Planar bone Scintigraphy has been frequently used to assess the active or inactive nature of mandibular hypercondylia. We report here the case of a patient whose diagnosis of active mandibular hypercondylia was retain...Planar bone Scintigraphy has been frequently used to assess the active or inactive nature of mandibular hypercondylia. We report here the case of a patient whose diagnosis of active mandibular hypercondylia was retained after a complement with SPECT/CT imaging, the planar bone scan being negative. This case confirms the use of SPECT/ CT as the examination of choice for full assessment of mandibular hypercondylia in adults. Using bone Scintigraphy SPECT/CT improves both sensitivity and specificity of diagnosing this condition.展开更多
Objectives: To 1) explore the planar scintigraphic findings in asymmetry patients caused by unilateral condylar hyperplasia (UCH) or asymmetric mandibular hyperplasia (AMH);2) develop a local agecondylar activity refe...Objectives: To 1) explore the planar scintigraphic findings in asymmetry patients caused by unilateral condylar hyperplasia (UCH) or asymmetric mandibular hyperplasia (AMH);2) develop a local agecondylar activity reference norm;and 3) check the accuracy of the new norm and compare with other analytical methods. Material and Method: Chinese patients with mandibular asymmetry and scintigraphic findings available were recruited. Clinical, radiographic records and scintigraphic condylar activity ratio (CAR) were studied. Regression analysis was performed to quantify the relationship between age and CAR to develop a new norm. The sensitivity of condylar activity assessment using a) traditional norm;b) new norm;and c) percentile difference was compared. In patients with serial data available, longitudinal analysis of the scintigraphic changes were checked. Result: 109 patients were eligible for the study. Significant difference in CAR was noted between UCH and AMH patients. Linear relationship was observed between age and CAR. A new norm of the age-CAR was established, which showed improved sensitivity in condylar activity prediction in UCH and AMH when compared with traditional norm. Relative to percentile difference, the sensitivity of new norm was lower in AMH but not in UCH patients. Serial analysis revealed gradual decline in CAR with minimal change in percentile difference. Conclusion and Clinical Relevance: There is difference in scintigraphic condylar activity between UCH and AMH patients. A norm of age-CAR relationship was established, which showed improved sensitivity in condylar activity prediction in UCH patients. Further study is required to confirm the role of scintigraphy in AMH.展开更多
文摘目的:探讨Sonic hedgehog(Shh)信号通路对髁突肥大软骨细胞凋亡活性的影响。方法:取正常髁突软骨3例,髁突肥大软骨6例,酶消化法分离培养其软骨细胞后,用Western blotting和Real-time PCR法分别检测两种软骨细胞中凋亡效应因子cleaved-caspase-3和BCL-2的表达;用免疫组化和Western blotting法比较正常髁突软骨和髁突肥大软骨中Shh和Smo的表达;用Shh、Cyclopamine、LY294002和U0126分别刺激两种软骨细胞,观察cleaved-caspase-3和BCL-2表达的变化。结果:与正常髁突软骨相比,髁突肥大软骨细胞中cleaved-caspase-3的表达水平降低,BCL-2 m RNA的表达水平升高(P<0.05);在髁突肥大软骨中Shh、Smo呈高表达;Shh刺激组软骨细胞的凋亡活性降低(P<0.05),Cyclopamine刺激组软骨细胞的凋亡活性增加(P<0.05),LY294002及U0126刺激组软骨细胞的BCL-2 m RNA表达水平均降低(P<0.05)。结论:Shh可通过介导PI3K/AKT和MAPK/ERK通路而抑制髁突肥大软骨细胞的凋亡,促进髁突肥大的病理进程。
文摘Planar bone Scintigraphy has been frequently used to assess the active or inactive nature of mandibular hypercondylia. We report here the case of a patient whose diagnosis of active mandibular hypercondylia was retained after a complement with SPECT/CT imaging, the planar bone scan being negative. This case confirms the use of SPECT/ CT as the examination of choice for full assessment of mandibular hypercondylia in adults. Using bone Scintigraphy SPECT/CT improves both sensitivity and specificity of diagnosing this condition.
文摘Objectives: To 1) explore the planar scintigraphic findings in asymmetry patients caused by unilateral condylar hyperplasia (UCH) or asymmetric mandibular hyperplasia (AMH);2) develop a local agecondylar activity reference norm;and 3) check the accuracy of the new norm and compare with other analytical methods. Material and Method: Chinese patients with mandibular asymmetry and scintigraphic findings available were recruited. Clinical, radiographic records and scintigraphic condylar activity ratio (CAR) were studied. Regression analysis was performed to quantify the relationship between age and CAR to develop a new norm. The sensitivity of condylar activity assessment using a) traditional norm;b) new norm;and c) percentile difference was compared. In patients with serial data available, longitudinal analysis of the scintigraphic changes were checked. Result: 109 patients were eligible for the study. Significant difference in CAR was noted between UCH and AMH patients. Linear relationship was observed between age and CAR. A new norm of the age-CAR was established, which showed improved sensitivity in condylar activity prediction in UCH and AMH when compared with traditional norm. Relative to percentile difference, the sensitivity of new norm was lower in AMH but not in UCH patients. Serial analysis revealed gradual decline in CAR with minimal change in percentile difference. Conclusion and Clinical Relevance: There is difference in scintigraphic condylar activity between UCH and AMH patients. A norm of age-CAR relationship was established, which showed improved sensitivity in condylar activity prediction in UCH patients. Further study is required to confirm the role of scintigraphy in AMH.
