目的 研究NG D 硝基精氨酸 (NG nitro D arginine,D NNA)在体内发生手性转化的的部位。方法 考察肾脏结扎对于D NNA诱导大鼠动脉压升高活性的变化 ,并运用毛细管电色谱 (capillaryelectrochromatography ,CEC)分析技术测定D NNA在体...目的 研究NG D 硝基精氨酸 (NG nitro D arginine,D NNA)在体内发生手性转化的的部位。方法 考察肾脏结扎对于D NNA诱导大鼠动脉压升高活性的变化 ,并运用毛细管电色谱 (capillaryelectrochromatography ,CEC)分析技术测定D NNA在体内手性转化的情况。结果 肾脏结扎使大鼠完全丧失对D NNA (32mg·kg-1)升高血压反应 ,但不影响由NG L 硝基精氨酸 (NG nitro L arginine ,L NNA)(16mg·kg-1)引起的升压反应。而D NNA/肾匀浆孵育液(32mg·kg-1)则可使肾脏结扎大鼠产生升压反应。CEC血药检测证实D NNA在大鼠体内转化生成L NNA ,而L NNA在体内未被代谢生成D NNA ;肾脏结扎则使D NNA的手性转化大量减少。结论 D NNA在大鼠体内可单向代谢转化L NNA ,肾脏是D展开更多
Reentry attitude control for reusable launch vehicles （RLVs） is challenging due to the characters of fast nonlinear dy- namics and large flight envelop. A hierarchical structured attitude control system for an RLV i...Reentry attitude control for reusable launch vehicles （RLVs） is challenging due to the characters of fast nonlinear dy- namics and large flight envelop. A hierarchical structured attitude control system for an RLV is proposed and an unpowered RLV con- trol model is developed. Then, the hierarchical structured control frame consisting of attitude controller, compound control strategy and control allocation is presented. At the core of the design is a robust adaptive control （RAC） law based on dual loop time-scale separation. A radial basis function neural network （RBFNN） is implemented for compensation of uncertain model dynamics and external disturbances in the inner loop. And then the robust op- timization is applied in the outer loop to guarantee performance robustness. The overall control design frame retains the simplicity in design while simultaneously assuring the adaptive and robust performance. The hierarchical structured robust adaptive con- troller （HSRAC） incorporates flexibility into the design with regard to controller versatility to various reentry mission requirements. Simulation results show that the improved tracking performance is achieved by means of RAC.展开更多
文摘目的 研究NG D 硝基精氨酸 (NG nitro D arginine,D NNA)在体内发生手性转化的的部位。方法 考察肾脏结扎对于D NNA诱导大鼠动脉压升高活性的变化 ,并运用毛细管电色谱 (capillaryelectrochromatography ,CEC)分析技术测定D NNA在体内手性转化的情况。结果 肾脏结扎使大鼠完全丧失对D NNA (32mg·kg-1)升高血压反应 ,但不影响由NG L 硝基精氨酸 (NG nitro L arginine ,L NNA)(16mg·kg-1)引起的升压反应。而D NNA/肾匀浆孵育液(32mg·kg-1)则可使肾脏结扎大鼠产生升压反应。CEC血药检测证实D NNA在大鼠体内转化生成L NNA ,而L NNA在体内未被代谢生成D NNA ;肾脏结扎则使D NNA的手性转化大量减少。结论 D NNA在大鼠体内可单向代谢转化L NNA ,肾脏是D
基金supported by the National Natural Science Foundation of China(61174221)
文摘Reentry attitude control for reusable launch vehicles （RLVs） is challenging due to the characters of fast nonlinear dy- namics and large flight envelop. A hierarchical structured attitude control system for an RLV is proposed and an unpowered RLV con- trol model is developed. Then, the hierarchical structured control frame consisting of attitude controller, compound control strategy and control allocation is presented. At the core of the design is a robust adaptive control （RAC） law based on dual loop time-scale separation. A radial basis function neural network （RBFNN） is implemented for compensation of uncertain model dynamics and external disturbances in the inner loop. And then the robust op- timization is applied in the outer loop to guarantee performance robustness. The overall control design frame retains the simplicity in design while simultaneously assuring the adaptive and robust performance. The hierarchical structured robust adaptive con- troller （HSRAC） incorporates flexibility into the design with regard to controller versatility to various reentry mission requirements. Simulation results show that the improved tracking performance is achieved by means of RAC.
