markers in chronic-kidney-disease-CKD patients. Method: An observational-clinical study of all pat...Background: To evaluate bone-mineral-density-BMD determined by dual-energy X-ray absorptiometry-DEXA and bone turnover markers in chronic-kidney-disease-CKD patients. Method: An observational-clinical study of all patients who were scanned by DEXA-scan in 2018. All patients with low-bone-density or osteoporosis-based on World-Health-Organization-WHO definition were included. Results: 505 patients with abnormal-BMD, 87.3% were in early-stage CKD-stage I - II, 8.5% were in CKD-stage III - V and 4.2% did not have renal tests. 95 (18.8%) were male with a mean age of 57.0 years and 410 (81.2%) were females with a mean age of 55.8 years. Patients of ≥65 years had lower T-score than those who were younger than 65 years-old. Among CKD patients, those with late-CKD (stage III - V) had less BMD-measurements and lower T-score than those with early-CKD (stage I - II). A significant positive correlation exists between parathyroid hormone-PTH-level and the lower T-score. Female had a worse T-score at the lumbar-region whereas male had a worse T-score at the femoral-region. There was no significant difference between males and females for the T-score at hip-region. Conclusion: We observed a distribution of abnormal BMD among different age, sex and CKD groups. Measurements of BMD by DEXA might be a useful test to diagnose osteoporosis in CKD patients. Femoral and total hip areas were more affected, however DEXA might not be able to detect osteoporosis in the lumbar area of CKD patients. T-scores are lower in patients with more severe CKD and lower in elderly patients. PTH level is associated proportionally to the degree of bone loss. Early intervention and proper management must be implemented early among CKD patients with multidisciplinary team approach strategy. More studies are needed to determine if DEXA techniques are enough to distinguish the quantity of bone loss between different stages of CKD.展开更多
目的:探讨70岁以上老年骨质疏松症(osteoporsis,OP)用双能X线骨密度仪(dual energy x-ray absorptiometry,DEXA)诊断检查时,测定部位的不同是否造成漏诊。方法:应用DEXA测定了50例70岁以上临床上有明显的骨质疏松症状者(有症状组)以及50...目的:探讨70岁以上老年骨质疏松症(osteoporsis,OP)用双能X线骨密度仪(dual energy x-ray absorptiometry,DEXA)诊断检查时,测定部位的不同是否造成漏诊。方法:应用DEXA测定了50例70岁以上临床上有明显的骨质疏松症状者(有症状组)以及50例70岁以上无临床症状的健康体检者(无症状组),对同一检查对象同时测定腰椎(L2-4)正位及左股骨(total)、股骨颈(neck)的骨密度(bone mineral density,BMD),并比较两组不同部位OP的检出率。结果:50例有症状组腰椎(L2-4)测出OP31例(62%),股骨(total)和股骨颈(neck)共测出OP45例(90%)(t=10.638,P<0.01);,50例无症状组腰椎(L2-4)测出OP20例(40%),股骨(total)和股骨颈(neck)共测出OP38例(76%)(t=13.16,P<0.01);结论:70岁以上老年人临床上无论是否合并明显的OP症状,用DEXA诊断检查时,测定部位的不同可能对OP的诊断有影响,髋部OP检出率高于腰椎,最好是同时测定腰椎和髋部的BMD,以防造成漏诊。展开更多
目的了解昆明12～14岁女性骨密度水平并就影响因素进行分析。方法利用双能X线骨密度测定仪测量昆明市某中学98名12～14岁青少年腰椎及髋部骨密度（Bone Mineral Density，BMD），采用问卷调查形式了解与骨密度相关因素。结果女生腰椎、...目的了解昆明12～14岁女性骨密度水平并就影响因素进行分析。方法利用双能X线骨密度测定仪测量昆明市某中学98名12～14岁青少年腰椎及髋部骨密度（Bone Mineral Density，BMD），采用问卷调查形式了解与骨密度相关因素。结果女生腰椎、股骨颈、大转子骨密度明显高于男生（P〈0．05）；月经初潮年龄早的女生骨密度较高（P〈0．05）。结论青春期（12～14岁）阶段女生骨密度较同年龄段男生高，该年龄段女生骨密度与月经初潮年龄有关。展开更多
文摘Background: To evaluate bone-mineral-density-BMD determined by dual-energy X-ray absorptiometry-DEXA and bone turnover markers in chronic-kidney-disease-CKD patients. Method: An observational-clinical study of all patients who were scanned by DEXA-scan in 2018. All patients with low-bone-density or osteoporosis-based on World-Health-Organization-WHO definition were included. Results: 505 patients with abnormal-BMD, 87.3% were in early-stage CKD-stage I - II, 8.5% were in CKD-stage III - V and 4.2% did not have renal tests. 95 (18.8%) were male with a mean age of 57.0 years and 410 (81.2%) were females with a mean age of 55.8 years. Patients of ≥65 years had lower T-score than those who were younger than 65 years-old. Among CKD patients, those with late-CKD (stage III - V) had less BMD-measurements and lower T-score than those with early-CKD (stage I - II). A significant positive correlation exists between parathyroid hormone-PTH-level and the lower T-score. Female had a worse T-score at the lumbar-region whereas male had a worse T-score at the femoral-region. There was no significant difference between males and females for the T-score at hip-region. Conclusion: We observed a distribution of abnormal BMD among different age, sex and CKD groups. Measurements of BMD by DEXA might be a useful test to diagnose osteoporosis in CKD patients. Femoral and total hip areas were more affected, however DEXA might not be able to detect osteoporosis in the lumbar area of CKD patients. T-scores are lower in patients with more severe CKD and lower in elderly patients. PTH level is associated proportionally to the degree of bone loss. Early intervention and proper management must be implemented early among CKD patients with multidisciplinary team approach strategy. More studies are needed to determine if DEXA techniques are enough to distinguish the quantity of bone loss between different stages of CKD.
文摘目的:探讨70岁以上老年骨质疏松症(osteoporsis,OP)用双能X线骨密度仪(dual energy x-ray absorptiometry,DEXA)诊断检查时,测定部位的不同是否造成漏诊。方法:应用DEXA测定了50例70岁以上临床上有明显的骨质疏松症状者(有症状组)以及50例70岁以上无临床症状的健康体检者(无症状组),对同一检查对象同时测定腰椎(L2-4)正位及左股骨(total)、股骨颈(neck)的骨密度(bone mineral density,BMD),并比较两组不同部位OP的检出率。结果:50例有症状组腰椎(L2-4)测出OP31例(62%),股骨(total)和股骨颈(neck)共测出OP45例(90%)(t=10.638,P<0.01);,50例无症状组腰椎(L2-4)测出OP20例(40%),股骨(total)和股骨颈(neck)共测出OP38例(76%)(t=13.16,P<0.01);结论:70岁以上老年人临床上无论是否合并明显的OP症状,用DEXA诊断检查时,测定部位的不同可能对OP的诊断有影响,髋部OP检出率高于腰椎,最好是同时测定腰椎和髋部的BMD,以防造成漏诊。
文摘目的了解昆明12～14岁女性骨密度水平并就影响因素进行分析。方法利用双能X线骨密度测定仪测量昆明市某中学98名12～14岁青少年腰椎及髋部骨密度（Bone Mineral Density，BMD），采用问卷调查形式了解与骨密度相关因素。结果女生腰椎、股骨颈、大转子骨密度明显高于男生（P〈0．05）；月经初潮年龄早的女生骨密度较高（P〈0．05）。结论青春期（12～14岁）阶段女生骨密度较同年龄段男生高，该年龄段女生骨密度与月经初潮年龄有关。
