In order to incorporate airworthiness requirements for flight characteristics into the entire development cycle of electronic flight control system（EFCS） equipped civil aircraft, digital virtual flight testing and e...In order to incorporate airworthiness requirements for flight characteristics into the entire development cycle of electronic flight control system（EFCS） equipped civil aircraft, digital virtual flight testing and evaluation method based on handling qualities rating method（HQRM）is proposed. First, according to HQRM, flight characteristics airworthiness requirements of civil aircraft in EFCS failure states are determined. On this basis, digital virtual flight testing model,comprising flight task digitized model, pilot controlling model, aircraft motion and atmospheric turbulence model, is used to simulate the realistic process of a pilot controlling an airplane to perform assigned flight tasks. According to the simulation results, flight characteristics airworthiness compliance of the airplane can be evaluated relying on the relevant regulations for handling qualities（HQ） rating. Finally, this method is applied to a type of passenger airplane in a typical EFCS failure state, and preliminary conclusions concerning airworthiness compliance are derived quickly. The research results of this manuscript can provide important theoretical reference for EFCS design and actual airworthiness compliance verification of civil aircraft.展开更多
Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body.The molecular mechanisms of OA are currently unknown.OA is a heterogeneous di...Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body.The molecular mechanisms of OA are currently unknown.OA is a heterogeneous disease that affects the entire joint,and multiple tissues are altered during OA development.To better understand the pathological mechanisms of OA,new approaches,methods,and techniques need to be used to understand OA pathogenesis.In this review,we first focus on the epigenetic regulation of OA,with a particular focus on DNA methylation,histone modification,and microRNA regulation,followed by a summary of several key mediators in OA-associated pain.We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain,such as CRISPR,scRNA sequencing,and lineage tracing.Next,we discuss the timely updates concerning cell death regulation in OA pathology,including pyroptosis,ferroptosis,and autophagy,as well as their individual roles in OA and potential molecular targets in treating OA.Finally,our review highlights new directions on the role of the synovial lymphatic system in OA.An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA.展开更多
Light signals mediate a number of physio-logical and developmental processes in plants, such as flowering, photomorphogenesis, and pigment accu-mulation. Emerging evidence has revealed that a group of B-box proteins (...Light signals mediate a number of physio-logical and developmental processes in plants, such as flowering, photomorphogenesis, and pigment accu-mulation. Emerging evidence has revealed that a group of B-box proteins (BBXs) function as central players in these light-mediated developmental processes. B-box proteins are a class of zinc-coordinated transcription factors or regulators that not only directly mediate the transcription of target genes but also interact with various other factors to create a complex regulatory network involved in the precise control of plant growth and development. This review summarizes and highlights the recent findings concerning the critical regulatory functions of BBXs in photoperiodic flow-ering, light signal transduction and light-induced pigment accumulation and their molecular modes of action at the transcriptional and post-translational levels in plants.展开更多
The current situation of medical staff＇s awareness about high alert medication was investigated in order to promote safe medication and standardized management of the high alert medication in China. Twenty questions ...The current situation of medical staff＇s awareness about high alert medication was investigated in order to promote safe medication and standardized management of the high alert medication in China. Twenty questions were designed concerning elementary knowledge of high alert medications, storage management, medication issues and risks. In order to understand the knowledge level and education status of high alert medication, a convenient survey was conducted among 300 medical staffs in Tianjin. Medical staff＇s average score of high alert medication knowledge was 12.43±0.27, and the average scores of elementary knowledge of high alert medication, storage management, medication issues and risks were 3.38±0.11, 2.46±0.14, 3.17±0.11 and 3.41±0.12 respectively. Occupation（F=4.86, P=0.003）, education background（F=5.57, P=0.019） and professional titles（F=13.44, P≤0.001） contributed to the high alert medications knowledge scores. Currently, the most important channel to obtain high alert medication knowledge was hospital files or administrative rules, and clinical pharmacist seminars were the most popular education form. It was suggested that the high alert medication knowledge level of the medical staff needs to increase, and it might benefit from targeted, systematic and diverse training to the medical staff working in the different circulation nodes of the medications. Further research to develop and validate the instrument is needed.展开更多
Summary What is already known about this topic?The significance of maternal liver health concerning preterm birth(PTB)is well recognized;however,there is a gap in understanding the precise influence of preconception s...Summary What is already known about this topic?The significance of maternal liver health concerning preterm birth(PTB)is well recognized;however,there is a gap in understanding the precise influence of preconception serum alanine aminotransferase(ALT)levels on the risk of PTB.What is added by this report?展开更多
Three-dimensional(3D)surface geometry provides elemental information in various sciences and precision engineering.Fringe Projection Profilometry(FPP)is one of the most powerful non-contact(thus non-destructive)and no...Three-dimensional(3D)surface geometry provides elemental information in various sciences and precision engineering.Fringe Projection Profilometry(FPP)is one of the most powerful non-contact(thus non-destructive)and non-interferometric(thus less restrictive)3D measurement techniques,featuring at its high precision.However,the measurement precision of FPP is currently evaluated experimentally,lacking a complete theoretical model for guidance.We propose the first complete FPP precision model chain including four stage models(camera intensity,fringe intensity,phase and 3D geometry)and two transfer models(from fringe intensity to phase and from phase to 3D geometry).The most significant contributions include the adoption of a non-Gaussian camera noise model,which,for the first time,establishes the connection between camera’s electronics parameters(known in advance from the camera manufacturer)and the phase precision,and the formulation of the phase to geometry transfer,which makes the precision of the measured geometry representable in an explicit and concise form.As a result,we not only establish the full precision model of the 3D geometry to characterize the performance of an FPP system that has already been set up,but also explore the expression of the highest possible precision limit to guide the error distribution of an FPP system that is yet to build.Our theoretical models make FPP a more designable technique to meet the challenges from various measurement demands concerning different object sizes from macro to micro and requiring different measurement precisions from a few millimeters to a few micrometers.展开更多
Introduction Types of paper Chinese Journal of Traumatology(CJT)is a bimonthly peer reviewed journal,publishes original research articles,technical advances and study protocols in medical science or clinical practice ...Introduction Types of paper Chinese Journal of Traumatology(CJT)is a bimonthly peer reviewed journal,publishes original research articles,technical advances and study protocols in medical science or clinical practice concerning trauma.The journal welcomes contributions on all aspects of trauma and critical care.The article type includes:original articles,latest or important laboratory findings,novel and effective solutions to trauma patients,comments,reviews,case reports,letters to the editor,worldwide meeting reports,etc.展开更多
The concerning rise in juvenile sexual bullying and sexual crimes sounds the alarm about the inadequate state of sex education in China's schools and the reluctance to go beyond basic information.
BACKGROUND President Xi Jinping emphasized the paramount importance of bolstering early surveillance and early warning capacities within a robust public health system(1).These elements constitute one of the five major...BACKGROUND President Xi Jinping emphasized the paramount importance of bolstering early surveillance and early warning capacities within a robust public health system(1).These elements constitute one of the five major functionalities of the National Bureau of Disease Control and Prevention(2).As an integral division of the National Bureau of Disease Control and Prevention,the Center for Disease Control and Prevention(CDC)is responsible for executing early surveillance and warning procedures in the realm of public health.Nonetheless,a deficiency persists concerning the early warning of public health risk factors.展开更多
Aims and scope With the tenet of concerning ecology and serving economy,Ecological Economy focuses on the sustainable development of economy and environment,and puts attention on theories,methods and technical innovat...Aims and scope With the tenet of concerning ecology and serving economy,Ecological Economy focuses on the sustainable development of economy and environment,and puts attention on theories,methods and technical innovations concerning ecological/green economy,circular economy and ecological/green industry.The sustainable development of economy and society,and the sustainable development of the population,resource and environment are also within the concern of the journal.展开更多
0n January 31,2024,General Secretary Xi Jinping delivered a speech while chairing the 11th group study session of the CPC Central Committee's Political Bureau.In his speech,he drew on both theory and practice to s...0n January 31,2024,General Secretary Xi Jinping delivered a speech while chairing the 11th group study session of the CPC Central Committee's Political Bureau.In his speech,he drew on both theory and practice to systematically expound on the essence of new quality productive forces,elucidating the great significance of their development and setting clear requirements for doing so.From this concept's initial introduction during a tour of Heilongjiang Province last year to the call to develop new quality productive forces at the last Central Economic Work Conference in late 2023 and to the detailed analysis at the aforementioned group study session,Xi Jinping has put forward a series of important expositions and major plans concerning this idea.展开更多
Increasing demand for collectables from ACGN(animation,comics,games and novels)has created a surging market that is catapulting previously niche franchises into the pop culture consciousness.However,the added attentio...Increasing demand for collectables from ACGN(animation,comics,games and novels)has created a surging market that is catapulting previously niche franchises into the pop culture consciousness.However,the added attention and increasing prices are concerning core fanbases over their favorite IPs'futures.展开更多
Hello, everyone! My name is Elsa, and I have a passion for playing sports. I frequently engage in physical activities with my parents. However, I’ve noticed a concerning trend among many people——they often stay up ...Hello, everyone! My name is Elsa, and I have a passion for playing sports. I frequently engage in physical activities with my parents. However, I’ve noticed a concerning trend among many people——they often stay up late and neglect to exercise. Today, I’d like to discuss the importance of maintaining good health.展开更多
The document known as Gu Ying Taiji's Memorial,featured in The Sixth Volume of the Qing Cabinet Mongolian Hall Archives,stands as a significant historical text concerning the Abaga and Abhanar.It offers invaluable...The document known as Gu Ying Taiji's Memorial,featured in The Sixth Volume of the Qing Cabinet Mongolian Hall Archives,stands as a significant historical text concerning the Abaga and Abhanar.It offers invaluable insights for Mongolian hitorical studies during the 16hand 17thcenturies.Building upon the work of previous scholars,the author has transcribed the entire memorial in modern Mongolian and provided annotations,addressing and correcting previously overlooked or misinterpreted areas.展开更多
Introduction Typesof paper Chinese Journal of Traumatology(CJT)is a bimonthly peer reviewed journal,publishes original research articles,technical advances and study protocols in medical science or clinical practice c...Introduction Typesof paper Chinese Journal of Traumatology(CJT)is a bimonthly peer reviewed journal,publishes original research articles,technical advances and study protocols in medical science or clinical practice concerning trauma.The journal welcomes contributions on all aspects of trauma and critical care.The article type includes:original articles,latest or important laboratory findings,novel and effective solutions to trauma patients,comments,reviews,case reports,letters to the editor,worldwide meeting reports,etc.展开更多
Since the 18th National Congress of the Communist Party of China(CPC)in 2012,President Xi Jinping has made the development of human rights an important national governance priority.In a series of speeches and statemen...Since the 18th National Congress of the Communist Party of China(CPC)in 2012,President Xi Jinping has made the development of human rights an important national governance priority.In a series of speeches and statements on the issue of respecting and protecting human rights,he has put forward in-depth answers to major questions concerning the nature of human rights,how best to advance human rights in China,and their governance on a global level.展开更多
Introduction to The Regional Geology of China In 2008, a new project concerning the recompilation of The Regional Geology of China (RGC) was assigned by the Chinese Geological Survey (CGS) and undertaken by the Instit...Introduction to The Regional Geology of China In 2008, a new project concerning the recompilation of The Regional Geology of China (RGC) was assigned by the Chinese Geological Survey (CGS) and undertaken by the Institute of Geology, Chinese Academy of Geological Sciences (CAGS). Li Tingdong, an academician of the Chinese Academy of Sciences (CAS), is the chief leader and chief scientist of the project. The last time The Regional Geology of China was compiled was in the 1980s (Cheng, 1994).展开更多
Aims and scopeWith the tenet of concerning ecology and serving economy, aimed at constructing a harmonious society of man and nature, Ecological Economy focuses on the sustainable development of economy and environmen...Aims and scopeWith the tenet of concerning ecology and serving economy, aimed at constructing a harmonious society of man and nature, Ecological Economy focuses on the sustainable development of economy and environment, and puts attention on theories, methods and technical innovations concerning ecological/green econ-omy, circular economy and ecological/green industry.展开更多
基金supported by the National High-tech Research and Development Program of China(No.2014AA110500)
文摘In order to incorporate airworthiness requirements for flight characteristics into the entire development cycle of electronic flight control system（EFCS） equipped civil aircraft, digital virtual flight testing and evaluation method based on handling qualities rating method（HQRM）is proposed. First, according to HQRM, flight characteristics airworthiness requirements of civil aircraft in EFCS failure states are determined. On this basis, digital virtual flight testing model,comprising flight task digitized model, pilot controlling model, aircraft motion and atmospheric turbulence model, is used to simulate the realistic process of a pilot controlling an airplane to perform assigned flight tasks. According to the simulation results, flight characteristics airworthiness compliance of the airplane can be evaluated relying on the relevant regulations for handling qualities（HQ） rating. Finally, this method is applied to a type of passenger airplane in a typical EFCS failure state, and preliminary conclusions concerning airworthiness compliance are derived quickly. The research results of this manuscript can provide important theoretical reference for EFCS design and actual airworthiness compliance verification of civil aircraft.
基金supported by the National Natural Science Foundation of China(NSFC)grants(82030067,82161160342,and 82172397)to D.C.and L.T.a grant from the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020353)to L.T.+1 种基金supported by the National Key Research and Development Program of China(2021YFB3800800 to L.T.and D.C)supported by the research grant NIH AG0599775.
文摘Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body.The molecular mechanisms of OA are currently unknown.OA is a heterogeneous disease that affects the entire joint,and multiple tissues are altered during OA development.To better understand the pathological mechanisms of OA,new approaches,methods,and techniques need to be used to understand OA pathogenesis.In this review,we first focus on the epigenetic regulation of OA,with a particular focus on DNA methylation,histone modification,and microRNA regulation,followed by a summary of several key mediators in OA-associated pain.We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain,such as CRISPR,scRNA sequencing,and lineage tracing.Next,we discuss the timely updates concerning cell death regulation in OA pathology,including pyroptosis,ferroptosis,and autophagy,as well as their individual roles in OA and potential molecular targets in treating OA.Finally,our review highlights new directions on the role of the synovial lymphatic system in OA.An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA.
基金a grant from National Natural ScienceFoundation of China(31970258),by start-up funding from Nanjing Agricultural University(to D.X.),by.grants from Nanjing Science and Technology In-novation Program for Overseas Students(to D.X.),and the Jiangsu Collaborative Innovation Center for Modern Crop Production.
文摘Light signals mediate a number of physio-logical and developmental processes in plants, such as flowering, photomorphogenesis, and pigment accu-mulation. Emerging evidence has revealed that a group of B-box proteins (BBXs) function as central players in these light-mediated developmental processes. B-box proteins are a class of zinc-coordinated transcription factors or regulators that not only directly mediate the transcription of target genes but also interact with various other factors to create a complex regulatory network involved in the precise control of plant growth and development. This review summarizes and highlights the recent findings concerning the critical regulatory functions of BBXs in photoperiodic flow-ering, light signal transduction and light-induced pigment accumulation and their molecular modes of action at the transcriptional and post-translational levels in plants.
基金supported by grants from Basic Scientific Research Business Expenses Foundation of Huazhong University of Science and Technology,China(No2014QN136)Natural Science Foundation of Hube Province,China(No.2014CFB955)
文摘The current situation of medical staff＇s awareness about high alert medication was investigated in order to promote safe medication and standardized management of the high alert medication in China. Twenty questions were designed concerning elementary knowledge of high alert medications, storage management, medication issues and risks. In order to understand the knowledge level and education status of high alert medication, a convenient survey was conducted among 300 medical staffs in Tianjin. Medical staff＇s average score of high alert medication knowledge was 12.43±0.27, and the average scores of elementary knowledge of high alert medication, storage management, medication issues and risks were 3.38±0.11, 2.46±0.14, 3.17±0.11 and 3.41±0.12 respectively. Occupation（F=4.86, P=0.003）, education background（F=5.57, P=0.019） and professional titles（F=13.44, P≤0.001） contributed to the high alert medications knowledge scores. Currently, the most important channel to obtain high alert medication knowledge was hospital files or administrative rules, and clinical pharmacist seminars were the most popular education form. It was suggested that the high alert medication knowledge level of the medical staff needs to increase, and it might benefit from targeted, systematic and diverse training to the medical staff working in the different circulation nodes of the medications. Further research to develop and validate the instrument is needed.
基金Supported by the National Key Research and Development Program of China(NKPs)under grants 2021YFC2700705(Ms.Yang)and 2016YFC100307(Mr.Ma).
文摘Summary What is already known about this topic?The significance of maternal liver health concerning preterm birth(PTB)is well recognized;however,there is a gap in understanding the precise influence of preconception serum alanine aminotransferase(ALT)levels on the risk of PTB.What is added by this report?
基金This study was kindly supported by the Ministry of Education-Singapore(MOE-T2EP20220-0008).We thank Weiwei Xue from the University of Science and Technology of China for helpful discussions.The authors appreciate the experimental assistance provided by the Quality Inspection Center of Changchun Institute of Optics,Fine Mechanics,and Physics(CIOMP),CAS for camera testing.
文摘Three-dimensional(3D)surface geometry provides elemental information in various sciences and precision engineering.Fringe Projection Profilometry(FPP)is one of the most powerful non-contact(thus non-destructive)and non-interferometric(thus less restrictive)3D measurement techniques,featuring at its high precision.However,the measurement precision of FPP is currently evaluated experimentally,lacking a complete theoretical model for guidance.We propose the first complete FPP precision model chain including four stage models(camera intensity,fringe intensity,phase and 3D geometry)and two transfer models(from fringe intensity to phase and from phase to 3D geometry).The most significant contributions include the adoption of a non-Gaussian camera noise model,which,for the first time,establishes the connection between camera’s electronics parameters(known in advance from the camera manufacturer)and the phase precision,and the formulation of the phase to geometry transfer,which makes the precision of the measured geometry representable in an explicit and concise form.As a result,we not only establish the full precision model of the 3D geometry to characterize the performance of an FPP system that has already been set up,but also explore the expression of the highest possible precision limit to guide the error distribution of an FPP system that is yet to build.Our theoretical models make FPP a more designable technique to meet the challenges from various measurement demands concerning different object sizes from macro to micro and requiring different measurement precisions from a few millimeters to a few micrometers.
文摘Introduction Types of paper Chinese Journal of Traumatology(CJT)is a bimonthly peer reviewed journal,publishes original research articles,technical advances and study protocols in medical science or clinical practice concerning trauma.The journal welcomes contributions on all aspects of trauma and critical care.The article type includes:original articles,latest or important laboratory findings,novel and effective solutions to trauma patients,comments,reviews,case reports,letters to the editor,worldwide meeting reports,etc.
文摘The concerning rise in juvenile sexual bullying and sexual crimes sounds the alarm about the inadequate state of sex education in China's schools and the reluctance to go beyond basic information.
基金funded by the National Highlevel Talents Special Support Plan of China for Young Talents.
文摘BACKGROUND President Xi Jinping emphasized the paramount importance of bolstering early surveillance and early warning capacities within a robust public health system(1).These elements constitute one of the five major functionalities of the National Bureau of Disease Control and Prevention(2).As an integral division of the National Bureau of Disease Control and Prevention,the Center for Disease Control and Prevention(CDC)is responsible for executing early surveillance and warning procedures in the realm of public health.Nonetheless,a deficiency persists concerning the early warning of public health risk factors.
文摘Aims and scope With the tenet of concerning ecology and serving economy,Ecological Economy focuses on the sustainable development of economy and environment,and puts attention on theories,methods and technical innovations concerning ecological/green economy,circular economy and ecological/green industry.The sustainable development of economy and society,and the sustainable development of the population,resource and environment are also within the concern of the journal.
文摘0n January 31,2024,General Secretary Xi Jinping delivered a speech while chairing the 11th group study session of the CPC Central Committee's Political Bureau.In his speech,he drew on both theory and practice to systematically expound on the essence of new quality productive forces,elucidating the great significance of their development and setting clear requirements for doing so.From this concept's initial introduction during a tour of Heilongjiang Province last year to the call to develop new quality productive forces at the last Central Economic Work Conference in late 2023 and to the detailed analysis at the aforementioned group study session,Xi Jinping has put forward a series of important expositions and major plans concerning this idea.
文摘Increasing demand for collectables from ACGN(animation,comics,games and novels)has created a surging market that is catapulting previously niche franchises into the pop culture consciousness.However,the added attention and increasing prices are concerning core fanbases over their favorite IPs'futures.
文摘Hello, everyone! My name is Elsa, and I have a passion for playing sports. I frequently engage in physical activities with my parents. However, I’ve noticed a concerning trend among many people——they often stay up late and neglect to exercise. Today, I’d like to discuss the importance of maintaining good health.
文摘The document known as Gu Ying Taiji's Memorial,featured in The Sixth Volume of the Qing Cabinet Mongolian Hall Archives,stands as a significant historical text concerning the Abaga and Abhanar.It offers invaluable insights for Mongolian hitorical studies during the 16hand 17thcenturies.Building upon the work of previous scholars,the author has transcribed the entire memorial in modern Mongolian and provided annotations,addressing and correcting previously overlooked or misinterpreted areas.
文摘Introduction Typesof paper Chinese Journal of Traumatology(CJT)is a bimonthly peer reviewed journal,publishes original research articles,technical advances and study protocols in medical science or clinical practice concerning trauma.The journal welcomes contributions on all aspects of trauma and critical care.The article type includes:original articles,latest or important laboratory findings,novel and effective solutions to trauma patients,comments,reviews,case reports,letters to the editor,worldwide meeting reports,etc.
文摘Since the 18th National Congress of the Communist Party of China(CPC)in 2012,President Xi Jinping has made the development of human rights an important national governance priority.In a series of speeches and statements on the issue of respecting and protecting human rights,he has put forward in-depth answers to major questions concerning the nature of human rights,how best to advance human rights in China,and their governance on a global level.
文摘Introduction to The Regional Geology of China In 2008, a new project concerning the recompilation of The Regional Geology of China (RGC) was assigned by the Chinese Geological Survey (CGS) and undertaken by the Institute of Geology, Chinese Academy of Geological Sciences (CAGS). Li Tingdong, an academician of the Chinese Academy of Sciences (CAS), is the chief leader and chief scientist of the project. The last time The Regional Geology of China was compiled was in the 1980s (Cheng, 1994).
文摘Aims and scopeWith the tenet of concerning ecology and serving economy, aimed at constructing a harmonious society of man and nature, Ecological Economy focuses on the sustainable development of economy and environment, and puts attention on theories, methods and technical innovations concerning ecological/green econ-omy, circular economy and ecological/green industry.
