BACKGROUND： Low-frequency repetitive transcranial magnetic stimulation （rTMS） has been shown to significantly reduce epileptiform discharges and control clinical seizures in intractable epilepsy patients. The locat...BACKGROUND： Low-frequency repetitive transcranial magnetic stimulation （rTMS） has been shown to significantly reduce epileptiform discharges and control clinical seizures in intractable epilepsy patients. The location of epileptic foci and magnetic stimulation sites remain uncertain. The effects of rTMS on electroencephalogram and seizure remain unclear in epileptic patients following dipole source localization. OBJECTIVE： To investigate the effects of low-frequency rTMS on electroencephalogram and seizure in temporal lobe epilepsy patients after dipole source localization. DESIGN, TIME AND SETTING： The randomized, controlled study was performed at the outpatient clinic Department of Neurology, Hospital Affiliated to North Sichuan Medical College from December 2003 to February 2007. PARTICIPANTS： A total of 30 temporal lobe epilepsy patients, comprising 19 males and 11 females, aged 1749 years, presented with epileptiform discharges and were enrolled for this study. Disease course ranged between 1-6 years, with 1-5 seizures per month. Imaging examinations revealed 11 patients with structural changes in the brain. The patients were randomly and equally assigned into drug treatment and transcranial magnetic stimulation （TMS） groups. METHODS： Patients in the drug treatment group were orally treated with carbamazepine. Patients in the TMS group received oral carbamazepine treatment of and TMS. A Maglite-r25 magnetic stimulator （Dantec Dynamics, Denmark） was used to stimulate epileptic foci in the temporal lobe following electroencephalogram dipole localization （1 Hz, 90% threshold intensity, at a stimulation frequency of 500 times, once a day, for 7 days）. MAIN OUTCOME MEASURES： At 30 days after TMS, seizure frequency and rate of epileptiform discharges were observed in patients from both groups. Therapeutic safety was investigated during treatment. RESULTS： Within 30 days of treatment, there were no significant differences in seizure frequency between the TMS group （1.5 ± 0.3） seiz展开更多
Most fish and aquatic amphibians use the lateral line system,consisting of arrays of hair-like neuromasts,as an important sensory organ for prey/predator detection,communication,and navigation.In this paper a novel bi...Most fish and aquatic amphibians use the lateral line system,consisting of arrays of hair-like neuromasts,as an important sensory organ for prey/predator detection,communication,and navigation.In this paper a novel bio-inspired artificial lateral line system is proposed for underwater robots and vehicles by exploiting the inherent sensing capability of ionic polymer-metal composites(IPMCs).Analogous to its biological counterpart,the IPMC-based lateral line processes the sensor signals through a neural network.The effectiveness of the proposed lateral line is validated experimentally in the localization of a dipole source(vibrating sphere)underwater.In particular,as a proof of concept,a prototype with body length(BL)of 10 cm,comprising six millimeter-scale IPMC sensors,is constructed and tested.Experimental results have shown that the IPMC-based lateral line can localize the source from 1-2 BLs away,with a maximum localization error of 0.3 cm,when the data for training the neural network are collected from a grid of 2 cm by 2 cm lattices.The effect of the number of sensors on the localization accuracy has also been examined.展开更多
基金the Youth Foundation Program of Sichuan Province,No.04ZQ026-010
文摘BACKGROUND： Low-frequency repetitive transcranial magnetic stimulation （rTMS） has been shown to significantly reduce epileptiform discharges and control clinical seizures in intractable epilepsy patients. The location of epileptic foci and magnetic stimulation sites remain uncertain. The effects of rTMS on electroencephalogram and seizure remain unclear in epileptic patients following dipole source localization. OBJECTIVE： To investigate the effects of low-frequency rTMS on electroencephalogram and seizure in temporal lobe epilepsy patients after dipole source localization. DESIGN, TIME AND SETTING： The randomized, controlled study was performed at the outpatient clinic Department of Neurology, Hospital Affiliated to North Sichuan Medical College from December 2003 to February 2007. PARTICIPANTS： A total of 30 temporal lobe epilepsy patients, comprising 19 males and 11 females, aged 1749 years, presented with epileptiform discharges and were enrolled for this study. Disease course ranged between 1-6 years, with 1-5 seizures per month. Imaging examinations revealed 11 patients with structural changes in the brain. The patients were randomly and equally assigned into drug treatment and transcranial magnetic stimulation （TMS） groups. METHODS： Patients in the drug treatment group were orally treated with carbamazepine. Patients in the TMS group received oral carbamazepine treatment of and TMS. A Maglite-r25 magnetic stimulator （Dantec Dynamics, Denmark） was used to stimulate epileptic foci in the temporal lobe following electroencephalogram dipole localization （1 Hz, 90% threshold intensity, at a stimulation frequency of 500 times, once a day, for 7 days）. MAIN OUTCOME MEASURES： At 30 days after TMS, seizure frequency and rate of epileptiform discharges were observed in patients from both groups. Therapeutic safety was investigated during treatment. RESULTS： Within 30 days of treatment, there were no significant differences in seizure frequency between the TMS group （1.5 ± 0.3） seiz
基金supported in part by the National Science Foundation(ECCS 0547131,CCF 0820220,IIS 0916720)the Office of Naval Research(Grant N000140810640).
文摘Most fish and aquatic amphibians use the lateral line system,consisting of arrays of hair-like neuromasts,as an important sensory organ for prey/predator detection,communication,and navigation.In this paper a novel bio-inspired artificial lateral line system is proposed for underwater robots and vehicles by exploiting the inherent sensing capability of ionic polymer-metal composites(IPMCs).Analogous to its biological counterpart,the IPMC-based lateral line processes the sensor signals through a neural network.The effectiveness of the proposed lateral line is validated experimentally in the localization of a dipole source(vibrating sphere)underwater.In particular,as a proof of concept,a prototype with body length(BL)of 10 cm,comprising six millimeter-scale IPMC sensors,is constructed and tested.Experimental results have shown that the IPMC-based lateral line can localize the source from 1-2 BLs away,with a maximum localization error of 0.3 cm,when the data for training the neural network are collected from a grid of 2 cm by 2 cm lattices.The effect of the number of sensors on the localization accuracy has also been examined.
