At present,humanity is suffering from affliction caused by cancer,cardiovascular disease,viral infection,aging and other human disease,which are seriously increasing.The spread of these diseases is leading to social c...At present,humanity is suffering from affliction caused by cancer,cardiovascular disease,viral infection,aging and other human disease,which are seriously increasing.The spread of these diseases is leading to social crisis,thereby threatening human civilization.To conquer these human diseases,it has become necessary ot find new ways to understand the mechanisms of disease genesis,as well as to discover new drugs specific for these diseases.One possible way is“Regulation of DNA Replication and Human Diseases”.\;As discussed in the afore\|mentioned articles,the most essential aspect of biology is DNA replication.The interactions between some factors in cell regulation network and cell cycle form the regulation system of DNA replication,which allows the cell to finish exact DNA replication and to maintain stability of the genome.As stated in this review,many unknown questions related with cancere cell proliferation,cell pathogenesis or ageing and viral replication are raised in the relationship between regulation of DNA replication and human diseases.Based on the developments of biological science,the study of “Regulation of DNA Replication and Human Diseases” has an abundant potential of original and sustained innovations,as well as being an important developmental step of modern biomedical research area in the post\|genomic era.Upon the application of systematic longitudinal difference studies that are embodied in the methodology of Bio\|omics,the studies of “Regulation of DNA Replication and Human Diseases” could profoundly explore DNA mutations,regulation factors and metabolic molecules related closely with human diseases.This information could offere theoretical basis and exact targets for new drug devlopments to inhibit candcer cell proliferation,to reverse pathogenetic or aged cells,and to prevent viral replication.This will result in the creation of new and innovative ways to treat human diseases.In conclusion,the studies of “Regulation of DNA Replication and Human Diseases” possess great sig展开更多
目的探讨乙型肝炎性肝癌患者肿瘤微环境中淋巴细胞浸润情况及其临床意义。方法前瞻性纳入内蒙古医科大学附属医院2014年1月至2016年1月收治的乙型肝炎(HBV)性肝癌患者40例作为研究组,同期收集非肝炎性肝癌患者40例作为对照组。观察两组...目的探讨乙型肝炎性肝癌患者肿瘤微环境中淋巴细胞浸润情况及其临床意义。方法前瞻性纳入内蒙古医科大学附属医院2014年1月至2016年1月收治的乙型肝炎(HBV)性肝癌患者40例作为研究组,同期收集非肝炎性肝癌患者40例作为对照组。观察两组患者肿瘤微环境中CD4^+T细胞、CD8^+T细胞、Treg细胞水平,以及外周血中IL-2、IL-10、TGF-β水平。同时观察HBV DNA病毒载量与免疫指标的相关性。结果与对照组比较,研究组患者CD4+T细胞水平显著升高[(21.08±3.12)%vs(19.72±2.89)%,P=0.047],CD8+T细胞水平显著降低[(28.83±2.52)%vs(30.07±2.41)%,P=0.027],Treg细胞水平显著升高[(8.12±1.47)%vs(6.62±1.42)%,P<0.001];IL-2水平显著降低[(15.48±4.30)pg/m L vs(27.28±5.95)pg/m L,P<0.001),IL-10水平显著升高[(36.39±7.69)pg/m L vs(29.82±6.17)pg/m L,P<0.001),TGF-β水平显著升高[(31.95±3.72)pg/m L vs(23.49±3.83)pg/m L,P<0.001)。Pearson线性相关性分析显示,HBV DNA病毒载量与CD8+T细胞及IL-2水平负相关,与CD4+T细胞、Treg和TGF-β水平正相关(P<0.05)。结论乙型肝炎性肝癌患者肿瘤组织微环境中淋巴细胞失衡,且与HBV DNA病毒载量有关。展开更多
文摘At present,humanity is suffering from affliction caused by cancer,cardiovascular disease,viral infection,aging and other human disease,which are seriously increasing.The spread of these diseases is leading to social crisis,thereby threatening human civilization.To conquer these human diseases,it has become necessary ot find new ways to understand the mechanisms of disease genesis,as well as to discover new drugs specific for these diseases.One possible way is“Regulation of DNA Replication and Human Diseases”.\;As discussed in the afore\|mentioned articles,the most essential aspect of biology is DNA replication.The interactions between some factors in cell regulation network and cell cycle form the regulation system of DNA replication,which allows the cell to finish exact DNA replication and to maintain stability of the genome.As stated in this review,many unknown questions related with cancere cell proliferation,cell pathogenesis or ageing and viral replication are raised in the relationship between regulation of DNA replication and human diseases.Based on the developments of biological science,the study of “Regulation of DNA Replication and Human Diseases” has an abundant potential of original and sustained innovations,as well as being an important developmental step of modern biomedical research area in the post\|genomic era.Upon the application of systematic longitudinal difference studies that are embodied in the methodology of Bio\|omics,the studies of “Regulation of DNA Replication and Human Diseases” could profoundly explore DNA mutations,regulation factors and metabolic molecules related closely with human diseases.This information could offere theoretical basis and exact targets for new drug devlopments to inhibit candcer cell proliferation,to reverse pathogenetic or aged cells,and to prevent viral replication.This will result in the creation of new and innovative ways to treat human diseases.In conclusion,the studies of “Regulation of DNA Replication and Human Diseases” possess great sig
文摘目的探讨乙型肝炎性肝癌患者肿瘤微环境中淋巴细胞浸润情况及其临床意义。方法前瞻性纳入内蒙古医科大学附属医院2014年1月至2016年1月收治的乙型肝炎(HBV)性肝癌患者40例作为研究组,同期收集非肝炎性肝癌患者40例作为对照组。观察两组患者肿瘤微环境中CD4^+T细胞、CD8^+T细胞、Treg细胞水平,以及外周血中IL-2、IL-10、TGF-β水平。同时观察HBV DNA病毒载量与免疫指标的相关性。结果与对照组比较,研究组患者CD4+T细胞水平显著升高[(21.08±3.12)%vs(19.72±2.89)%,P=0.047],CD8+T细胞水平显著降低[(28.83±2.52)%vs(30.07±2.41)%,P=0.027],Treg细胞水平显著升高[(8.12±1.47)%vs(6.62±1.42)%,P<0.001];IL-2水平显著降低[(15.48±4.30)pg/m L vs(27.28±5.95)pg/m L,P<0.001),IL-10水平显著升高[(36.39±7.69)pg/m L vs(29.82±6.17)pg/m L,P<0.001),TGF-β水平显著升高[(31.95±3.72)pg/m L vs(23.49±3.83)pg/m L,P<0.001)。Pearson线性相关性分析显示,HBV DNA病毒载量与CD8+T细胞及IL-2水平负相关,与CD4+T细胞、Treg和TGF-β水平正相关(P<0.05)。结论乙型肝炎性肝癌患者肿瘤组织微环境中淋巴细胞失衡,且与HBV DNA病毒载量有关。
