Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus ...Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery.展开更多
建立牛角膜浑浊和渗透性(BCOP)结合基于细胞活性生物标记物的荧光染色用于评价化妆品眼刺激性的方法。采用BCOP法对市售的洗发水、沐浴类和洁面类化妆品进行眼刺激性检测,同时对角膜进行冰冻切片并染色,鬼笔环肽对胞内的f-actin(filamen...建立牛角膜浑浊和渗透性(BCOP)结合基于细胞活性生物标记物的荧光染色用于评价化妆品眼刺激性的方法。采用BCOP法对市售的洗发水、沐浴类和洁面类化妆品进行眼刺激性检测,同时对角膜进行冰冻切片并染色,鬼笔环肽对胞内的f-actin(filamentous actin)丝状肌动蛋白进行染色,DAPI染色检测细胞核后,测量损伤深度(depth of injury,DOI),依据BCOP测试结果、Draize试验结果及DOI,建立预测模型。结果表明,通过DOI检测,可对化妆品轻刺激性和中刺激性进行区分,DOI检测显然能够为眼刺激性分类提供更可靠的依据,适用于化妆品眼刺激性的评价。展开更多
文摘Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery.
文摘建立牛角膜浑浊和渗透性(BCOP)结合基于细胞活性生物标记物的荧光染色用于评价化妆品眼刺激性的方法。采用BCOP法对市售的洗发水、沐浴类和洁面类化妆品进行眼刺激性检测,同时对角膜进行冰冻切片并染色,鬼笔环肽对胞内的f-actin(filamentous actin)丝状肌动蛋白进行染色,DAPI染色检测细胞核后,测量损伤深度(depth of injury,DOI),依据BCOP测试结果、Draize试验结果及DOI,建立预测模型。结果表明,通过DOI检测,可对化妆品轻刺激性和中刺激性进行区分,DOI检测显然能够为眼刺激性分类提供更可靠的依据,适用于化妆品眼刺激性的评价。
