Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases. Reactive oxygen species(ROS) are pri...Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases. Reactive oxygen species(ROS) are primarily produced in the mitochondria and in the endoplasmic reticulum of hepatocytes via the cytochrome P450 enzymes. Under the proper conditions, cells are equipped with special molecular strategies that control the level of oxidative stress and maintain a balance between oxidant and antioxidant particles. Oxidative stress represents an imbalance between oxidant and antioxidant agents. Hepatocytic proteins, lipids and DNA are among the cellular structures that are primarily affected by ROS and reactive nitrogen species. The process results in structural and functional abnormalities in the liver. Thus, the phenomenon of oxidative stress should be investigated for several reasons. First, it may explain the pathogenesis of various liver disorders. Moreover, monitoring oxidative markers among hepatocytes offers the potential to diagnose the degree of liver damage and ultimately to observe the response to pharmacological therapies. The present report focuses on the role of oxidative stress in selected liver diseases.展开更多
目的:分析老年痴呆患者盐酸多奈哌齐的疗效和对生活能力量表(activity of daily living scale,ADL)评分及简易智力状态检查量表(mini-mental state examination,MMSE)评分产生的影响。方法:将老年痴呆患者以入院顺序分乙组、甲组,甲组患...目的:分析老年痴呆患者盐酸多奈哌齐的疗效和对生活能力量表(activity of daily living scale,ADL)评分及简易智力状态检查量表(mini-mental state examination,MMSE)评分产生的影响。方法:将老年痴呆患者以入院顺序分乙组、甲组,甲组患者57例,乙组患者55例;甲组用盐酸多奈哌齐治疗,乙组用石杉碱甲治疗,观察患者的疗效、ADL评分、MMSE评分。结果:治疗前,两组MMSE评分、ADL评分间差异均无统计学意义(P>0.05);治疗后,乙组MMSE评分、ADL评分均小于甲组(P<0.05);乙组治疗的总有效率小于甲组(P<0.05)。结论:在老年痴呆患者中,盐酸多奈哌齐可明显提高其生活能力,改善智力水平,治疗有效率较高。展开更多
文摘Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases. Reactive oxygen species(ROS) are primarily produced in the mitochondria and in the endoplasmic reticulum of hepatocytes via the cytochrome P450 enzymes. Under the proper conditions, cells are equipped with special molecular strategies that control the level of oxidative stress and maintain a balance between oxidant and antioxidant particles. Oxidative stress represents an imbalance between oxidant and antioxidant agents. Hepatocytic proteins, lipids and DNA are among the cellular structures that are primarily affected by ROS and reactive nitrogen species. The process results in structural and functional abnormalities in the liver. Thus, the phenomenon of oxidative stress should be investigated for several reasons. First, it may explain the pathogenesis of various liver disorders. Moreover, monitoring oxidative markers among hepatocytes offers the potential to diagnose the degree of liver damage and ultimately to observe the response to pharmacological therapies. The present report focuses on the role of oxidative stress in selected liver diseases.
文摘目的:分析老年痴呆患者盐酸多奈哌齐的疗效和对生活能力量表(activity of daily living scale,ADL)评分及简易智力状态检查量表(mini-mental state examination,MMSE)评分产生的影响。方法:将老年痴呆患者以入院顺序分乙组、甲组,甲组患者57例,乙组患者55例;甲组用盐酸多奈哌齐治疗,乙组用石杉碱甲治疗,观察患者的疗效、ADL评分、MMSE评分。结果:治疗前,两组MMSE评分、ADL评分间差异均无统计学意义(P>0.05);治疗后,乙组MMSE评分、ADL评分均小于甲组(P<0.05);乙组治疗的总有效率小于甲组(P<0.05)。结论:在老年痴呆患者中,盐酸多奈哌齐可明显提高其生活能力,改善智力水平,治疗有效率较高。
