目的:研究地塞米松棕榈酸酯联合利多卡因治疗肩袖损伤患者的临床疗效。方法:回顾性分析2019年8月至2022年10月期间本院康复科收治的78例肩袖损伤患者的临床资料,按照治疗方法不同将患者分为对照组(肩关节镜下手术治疗,37例)和观察组(肩...目的:研究地塞米松棕榈酸酯联合利多卡因治疗肩袖损伤患者的临床疗效。方法:回顾性分析2019年8月至2022年10月期间本院康复科收治的78例肩袖损伤患者的临床资料,按照治疗方法不同将患者分为对照组(肩关节镜下手术治疗,37例)和观察组(肩关节镜下手术治疗基础上采用地塞米松棕榈酸酯联合利多卡因治疗,41例)。治疗1 m后以美国加州大学肩关节评分量表(the university of California at Los Angeles shoulder rating scale,UCLA)评估肩关节功能,采用酶联免疫吸附试验法检测白细胞介素6(Interleukin-6,IL-6)、C反应蛋白(C reactive protein,CRP)水平,同时观察药物安全性。结果:治疗后,两组UCLA各维度评分均升高,且观察组UCLA各维度评分均显著高于对照组(P<0.05)。治疗后,两组炎性因子IL-6、CRP水平均降低,且观察组的IL-6、CRP水平均显著低于对照组(P<0.05)。治疗后,两组不良反应总发生率比较无显著差异(P>0.05)。结论:地塞米松棕榈酸酯联合利多卡因治疗肩袖损伤的临床疗效显著,可减轻机体的炎症反应状态,改善肩关节功能。展开更多
A high-performance liquid chromatography (HPLC) method has been developed and validated for the determination of dexamethasone palmitate (DXP) in bronchoalveolar fluid lavage samples (BALF). DXP in rat BALFs containin...A high-performance liquid chromatography (HPLC) method has been developed and validated for the determination of dexamethasone palmitate (DXP) in bronchoalveolar fluid lavage samples (BALF). DXP in rat BALFs containing the internal standard (IS), testosterone decanoate (TD), was extracted using a mixture of chloroform and methanol (9:1, v/v). Extracts were then centrifuged, dried and dissolved in acetonitrile. A chromatographic separation based on an isocratic elution was done using acetonitrile and water (85:15, v/v) as a mobile phase at a flow rate of 1.2 mL/min. The graph of the developed method was linear within the tested calibration range of 0.5 - 40 μg/mL. The overall extraction recovery of DXP from BALF samples was 84.3% ± 1.6%. The accuracy (relative error) and precision (coefficient of variation) values were within the pre-defined limits of ≤15% at all concentrations. This methodology has been applied to determine levels of DXP in BALF samples collected from rats treated with DXP large porous particles. The measured concentrations were successfully evaluated using a non-compartment pharmacokinetic model. Since the developed method requires only a microvolume (100 μL) of BALF sample for analysis, it is therefore particularly suitable for the evaluation of drug biodistribution in lung.展开更多
文摘目的:研究地塞米松棕榈酸酯联合利多卡因治疗肩袖损伤患者的临床疗效。方法:回顾性分析2019年8月至2022年10月期间本院康复科收治的78例肩袖损伤患者的临床资料,按照治疗方法不同将患者分为对照组(肩关节镜下手术治疗,37例)和观察组(肩关节镜下手术治疗基础上采用地塞米松棕榈酸酯联合利多卡因治疗,41例)。治疗1 m后以美国加州大学肩关节评分量表(the university of California at Los Angeles shoulder rating scale,UCLA)评估肩关节功能,采用酶联免疫吸附试验法检测白细胞介素6(Interleukin-6,IL-6)、C反应蛋白(C reactive protein,CRP)水平,同时观察药物安全性。结果:治疗后,两组UCLA各维度评分均升高,且观察组UCLA各维度评分均显著高于对照组(P<0.05)。治疗后,两组炎性因子IL-6、CRP水平均降低,且观察组的IL-6、CRP水平均显著低于对照组(P<0.05)。治疗后,两组不良反应总发生率比较无显著差异(P>0.05)。结论:地塞米松棕榈酸酯联合利多卡因治疗肩袖损伤的临床疗效显著,可减轻机体的炎症反应状态,改善肩关节功能。
文摘A high-performance liquid chromatography (HPLC) method has been developed and validated for the determination of dexamethasone palmitate (DXP) in bronchoalveolar fluid lavage samples (BALF). DXP in rat BALFs containing the internal standard (IS), testosterone decanoate (TD), was extracted using a mixture of chloroform and methanol (9:1, v/v). Extracts were then centrifuged, dried and dissolved in acetonitrile. A chromatographic separation based on an isocratic elution was done using acetonitrile and water (85:15, v/v) as a mobile phase at a flow rate of 1.2 mL/min. The graph of the developed method was linear within the tested calibration range of 0.5 - 40 μg/mL. The overall extraction recovery of DXP from BALF samples was 84.3% ± 1.6%. The accuracy (relative error) and precision (coefficient of variation) values were within the pre-defined limits of ≤15% at all concentrations. This methodology has been applied to determine levels of DXP in BALF samples collected from rats treated with DXP large porous particles. The measured concentrations were successfully evaluated using a non-compartment pharmacokinetic model. Since the developed method requires only a microvolume (100 μL) of BALF sample for analysis, it is therefore particularly suitable for the evaluation of drug biodistribution in lung.
