The electroencephalographic research has focused on the variety of responses to emotional auditory stimulation in patients at different stages after craniocerebral trauma. The patients sampling consisted of three grou...The electroencephalographic research has focused on the variety of responses to emotional auditory stimulation in patients at different stages after craniocerebral trauma. The patients sampling consisted of three groups: 13 comatose patients, 14 severe TBI patients, 12 moderate TBI patients, the control group consisting of the 28 healthy adults. The subjects were stimulated with auditory stimuli containing significant sounds (coughing, laughing, crying, bird singing, barking, scraping) and control sounds (white noise). We have analyzed statistically significant differences of power of the rhythmic activity registered during the presentation of different types of stimuli using Matlab. The t-test differences for each type of stimuli and the background were calculated as well as major ANOVA-effects. The results showed that EEG-response was based on the emotional stimuli valence, the consciousness levels, the severity of injury and the recovery process. The TBI patients showed lower theta-rhythm power in the frontal areas in response to the all emotional stimuli. The alpha-activity was reduced in the TBI patients: the alpha-rhythm depression was most vividly pronounced in the control group. The alpha-rhythm acceleration in the occipital areas was found only in the moderate TBI patients and only to the emotional stimuli. The severe TBI and comatose patients showed lower response rates to the neutral stimuli and higher response rates to the unpleasant physiological stimuli.展开更多
目的探讨影响老年脑出血后患者昏迷苏醒时间的相关因素。方法选取本院2012年6月~2015年10月收治的82例老年脑出血昏迷患者为研究对象,以性别、年龄、术前格拉斯哥昏迷评分(GCS,Glasgow Coma Scale)、脑血肿量、血肿是否破入脑室、高血...目的探讨影响老年脑出血后患者昏迷苏醒时间的相关因素。方法选取本院2012年6月~2015年10月收治的82例老年脑出血昏迷患者为研究对象,以性别、年龄、术前格拉斯哥昏迷评分(GCS,Glasgow Coma Scale)、脑血肿量、血肿是否破入脑室、高血压病史、是否气管切开、治疗、并发感染等为自变量,昏迷至苏醒的时间为因变量,先进行单因素分析,对有统计学意义的变量采用Cox回归模型进行多因素分析。结果单因素分析显示,术前GCS评分≤5分、脑血肿量>50mL、血肿破入脑室、高血压病史、气管切开、未采用盐酸纳洛酮联合正中神经电刺激治疗、并发感染的患者昏迷苏醒时间更长(P<0.05);多因素分析显示,血肿破入脑室、气管切开、并发感染是导致昏迷苏醒时间延长的危险性因素(P<0.05),术前GCS评分高与采用盐酸纳洛酮联合正中神经电刺激治疗可能是昏迷苏醒时间的保护性因素(P<0.05)。结论血肿破入脑室、气管切开、并发感染、术前GCS评分低是导致老年脑出血患者昏迷苏醒时间延长的主要影响因素,应尽量选择盐酸纳洛酮联合正中神经电刺激治疗方案,强化无菌医疗操作,加强抗感染护理干预,以缩短苏醒时间及改善预后。展开更多
Thirty patients in coma state underwent dynamic SPECT with 133Xe, a validated technique for the quantitation of CBF by SPECT, using a new brain dedicated tomograph: CERTO-96. CMRO2 was computed by multiplying the mean...Thirty patients in coma state underwent dynamic SPECT with 133Xe, a validated technique for the quantitation of CBF by SPECT, using a new brain dedicated tomograph: CERTO-96. CMRO2 was computed by multiplying the mean CBF by AVDO2 according to the Fick’s principle. The mean values of CBF, AVDO2 and CMRO2 in patients with good outcome were significantly different from those with worse outcome. On the basis of the best "discriminant threshold", CBF and AVDO2 demonstrated an intermediate accuracy in separating the two groups, while CMRO2 showed a satisfactory accuracy.展开更多
文摘The electroencephalographic research has focused on the variety of responses to emotional auditory stimulation in patients at different stages after craniocerebral trauma. The patients sampling consisted of three groups: 13 comatose patients, 14 severe TBI patients, 12 moderate TBI patients, the control group consisting of the 28 healthy adults. The subjects were stimulated with auditory stimuli containing significant sounds (coughing, laughing, crying, bird singing, barking, scraping) and control sounds (white noise). We have analyzed statistically significant differences of power of the rhythmic activity registered during the presentation of different types of stimuli using Matlab. The t-test differences for each type of stimuli and the background were calculated as well as major ANOVA-effects. The results showed that EEG-response was based on the emotional stimuli valence, the consciousness levels, the severity of injury and the recovery process. The TBI patients showed lower theta-rhythm power in the frontal areas in response to the all emotional stimuli. The alpha-activity was reduced in the TBI patients: the alpha-rhythm depression was most vividly pronounced in the control group. The alpha-rhythm acceleration in the occipital areas was found only in the moderate TBI patients and only to the emotional stimuli. The severe TBI and comatose patients showed lower response rates to the neutral stimuli and higher response rates to the unpleasant physiological stimuli.
文摘目的探讨影响老年脑出血后患者昏迷苏醒时间的相关因素。方法选取本院2012年6月~2015年10月收治的82例老年脑出血昏迷患者为研究对象,以性别、年龄、术前格拉斯哥昏迷评分(GCS,Glasgow Coma Scale)、脑血肿量、血肿是否破入脑室、高血压病史、是否气管切开、治疗、并发感染等为自变量,昏迷至苏醒的时间为因变量,先进行单因素分析,对有统计学意义的变量采用Cox回归模型进行多因素分析。结果单因素分析显示,术前GCS评分≤5分、脑血肿量>50mL、血肿破入脑室、高血压病史、气管切开、未采用盐酸纳洛酮联合正中神经电刺激治疗、并发感染的患者昏迷苏醒时间更长(P<0.05);多因素分析显示,血肿破入脑室、气管切开、并发感染是导致昏迷苏醒时间延长的危险性因素(P<0.05),术前GCS评分高与采用盐酸纳洛酮联合正中神经电刺激治疗可能是昏迷苏醒时间的保护性因素(P<0.05)。结论血肿破入脑室、气管切开、并发感染、术前GCS评分低是导致老年脑出血患者昏迷苏醒时间延长的主要影响因素,应尽量选择盐酸纳洛酮联合正中神经电刺激治疗方案,强化无菌医疗操作,加强抗感染护理干预,以缩短苏醒时间及改善预后。
文摘Thirty patients in coma state underwent dynamic SPECT with 133Xe, a validated technique for the quantitation of CBF by SPECT, using a new brain dedicated tomograph: CERTO-96. CMRO2 was computed by multiplying the mean CBF by AVDO2 according to the Fick’s principle. The mean values of CBF, AVDO2 and CMRO2 in patients with good outcome were significantly different from those with worse outcome. On the basis of the best "discriminant threshold", CBF and AVDO2 demonstrated an intermediate accuracy in separating the two groups, while CMRO2 showed a satisfactory accuracy.
