Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with appa...Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavai lable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men （mean age： 52.8--- 9.3 years） not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log （sex hormone） levels and log （coronary calcium score） after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ~〉 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score （P=0.046） after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein （HDL） cholesterol, hypertension medication and hyperlipidernia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not （P=0.674, P=O. 121 and P=O. 102, respectively）. Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.展开更多
AIM To investigate the relationship between coronary calcium score(CCS) and vulnerable plaque/significant stenosis using coronary computed tomographic angiography(CCTA). METHODS CCTA was performed in 651 patients and ...AIM To investigate the relationship between coronary calcium score(CCS) and vulnerable plaque/significant stenosis using coronary computed tomographic angiography(CCTA). METHODS CCTA was performed in 651 patients and these patients were divided into the four groups(CCS 0, 1-100, 101-400 and > 400). We studied the incidence of high-risk plaque, including positive remodeling, low attenuation plaque, spotty calcification, and napkin-ring sign, and significant stenosis in each group. RESULTS High-risk plaque was found in 1.3%, 10.1%, 13.3% and 13.4% of patients with CCS 0, 1-100, 101-400 and > 400, respectively(P < 0.001). The difference was only significant for patients with zero CCS. The incidence of significant stenosis was 0.6%, 7.6%, 13.3% and 26.9% for each patient group, respectively(P < 0.001), which represented a significant stepwise increase as CCS increased. The combined incidence of high-risk plaque and significant stenosis was 1.9%, 17.7%, 26.9% and 40.3% in each patient group, respectively(P < 0.001), again representing a significant stepwise increase with CCS. The rate of major coronary event was 0%, 4.0%, 7.9% and 17.2% in each patient group, respectively(P < 0.001), another significant stepwise increase as CCS increased. CONCLUSION Stepwise increased risk of coronary events associated with increasing CCS is caused by increasing incidence of significant stenosis, while that of high-risk plaque remains the same.展开更多
Background Previous studies have compared single-photon emission computed tomography (SPECT) and electron beam computed tomography (EBCT) in detection of coronary artery disease (CAD) in patients with myocardial infa...Background Previous studies have compared single-photon emission computed tomography (SPECT) and electron beam computed tomography (EBCT) in detection of coronary artery disease (CAD) in patients with myocardial infarction (MI) The purpose of this study was to compare SPECT with EBCT in detection of CAD in patients with no MI Methods One hundred and forty-seven patients with suspected CAD underwent stress-rest 99m Tc-methoxyisobutylisonitrile ( 99m Tc-MIBI) myocardial SPECT, cardiac EBCT and coronary angiography (CAG) within one month Of them, 73 patients (aged 52 6±10 6 years old) with no history of MI were included in this study Coronary artery calcium (CAC) was defined as a CT value ≥130 HU within the boundary of coronary artery on EBCT Results There were 35 and 38 patients with or without CAD according to CAG Ninety-six percent of the patients with abnormal SPECT and CAC had a coronary arteries stenosis ≥50%, and 90 9% patients with normal SPECT and EBCT showed no CAD The sensitivity of SPECT and EBCT in detection of CAD was comparable, and the specificity of SPECT (92 1%) was significantly higher than that of EBCT (55 3%) ( P <0 005) For the detection of individual coronary artery stenosis, both sensitivity and specificity of SPECT (75 0% and 93 7%) were significantly higher than those of EBCT (53 3% and 76 7%) ( P <0 025 and P <0 005, respectively) In patients without chest pain, the sensitivity and specificity of SPECT (76 9% and 91 4%) were significantly higher than those of EBCT (23 1% and 69 0%) in detection of a coronary artery stenosis of ≥50% ( P <0 01 and P <0 005, respectively) However, in patients with chest pain, both sensitivity and specificity of SPECT were comparable to those of EBCT In patients ≤45 years old, the sensitivity of SPECT (77 8%) was significantly higher than that of EBCT (27 8%) in assessing a coronary artery stenosis of ≥50% ( P <0 005), and the specificity of SPECT was comparable to that of EBCT In展开更多
文摘Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavai lable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men （mean age： 52.8--- 9.3 years） not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log （sex hormone） levels and log （coronary calcium score） after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ~〉 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score （P=0.046） after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein （HDL） cholesterol, hypertension medication and hyperlipidernia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not （P=0.674, P=O. 121 and P=O. 102, respectively）. Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.
文摘AIM To investigate the relationship between coronary calcium score(CCS) and vulnerable plaque/significant stenosis using coronary computed tomographic angiography(CCTA). METHODS CCTA was performed in 651 patients and these patients were divided into the four groups(CCS 0, 1-100, 101-400 and > 400). We studied the incidence of high-risk plaque, including positive remodeling, low attenuation plaque, spotty calcification, and napkin-ring sign, and significant stenosis in each group. RESULTS High-risk plaque was found in 1.3%, 10.1%, 13.3% and 13.4% of patients with CCS 0, 1-100, 101-400 and > 400, respectively(P < 0.001). The difference was only significant for patients with zero CCS. The incidence of significant stenosis was 0.6%, 7.6%, 13.3% and 26.9% for each patient group, respectively(P < 0.001), which represented a significant stepwise increase as CCS increased. The combined incidence of high-risk plaque and significant stenosis was 1.9%, 17.7%, 26.9% and 40.3% in each patient group, respectively(P < 0.001), again representing a significant stepwise increase with CCS. The rate of major coronary event was 0%, 4.0%, 7.9% and 17.2% in each patient group, respectively(P < 0.001), another significant stepwise increase as CCS increased. CONCLUSION Stepwise increased risk of coronary events associated with increasing CCS is caused by increasing incidence of significant stenosis, while that of high-risk plaque remains the same.
文摘Background Previous studies have compared single-photon emission computed tomography (SPECT) and electron beam computed tomography (EBCT) in detection of coronary artery disease (CAD) in patients with myocardial infarction (MI) The purpose of this study was to compare SPECT with EBCT in detection of CAD in patients with no MI Methods One hundred and forty-seven patients with suspected CAD underwent stress-rest 99m Tc-methoxyisobutylisonitrile ( 99m Tc-MIBI) myocardial SPECT, cardiac EBCT and coronary angiography (CAG) within one month Of them, 73 patients (aged 52 6±10 6 years old) with no history of MI were included in this study Coronary artery calcium (CAC) was defined as a CT value ≥130 HU within the boundary of coronary artery on EBCT Results There were 35 and 38 patients with or without CAD according to CAG Ninety-six percent of the patients with abnormal SPECT and CAC had a coronary arteries stenosis ≥50%, and 90 9% patients with normal SPECT and EBCT showed no CAD The sensitivity of SPECT and EBCT in detection of CAD was comparable, and the specificity of SPECT (92 1%) was significantly higher than that of EBCT (55 3%) ( P <0 005) For the detection of individual coronary artery stenosis, both sensitivity and specificity of SPECT (75 0% and 93 7%) were significantly higher than those of EBCT (53 3% and 76 7%) ( P <0 025 and P <0 005, respectively) In patients without chest pain, the sensitivity and specificity of SPECT (76 9% and 91 4%) were significantly higher than those of EBCT (23 1% and 69 0%) in detection of a coronary artery stenosis of ≥50% ( P <0 01 and P <0 005, respectively) However, in patients with chest pain, both sensitivity and specificity of SPECT were comparable to those of EBCT In patients ≤45 years old, the sensitivity of SPECT (77 8%) was significantly higher than that of EBCT (27 8%) in assessing a coronary artery stenosis of ≥50% ( P <0 005), and the specificity of SPECT was comparable to that of EBCT In
