BACKGROUND Colorectal cancer is the second leading cause of cancer-related deaths among digestive tract malignancies,following gastric cancer.Sleep is of great significance for maintaining human health.The incidence o...BACKGROUND Colorectal cancer is the second leading cause of cancer-related deaths among digestive tract malignancies,following gastric cancer.Sleep is of great significance for maintaining human health.The incidence of sleep disorders in patients with cancer is approximately twice that observed in the general population.Lack of sleep can prolong hospital stays,increase the likelihood of infection,and increase mortality rates.Therefore,studying the factors related to sleep quality is significant for improving the quality of life of patients with malignant tumors of the digestive tract.AIM To investigate the relationships among sleep quality,disease uncertainty,and psychological resilience in patients undergoing chemotherapy for digestive tract malignancies.METHODS A total of 131 patients with malignant digestive tract tumors who were treated at Hefei BOE Hospital between April 2021 and September 2022 were selected as research participants.Based on their Pittsburgh Sleep Quality Index(PSQI)scores,participants were divided into either the sleep disorder group(PSQI score>7)or the normal sleep group(PSQI score≤7).The clinical data—together with the Mishel Uncertainty in Illness Scale for Adults(MUIS-A)and Connor-Davidson Resilience Scale(CD-RISC)scores—were compared.RESULTS In this study,78(59.54%)patients with digestive tract malignancies developed sleep disorders after chemotherapy.Sleep disorder incidence was higher in patients with colorectal cancer than in those with gastric and esophageal cancers(P<0.05).The total MUIS-A score and those for each item in the sleep disorder group were higher than those in the normal sleep group.The total CD-RISC score and those for each item in the sleep disorder group were lower than those in the normal sleep group(P<0.05).The PSQI scores of patients with malignant digestive tract tumors were positively correlated with the scores for lack of disease information,disease uncertainty,and unpredictability in the MUIS-A and negatively correlated with the scores for tenacity,self展开更多
AIM: To study the palliative treatment of malignant obstruction of digestive tract with placement of intraluminal stent combined with intra-arterial infusion of chemotherapeutic drugs. METHODS: A total of 281 cases of...AIM: To study the palliative treatment of malignant obstruction of digestive tract with placement of intraluminal stent combined with intra-arterial infusion of chemotherapeutic drugs. METHODS: A total of 281 cases of digestive tract malignant obstruction were given per oral (esophagus, stomach, duodenum and jejunum), per anal (colon and rectum) and percutaneous transhepatic (biliary) installation of metallic stent. Among them, 203 cases received drug infusion by cannulation of tumor supplying artery with Seldinger's technique. RESULTS: Altogether 350 stents were installed in 281 cases, obstructive symptoms were relieved or ameliorated after installation. Occurrence of restenotic obstruction was 8-43 weeks among those with intra-arterial drug infusion, which was later than 4-26 weeks in the group with only stent installation. The average survival time of the former group was 43 (3-105) weeks, which was significantly longer than 13 (3-24) weeks of the latter group. CONCLUSION: Intraluminal placement of stent combined with intra-arterial infusion chemotherapy is one of the effective palliative therapies for malignant obstruction of the digestive tract with symptomatic as well as etiological treatment.展开更多
目的 分析1990—2019年中国胃癌、食管癌、结直肠癌和肝癌四种消化道肿瘤的发病和死亡情况及变化趋势,为我国消化道肿瘤的预防和控制策略的制定提供科学依据。方法 利用2019全球疾病负担研究(Global burden of disease study 2019,GBD 2...目的 分析1990—2019年中国胃癌、食管癌、结直肠癌和肝癌四种消化道肿瘤的发病和死亡情况及变化趋势,为我国消化道肿瘤的预防和控制策略的制定提供科学依据。方法 利用2019全球疾病负担研究(Global burden of disease study 2019,GBD 2019)数据库,采用Joinpoint回归模型分析中国消化道肿瘤标化发病率、标化死亡率的变化趋势,基于年龄-时期-队列模型探讨消化道肿瘤发病和死亡的年龄、时期和队列效应。结果 2019年消化道肿瘤发病顺位为胃癌(43.09/10万)、结直肠癌(42.74/10万)、食管癌(19.55/10万)和肝癌(14.80/10万)。死亡顺位为胃癌(29.64/10万)、结直肠癌(18.40/10万)、食管癌(18.09/10万)和肝癌(13.20/10万)。消除人口年龄结构的影响后,1990—2019年肝癌、胃癌、食管癌标化发病率、标化死亡率整体上呈逐年降低的趋势(AAPC肝癌发病=-3.1%、AAPC胃癌发病=-0.07%、AAPC食管癌发病=-1.5%;AAPC肝癌死亡=-3.4%、AAPC胃癌死亡=-1.9%、AAPC食管癌死亡=-1.8%)(P<0.001),结直肠癌标化发病率、标化死亡率呈逐年升高趋势(AAPC结直肠癌发病=3.1%、AAPC结直肠癌死亡=1.1%)(P<0.001)。年龄-时期-队列模型结果显示,胃癌、食管癌和结直肠癌的发病率及死亡率整体上呈现随着年龄的增长逐渐上升的趋势,分别在85+组、80~84组、85+组达到峰值;肝癌的发病率及死亡率均在55~59组达到峰值而后下降。结直肠癌发病风险呈现逐年上升的趋势,死亡风险呈现先上升后下降趋势;肝癌发病和死亡风险呈现先降低后上升的趋势,胃癌和食管癌发病和死亡风险整体上呈现逐年下降的趋势。食管癌和肝癌的出生队列越早发病和死亡风险越高,结直肠癌的出生队列越晚发病和死亡风险越高,而胃癌发病风险呈现波动变化。结论 我国消化道肿瘤疾病负担仍然较重,尤其是结直肠癌标化发病率、标化死亡率仍呈逐年升高趋势,应有针对性地实�展开更多
基金National Nature Science foundation of China,No.81900755and the Health Commission of Shanghai Municipality,No.20194Yo384.
文摘BACKGROUND Colorectal cancer is the second leading cause of cancer-related deaths among digestive tract malignancies,following gastric cancer.Sleep is of great significance for maintaining human health.The incidence of sleep disorders in patients with cancer is approximately twice that observed in the general population.Lack of sleep can prolong hospital stays,increase the likelihood of infection,and increase mortality rates.Therefore,studying the factors related to sleep quality is significant for improving the quality of life of patients with malignant tumors of the digestive tract.AIM To investigate the relationships among sleep quality,disease uncertainty,and psychological resilience in patients undergoing chemotherapy for digestive tract malignancies.METHODS A total of 131 patients with malignant digestive tract tumors who were treated at Hefei BOE Hospital between April 2021 and September 2022 were selected as research participants.Based on their Pittsburgh Sleep Quality Index(PSQI)scores,participants were divided into either the sleep disorder group(PSQI score>7)or the normal sleep group(PSQI score≤7).The clinical data—together with the Mishel Uncertainty in Illness Scale for Adults(MUIS-A)and Connor-Davidson Resilience Scale(CD-RISC)scores—were compared.RESULTS In this study,78(59.54%)patients with digestive tract malignancies developed sleep disorders after chemotherapy.Sleep disorder incidence was higher in patients with colorectal cancer than in those with gastric and esophageal cancers(P<0.05).The total MUIS-A score and those for each item in the sleep disorder group were higher than those in the normal sleep group.The total CD-RISC score and those for each item in the sleep disorder group were lower than those in the normal sleep group(P<0.05).The PSQI scores of patients with malignant digestive tract tumors were positively correlated with the scores for lack of disease information,disease uncertainty,and unpredictability in the MUIS-A and negatively correlated with the scores for tenacity,self
文摘AIM: To study the palliative treatment of malignant obstruction of digestive tract with placement of intraluminal stent combined with intra-arterial infusion of chemotherapeutic drugs. METHODS: A total of 281 cases of digestive tract malignant obstruction were given per oral (esophagus, stomach, duodenum and jejunum), per anal (colon and rectum) and percutaneous transhepatic (biliary) installation of metallic stent. Among them, 203 cases received drug infusion by cannulation of tumor supplying artery with Seldinger's technique. RESULTS: Altogether 350 stents were installed in 281 cases, obstructive symptoms were relieved or ameliorated after installation. Occurrence of restenotic obstruction was 8-43 weeks among those with intra-arterial drug infusion, which was later than 4-26 weeks in the group with only stent installation. The average survival time of the former group was 43 (3-105) weeks, which was significantly longer than 13 (3-24) weeks of the latter group. CONCLUSION: Intraluminal placement of stent combined with intra-arterial infusion chemotherapy is one of the effective palliative therapies for malignant obstruction of the digestive tract with symptomatic as well as etiological treatment.
