Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired.Electrospun nanofibrous materials show great application po...Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired.Electrospun nanofibrous materials show great application potentials for wound healing owing to relatively large surface area,better mimicry of native extracellular matrix,adjustable waterproofness and breathability,and programmable drug delivery process.In this review article,we begin with a discussion of wound healing process and current commercial wound dressing materials.Then,we emphasize on electrospun nanofibrous materials for wound dressing,covering the efforts for controlling fiber alignment and morphology,constructing 3D scaffolds,developing waterproof-breathable membrane,governing drug delivery performance,and regulating stem cell behavior.Finally,we finish with challenges and future prospects of electrospun nanofibrous materials for wound dressings.展开更多
Background Transparent dressings are commonly used to cover central venous catheter sites. However, it has been suggested that they might not allow adequate moisture vapor transmission, resulting in local moistness th...Background Transparent dressings are commonly used to cover central venous catheter sites. However, it has been suggested that they might not allow adequate moisture vapor transmission, resulting in local moistness that promotes bacterial growth. We compared the moisture vapor transmission rates （MVTRs） of different, currently used transparent and traditional gauze dressings. We aimed to determine the MVTRs at different temperatures and humidities. Methods The dressings were used to seal 50-ml plastic centrifuge tubes containing 20 ml deionized water： Tubes in group 1 were covered with 12 layers of ordinary gauze, group 2 with IV3000, group 3 with OPSITE FLEXlGRID, group 4 with 3M HP Tegaderm, and group 5 with 3M Tegaderm. The tubes were placed upright in an artificial climate cabinet, so that the dressings were not touching the water, in order to simulate the conditions of medical dressings in contact with the skin. The average MVTRs were determined under different conditions. MVTRs were also determined with tubes from groups 2-5 laid on their sides, allowing the dressings to touch the water, so simulating contact of the dressings with sweating skin, or wounded skin with exudates. We also calculated the dressings＇ self-reactive abilities by comparing their MVTRs in contact with the water surface with those when not in contact with the water surface. Results Group 1 demonstrated the highest MVTR, followed by groups 2, 4, 3 and 5 under conditions simulating contact of the dressings with normal skin at the following temperatures and humidities： 20℃/30%, 20℃/60%, 20℃/90%, 37℃/30%, 37℃/60% and 37℃/90%. When the relative humidity （RH） increased, the MVTRs decreased. The MVTRs differed significantly among different dressings and RHs： At high temperature （37℃） and high humidity （90%）, the MVTR of the transparent dressings in group 2 was higher than that of group 1 （P 〈0.01）. The reactive MVTR was highest in group 2 （10.2-16.3 times 〉MVTR） while that of group 4 was second展开更多
目的观察早期应用水胶体敷料预防经外周静脉穿刺中心静脉置管（peripherally inserted central catheter,PICC）术后机械性静脉炎的效果。方法选取2014年1月-2015年11月行PICC治疗的肿瘤患者62例,随机将其分为对照组和观察组各31例。观...目的观察早期应用水胶体敷料预防经外周静脉穿刺中心静脉置管（peripherally inserted central catheter,PICC）术后机械性静脉炎的效果。方法选取2014年1月-2015年11月行PICC治疗的肿瘤患者62例,随机将其分为对照组和观察组各31例。观察组患者置管后在置管部位上方5～6cm处沿静脉穿刺走向覆盖10cm×10cm的水胶体敷料,7d更换1次;对照组患者置管后给予11cm×12cm透明敷贴固定,7d更换1次。2组患者均按PICC护理常规进行护理,观察2组患者机械性静脉炎的发生情况。结果观察组患者中仅有1例发生I级静脉炎,发生率为3.23%;对照组患者中7例发生静脉炎,其中5例为I级静脉炎,2例为II级静脉炎,发生率为22.58%。观察组患者静脉炎发生率显著低于对照组。结论早期应用水胶体敷料能有效预防PICC置管术后机械性静脉炎的发生。展开更多
A good wound dressing needs to promote wound healing and tissue repair when the skin is injured.In this study,a self-made spherical section free surface electrospinning device was used to produce large quantities of e...A good wound dressing needs to promote wound healing and tissue repair when the skin is injured.In this study,a self-made spherical section free surface electrospinning device was used to produce large quantities of electrospun porous polylactic acid(PLA)/chitosan(CS)/aloin nanofiber membranes(NFMs)for antibacterial wound dressing.The porous structures of PLAbased nanofibers were controlled by adjusting the weight ratios of mixed solvent and solute.The results showed that highquality porous PLA/CS/aloin(PCA)NFMs were obtained when the weight ratios of chloroform/N,N-dimethylformamide and PLA:CS were 90/10 and 7:1,respectively.The porous PCA NFMs exhibited high porosity,acceptable mechanical properties,moderate hydrophobicity,good swelling property,and high water vapor transmission rate.Moreover,they also showed excellent blood coagulative,antibacterial,biocompatible properties,which had the potential to be used in the application of antibacterial wound dressings.展开更多
A hydrogel dressing based on bacterial cellulose(BC),which is grafted with quaternary ammonium func-tional and crosslinked with the gelatin-heparin system,is prepared to provide the features mainly con-cerning softnes...A hydrogel dressing based on bacterial cellulose(BC),which is grafted with quaternary ammonium func-tional and crosslinked with the gelatin-heparin system,is prepared to provide the features mainly con-cerning softness,high swelling ratio,antibacterial property,and biocompatibility.An innovation of prepa-ration is that the BC is beaten into short-chain scaffolds to improve the efficiency of grafting,which not only simplifies the preparation process but also avoids the biotoxicity caused by the introduction of toxic catalyst such as dimethyl sulfoxide(DMSO)or uncertain toxic side products in long-chain graft-ing.Scanning electron microscopy(SEM)shows that the QBC/Hep/Gel composite hydrogel possesses a three-dimensional mesh structure with high porosity.The hydrogel shows outstanding water manage-ment performance indicated by the swelling ratio of 1476%,water retention ratio of more than 90%at 120 h,and moisture permeability of 3296 g m^(-2) 24 h^(-1).The antibacterial experiment is implemented with staphylococcus aureus,and the antibacterial effect is represented by an inhibition zone of 3 cm in diameter.In vivo animal experiments suggested that QBC/Hep/Gel could effectively promote epithelial reconstruction,collagen deposition,and angiogenesis in normal wounds,reduce inflammation,and ac-celerate wound healing.All these results indicate that the proposed QBC/Hep/Gel hydrogel is a potential composite for antibacterial dressing.展开更多
Bioactive tragacanth gum(TG)was functionalized by covalent crosslinking of poly[2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide(PMEDSAH)to design network structure in form of hydrogel wound dressin...Bioactive tragacanth gum(TG)was functionalized by covalent crosslinking of poly[2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide(PMEDSAH)to design network structure in form of hydrogel wound dressings(HWD).These copolymers were encapsulated with antibiotic drug vancomycin to enhance wound healing potential of the dressings.The copolymers were characterized by SEM,AFM,FTIR,13C NMR,XRD,and TGA-DSC analysis.SEM demonstrated uneven heterogeneous morphology and AFM revealed rough surface of copolymer.Inclusion of synthetic component into HD was confirmed by FTIR and 13C NMR.Hydrogel dressings absorbed 8.491.03 g/g simulated wound fluid and exhibited non-hemolytic(3.70.02%hemolytic potential)and antioxidant(37.421.54%free radical scavenging in DPPH assay)properties.Polymers required 35.05.0 mN detachment force to get it detach from the mucosal surface during mucoadhesive test.Tensile strength was found to be 1.880.13 N/mm2 during mechanical stability test.Hydrogel dressings were permeable to O2/H2O and impermeable to microbes.Release of drug vancomycin occurred through non-Fickian diffusion mechanism and release profile was best described by Korsmeyer-Peppas kinetic model.Overall,these results revealed that these hydrogels could be explored as materials for hydrogel wound dressings.展开更多
基金This work was supported by the National Natural Science Foundation of China(81771338)Natural Science Foundation of Shanghai(19ZR1470500)+1 种基金the Science and Technology Commission of Shanghai Municipality(18511109500)the Fundamental Research Funds for the Central Universities(223201900081).
文摘Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired.Electrospun nanofibrous materials show great application potentials for wound healing owing to relatively large surface area,better mimicry of native extracellular matrix,adjustable waterproofness and breathability,and programmable drug delivery process.In this review article,we begin with a discussion of wound healing process and current commercial wound dressing materials.Then,we emphasize on electrospun nanofibrous materials for wound dressing,covering the efforts for controlling fiber alignment and morphology,constructing 3D scaffolds,developing waterproof-breathable membrane,governing drug delivery performance,and regulating stem cell behavior.Finally,we finish with challenges and future prospects of electrospun nanofibrous materials for wound dressings.
文摘Background Transparent dressings are commonly used to cover central venous catheter sites. However, it has been suggested that they might not allow adequate moisture vapor transmission, resulting in local moistness that promotes bacterial growth. We compared the moisture vapor transmission rates （MVTRs） of different, currently used transparent and traditional gauze dressings. We aimed to determine the MVTRs at different temperatures and humidities. Methods The dressings were used to seal 50-ml plastic centrifuge tubes containing 20 ml deionized water： Tubes in group 1 were covered with 12 layers of ordinary gauze, group 2 with IV3000, group 3 with OPSITE FLEXlGRID, group 4 with 3M HP Tegaderm, and group 5 with 3M Tegaderm. The tubes were placed upright in an artificial climate cabinet, so that the dressings were not touching the water, in order to simulate the conditions of medical dressings in contact with the skin. The average MVTRs were determined under different conditions. MVTRs were also determined with tubes from groups 2-5 laid on their sides, allowing the dressings to touch the water, so simulating contact of the dressings with sweating skin, or wounded skin with exudates. We also calculated the dressings＇ self-reactive abilities by comparing their MVTRs in contact with the water surface with those when not in contact with the water surface. Results Group 1 demonstrated the highest MVTR, followed by groups 2, 4, 3 and 5 under conditions simulating contact of the dressings with normal skin at the following temperatures and humidities： 20℃/30%, 20℃/60%, 20℃/90%, 37℃/30%, 37℃/60% and 37℃/90%. When the relative humidity （RH） increased, the MVTRs decreased. The MVTRs differed significantly among different dressings and RHs： At high temperature （37℃） and high humidity （90%）, the MVTR of the transparent dressings in group 2 was higher than that of group 1 （P 〈0.01）. The reactive MVTR was highest in group 2 （10.2-16.3 times 〉MVTR） while that of group 4 was second
文摘目的观察早期应用水胶体敷料预防经外周静脉穿刺中心静脉置管（peripherally inserted central catheter,PICC）术后机械性静脉炎的效果。方法选取2014年1月-2015年11月行PICC治疗的肿瘤患者62例,随机将其分为对照组和观察组各31例。观察组患者置管后在置管部位上方5～6cm处沿静脉穿刺走向覆盖10cm×10cm的水胶体敷料,7d更换1次;对照组患者置管后给予11cm×12cm透明敷贴固定,7d更换1次。2组患者均按PICC护理常规进行护理,观察2组患者机械性静脉炎的发生情况。结果观察组患者中仅有1例发生I级静脉炎,发生率为3.23%;对照组患者中7例发生静脉炎,其中5例为I级静脉炎,2例为II级静脉炎,发生率为22.58%。观察组患者静脉炎发生率显著低于对照组。结论早期应用水胶体敷料能有效预防PICC置管术后机械性静脉炎的发生。
基金The work is supported financially by National Natural Science Foundation of China(Grant no.11672198)Jiangsu Higher Education Institutions of China(Grant no.20KJA130001)+1 种基金Six Talent Peaks Project of Jiangsu Province(Grant no.GDZB-050)PAPD(A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions).
文摘A good wound dressing needs to promote wound healing and tissue repair when the skin is injured.In this study,a self-made spherical section free surface electrospinning device was used to produce large quantities of electrospun porous polylactic acid(PLA)/chitosan(CS)/aloin nanofiber membranes(NFMs)for antibacterial wound dressing.The porous structures of PLAbased nanofibers were controlled by adjusting the weight ratios of mixed solvent and solute.The results showed that highquality porous PLA/CS/aloin(PCA)NFMs were obtained when the weight ratios of chloroform/N,N-dimethylformamide and PLA:CS were 90/10 and 7:1,respectively.The porous PCA NFMs exhibited high porosity,acceptable mechanical properties,moderate hydrophobicity,good swelling property,and high water vapor transmission rate.Moreover,they also showed excellent blood coagulative,antibacterial,biocompatible properties,which had the potential to be used in the application of antibacterial wound dressings.
基金Science and Technology Program of Shaanxi Province(No.2019GY-200).
文摘A hydrogel dressing based on bacterial cellulose(BC),which is grafted with quaternary ammonium func-tional and crosslinked with the gelatin-heparin system,is prepared to provide the features mainly con-cerning softness,high swelling ratio,antibacterial property,and biocompatibility.An innovation of prepa-ration is that the BC is beaten into short-chain scaffolds to improve the efficiency of grafting,which not only simplifies the preparation process but also avoids the biotoxicity caused by the introduction of toxic catalyst such as dimethyl sulfoxide(DMSO)or uncertain toxic side products in long-chain graft-ing.Scanning electron microscopy(SEM)shows that the QBC/Hep/Gel composite hydrogel possesses a three-dimensional mesh structure with high porosity.The hydrogel shows outstanding water manage-ment performance indicated by the swelling ratio of 1476%,water retention ratio of more than 90%at 120 h,and moisture permeability of 3296 g m^(-2) 24 h^(-1).The antibacterial experiment is implemented with staphylococcus aureus,and the antibacterial effect is represented by an inhibition zone of 3 cm in diameter.In vivo animal experiments suggested that QBC/Hep/Gel could effectively promote epithelial reconstruction,collagen deposition,and angiogenesis in normal wounds,reduce inflammation,and ac-celerate wound healing.All these results indicate that the proposed QBC/Hep/Gel hydrogel is a potential composite for antibacterial dressing.
文摘Bioactive tragacanth gum(TG)was functionalized by covalent crosslinking of poly[2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide(PMEDSAH)to design network structure in form of hydrogel wound dressings(HWD).These copolymers were encapsulated with antibiotic drug vancomycin to enhance wound healing potential of the dressings.The copolymers were characterized by SEM,AFM,FTIR,13C NMR,XRD,and TGA-DSC analysis.SEM demonstrated uneven heterogeneous morphology and AFM revealed rough surface of copolymer.Inclusion of synthetic component into HD was confirmed by FTIR and 13C NMR.Hydrogel dressings absorbed 8.491.03 g/g simulated wound fluid and exhibited non-hemolytic(3.70.02%hemolytic potential)and antioxidant(37.421.54%free radical scavenging in DPPH assay)properties.Polymers required 35.05.0 mN detachment force to get it detach from the mucosal surface during mucoadhesive test.Tensile strength was found to be 1.880.13 N/mm2 during mechanical stability test.Hydrogel dressings were permeable to O2/H2O and impermeable to microbes.Release of drug vancomycin occurred through non-Fickian diffusion mechanism and release profile was best described by Korsmeyer-Peppas kinetic model.Overall,these results revealed that these hydrogels could be explored as materials for hydrogel wound dressings.
