Coronary stents have been used as standard mechanical devices for percutaneous coronary intervention （PCI） in patients with coronary artery disease （CAD）.They provide vessel wall scaffolding and prevent early elas...Coronary stents have been used as standard mechanical devices for percutaneous coronary intervention （PCI） in patients with coronary artery disease （CAD）.They provide vessel wall scaffolding and prevent early elastic recoil and restenosis, which are major limitations of balloon angioplasty. Consequently, coronary stenting has a higher successful rate of PCI and improves the clinical outcome of the patients with CAD. Because of the permanent nature of metallic stents, however, their presence on the intimal surface of a coronary artery poses a risk associated with the continuous interaction between the metal and the surrounding tissue. This can lead to long-term endothelial dysfunction or chronic inflammation and may result in many potential concerns such as in-stent neointimal hyperplasia and thrombogenesis7展开更多
基金This study was partly supported by the grants from the National Natural Science Foundation of China （No. 30670861, 30871055）, Beijing Natural Science Foundation （No. 7082081）, and Specialized Research Fund for the Doctoral Program of Higher Education of China （No. 20060023044, 20070023047）.
文摘Coronary stents have been used as standard mechanical devices for percutaneous coronary intervention （PCI） in patients with coronary artery disease （CAD）.They provide vessel wall scaffolding and prevent early elastic recoil and restenosis, which are major limitations of balloon angioplasty. Consequently, coronary stenting has a higher successful rate of PCI and improves the clinical outcome of the patients with CAD. Because of the permanent nature of metallic stents, however, their presence on the intimal surface of a coronary artery poses a risk associated with the continuous interaction between the metal and the surrounding tissue. This can lead to long-term endothelial dysfunction or chronic inflammation and may result in many potential concerns such as in-stent neointimal hyperplasia and thrombogenesis7
