OBJECTIVES： Rheumatoid arthritis （RA） is one of the most prevalent chronic autoimmune diseases; it typically involves the hands, wrists, ankles, and eventually all joints. Some studies have reported that zinc serum...OBJECTIVES： Rheumatoid arthritis （RA） is one of the most prevalent chronic autoimmune diseases; it typically involves the hands, wrists, ankles, and eventually all joints. Some studies have reported that zinc serum levels are lower in patients with RA than in healthy individuals. MATERIALS and METHODS： Seventy-nine patients with RAwere selected. The patients were all less than 75 years old and were diagnosed by a rheumatologist. Serum zinc levels were measured using the flame photometry method with a blood sample of 5 mL. The relationship between the average serum zinc level and disease activity was analyzed based on the DAS28 scoring scale for different RA groups. The significance threshold was set atp 〈 0.05. Data analyses were implemented in SPSS 22.0. RESULTS： There was a significant inverse relationship between the serum zinc levels and disease activity. Chi-square tests were used to compare zinc serum levels with respect to disease activity. There were significant differences in zinc levels among three groups of patients with different levels of disease severity, such that disease activity increased as the serum zinc level decreased （p 〈 0.001）. CONCLUSION： There was a significant inverse relationship between the serum zinc level and RA activity based on the DAS28 score. Therefore, it is recommended that mineral deficiencies should be addressed by optimizing the zinc supply along with other standard medications in order to reduce RA activity.展开更多
目的评价计步器干预对慢性阻塞性肺疾病(COPD)患者体力活动水平、运动能力以及生活质量的影响。方法计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Cochrane Library、Web of Science、Embase发表的关...目的评价计步器干预对慢性阻塞性肺疾病(COPD)患者体力活动水平、运动能力以及生活质量的影响。方法计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Cochrane Library、Web of Science、Embase发表的关于计步器干预COPD人群体力活动、运动能力、生活质量的临床随机对照试验,检索时限为建库至2021年8月6日。使用RevMan 5.3软件进行数据合成与分析。结果最终纳入20篇文献,其中英文文献15篇,中文文献5篇,样本量总计2563例。经亚组分析发现,计步器干预可以提高年龄>65岁、采用不同方式进行反馈、干预时长<3个月或3~12个月的COPD患者的体力活动水平(每日步数)(P<0.05)。以干预组是否有理论指导为区分进行亚组分析后发现,计步器干预可以提高无理论指导组6 min步行试验距离(P<0.01)。Meta分析结果显示,计步器干预对COPD患者生活质量、FEV1/FVC无影响(P>0.05),对FEV1%预计值有影响(P=0.004)。结论计步器干预可以增加COPD患者的体力活动水平及运动能力,改善患者肺功能,但对生活质量无明显改善作用。展开更多
Disease is a serious threat to human society.Understanding the characteristics of disease transmission is helpful for people to effectively control disease.In real life,it is natural to take various measures when peop...Disease is a serious threat to human society.Understanding the characteristics of disease transmission is helpful for people to effectively control disease.In real life,it is natural to take various measures when people are aware of disease.In this paper,a novel coupled model considering asymmetric activity is proposed to describe the interactions between information diffusion and disease transmission in multiplex networks.Then,the critical threshold for disease transmission is derived by using the micro-Markov chain method.Finally,the theoretical results are verified by numerical simulations.The results show that reducing the activity level of individuals in the physical contact layer will have a continuous impact on reducing the disease outbreak threshold and suppressing the disease.In addition,the activity level of individuals in the virtual network has little impact on the transmission of the disease.Meanwhile,when individuals are aware of more disease-related information,the higher their awareness of prevention will be,which can effectively inhibit the transmission of disease.Our research results can provide a useful reference for the control of disease transmission.展开更多
文摘OBJECTIVES： Rheumatoid arthritis （RA） is one of the most prevalent chronic autoimmune diseases; it typically involves the hands, wrists, ankles, and eventually all joints. Some studies have reported that zinc serum levels are lower in patients with RA than in healthy individuals. MATERIALS and METHODS： Seventy-nine patients with RAwere selected. The patients were all less than 75 years old and were diagnosed by a rheumatologist. Serum zinc levels were measured using the flame photometry method with a blood sample of 5 mL. The relationship between the average serum zinc level and disease activity was analyzed based on the DAS28 scoring scale for different RA groups. The significance threshold was set atp 〈 0.05. Data analyses were implemented in SPSS 22.0. RESULTS： There was a significant inverse relationship between the serum zinc levels and disease activity. Chi-square tests were used to compare zinc serum levels with respect to disease activity. There were significant differences in zinc levels among three groups of patients with different levels of disease severity, such that disease activity increased as the serum zinc level decreased （p 〈 0.001）. CONCLUSION： There was a significant inverse relationship between the serum zinc level and RA activity based on the DAS28 score. Therefore, it is recommended that mineral deficiencies should be addressed by optimizing the zinc supply along with other standard medications in order to reduce RA activity.
基金partially supported by the Project for the National Natural Science Foundation of China(72174121,71774111)the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning+2 种基金the Project for the Natural Science Foundation of Shanghai(21ZR1444100)Project soft science research of Shanghai(22692112600)National Social Science Foundation of China(21BGL217,22BGL240)。
文摘Disease is a serious threat to human society.Understanding the characteristics of disease transmission is helpful for people to effectively control disease.In real life,it is natural to take various measures when people are aware of disease.In this paper,a novel coupled model considering asymmetric activity is proposed to describe the interactions between information diffusion and disease transmission in multiplex networks.Then,the critical threshold for disease transmission is derived by using the micro-Markov chain method.Finally,the theoretical results are verified by numerical simulations.The results show that reducing the activity level of individuals in the physical contact layer will have a continuous impact on reducing the disease outbreak threshold and suppressing the disease.In addition,the activity level of individuals in the virtual network has little impact on the transmission of the disease.Meanwhile,when individuals are aware of more disease-related information,the higher their awareness of prevention will be,which can effectively inhibit the transmission of disease.Our research results can provide a useful reference for the control of disease transmission.
