Diagnostic comparison of the East Asian subtropical jet （EASJ） and polar-front jet （EAPJ） in winter season is carried out by using the ERA-40 dataset. The large-scale circulation characteristics and synopticscale ...Diagnostic comparison of the East Asian subtropical jet （EASJ） and polar-front jet （EAPJ） in winter season is carried out by using the ERA-40 dataset. The large-scale circulation characteristics and synopticscale transient eddy activities （STEAs） associated with the EASJ and EAPJ are examined. The results show that the EASJ and EAPJ in the upper-level monthly mean data have no clear geographical border, while the distribution of the numbers of jet cores from the daily data exhibits a distinct boundary at the latitudes of the northern Tibetan Plateau. The two areas with large numbers of jet cores correspond to the EASJ and EAPJ regions. The analysis of STEAs over the East Asian region shows a spatial match of STEAs with the EASJ and EAPJ in winter： the strong EASJ is located within the weak southern branch of the STEA while the relatively weak EAPJ appears within the active northern branch of the STEA, indicating that the EAPJ is the jet coexisting with the STEA. Further analysis shows two anomalous modes of the winter EAPJ： the anomalous anticyclonic/cyclonic circulation and the weakened/strengthened local westerly wind. The large-scale circulation anomalies in the Northern Hemisphere related to the first mode are concentrated in the Eurasian mid to high latitudes, and are also influenced by the anomalous circulation in the upstream area. When the local westerly wind over the EAPJ region is weakened/strengthened, the westerly jet in the eastern part of the EASJ and that in the western Pacific region show opposite variations. The corresponding anomalous atmospheric circulation demonstrates the Eurasian （EU） pattern. The EAPJ anomalies are also closely linked with the STEA anomalies over East Asia. The anomalies in the northern branch of the STEA propagate as a wave train along its axis into the East Asian coastal waters, and then migrate eastward to the oceanic region. However, the ones near the southern branch are trapped over the eastern part of East Asia and its coastal waters at 200 hPa.展开更多
目的本研究利用间接比较Meta分析的方法评价在乳腺癌中众多甲基化的基因中价值较大的基因。方法计算机检索Cochrane Library、Pub Med、EMbase、Chinese Bio Medical Literature Database(CBM)、Web of Science、中国知网(China Nationa...目的本研究利用间接比较Meta分析的方法评价在乳腺癌中众多甲基化的基因中价值较大的基因。方法计算机检索Cochrane Library、Pub Med、EMbase、Chinese Bio Medical Literature Database(CBM)、Web of Science、中国知网(China National Knowledge Infrastructure,CNKI)和万方数据库,收集涉及抑癌基因启动子甲基化与乳腺癌关系的Meta研究。采用间接比较Meta分析的方法评价在乳腺癌病人中甲基化的抑癌基因的诊断价值。结果最终共纳入10个甲基化基因(10个Meta研究),共计130个原始研究。在汇总的Meta分析中,甲基化的同源性磷酸酶-张力蛋白基因(phosphatase and tensin homolog,PTEN)比值比[odds ratio(OR)=66.16(24.48~178.82)]、人类相关转录因子基因(Runt-related transcription factor 3,RUNX3)[OR=28.88(15.48~54.25)]对乳腺癌的风险最大,虽然乳腺癌1号基因(breast cancer 1,BRCA1)[OR=2.11(1.88~2.35)]最小,但是在10个Meta研究中BRCA1的权重是57.1%。根据灵敏度相比之下,RUNX3基因[0.62(0.56~0.67)]最大,其次是脆性组氨酸三联体基因(fragile histidine triad protein,FHIT)[0.59(0.54~0.63)],但是RUNX3基因的特异度[0.95(0.91~0.97)]大于FHIT基因[0.65(0.61~0.69)]。综合甲基化基因的灵敏度和特异度,利用间接比较的方法,RUNX3基因对乳腺癌的诊断价值最大。结论在乳腺癌的早期筛查和辅助检查中,提倡对RUNX3和BRCA1甲基化的基因加以利用。展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos. 40775044 and 40730953the Natural Science Foundation of Jiangsu Province under Grant No. BK2008027
文摘Diagnostic comparison of the East Asian subtropical jet （EASJ） and polar-front jet （EAPJ） in winter season is carried out by using the ERA-40 dataset. The large-scale circulation characteristics and synopticscale transient eddy activities （STEAs） associated with the EASJ and EAPJ are examined. The results show that the EASJ and EAPJ in the upper-level monthly mean data have no clear geographical border, while the distribution of the numbers of jet cores from the daily data exhibits a distinct boundary at the latitudes of the northern Tibetan Plateau. The two areas with large numbers of jet cores correspond to the EASJ and EAPJ regions. The analysis of STEAs over the East Asian region shows a spatial match of STEAs with the EASJ and EAPJ in winter： the strong EASJ is located within the weak southern branch of the STEA while the relatively weak EAPJ appears within the active northern branch of the STEA, indicating that the EAPJ is the jet coexisting with the STEA. Further analysis shows two anomalous modes of the winter EAPJ： the anomalous anticyclonic/cyclonic circulation and the weakened/strengthened local westerly wind. The large-scale circulation anomalies in the Northern Hemisphere related to the first mode are concentrated in the Eurasian mid to high latitudes, and are also influenced by the anomalous circulation in the upstream area. When the local westerly wind over the EAPJ region is weakened/strengthened, the westerly jet in the eastern part of the EASJ and that in the western Pacific region show opposite variations. The corresponding anomalous atmospheric circulation demonstrates the Eurasian （EU） pattern. The EAPJ anomalies are also closely linked with the STEA anomalies over East Asia. The anomalies in the northern branch of the STEA propagate as a wave train along its axis into the East Asian coastal waters, and then migrate eastward to the oceanic region. However, the ones near the southern branch are trapped over the eastern part of East Asia and its coastal waters at 200 hPa.
文摘目的本研究利用间接比较Meta分析的方法评价在乳腺癌中众多甲基化的基因中价值较大的基因。方法计算机检索Cochrane Library、Pub Med、EMbase、Chinese Bio Medical Literature Database(CBM)、Web of Science、中国知网(China National Knowledge Infrastructure,CNKI)和万方数据库,收集涉及抑癌基因启动子甲基化与乳腺癌关系的Meta研究。采用间接比较Meta分析的方法评价在乳腺癌病人中甲基化的抑癌基因的诊断价值。结果最终共纳入10个甲基化基因(10个Meta研究),共计130个原始研究。在汇总的Meta分析中,甲基化的同源性磷酸酶-张力蛋白基因(phosphatase and tensin homolog,PTEN)比值比[odds ratio(OR)=66.16(24.48~178.82)]、人类相关转录因子基因(Runt-related transcription factor 3,RUNX3)[OR=28.88(15.48~54.25)]对乳腺癌的风险最大,虽然乳腺癌1号基因(breast cancer 1,BRCA1)[OR=2.11(1.88~2.35)]最小,但是在10个Meta研究中BRCA1的权重是57.1%。根据灵敏度相比之下,RUNX3基因[0.62(0.56~0.67)]最大,其次是脆性组氨酸三联体基因(fragile histidine triad protein,FHIT)[0.59(0.54~0.63)],但是RUNX3基因的特异度[0.95(0.91~0.97)]大于FHIT基因[0.65(0.61~0.69)]。综合甲基化基因的灵敏度和特异度,利用间接比较的方法,RUNX3基因对乳腺癌的诊断价值最大。结论在乳腺癌的早期筛查和辅助检查中,提倡对RUNX3和BRCA1甲基化的基因加以利用。
