BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis ...BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion.Direct liver biopsy is regarded as the gold standard to detect and assess fibrosis;however,this method is invasive and prone to clinical sampling error.In order to address these issues,we attempted to find more convenient and effective serum markers for detecting HBV-induced early-stage liver fibrosis.AIM To investigate serum N-glycan profiling related to HBV-induced liver fibrosis and verify multiparameter diagnostic models related to serum N-glycan changes.METHODS N-glycan profiles from the sera of 432 HBV-infected patients with liver fibrosis were analyzed.Significant changed N-glycan levels (peaks)(P <0.05) in differentfibrosis stages were selected in the modeling group,and multiparameter diagnostic models were established based on changed N-glycan levels by logistic regression analysis.The receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic efficacy of N-glycans models.These models were then compared with the aspartate aminotransferase to platelet ratio index (APRI),fibrosis index based on the four factors (FIB-4),glutamyltranspeptidase platelet albumin index (S index),GlycoCirrho-test,and GlycoFibro-test.Furthermore,we combined multiparameter diagnostic models with alanine aminotransferase (ALT) and platelet (PLT) tests and compared their diagnostic power.In addition,the diagnostic accuracy of N-glycan models was also verified in the validation group of patients.RESULTS Multiparameter diagnostic models constructed based on N-glycan peak 1,3,4and 8 could distinguish between different stages of liver fibrosis.The area under ROC curves (AUROCs) of Model A and Model B were 0.890 and 0.752,respectively differentiating fibrosis F0-F1 from F2-F4,and F0-F2 from F3-展开更多
目的:探讨彩色多普勒超声甲状腺影像学报告及数据系统(thyroid imaging reporting and data system,TI-R ADS)分级联合超声弹性对甲状腺癌的诊断价值。方法:对2018年3月至2021年4月宁国市人民医院收治的102例甲状腺癌患者进行回顾性分析...目的:探讨彩色多普勒超声甲状腺影像学报告及数据系统(thyroid imaging reporting and data system,TI-R ADS)分级联合超声弹性对甲状腺癌的诊断价值。方法:对2018年3月至2021年4月宁国市人民医院收治的102例甲状腺癌患者进行回顾性分析,以细针穿刺活检或手术病理结果作为“金标准”,比较TI-RADS分级、剪切波弹性成像(shear wave elastography,SWE)及二者联合诊断甲状腺良恶性结节的效能,并进一步作受试者工作特征(receiver operating characteristic,ROC)曲线分析。结果:102例患者共有甲状腺结节186个,其中恶性结节115个,良性结节71个。恶性组与良性组TI-RADS分级、SWE参数Ratio值比较,差异有统计学意义(P<0.05)。TI-RADS分级、SWE、二者联合诊断甲状腺良恶性结节的ROC曲线下面积(areas under the curve,AUC)分别为0.794、0.887、0.919,二者联合诊断甲状腺良恶性结节的价值高于SWE和TI-R ADS分级(P<0.05),SWE诊断价值高于TI-RADS分级(P<0.05)。结论:彩色多普勒超声TI-RADS分级与SWE联合可能对甲状腺癌的诊断价值更高。展开更多
In order to overcome the shortages of diagnostic method for distribution networks considering the reliability assessment,this paper proposed a method based on power supply safety standards.It profoundly analyzed the s...In order to overcome the shortages of diagnostic method for distribution networks considering the reliability assessment,this paper proposed a method based on power supply safety standards.It profoundly analyzed the security standard of supply for urban power networks,and established quantitative indicators of load groups based on different fault conditions.Then a method suitable for diagnostic evaluation of urban distribution networks in China was given.In the method,“N-1”calibration analysis of the distribution network was conducted.Then the results are compared with quantitative indicators of load groups on different conditions deriving the diagnostic conclusions and the standard revision is discussed.The feasibility and accuracy of the method is finally verified in the case study.展开更多
目的比较分析阴道镜下宫颈活检和宫颈锥切组织快速病理检查对宫颈上皮内瘤变(CIN)的诊断价值。方法选取2017年12月至2019年12月永城市人民医院妇产科收治并通过阴道镜下宫颈活检确诊为CIN的患者102例为研究对象,其中CIN I 20例,CINⅡ~...目的比较分析阴道镜下宫颈活检和宫颈锥切组织快速病理检查对宫颈上皮内瘤变(CIN)的诊断价值。方法选取2017年12月至2019年12月永城市人民医院妇产科收治并通过阴道镜下宫颈活检确诊为CIN的患者102例为研究对象,其中CIN I 20例,CINⅡ~Ⅲ77例,疑似早期宫颈浸润癌5例。均在本院进行宫颈锥形切除术治疗,将活检结果和术中快速冰冻病理检查结果分别与术后病理检查结果进行比较分析。结果经阴道镜下宫颈活检确诊的102例患者中,通过术后病理检查,有82例患者确诊,准确率为80.39%(80/102),漏诊早期浸润癌2例,阴道镜下宫颈活检病变检出率显著低于术后病理检查。通过术中快速病理检查,有99例患者与术后病理检查结果一致,准确率为97.06%(99/102),漏诊早期浸润癌1例。假阳性率为0.98%(1/102),假阴性率为1.96%(2/102),二者一致性较好。宫颈锥形切除术病变残留率为9.80%(10/102),诊断切缘残留病变准确度为96.08%(98/102),灵敏度为80.00%(8/10),特异度为97.83%(90/92),诊断效能较好。结论宫颈锥形切除术是目前临床诊断和治疗CIN的金标准,能有效避免因多中心病变或病变位置特殊等情况而导致的漏诊、误诊。术中快速病理检查对CIN的确诊准确性更高,还能有效判定切缘残留情况,能够有效指导宫颈锥形切除术的切除范围,值得临床推广。展开更多
基金Supported by Major Science and Technology Special Project of China Thirteenth Five-Year Plan,No.2018ZX10732401-003-015；Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis,No.GXCDCKL201901
文摘BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion.Direct liver biopsy is regarded as the gold standard to detect and assess fibrosis;however,this method is invasive and prone to clinical sampling error.In order to address these issues,we attempted to find more convenient and effective serum markers for detecting HBV-induced early-stage liver fibrosis.AIM To investigate serum N-glycan profiling related to HBV-induced liver fibrosis and verify multiparameter diagnostic models related to serum N-glycan changes.METHODS N-glycan profiles from the sera of 432 HBV-infected patients with liver fibrosis were analyzed.Significant changed N-glycan levels (peaks)(P <0.05) in differentfibrosis stages were selected in the modeling group,and multiparameter diagnostic models were established based on changed N-glycan levels by logistic regression analysis.The receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic efficacy of N-glycans models.These models were then compared with the aspartate aminotransferase to platelet ratio index (APRI),fibrosis index based on the four factors (FIB-4),glutamyltranspeptidase platelet albumin index (S index),GlycoCirrho-test,and GlycoFibro-test.Furthermore,we combined multiparameter diagnostic models with alanine aminotransferase (ALT) and platelet (PLT) tests and compared their diagnostic power.In addition,the diagnostic accuracy of N-glycan models was also verified in the validation group of patients.RESULTS Multiparameter diagnostic models constructed based on N-glycan peak 1,3,4and 8 could distinguish between different stages of liver fibrosis.The area under ROC curves (AUROCs) of Model A and Model B were 0.890 and 0.752,respectively differentiating fibrosis F0-F1 from F2-F4,and F0-F2 from F3-
文摘目的:探讨彩色多普勒超声甲状腺影像学报告及数据系统(thyroid imaging reporting and data system,TI-R ADS)分级联合超声弹性对甲状腺癌的诊断价值。方法:对2018年3月至2021年4月宁国市人民医院收治的102例甲状腺癌患者进行回顾性分析,以细针穿刺活检或手术病理结果作为“金标准”,比较TI-RADS分级、剪切波弹性成像(shear wave elastography,SWE)及二者联合诊断甲状腺良恶性结节的效能,并进一步作受试者工作特征(receiver operating characteristic,ROC)曲线分析。结果:102例患者共有甲状腺结节186个,其中恶性结节115个,良性结节71个。恶性组与良性组TI-RADS分级、SWE参数Ratio值比较,差异有统计学意义(P<0.05)。TI-RADS分级、SWE、二者联合诊断甲状腺良恶性结节的ROC曲线下面积(areas under the curve,AUC)分别为0.794、0.887、0.919,二者联合诊断甲状腺良恶性结节的价值高于SWE和TI-R ADS分级(P<0.05),SWE诊断价值高于TI-RADS分级(P<0.05)。结论:彩色多普勒超声TI-RADS分级与SWE联合可能对甲状腺癌的诊断价值更高。
文摘In order to overcome the shortages of diagnostic method for distribution networks considering the reliability assessment,this paper proposed a method based on power supply safety standards.It profoundly analyzed the security standard of supply for urban power networks,and established quantitative indicators of load groups based on different fault conditions.Then a method suitable for diagnostic evaluation of urban distribution networks in China was given.In the method,“N-1”calibration analysis of the distribution network was conducted.Then the results are compared with quantitative indicators of load groups on different conditions deriving the diagnostic conclusions and the standard revision is discussed.The feasibility and accuracy of the method is finally verified in the case study.
文摘目的比较分析阴道镜下宫颈活检和宫颈锥切组织快速病理检查对宫颈上皮内瘤变(CIN)的诊断价值。方法选取2017年12月至2019年12月永城市人民医院妇产科收治并通过阴道镜下宫颈活检确诊为CIN的患者102例为研究对象,其中CIN I 20例,CINⅡ~Ⅲ77例,疑似早期宫颈浸润癌5例。均在本院进行宫颈锥形切除术治疗,将活检结果和术中快速冰冻病理检查结果分别与术后病理检查结果进行比较分析。结果经阴道镜下宫颈活检确诊的102例患者中,通过术后病理检查,有82例患者确诊,准确率为80.39%(80/102),漏诊早期浸润癌2例,阴道镜下宫颈活检病变检出率显著低于术后病理检查。通过术中快速病理检查,有99例患者与术后病理检查结果一致,准确率为97.06%(99/102),漏诊早期浸润癌1例。假阳性率为0.98%(1/102),假阴性率为1.96%(2/102),二者一致性较好。宫颈锥形切除术病变残留率为9.80%(10/102),诊断切缘残留病变准确度为96.08%(98/102),灵敏度为80.00%(8/10),特异度为97.83%(90/92),诊断效能较好。结论宫颈锥形切除术是目前临床诊断和治疗CIN的金标准,能有效避免因多中心病变或病变位置特殊等情况而导致的漏诊、误诊。术中快速病理检查对CIN的确诊准确性更高,还能有效判定切缘残留情况,能够有效指导宫颈锥形切除术的切除范围,值得临床推广。
