Transition metal-catalyzed decarboxylative cross-coupling reactions have recently emerged as a new and important category of organic transformations that find versatile applications in the construction of carbon-carbo...Transition metal-catalyzed decarboxylative cross-coupling reactions have recently emerged as a new and important category of organic transformations that find versatile applications in the construction of carbon-carbon and carbon-heteroatom bonds. The use of relatively cheap and stable carboxylic acids to replace organometallic reagents enables the decarboxylative cross-coupling reactions to proceed with good selectivities and functional group tolerance. In the present review we summarize the various types of decarboxylative cross-coupling reactions catalyzed by different transition metal complexes. The scope and applications of these reactions are described. The challenges and opportunities in the field are discussed.展开更多
An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes is described,providing a general method for installation of the challenging alkyl fragments containing a-electron-withdrawing...An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes is described,providing a general method for installation of the challenging alkyl fragments containing a-electron-withdrawing groups into a-trifluoromethyl alkenes.Mechanistic studies suggest that this process involves an SN2,-type synthetic route in the absence of transition-metal catalysts or photocatalysis.Moreover,this protocol can easily be scaled up,and successfully applied to the modification of biologically active molecules,thus complementing methodologies that give access to structurally versatile gem-difluoroalkenes.展开更多
An assembly of Keggin polyoxomolybdate and organic substrate （Hbipy）3[PM01204o] （1, bipy = 2,2＇- bipyridine） was synthesized and characterized by elemental analysis, infrared spectrum, and single- crystal X-ray a...An assembly of Keggin polyoxomolybdate and organic substrate （Hbipy）3[PM01204o] （1, bipy = 2,2＇- bipyridine） was synthesized and characterized by elemental analysis, infrared spectrum, and single- crystal X-ray analysis. The ligand bipy of compound 1 was generated by a decarboxylation coupling reaction of H2pdc （H2pdc = pyridine-2,6-dicarboxylic acid） in situ under hydrothermal reaction conditions and the control experiments illustrate that La（NO3）3 or Ce（NO3）3, which does not appear in the final structure, is necessary for the decarboxylation coupling reaction. Moreover, compound 1 displays strong photoluminescence property in the solid state at room temperature.展开更多
Under basic conditions, a series of 4,4-dialkylthio-l,2-diaza-l,3-butadienes were synthesized in good to excellent yields via a novel azo-coupling decarboxylation reaction by reacting a-carboxyl ketene dithioacetals w...Under basic conditions, a series of 4,4-dialkylthio-l,2-diaza-l,3-butadienes were synthesized in good to excellent yields via a novel azo-coupling decarboxylation reaction by reacting a-carboxyl ketene dithioacetals with aryldiazonium salts in aqueous medium.展开更多
文摘Transition metal-catalyzed decarboxylative cross-coupling reactions have recently emerged as a new and important category of organic transformations that find versatile applications in the construction of carbon-carbon and carbon-heteroatom bonds. The use of relatively cheap and stable carboxylic acids to replace organometallic reagents enables the decarboxylative cross-coupling reactions to proceed with good selectivities and functional group tolerance. In the present review we summarize the various types of decarboxylative cross-coupling reactions catalyzed by different transition metal complexes. The scope and applications of these reactions are described. The challenges and opportunities in the field are discussed.
基金the support from the National Natural Science Foundation of China(Nos.21732006,51821006 and 51961135104)the Natural Science Foundation of Anhui(No.2008085MB40)+1 种基金the USTC Research Funds of the Double First Class Initiative(No.YD2060002003)The authors thank Xi Lu(University of Science and Technology of China)for insightful discussion during the preparation of the manuscript.
文摘An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes is described,providing a general method for installation of the challenging alkyl fragments containing a-electron-withdrawing groups into a-trifluoromethyl alkenes.Mechanistic studies suggest that this process involves an SN2,-type synthetic route in the absence of transition-metal catalysts or photocatalysis.Moreover,this protocol can easily be scaled up,and successfully applied to the modification of biologically active molecules,thus complementing methodologies that give access to structurally versatile gem-difluoroalkenes.
基金Project supported by the 973 Program(Nos.2011CB932404,2011CBA00501)the National Natural Science Foundation of China(No.21103192)the Key Project from Chinese Academy of Sciences~~
基金supported by the National Natural Science Foundation of China(Nos.21173021,21231002, 21276026,20801036,51002180)the 111 Project(No. B07012)the Program of Cooperation of the Beijing Education Commission(No.20091739006)
文摘An assembly of Keggin polyoxomolybdate and organic substrate （Hbipy）3[PM01204o] （1, bipy = 2,2＇- bipyridine） was synthesized and characterized by elemental analysis, infrared spectrum, and single- crystal X-ray analysis. The ligand bipy of compound 1 was generated by a decarboxylation coupling reaction of H2pdc （H2pdc = pyridine-2,6-dicarboxylic acid） in situ under hydrothermal reaction conditions and the control experiments illustrate that La（NO3）3 or Ce（NO3）3, which does not appear in the final structure, is necessary for the decarboxylation coupling reaction. Moreover, compound 1 displays strong photoluminescence property in the solid state at room temperature.
基金Project supported by the National Natural Science Foundation of China （No. 20272008） and the Key Grant Project of Chinese Mimstry of Eucation （No. 10412）.
文摘Under basic conditions, a series of 4,4-dialkylthio-l,2-diaza-l,3-butadienes were synthesized in good to excellent yields via a novel azo-coupling decarboxylation reaction by reacting a-carboxyl ketene dithioacetals with aryldiazonium salts in aqueous medium.
