目的通过分析小鼠表皮内T淋巴细胞(dendritic epidermal T cells,DETCs)的形态、表型及细胞因子的表达情况,揭示小鼠DETCs活化后能够发挥抗原递呈功能。方法通过免疫荧光的方法观察DETCs的形态,通过流式细胞技术分析DETCs的表型及细胞...目的通过分析小鼠表皮内T淋巴细胞(dendritic epidermal T cells,DETCs)的形态、表型及细胞因子的表达情况,揭示小鼠DETCs活化后能够发挥抗原递呈功能。方法通过免疫荧光的方法观察DETCs的形态,通过流式细胞技术分析DETCs的表型及细胞因子的表达情况。通过DETCs和na觙ve CD4+T细胞进行共培养,观察DETCs对淋巴细胞分化方向的影响。结果 DETCs在形态上表现出抗原递呈细胞的树突状特征,活化后分泌一定水平的IFN-γ,DETCs活化后在体外与na觙ve CD4+T细胞共培养可以诱导该型T细胞向Th1方向分化。结论小鼠DETCs具有抗原递呈细胞的基本特征,是皮肤免疫微环境的重要组成部分。展开更多
This paper studies the dynamic event-triggered leader-follower consensus of nonlinear multi-agent systems(MASs)under directed weighted graph containing a directed spanning tree,and also considers the effects of distur...This paper studies the dynamic event-triggered leader-follower consensus of nonlinear multi-agent systems(MASs)under directed weighted graph containing a directed spanning tree,and also considers the effects of disturbances and leader of non-zero control inputs in the system.Firstly,a novel distributed control protocol is designed for uncertain disturbances and leader of non-zero control inputs in MASs.Secondly,a novel dynamic event-triggered control(DETC)strategy is proposed,which eliminates the need for continuous communication between agents and reduces communication resources between agents.By introducing dynamic thresholds,the complexity of excluding Zeno behavior within the system is reduced.Finally,the effectiveness of the proposed theory is validated through numerical simulation.展开更多
目的通过对 CD3^+表皮内 T 细胞在人体正常皮肤及瘢痕组织中的分布密度的研究,阐明表皮内 T 细咆对表皮细胞发育分化、分裂再生的影响。方法利用组织学和免疫组织化学法,观察表皮内 T 细胞在表皮组织中的分布。结果正常表皮组织中存在...目的通过对 CD3^+表皮内 T 细胞在人体正常皮肤及瘢痕组织中的分布密度的研究,阐明表皮内 T 细咆对表皮细胞发育分化、分裂再生的影响。方法利用组织学和免疫组织化学法,观察表皮内 T 细胞在表皮组织中的分布。结果正常表皮组织中存在有少量 CD3^+表皮内 T 细胞,增生性瘢痕组织中可见较正常组织数量多的 CD3^+表皮内 T 细胞,表皮细胞增生活跃,萎缩性瘢痕组织中未发现有 CD3^+表皮内 T 细胞存在,表皮细胞层平坦。结论正常皮肤组织和瘢痕组织中CD3^+表皮内 T 细胞的分布情况不同,提示 CD3^+表皮内 T 细胞可能与表皮细胞的发育分化、分裂再生有关,CD3^+表皮内 T 细胞在表皮组织中的正常分布,对维持表皮组织的正常形态可能具有特殊意义。展开更多
基金supported by the National Natural Science Foundation of China(62173175)。
文摘This paper studies the dynamic event-triggered leader-follower consensus of nonlinear multi-agent systems(MASs)under directed weighted graph containing a directed spanning tree,and also considers the effects of disturbances and leader of non-zero control inputs in the system.Firstly,a novel distributed control protocol is designed for uncertain disturbances and leader of non-zero control inputs in MASs.Secondly,a novel dynamic event-triggered control(DETC)strategy is proposed,which eliminates the need for continuous communication between agents and reduces communication resources between agents.By introducing dynamic thresholds,the complexity of excluding Zeno behavior within the system is reduced.Finally,the effectiveness of the proposed theory is validated through numerical simulation.
文摘目的通过对 CD3^+表皮内 T 细胞在人体正常皮肤及瘢痕组织中的分布密度的研究,阐明表皮内 T 细咆对表皮细胞发育分化、分裂再生的影响。方法利用组织学和免疫组织化学法,观察表皮内 T 细胞在表皮组织中的分布。结果正常表皮组织中存在有少量 CD3^+表皮内 T 细胞,增生性瘢痕组织中可见较正常组织数量多的 CD3^+表皮内 T 细胞,表皮细胞增生活跃,萎缩性瘢痕组织中未发现有 CD3^+表皮内 T 细胞存在,表皮细胞层平坦。结论正常皮肤组织和瘢痕组织中CD3^+表皮内 T 细胞的分布情况不同,提示 CD3^+表皮内 T 细胞可能与表皮细胞的发育分化、分裂再生有关,CD3^+表皮内 T 细胞在表皮组织中的正常分布,对维持表皮组织的正常形态可能具有特殊意义。
