Thermal boundary conditions of the turbine disk cavity system are of great importance in the design of secondary air systems in aero-engines.This study aims to investigate the complex heat transfer mechanisms of a rot...Thermal boundary conditions of the turbine disk cavity system are of great importance in the design of secondary air systems in aero-engines.This study aims to investigate the complex heat transfer mechanisms of a rotating turbine disk under high-speed conditions.A high-speed rotating free-disk model with Dorfman empirical solutions is developed to evaluate the heat transfer performance considering various factors.Specifically,the influence of compressibility,variable properties,and heat dissipation is determined using theoretical and numerical analyses.In particular,a novel combined solution method is proposed to simplify the complex heat transfer problem.The results indicate that the heat transfer performance of a free disk is primarily influenced by the rotating Mach number,rotating Reynolds number,Rossby number,and wall temperature ratio.The heat transfer temperature and Nusselt number of the free disk are strongly correlated with the rotating Mach number and rotating Reynolds number.Analysis reveals that heat dissipation is a critical factor affecting the accurate evaluation of the heat transfer performance of the turbine disk.Thus,the combined solution method can serve as a reference for future investigations of flow and heat transfer in high-speed rotating turbine disk cavity systems in aero-engines.展开更多
Rosai Dorfman’s Disease (RDD) Destombes also called sinus histiocytosis with massive lymphadenopathy is a lymphoproliferative pathology usually benign, of unknown etiology, and of low incidence. It is a rare, but wel...Rosai Dorfman’s Disease (RDD) Destombes also called sinus histiocytosis with massive lymphadenopathy is a lymphoproliferative pathology usually benign, of unknown etiology, and of low incidence. It is a rare, but well-defined clinicopathological entity, which predominantly affects children and adolescents without distinction of gender or race. It manifests itself generally by bulky cervical lymphadenopathies, most often bilateral, painless, of benign but persistent evolution and a long-term fever associated with a non-specific biological inflammatory syndrome. Extra lymph node locations are described in association with lymph node involvement or isolation. The definitive diagnosis of Rosai Dorfman’s disease is histological, characterized by histiocytic infiltration with emperipolesis essentially of lymphocytes. The etiopathogenesis of the condition remains unclear, based on infectious and immunological hypotheses without clear evidence. The management is not well codified, it combines depending on the case, surgery;corticosteroids;antimetabolites and interferon alpha. Studies devoted to this condition in tropical Africa are rare. We report the clinical and progressive features of 5 observations of Rosai Dorfman’s disease.展开更多
Rosai Dorfman disease, also known as histiocytosis with massive lymphadenopathy, is a very rare idiopathic disease. It is characterized by over production and accumulation of non Langerhans sinus histiocyte most often...Rosai Dorfman disease, also known as histiocytosis with massive lymphadenopathy, is a very rare idiopathic disease. It is characterized by over production and accumulation of non Langerhans sinus histiocyte most often in lymph nodes, but may occur in other areas leading to organ damage. Based on the research, it can be caused by an infectious agent, immunodeficiency or autoimmunity and genetic causes. Extranodal manifestation is uncommon, however extranodal sites include liver, kidney, respiratory organs, orbit and eyeball. We present a case report of a 44-year-old female with recurrent bilateral orbital infiltration as first location of Rosai Dorfman disease.展开更多
In this paper, we study the relation of the algebraic properties of the higher-order Courant bracket and Dorfman bracket on the direct sum bundle TM⊕∧<sup>p</sup>T*M for an m-dimensional smooth mani...In this paper, we study the relation of the algebraic properties of the higher-order Courant bracket and Dorfman bracket on the direct sum bundle TM⊕∧<sup>p</sup>T*M for an m-dimensional smooth manifold M, and a Lie 2-algebra which is a “categorified” version of a Lie algebra. We prove that the higher-order Courant algebroids give rise to a semistrict Lie 2-algebra, and we prove that the higher-order Dorfman algebroids give rise to a hemistrict Lie 2-algebra. Consequently, there is an isomorphism from the higher-order Courant algebroids to the higher-order Dorfman algebroids as Lie 2-algebras homomorphism.展开更多
早在1966年Azoury[1]发现了一例不寻常的组织细胞增生病例,其镜下特点与组织细胞增生症又有所区别,当时他们把它考虑为＂网状内皮组织细胞增生＂.Rosai和Dorfman[2]于1969年报道了4例具有独特临床和病理特点的病例,最先将其称为＂窦性...早在1966年Azoury[1]发现了一例不寻常的组织细胞增生病例,其镜下特点与组织细胞增生症又有所区别,当时他们把它考虑为＂网状内皮组织细胞增生＂.Rosai和Dorfman[2]于1969年报道了4例具有独特临床和病理特点的病例,最先将其称为＂窦性组织细胞增生伴巨大淋巴结病（sinus histiocytosis with massive lymphoadenopathy）＂,该4例患者皆为儿童,主要临床表现为大块状颈部淋巴结肿大、低热、白细胞增多和高丙种球蛋白血症,淋巴结肿大持续时间虽长,但呈良性经过.展开更多
Rosai-Dorfman disease （RDD）, also known as sinus histiocytosis with massive lymphadenopathy （SHML）, is a rare benign entity of unknown etiology. Extranodal SHML （ESHML） may occur as part of a generalized process...Rosai-Dorfman disease （RDD）, also known as sinus histiocytosis with massive lymphadenopathy （SHML）, is a rare benign entity of unknown etiology. Extranodal SHML （ESHML） may occur as part of a generalized process involving lymph nodes or may involve extranodal sites independent of the lymph node status. Here we report a case with a Rosai-Dorfman disease of the lung and review the literature.展开更多
Background： Rosai-Dorfman disease （RDD） is typically characterized by painless bilateral and symmetrical cervical lymphadenopathy, with associated fever and leukocytosis. The aim of the current study was to summari...Background： Rosai-Dorfman disease （RDD） is typically characterized by painless bilateral and symmetrical cervical lymphadenopathy, with associated fever and leukocytosis. The aim of the current study was to summarize the clinical features and imaging characteristics of RDD, in an effort to improve its diagnostic accuracy. Methods： The study was analyzed from 32 patients between January 2011 and December 2017; of these, 16 patients had pathologically diagnosed RDD, eight had pathologically diagnosed meningioma, and eight pathologically diagnosed lymphoma. All patients underwent computed tomography and magnetic resonance imaging （MRI）. Clinical features and imaging characteristics of RDD were analyzed retrospectively. The mean apparent diffusion coefficient （ADC） values of lesions at different sites were measured, and one-way analysis of variance and the least significant difference t-test were used to compare the differences between groups and draw receiver operating characteristic curves. The tumors were excised for biopsy and analyzed using immunohistochemistry. Results： The mean ADCs were （0.81 ± 0.10） × 10^-3mm^2/s for intercranial RDD, （0.73 ± 0.05） × 10^-3mm^2/s for nasopharyngeal RDD, （0.74 ± 0.11） × 10^-3mm2/s for bone RDD, and （0.71 ± 0.04） × 10^-3mm2/s for soft-tissue RDD. The optimum ADC to distinguish intracranial RDD from lymphoma was 0.79 × 10^-3mm2/s （62.5% sensitivity and 100% specificity） and to distinguish meningioma from intracranial RDD was 0.92 × 10^-3mm^2/s （62.5% sensitivity and 100% specificity）. Levels of C-reactive protein, erythrocyte sediment rate and D-dimer were significantly elevated （81%, 87%, and 75%, respectively）. On immunohistochemistry, RDD was positive for both S-100 and CD68 proteins but negative for CD1a. Conclusions： Conventional MRI, combined with diffusion-weighted imaging and ADC mapping, is an important diagnostic tool in evaluating RDD patients. An accurate diagnosis of RDD should consider the clinical features,展开更多
A case of cutaneous Rosai-Dorfman disease （CRDD） presenting as a granulomatous rosacea-like rashs was reported. A 45-year-old Chinese woman presented with a 1-month history of a widespread nonpruiginous papulonodula...A case of cutaneous Rosai-Dorfman disease （CRDD） presenting as a granulomatous rosacea-like rashs was reported. A 45-year-old Chinese woman presented with a 1-month history of a widespread nonpruiginous papulonodular eruption. The rash had begun on her face and rapidly progressed to involve the neck and extremities. She was otherwise healthy, with no history of fever, malaise, or weight loss. Physical examination revealed multiple symmetrically distributed discrete and coalescing red plaques, papules and nodules scattered over the face, neck and extremities. No appreciable lymphadenopathy or hepatosplenomegaly was noted. There was no mucosal involvement. The biopsy specimen obtained from the face demonstrated the epidermis was normal, while the superficial dermis contained sheets of histiocytes with abundant, focally foamy cytoplasm. The histiocytes were surrounded by a patchy lymphocytic and plasma cell infiltrate. There was no significant histiocytic atypia. Some of these histiocytes engulfed, without destroying, lymphocytes and neutrophils （emperipolesis）. Immunohistochemical staining revealed that the histiocytes were strongly positive for S100 protein, weakly positive for CD68, and negative for CDla. A diagnosis of CRDD was made. Oral prednisone therapy was initiated at a dosage of 30 mg/d for 3 weeks and then tapered over the ensuing 2 weeks. After 5 weeks of treatment, the lesions had markedly improved.展开更多
基金supported by the National Science and Technology Major Project of China(2017-II-0011-0037)In addition,special thanks are addressed to the support of China Postdoctoral Science Foundation(2023M742834)Guangdong Basic and Applied Basic Research Foundation,China(2023A1515011597).
文摘Thermal boundary conditions of the turbine disk cavity system are of great importance in the design of secondary air systems in aero-engines.This study aims to investigate the complex heat transfer mechanisms of a rotating turbine disk under high-speed conditions.A high-speed rotating free-disk model with Dorfman empirical solutions is developed to evaluate the heat transfer performance considering various factors.Specifically,the influence of compressibility,variable properties,and heat dissipation is determined using theoretical and numerical analyses.In particular,a novel combined solution method is proposed to simplify the complex heat transfer problem.The results indicate that the heat transfer performance of a free disk is primarily influenced by the rotating Mach number,rotating Reynolds number,Rossby number,and wall temperature ratio.The heat transfer temperature and Nusselt number of the free disk are strongly correlated with the rotating Mach number and rotating Reynolds number.Analysis reveals that heat dissipation is a critical factor affecting the accurate evaluation of the heat transfer performance of the turbine disk.Thus,the combined solution method can serve as a reference for future investigations of flow and heat transfer in high-speed rotating turbine disk cavity systems in aero-engines.
文摘Rosai Dorfman’s Disease (RDD) Destombes also called sinus histiocytosis with massive lymphadenopathy is a lymphoproliferative pathology usually benign, of unknown etiology, and of low incidence. It is a rare, but well-defined clinicopathological entity, which predominantly affects children and adolescents without distinction of gender or race. It manifests itself generally by bulky cervical lymphadenopathies, most often bilateral, painless, of benign but persistent evolution and a long-term fever associated with a non-specific biological inflammatory syndrome. Extra lymph node locations are described in association with lymph node involvement or isolation. The definitive diagnosis of Rosai Dorfman’s disease is histological, characterized by histiocytic infiltration with emperipolesis essentially of lymphocytes. The etiopathogenesis of the condition remains unclear, based on infectious and immunological hypotheses without clear evidence. The management is not well codified, it combines depending on the case, surgery;corticosteroids;antimetabolites and interferon alpha. Studies devoted to this condition in tropical Africa are rare. We report the clinical and progressive features of 5 observations of Rosai Dorfman’s disease.
文摘Rosai Dorfman disease, also known as histiocytosis with massive lymphadenopathy, is a very rare idiopathic disease. It is characterized by over production and accumulation of non Langerhans sinus histiocyte most often in lymph nodes, but may occur in other areas leading to organ damage. Based on the research, it can be caused by an infectious agent, immunodeficiency or autoimmunity and genetic causes. Extranodal manifestation is uncommon, however extranodal sites include liver, kidney, respiratory organs, orbit and eyeball. We present a case report of a 44-year-old female with recurrent bilateral orbital infiltration as first location of Rosai Dorfman disease.
文摘In this paper, we study the relation of the algebraic properties of the higher-order Courant bracket and Dorfman bracket on the direct sum bundle TM⊕∧<sup>p</sup>T*M for an m-dimensional smooth manifold M, and a Lie 2-algebra which is a “categorified” version of a Lie algebra. We prove that the higher-order Courant algebroids give rise to a semistrict Lie 2-algebra, and we prove that the higher-order Dorfman algebroids give rise to a hemistrict Lie 2-algebra. Consequently, there is an isomorphism from the higher-order Courant algebroids to the higher-order Dorfman algebroids as Lie 2-algebras homomorphism.
文摘早在1966年Azoury[1]发现了一例不寻常的组织细胞增生病例,其镜下特点与组织细胞增生症又有所区别,当时他们把它考虑为＂网状内皮组织细胞增生＂.Rosai和Dorfman[2]于1969年报道了4例具有独特临床和病理特点的病例,最先将其称为＂窦性组织细胞增生伴巨大淋巴结病（sinus histiocytosis with massive lymphoadenopathy）＂,该4例患者皆为儿童,主要临床表现为大块状颈部淋巴结肿大、低热、白细胞增多和高丙种球蛋白血症,淋巴结肿大持续时间虽长,但呈良性经过.
文摘Rosai-Dorfman disease （RDD）, also known as sinus histiocytosis with massive lymphadenopathy （SHML）, is a rare benign entity of unknown etiology. Extranodal SHML （ESHML） may occur as part of a generalized process involving lymph nodes or may involve extranodal sites independent of the lymph node status. Here we report a case with a Rosai-Dorfman disease of the lung and review the literature.
文摘Background： Rosai-Dorfman disease （RDD） is typically characterized by painless bilateral and symmetrical cervical lymphadenopathy, with associated fever and leukocytosis. The aim of the current study was to summarize the clinical features and imaging characteristics of RDD, in an effort to improve its diagnostic accuracy. Methods： The study was analyzed from 32 patients between January 2011 and December 2017; of these, 16 patients had pathologically diagnosed RDD, eight had pathologically diagnosed meningioma, and eight pathologically diagnosed lymphoma. All patients underwent computed tomography and magnetic resonance imaging （MRI）. Clinical features and imaging characteristics of RDD were analyzed retrospectively. The mean apparent diffusion coefficient （ADC） values of lesions at different sites were measured, and one-way analysis of variance and the least significant difference t-test were used to compare the differences between groups and draw receiver operating characteristic curves. The tumors were excised for biopsy and analyzed using immunohistochemistry. Results： The mean ADCs were （0.81 ± 0.10） × 10^-3mm^2/s for intercranial RDD, （0.73 ± 0.05） × 10^-3mm^2/s for nasopharyngeal RDD, （0.74 ± 0.11） × 10^-3mm2/s for bone RDD, and （0.71 ± 0.04） × 10^-3mm2/s for soft-tissue RDD. The optimum ADC to distinguish intracranial RDD from lymphoma was 0.79 × 10^-3mm2/s （62.5% sensitivity and 100% specificity） and to distinguish meningioma from intracranial RDD was 0.92 × 10^-3mm^2/s （62.5% sensitivity and 100% specificity）. Levels of C-reactive protein, erythrocyte sediment rate and D-dimer were significantly elevated （81%, 87%, and 75%, respectively）. On immunohistochemistry, RDD was positive for both S-100 and CD68 proteins but negative for CD1a. Conclusions： Conventional MRI, combined with diffusion-weighted imaging and ADC mapping, is an important diagnostic tool in evaluating RDD patients. An accurate diagnosis of RDD should consider the clinical features,
文摘A case of cutaneous Rosai-Dorfman disease （CRDD） presenting as a granulomatous rosacea-like rashs was reported. A 45-year-old Chinese woman presented with a 1-month history of a widespread nonpruiginous papulonodular eruption. The rash had begun on her face and rapidly progressed to involve the neck and extremities. She was otherwise healthy, with no history of fever, malaise, or weight loss. Physical examination revealed multiple symmetrically distributed discrete and coalescing red plaques, papules and nodules scattered over the face, neck and extremities. No appreciable lymphadenopathy or hepatosplenomegaly was noted. There was no mucosal involvement. The biopsy specimen obtained from the face demonstrated the epidermis was normal, while the superficial dermis contained sheets of histiocytes with abundant, focally foamy cytoplasm. The histiocytes were surrounded by a patchy lymphocytic and plasma cell infiltrate. There was no significant histiocytic atypia. Some of these histiocytes engulfed, without destroying, lymphocytes and neutrophils （emperipolesis）. Immunohistochemical staining revealed that the histiocytes were strongly positive for S100 protein, weakly positive for CD68, and negative for CDla. A diagnosis of CRDD was made. Oral prednisone therapy was initiated at a dosage of 30 mg/d for 3 weeks and then tapered over the ensuing 2 weeks. After 5 weeks of treatment, the lesions had markedly improved.
