Background Outcomes in patients requiring coronary artery bypass graft （CABG） surgery have been improved with devices such as the intra-aortic balloon pump （IABP）.Good coronary collateral circulation （CCC） has b...Background Outcomes in patients requiring coronary artery bypass graft （CABG） surgery have been improved with devices such as the intra-aortic balloon pump （IABP）.Good coronary collateral circulation （CCC） has been shown to reduce mortality in patients with coronary artery disease （CAD）.We aimed to investigate whether poor preoperative CCC grade is a predictor of in-hospital mortality in CABG surgery requiring IABP support.Methods Fifty-five consecutive patients who were undergoing isolated first time on-pump CABG surgery with IABP support were enrolled into this study and CCC of those patients was evaluated.Results Twenty-seven patients had poor CCC and 28 patients had good CCC.In-hospital mortality rate in poor CCC group was significantly higher than good CCC group （14 （50％） vs.4 （13％）,P=0.013）.Preoperative hemoglobin level （OR：0.752; 95％ CI,0.571-0.991,P=0.043）,chronic obstructive pulmonary disease （OR：6.731; 95％ CI,1.159-39.085,P=0.034） and poor CCC grade （OR：5.750; 95％ CI,1.575-20.986,P=0.008） were associated with post-CABG in-hospital mortality.Poor CCC grade （OR：4.853; 95％ CI,1.124-20.952,P=0.034） and preoperative hemoglobin level （OR：0.624; 95％ CI,0.476-0.954,P=0.026） were independent predictors of in-hospital mortality after CABG.Conclusion Preoperative poor CCC and hemoglobin are predictors of in-hospital mortality after CABG with IABP support.展开更多
目的比较依托咪酯与咪达唑仑对非体外循环冠状动脉搭桥手术气管插管期间血流动力学的影响。方法非体外循环冠状动脉搭桥手术患者60例,随机分为依托咪酯组(E组)和咪达唑仑组(M组)各30例。麻醉诱导用药:E组给予依托咪酯0.3 mg.kg-1,舒芬太...目的比较依托咪酯与咪达唑仑对非体外循环冠状动脉搭桥手术气管插管期间血流动力学的影响。方法非体外循环冠状动脉搭桥手术患者60例,随机分为依托咪酯组(E组)和咪达唑仑组(M组)各30例。麻醉诱导用药:E组给予依托咪酯0.3 mg.kg-1,舒芬太尼1.0μg.k-g1、罗库溴铵0.9 mg.kg-1;M组给予咪达唑仑0.15mg.kg-1、舒芬尼1.0μg.kg-1、罗库溴铵0.9 mg.kg-1。在麻醉期间连续监测和记录心电图(ECG)、收缩压(SBP)、舒张压(DBP)、心率(HR)及脉搏血氧饱和度(SpO2)的变化,并计算心率和收缩压乘积(RPP)。记录气管插管时间。结果M组麻醉诱导后气管插管开始时SBP、DBP均较气管插管前明显下降(P<0.05),气管插管后1 m in SBP、DBP、RPP和HR均较气管插管开始时显著升高(P<0.01),且插管后1 m in RPP比气管插管前明显升高(P<0.01)。与E组对应值比较,气管插管开始时M组SBP、DBP显著降低(P<0.05或0.01),而气管插管后1 m inM组SBP、DBP和RPP均显著升高(P<0.05或P<0.01)。结论与咪达唑仑相比,非体外循环冠脉搭桥手术患者麻醉诱导时使用依托咪酯可更有效抑制气管插管时的心血管反应。展开更多
文摘Background Outcomes in patients requiring coronary artery bypass graft （CABG） surgery have been improved with devices such as the intra-aortic balloon pump （IABP）.Good coronary collateral circulation （CCC） has been shown to reduce mortality in patients with coronary artery disease （CAD）.We aimed to investigate whether poor preoperative CCC grade is a predictor of in-hospital mortality in CABG surgery requiring IABP support.Methods Fifty-five consecutive patients who were undergoing isolated first time on-pump CABG surgery with IABP support were enrolled into this study and CCC of those patients was evaluated.Results Twenty-seven patients had poor CCC and 28 patients had good CCC.In-hospital mortality rate in poor CCC group was significantly higher than good CCC group （14 （50％） vs.4 （13％）,P=0.013）.Preoperative hemoglobin level （OR：0.752; 95％ CI,0.571-0.991,P=0.043）,chronic obstructive pulmonary disease （OR：6.731; 95％ CI,1.159-39.085,P=0.034） and poor CCC grade （OR：5.750; 95％ CI,1.575-20.986,P=0.008） were associated with post-CABG in-hospital mortality.Poor CCC grade （OR：4.853; 95％ CI,1.124-20.952,P=0.034） and preoperative hemoglobin level （OR：0.624; 95％ CI,0.476-0.954,P=0.026） were independent predictors of in-hospital mortality after CABG.Conclusion Preoperative poor CCC and hemoglobin are predictors of in-hospital mortality after CABG with IABP support.
文摘目的比较依托咪酯与咪达唑仑对非体外循环冠状动脉搭桥手术气管插管期间血流动力学的影响。方法非体外循环冠状动脉搭桥手术患者60例,随机分为依托咪酯组(E组)和咪达唑仑组(M组)各30例。麻醉诱导用药:E组给予依托咪酯0.3 mg.kg-1,舒芬太尼1.0μg.k-g1、罗库溴铵0.9 mg.kg-1;M组给予咪达唑仑0.15mg.kg-1、舒芬尼1.0μg.kg-1、罗库溴铵0.9 mg.kg-1。在麻醉期间连续监测和记录心电图(ECG)、收缩压(SBP)、舒张压(DBP)、心率(HR)及脉搏血氧饱和度(SpO2)的变化,并计算心率和收缩压乘积(RPP)。记录气管插管时间。结果M组麻醉诱导后气管插管开始时SBP、DBP均较气管插管前明显下降(P<0.05),气管插管后1 m in SBP、DBP、RPP和HR均较气管插管开始时显著升高(P<0.01),且插管后1 m in RPP比气管插管前明显升高(P<0.01)。与E组对应值比较,气管插管开始时M组SBP、DBP显著降低(P<0.05或0.01),而气管插管后1 m inM组SBP、DBP和RPP均显著升高(P<0.05或P<0.01)。结论与咪达唑仑相比,非体外循环冠脉搭桥手术患者麻醉诱导时使用依托咪酯可更有效抑制气管插管时的心血管反应。
