In January 2013,a severe fog and haze event(FHE)of strong intensity,long duration,and extensive coverage occurred in eastern China.The present study investigates meteorological conditions for this FHE by diagnosing bo...In January 2013,a severe fog and haze event(FHE)of strong intensity,long duration,and extensive coverage occurred in eastern China.The present study investigates meteorological conditions for this FHE by diagnosing both its atmospheric background fields and daily evolution in January 2013.The results show that a weak East Asian winter monsoon existed in January2013.Over eastern China,the anomalous southerly winds in the middle and lower troposphere are favorable for more water vapor transported to eastern China.An anomalous high at 500 hPa suppresses convection.The weakened surface winds are favorable for the fog and haze concentrating in eastern China.The reduction of the vertical shear of horizontal winds weakens the synoptic disturbances and vertical mixing of atmosphere.The anomalous inversion in near-surface increases the stability of surface air.All these meteorological background fields in January 2013 were conducive to the maintenance and development of fog and haze over eastern China.The diagnosis of the daily evolution of the FHE shows that the surface wind velocity and the vertical shear of horizontal winds in the middle and lower troposphere can exert dynamic effects on fog and haze.The larger(smaller)they are,the weaker(stronger)the fog and haze are.The thermodynamic effects include stratification instability in middle and lower troposphere and the inversion and dew-point deficit in near-surface.The larger(smaller)the stratification instability and the inversion are,the stronger(weaker)the fog and haze are.Meanwhile,the smaller(larger)the dewpoint deficit is,the stronger(weaker)the fog and haze are.Based on the meteorological factors,a multi-variate linear regression model is set up.The model results show that the dynamic and thermodynamic effects on the variance of the fog and haze evolution are almost the same.The contribution of the meteorological factors to the variance of the daily fog and haze evolution reaches 0.68,which explains more than 2/3 of the variance.展开更多
INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 a...INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer .展开更多
AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellular carcinogenesisand their clinical significance.METHODS SP immunohistochemistry was usedto dete...AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellular carcinogenesisand their clinical significance.METHODS SP immunohistochemistry was usedto detect the expression of p42/44MAPK, p-Stat3,c-fos and c-jun proteins in 55 hepatocellularcarcinomas (HCC) and their surrounding livertissues.RESULTS The positive rates and expressionlevels of p42/44MAPK, p-Stat3, c-fos and c-junproteins in HCCs were significantly higher thanthose in pericarcinomatous liver tissues (PCLT).A positive correlation was observed between theexpression of p42/44MAPK and c-fos proteins, andbetween p-Stat3 and c-jun, but there was nosignificant correlation between p42/44MAPK and p-Stat3 in HCCs and their surrounding livertissues.CONCLUSION The abnormalities of Ras/Rat/MAPK and JAKs/ Stat3 cascade reaction maycontribute to malignant transformation ofhepatocytes. Hepatocytes which are positive forp42/ 44MAPK, c-fos or c-jun proteins may bepotential malignant pre-cancerous cells.Activation of MAPK and Stat3 proteins may be anearly event in hepatocellular carcinogenesis.展开更多
AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer（GC）and other gastric mucosallesions and their relations to Helicobacter pylori（H.pylori）infection,tumor stag...AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer（GC）and other gastric mucosallesions and their relations to Helicobacter pylori（H.pylori）infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or<sup>14</sup>C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia（IM）and/or dysplasia（Dys）.In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis（CAG）than those withnegative H.pylori（CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP【0.05）,Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori（Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P【0.05）.Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group（Ellipser:53±14,40±12μm,Area<sub>1</sub>:748±572,302±202 μm<sup>2</sup>,Area<sub>2</sub>:3050±1661,1681±1990 μm<sup>2</sup>,all P【0.05;Ellipseb:79±23,58±15 μm,Ratio<sub>1</sub>:22%±5%,13%±4%,Ratio<sub>2</sub>:79%±17%,53%±20%,all P【0.01）.There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis（Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP【0.05）.CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role 展开更多
In 2013,China issued the"Action Plan for the Prevention and Control of Air Pollution"("Ten Statements of Atmosphere")and implemented a series of pollution reduction measures from 2013 to 2017.In ke...In 2013,China issued the"Action Plan for the Prevention and Control of Air Pollution"("Ten Statements of Atmosphere")and implemented a series of pollution reduction measures from 2013 to 2017.In key regions of China,the mass concentrations of particulate matter with aerodynamic equivalent diameters less than 2.5μm(PM2.5)have dropped significantly.However,the contributions of meteorological changes to PM2.5 reduction are largely uncertain,which has attracted particular concern from the government and the public.Here,we investigated the impact of large-scale and boundary layer(BL)meteorological conditions on aerosol pollution and estimated the contributions of meteorological changes to PM2.5 reduction based on in-depth analysis and diagnosis of various observed meteorological elements and an integrated pollution-linked meteorological index(PLAM,which is approximately and linearly related to PM mass concentration).In this study,we found that the meteorological conditions worsened in 2014 and 2015 and improved in 2016 and 2017 relative to those in 2013 in key regions in China.In 2017 relative to 2013,only^5%(approximately 13%of the total PM2.5 decline)of the 39.6%reduction in PM2.5 mass concentrations can be attributed to meteorological changes in the Beijing-Tianjin-Hebei(BTH)region,and only^7%(approximately 20%of the total PM2.5 decline)of the 34.3%reduction can be attributable to meteorological changes in the Yangtze River Delta(YRD)region.Overall,the PM2.5 reduction due to meteorological improvement is much lower than the observed PM2.5 reduction in these areas,which indicates that emission reduction during the five-year implementation of the"Ten Statements of Atmosphere"is the dominant factor in the improvement in air quality.The changes in meteorology and climate are conducive to PM2.5 reduction but do not dominate the substantial improvement in air quality.Similar to the above regions,in the Pearl River Delta(PRD)region,the impact of meteorological changes on the annual averaged PM2.5 concentration from 2013 展开更多
A set of high resolution(25 km)21st century climate change projections using the regional climate model RegCM4 driven by four global model simulations were conducted over East Asia under the mid-range RCP4.5 scenario....A set of high resolution(25 km)21st century climate change projections using the regional climate model RegCM4 driven by four global model simulations were conducted over East Asia under the mid-range RCP4.5 scenario.In the present paper,the authors investigate the change in thermal comfort conditions over china based on an ensemble of the projections,using the index of effective temperature(ET),which considers the aggregate effects of temperature,relative humidity,and wind on human thermal perception.The analysis also accounts for exposure as measured by distributed population amount scenarios.The authors find that the general increase in ET leads to a large increase in population exposure to very hot days(a China-aggregated sixfold increase in‘person-days’by the end of the 21st century.There is a decrease in cool,cold,and very cold person-days.Meanwhile,a decrease in comfortable day conditions by 22%person-days is found despite an increase in climate-based comfortable days.Analysis of the different contributions to the changes(climate,population,and interactions between the two)show that climate effects play a more important role in the hot end of the thermal comfort categories,while the population effects tend to be dominant in the cold categories.Thus,overall,even a mid-level warming scenario is found to increase the thermal stress over China,although there is a strong geographical dependence.The inclusion of population exposure strongly modulates the climateonly signal,which highlights the need for including socioeconomic factors in the assessment of risks associated with climate change.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.41221064)the International S&T Cooperation Project othe Ministry of Science and Technology of China(Grant No.2009-DFA21430)
文摘In January 2013,a severe fog and haze event(FHE)of strong intensity,long duration,and extensive coverage occurred in eastern China.The present study investigates meteorological conditions for this FHE by diagnosing both its atmospheric background fields and daily evolution in January 2013.The results show that a weak East Asian winter monsoon existed in January2013.Over eastern China,the anomalous southerly winds in the middle and lower troposphere are favorable for more water vapor transported to eastern China.An anomalous high at 500 hPa suppresses convection.The weakened surface winds are favorable for the fog and haze concentrating in eastern China.The reduction of the vertical shear of horizontal winds weakens the synoptic disturbances and vertical mixing of atmosphere.The anomalous inversion in near-surface increases the stability of surface air.All these meteorological background fields in January 2013 were conducive to the maintenance and development of fog and haze over eastern China.The diagnosis of the daily evolution of the FHE shows that the surface wind velocity and the vertical shear of horizontal winds in the middle and lower troposphere can exert dynamic effects on fog and haze.The larger(smaller)they are,the weaker(stronger)the fog and haze are.The thermodynamic effects include stratification instability in middle and lower troposphere and the inversion and dew-point deficit in near-surface.The larger(smaller)the stratification instability and the inversion are,the stronger(weaker)the fog and haze are.Meanwhile,the smaller(larger)the dewpoint deficit is,the stronger(weaker)the fog and haze are.Based on the meteorological factors,a multi-variate linear regression model is set up.The model results show that the dynamic and thermodynamic effects on the variance of the fog and haze evolution are almost the same.The contribution of the meteorological factors to the variance of the daily fog and haze evolution reaches 0.68,which explains more than 2/3 of the variance.
基金Supported by the Medical Research Foundation of Guangdong Province,No.1997423
文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer .
文摘AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellular carcinogenesisand their clinical significance.METHODS SP immunohistochemistry was usedto detect the expression of p42/44MAPK, p-Stat3,c-fos and c-jun proteins in 55 hepatocellularcarcinomas (HCC) and their surrounding livertissues.RESULTS The positive rates and expressionlevels of p42/44MAPK, p-Stat3, c-fos and c-junproteins in HCCs were significantly higher thanthose in pericarcinomatous liver tissues (PCLT).A positive correlation was observed between theexpression of p42/44MAPK and c-fos proteins, andbetween p-Stat3 and c-jun, but there was nosignificant correlation between p42/44MAPK and p-Stat3 in HCCs and their surrounding livertissues.CONCLUSION The abnormalities of Ras/Rat/MAPK and JAKs/ Stat3 cascade reaction maycontribute to malignant transformation ofhepatocytes. Hepatocytes which are positive forp42/ 44MAPK, c-fos or c-jun proteins may bepotential malignant pre-cancerous cells.Activation of MAPK and Stat3 proteins may be anearly event in hepatocellular carcinogenesis.
基金the Natural Science Foundation of the Educational Committee of Jiangsu Province,No.125FA9608.
文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer（GC）and other gastric mucosallesions and their relations to Helicobacter pylori（H.pylori）infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or<sup>14</sup>C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia（IM）and/or dysplasia（Dys）.In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis（CAG）than those withnegative H.pylori（CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP【0.05）,Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori（Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P【0.05）.Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group（Ellipser:53±14,40±12μm,Area<sub>1</sub>:748±572,302±202 μm<sup>2</sup>,Area<sub>2</sub>:3050±1661,1681±1990 μm<sup>2</sup>,all P【0.05;Ellipseb:79±23,58±15 μm,Ratio<sub>1</sub>:22%±5%,13%±4%,Ratio<sub>2</sub>:79%±17%,53%±20%,all P【0.01）.There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis（Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP【0.05）.CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role
基金supported by the Atmospheric Pollution Control of the Prime Minister Fund (Grant No. DQGG0104)the National Key Project of MOST (Grant No. 2016YFC0203306)
文摘In 2013,China issued the"Action Plan for the Prevention and Control of Air Pollution"("Ten Statements of Atmosphere")and implemented a series of pollution reduction measures from 2013 to 2017.In key regions of China,the mass concentrations of particulate matter with aerodynamic equivalent diameters less than 2.5μm(PM2.5)have dropped significantly.However,the contributions of meteorological changes to PM2.5 reduction are largely uncertain,which has attracted particular concern from the government and the public.Here,we investigated the impact of large-scale and boundary layer(BL)meteorological conditions on aerosol pollution and estimated the contributions of meteorological changes to PM2.5 reduction based on in-depth analysis and diagnosis of various observed meteorological elements and an integrated pollution-linked meteorological index(PLAM,which is approximately and linearly related to PM mass concentration).In this study,we found that the meteorological conditions worsened in 2014 and 2015 and improved in 2016 and 2017 relative to those in 2013 in key regions in China.In 2017 relative to 2013,only^5%(approximately 13%of the total PM2.5 decline)of the 39.6%reduction in PM2.5 mass concentrations can be attributed to meteorological changes in the Beijing-Tianjin-Hebei(BTH)region,and only^7%(approximately 20%of the total PM2.5 decline)of the 34.3%reduction can be attributable to meteorological changes in the Yangtze River Delta(YRD)region.Overall,the PM2.5 reduction due to meteorological improvement is much lower than the observed PM2.5 reduction in these areas,which indicates that emission reduction during the five-year implementation of the"Ten Statements of Atmosphere"is the dominant factor in the improvement in air quality.The changes in meteorology and climate are conducive to PM2.5 reduction but do not dominate the substantial improvement in air quality.Similar to the above regions,in the Pearl River Delta(PRD)region,the impact of meteorological changes on the annual averaged PM2.5 concentration from 2013
基金supported by the National Key Research and Development Program of China(Grant No.2016YFA0600704)the National Natural Science Foundation of China(Grant No.41375104)
文摘A set of high resolution(25 km)21st century climate change projections using the regional climate model RegCM4 driven by four global model simulations were conducted over East Asia under the mid-range RCP4.5 scenario.In the present paper,the authors investigate the change in thermal comfort conditions over china based on an ensemble of the projections,using the index of effective temperature(ET),which considers the aggregate effects of temperature,relative humidity,and wind on human thermal perception.The analysis also accounts for exposure as measured by distributed population amount scenarios.The authors find that the general increase in ET leads to a large increase in population exposure to very hot days(a China-aggregated sixfold increase in‘person-days’by the end of the 21st century.There is a decrease in cool,cold,and very cold person-days.Meanwhile,a decrease in comfortable day conditions by 22%person-days is found despite an increase in climate-based comfortable days.Analysis of the different contributions to the changes(climate,population,and interactions between the two)show that climate effects play a more important role in the hot end of the thermal comfort categories,while the population effects tend to be dominant in the cold categories.Thus,overall,even a mid-level warming scenario is found to increase the thermal stress over China,although there is a strong geographical dependence.The inclusion of population exposure strongly modulates the climateonly signal,which highlights the need for including socioeconomic factors in the assessment of risks associated with climate change.
