Due to the excellent properties including high specificity,low side-effect and good biocompatibility,conjugated polymer nanomaterials have been served as efficient anticancer reagents in die past decades.According to ...Due to the excellent properties including high specificity,low side-effect and good biocompatibility,conjugated polymer nanomaterials have been served as efficient anticancer reagents in die past decades.According to the developed anticancer systems based on conjugated polymer nanomaterials,it could be summarized into three main cancer therapy strategies:photodynamic therapy(PDT),photothermal therapy(PTT)and combination therapy.In this mini review,we provide a brief introduction to three different cancer therapy modes,their mechanisms and potential biological applications.Furthermore,some perspectives on the further development of conjugated polymer nanomaterials are proposed in the territory of anticancer precision medicine.展开更多
The results brought out in the trials of slope protection along Qinghai-Tibet Highway are presented in this paper. The trials were carried out simultaneously at 5 sites in Qinghai-Tibet Plateau from 2000 to 2002. Alti...The results brought out in the trials of slope protection along Qinghai-Tibet Highway are presented in this paper. The trials were carried out simultaneously at 5 sites in Qinghai-Tibet Plateau from 2000 to 2002. Altitudes at the experimental sites range between （4 240） m and （5 040） m. 4 sites are in permafrost area, and 1 site is in seasonally frozen ground. According to the trials of slope protection, vegetation is preferred to protect slopes along Qinghai-Tibet Highway. Road-GoodR, a chemical stabilizer, is proved as a good material for slope protection, and soil engineering system, combined with vegetative component and grade stabilization structures is proved as the best slope protection measure in these areas. The results showed that high-altitude areas at an altitude lower than （5 040） m, annual average temperatures higher than （-5.6） ℃ and annual rainfall more than 262\^2 mm, slopes can be protected using vegetative components.\;Trials for plant species selection proved that cold resistant grasses, Elymus nutans and Elymus sibiricus can be used for vegetation recovery along Qinghai-Tibet Highway. The results demonstrated that high-altitude areas at an altitude lower than （5 040） m, annual average temperatures higher than （-5.6） ℃ and annual rainfall more than 262\^2 mm, could be replanted. Hydroseeding proved to be a good planting technique, and mulch materials benefited vegetation recovery in such area.\;The experiment also proved that planting could improve slope stability, protect the ecological environment, and improve the roadside landscape.展开更多
Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients, outcomes. However, treatment options remain limited for late-stage or refractory diseas...Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients, outcomes. However, treatment options remain limited for late-stage or refractory diseases. The efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmed by randomized clinical trials. In 2017, pembrolizumab was approved by the US Food and Drug Administration as the first agent for treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancer. Given the different mechanisms, oncologists have focused on determining whether ICIs-based combination strategies could achieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancer. This review discusses the current status of combining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer in terms of mechanisms, safety, and efficacy to provide basis for future research.展开更多
Triple-negative breast cancer(TNBC)is one type of the most aggressive breast can cers with poor prog no sis.It is of great urgency to develop new therapeutics for treati ng TNBC.Based on curre nt treatment guideline a...Triple-negative breast cancer(TNBC)is one type of the most aggressive breast can cers with poor prog no sis.It is of great urgency to develop new therapeutics for treati ng TNBC.Based on curre nt treatment guideline and genetic informatio n of TNBC,a combi nation al therapy platform in tegrati ng chemotherapy drugs and mRNA encoding tumor suppressor proteins may become an efficacious strategy.In this study,we developed paclitaxel amino lipid(PAL)derived nanoparticles(NPs)to incorporate both chemotherapy drugs and P53 mRNA.The PAL P53 mRNA NPs showed superior properties compared to Abraxane? and Lipusu? used in the clinic including high paclitaxel loading capacity(24 wt.%,calculated by paclitaxel in PAL),PAL encapsulation efficiency(94.7%±6.8%)and mRNA encapsulation efficiency(88.7%±0.7%).Meanwhile,these NPs displayed synergetic cytotoxicity of paclitaxel and P53 mRNA in cultured TNBC cells.More importantly,we demonstrated in vivo anti-tumor efficacy of PAL P53 mRNA NPs in an orthotopic TNBC mouse model.Overall,these chemotherapy drugs derived mRNA NPs provide a new platform to integrate chemotherapy and personalized medicine using tumor genetic information,and therefore represent a promising approach for TNBC treatment.展开更多
Objective:To observe the effect of warm-unblocking acupuncture plus fluticasone propionate nasal spray on the pulmonary ventilation,level of interferon-y(IFN-y)and sleep quality in parents with allergic rhinitis(AR).M...Objective:To observe the effect of warm-unblocking acupuncture plus fluticasone propionate nasal spray on the pulmonary ventilation,level of interferon-y(IFN-y)and sleep quality in parents with allergic rhinitis(AR).Methods:A total of 112 AR patients were enrolled between January 2013 and August 2018 and were divided into an observation group and a control group by the random number table method,with 56 cases in each group.Patients in the observation group received warm-unblocking acupuncture plus fluticasone propionate nasal spray,and patients in the control group only received fluticasone propionate nasal spray.The nasal symptom score,pulmonary function indexes,the levels of IFN-y and interleukin(IL)-4 in serum,and sleep quality in the two groups were compared.Results:After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).The nasal symptom score dropped in both groups after treatment(both P<0.05),and the score in the observation group was lower than that in the con trol group(P<0.05).The pulm onary ven tilati on indexes all in creased sign ificantly after treatment in the observation group(all P<0.05);the forced expiratory volume in 1 second(FEV1)to forced vital capacity(FVC)ratio(FEV1/FVC)and the forced expiratory flow at 50%,75%and 25%-75%of the vital capacity(FEF50%,FEF75%,FEF25%-75%)in creased after treatme nt in the control group(all P<0.05);the pulm onary ven tilati on in dexes were higher in the observati on group tha n those in the control group(all P<0.05).The level of IFN-y in creased sign ificantly after t reatment in the two groups(both P<0.05)and the level of IL-4 dropped significantly(both P<0.05);the observation group had a higher IFN-y level(P<0.05)and a lower IL-4 level(P<0.05)compared with the control group.Regarding the Pittsburgh sleep quality index(PSQI),the scores of subjective sleep quality,habitual sleep efficiency and sleep disturbances and the general PSQI score decreased significantly after treatment in both groups(all P<0.0展开更多
The effects of different wind input and wave dissipation formulations on the steady Ekman current solution are described. Two formulations are considered: one from the wave modeling(WAM) program proposed by Hasselmann...The effects of different wind input and wave dissipation formulations on the steady Ekman current solution are described. Two formulations are considered: one from the wave modeling(WAM) program proposed by Hasselmann and Komen and the other provided by Tsagareli and Babanin. The solution adopted for our study was presented by Song for the wave-modifi ed Ekman current model that included the Stokes drift, wind input, and wave dissipation with eddy viscosity increasing linearly with depth. Using the Combi spectrum with tail effects, the solutions are calculated using two formulations for wind input and wave dissipation, and compared. Differences in the results are not negligible. Furthermore, the solution presented by Song and Xu for the eddy viscosity formulated using the K-Profi le Parameterization scheme under wind input and wave dissipation given by Tsagareli and Babanin is compared with that obtained for a depth-dependent eddy viscosity. The solutions are further compared with the available well-known observational data. The result indicates that the Tsagareli and Babanin scheme is more suitable for use in the model when capillary waves are included, and the solution calculated using the K-Profi le Parameterization scheme agrees best with observations.展开更多
Ⅰ. INTRODUCTION In Ref. [2] a combinatory-logic foundation has been laid for the functional programming language FP which is shown to be a higher-level combinatory logic. As for the relation between the language FFP ...Ⅰ. INTRODUCTION In Ref. [2] a combinatory-logic foundation has been laid for the functional programming language FP which is shown to be a higher-level combinatory logic. As for the relation between the language FFP and the combinatory logic, it has been discussed in Ref. [3] that the basic combinators I, S and K can be defined as展开更多
Periomarthritis is seen mainly in themiddle aged of about 50 years, with a pro-tracted course diffcult to treat. In recentyears the author found that acupuncture atacupoints of the 3 Yang channels in combi-nation with...Periomarthritis is seen mainly in themiddle aged of about 50 years, with a pro-tracted course diffcult to treat. In recentyears the author found that acupuncture atacupoints of the 3 Yang channels in combi-nation with the method of contralateralneedling was effective in treating the disease,as reported in the following:展开更多
MOEP Collects Advice on Pesticides Project StandardTo comply with China’s Environmental Protection Law and Environmental Impact AssessmentLaw,the Ministry of Environmental Protection(MOEP)has compiled a new standard-...MOEP Collects Advice on Pesticides Project StandardTo comply with China’s Environmental Protection Law and Environmental Impact AssessmentLaw,the Ministry of Environmental Protection(MOEP)has compiled a new standard-the Technical Guideline of Environmental Impact Assessment for Pesticide ConstructionProject and recently made it public for collecting advice before May 20th.展开更多
Objective To investigate the drug resistance of My-coplasma pneumoniae among children with community-acquired pneumonia (CAP) ,and to explore the clinical and radiological characteristics of and the role of azithromyc...Objective To investigate the drug resistance of My-coplasma pneumoniae among children with community-acquired pneumonia (CAP) ,and to explore the clinical and radiological characteristics of and the role of azithromycin in the treatment of of macrolide-resistant (MR) Mycoplasma pneumoniae pneumonia.Methods Cases of CAP in children (n=179) were prospectively enrolled展开更多
基金Supported by the National Natural Science Foundation of China(Nos.21533012,91527306,21661132006)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA16020804)the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2016029).
文摘Due to the excellent properties including high specificity,low side-effect and good biocompatibility,conjugated polymer nanomaterials have been served as efficient anticancer reagents in die past decades.According to the developed anticancer systems based on conjugated polymer nanomaterials,it could be summarized into three main cancer therapy strategies:photodynamic therapy(PDT),photothermal therapy(PTT)and combination therapy.In this mini review,we provide a brief introduction to three different cancer therapy modes,their mechanisms and potential biological applications.Furthermore,some perspectives on the further development of conjugated polymer nanomaterials are proposed in the territory of anticancer precision medicine.
文摘The results brought out in the trials of slope protection along Qinghai-Tibet Highway are presented in this paper. The trials were carried out simultaneously at 5 sites in Qinghai-Tibet Plateau from 2000 to 2002. Altitudes at the experimental sites range between （4 240） m and （5 040） m. 4 sites are in permafrost area, and 1 site is in seasonally frozen ground. According to the trials of slope protection, vegetation is preferred to protect slopes along Qinghai-Tibet Highway. Road-GoodR, a chemical stabilizer, is proved as a good material for slope protection, and soil engineering system, combined with vegetative component and grade stabilization structures is proved as the best slope protection measure in these areas. The results showed that high-altitude areas at an altitude lower than （5 040） m, annual average temperatures higher than （-5.6） ℃ and annual rainfall more than 262\^2 mm, slopes can be protected using vegetative components.\;Trials for plant species selection proved that cold resistant grasses, Elymus nutans and Elymus sibiricus can be used for vegetation recovery along Qinghai-Tibet Highway. The results demonstrated that high-altitude areas at an altitude lower than （5 040） m, annual average temperatures higher than （-5.6） ℃ and annual rainfall more than 262\^2 mm, could be replanted. Hydroseeding proved to be a good planting technique, and mulch materials benefited vegetation recovery in such area.\;The experiment also proved that planting could improve slope stability, protect the ecological environment, and improve the roadside landscape.
基金National Natural Science Foundation of China (Nos.81672327 and 81802319)Program of Shanghai Academic/Technology Research Leader (No.17XD1402600)+1 种基金Program for Outstanding Medical Academic Leader and Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (No.20161410)Development Grant for Clinical Trial (No.SHDC12017X06).
文摘Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients, outcomes. However, treatment options remain limited for late-stage or refractory diseases. The efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmed by randomized clinical trials. In 2017, pembrolizumab was approved by the US Food and Drug Administration as the first agent for treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancer. Given the different mechanisms, oncologists have focused on determining whether ICIs-based combination strategies could achieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancer. This review discusses the current status of combining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer in terms of mechanisms, safety, and efficacy to provide basis for future research.
文摘Triple-negative breast cancer(TNBC)is one type of the most aggressive breast can cers with poor prog no sis.It is of great urgency to develop new therapeutics for treati ng TNBC.Based on curre nt treatment guideline and genetic informatio n of TNBC,a combi nation al therapy platform in tegrati ng chemotherapy drugs and mRNA encoding tumor suppressor proteins may become an efficacious strategy.In this study,we developed paclitaxel amino lipid(PAL)derived nanoparticles(NPs)to incorporate both chemotherapy drugs and P53 mRNA.The PAL P53 mRNA NPs showed superior properties compared to Abraxane? and Lipusu? used in the clinic including high paclitaxel loading capacity(24 wt.%,calculated by paclitaxel in PAL),PAL encapsulation efficiency(94.7%±6.8%)and mRNA encapsulation efficiency(88.7%±0.7%).Meanwhile,these NPs displayed synergetic cytotoxicity of paclitaxel and P53 mRNA in cultured TNBC cells.More importantly,we demonstrated in vivo anti-tumor efficacy of PAL P53 mRNA NPs in an orthotopic TNBC mouse model.Overall,these chemotherapy drugs derived mRNA NPs provide a new platform to integrate chemotherapy and personalized medicine using tumor genetic information,and therefore represent a promising approach for TNBC treatment.
文摘Objective:To observe the effect of warm-unblocking acupuncture plus fluticasone propionate nasal spray on the pulmonary ventilation,level of interferon-y(IFN-y)and sleep quality in parents with allergic rhinitis(AR).Methods:A total of 112 AR patients were enrolled between January 2013 and August 2018 and were divided into an observation group and a control group by the random number table method,with 56 cases in each group.Patients in the observation group received warm-unblocking acupuncture plus fluticasone propionate nasal spray,and patients in the control group only received fluticasone propionate nasal spray.The nasal symptom score,pulmonary function indexes,the levels of IFN-y and interleukin(IL)-4 in serum,and sleep quality in the two groups were compared.Results:After treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).The nasal symptom score dropped in both groups after treatment(both P<0.05),and the score in the observation group was lower than that in the con trol group(P<0.05).The pulm onary ven tilati on indexes all in creased sign ificantly after treatment in the observation group(all P<0.05);the forced expiratory volume in 1 second(FEV1)to forced vital capacity(FVC)ratio(FEV1/FVC)and the forced expiratory flow at 50%,75%and 25%-75%of the vital capacity(FEF50%,FEF75%,FEF25%-75%)in creased after treatme nt in the control group(all P<0.05);the pulm onary ven tilati on in dexes were higher in the observati on group tha n those in the control group(all P<0.05).The level of IFN-y in creased sign ificantly after t reatment in the two groups(both P<0.05)and the level of IL-4 dropped significantly(both P<0.05);the observation group had a higher IFN-y level(P<0.05)and a lower IL-4 level(P<0.05)compared with the control group.Regarding the Pittsburgh sleep quality index(PSQI),the scores of subjective sleep quality,habitual sleep efficiency and sleep disturbances and the general PSQI score decreased significantly after treatment in both groups(all P<0.0
基金Supported by the National Natural Science Foundation of China(No.41176016)the National Basic Research Program of China(973 Program)(Nos.2012CB417402,2011CB403501)the Fund for Creative Research Groups by National Natural Science Foundation of China(No.41121064)
文摘The effects of different wind input and wave dissipation formulations on the steady Ekman current solution are described. Two formulations are considered: one from the wave modeling(WAM) program proposed by Hasselmann and Komen and the other provided by Tsagareli and Babanin. The solution adopted for our study was presented by Song for the wave-modifi ed Ekman current model that included the Stokes drift, wind input, and wave dissipation with eddy viscosity increasing linearly with depth. Using the Combi spectrum with tail effects, the solutions are calculated using two formulations for wind input and wave dissipation, and compared. Differences in the results are not negligible. Furthermore, the solution presented by Song and Xu for the eddy viscosity formulated using the K-Profi le Parameterization scheme under wind input and wave dissipation given by Tsagareli and Babanin is compared with that obtained for a depth-dependent eddy viscosity. The solutions are further compared with the available well-known observational data. The result indicates that the Tsagareli and Babanin scheme is more suitable for use in the model when capillary waves are included, and the solution calculated using the K-Profi le Parameterization scheme agrees best with observations.
文摘Ⅰ. INTRODUCTION In Ref. [2] a combinatory-logic foundation has been laid for the functional programming language FP which is shown to be a higher-level combinatory logic. As for the relation between the language FFP and the combinatory logic, it has been discussed in Ref. [3] that the basic combinators I, S and K can be defined as
文摘Periomarthritis is seen mainly in themiddle aged of about 50 years, with a pro-tracted course diffcult to treat. In recentyears the author found that acupuncture atacupoints of the 3 Yang channels in combi-nation with the method of contralateralneedling was effective in treating the disease,as reported in the following:
文摘MOEP Collects Advice on Pesticides Project StandardTo comply with China’s Environmental Protection Law and Environmental Impact AssessmentLaw,the Ministry of Environmental Protection(MOEP)has compiled a new standard-the Technical Guideline of Environmental Impact Assessment for Pesticide ConstructionProject and recently made it public for collecting advice before May 20th.
文摘Objective To investigate the drug resistance of My-coplasma pneumoniae among children with community-acquired pneumonia (CAP) ,and to explore the clinical and radiological characteristics of and the role of azithromycin in the treatment of of macrolide-resistant (MR) Mycoplasma pneumoniae pneumonia.Methods Cases of CAP in children (n=179) were prospectively enrolled
