Objective:To investigate hemodynamic change of patients with cirrhosis by using Color Doppler ultrasound technique and to explore the significance of change in the content of vasoactive substances-plasma endothelin-1(...Objective:To investigate hemodynamic change of patients with cirrhosis by using Color Doppler ultrasound technique and to explore the significance of change in the content of vasoactive substances-plasma endothelin-1(ET-1)and calcitonin gene-related peptide(CGRP).Methods:A total of 178 cases with cirrhosis were regarded as study groups,and were divided into three degrees:A,B and C according to child-pugh and meanwhile 60 cases were regarded as normal control group.Portal vein and splenic vein of patients were explored by adopting Color Doppler ultrasound technique,related indexes were recorded and the blood flow as well as their ration in the two groups was calculated.Radio immunoassay was adopted to detect the content of plasma ET-1 and CGRP in both study group and contrast group.Results:Compared with the healthy cases in the contrast group,there was abnormal hemodynamics in the system of portal vein of patients with cirrhosis and the content of plasma ET-1 and CGRP was increased obviously.In the Child-Pugh liver function grades,the content of ET-1 and CGRP was increased as the degree of cirrhosis became more and more serious.There was no significant difference in the comparison between those without ascites and those in contrast group(P>0.05),the content of plasma ET-1and CGRP in patients without ascites was increased remarkably.Besides,there was positive correlation between the content of plasma ET-1 and CGRP and Dpv,Dsv and Qsv.Conclusion:Dotection of abnormal hemodynamics of portal vein and splenic vein by Color Doppler ultrasound technique can be one of the means for diagnosis of hypertension.Plasma ET-1 and CGRP of patients with cirrhosis reflect the serious degree of the damage in live function and play an important role in the formation and development of portal hypertension.展开更多
目的分析高频彩色多普勒超声与乳腺钼靶断层融合技术在早期乳腺癌患者中的诊断价值,为患者进行早期临床检查提供更准确的依据。方法选取2022年6月—2023年3月徐州市妇幼保健院收治的64疑似早期乳腺癌患者为研究对象,将病理检查作为金标...目的分析高频彩色多普勒超声与乳腺钼靶断层融合技术在早期乳腺癌患者中的诊断价值,为患者进行早期临床检查提供更准确的依据。方法选取2022年6月—2023年3月徐州市妇幼保健院收治的64疑似早期乳腺癌患者为研究对象,将病理检查作为金标准。患者均依次接受高频彩色多普勒超声与乳腺钼靶断层融合技术检查,对比两种检验方式的诊断效能,并进行受试者工作特征(receiver operating characteristic,ROC)曲线分析。结果高频彩色多普勒超声的检验结果中,阳性28例,阴性36例,灵敏度为78.13%,特异度为90.63%,阳性预测值为89.29%,阴性预测值为80.56%;乳腺钼靶断层融合技术的检验结果中,阳性29例,阴性35例,灵敏度为84.38%,特异度为93.75%,阳性预测值为93.10%,阴性预测值为85.71%;两者联合检验结果中,阳性31例,阴性为33例,灵敏度为93.75%,特异度为96.88%,阳性预测值为96.77%,阴性预测值为93.94%。高频彩色多普勒超声检验的曲线下面积(area under curve,AUC)值为0.906,95%CI(0.823~0.989);乳腺钼靶断层融合技术检验的AUC值为0.938,95%CI(0.868~0.992);两者联合检验的AUC值为0.969,95%CI(0.919~0.999)。结论采用高频彩色多普勒超声联合乳腺钼靶断层融合技术诊断早期乳腺癌患者的效果显著,较单独检验更具临床价值。展开更多
基金supported by a grant of New Century Excellent Talents in University,Ministry of Education China(No.NCET-11-0949)
文摘Objective:To investigate hemodynamic change of patients with cirrhosis by using Color Doppler ultrasound technique and to explore the significance of change in the content of vasoactive substances-plasma endothelin-1(ET-1)and calcitonin gene-related peptide(CGRP).Methods:A total of 178 cases with cirrhosis were regarded as study groups,and were divided into three degrees:A,B and C according to child-pugh and meanwhile 60 cases were regarded as normal control group.Portal vein and splenic vein of patients were explored by adopting Color Doppler ultrasound technique,related indexes were recorded and the blood flow as well as their ration in the two groups was calculated.Radio immunoassay was adopted to detect the content of plasma ET-1 and CGRP in both study group and contrast group.Results:Compared with the healthy cases in the contrast group,there was abnormal hemodynamics in the system of portal vein of patients with cirrhosis and the content of plasma ET-1 and CGRP was increased obviously.In the Child-Pugh liver function grades,the content of ET-1 and CGRP was increased as the degree of cirrhosis became more and more serious.There was no significant difference in the comparison between those without ascites and those in contrast group(P>0.05),the content of plasma ET-1and CGRP in patients without ascites was increased remarkably.Besides,there was positive correlation between the content of plasma ET-1 and CGRP and Dpv,Dsv and Qsv.Conclusion:Dotection of abnormal hemodynamics of portal vein and splenic vein by Color Doppler ultrasound technique can be one of the means for diagnosis of hypertension.Plasma ET-1 and CGRP of patients with cirrhosis reflect the serious degree of the damage in live function and play an important role in the formation and development of portal hypertension.
文摘目的分析高频彩色多普勒超声与乳腺钼靶断层融合技术在早期乳腺癌患者中的诊断价值,为患者进行早期临床检查提供更准确的依据。方法选取2022年6月—2023年3月徐州市妇幼保健院收治的64疑似早期乳腺癌患者为研究对象,将病理检查作为金标准。患者均依次接受高频彩色多普勒超声与乳腺钼靶断层融合技术检查,对比两种检验方式的诊断效能,并进行受试者工作特征(receiver operating characteristic,ROC)曲线分析。结果高频彩色多普勒超声的检验结果中,阳性28例,阴性36例,灵敏度为78.13%,特异度为90.63%,阳性预测值为89.29%,阴性预测值为80.56%;乳腺钼靶断层融合技术的检验结果中,阳性29例,阴性35例,灵敏度为84.38%,特异度为93.75%,阳性预测值为93.10%,阴性预测值为85.71%;两者联合检验结果中,阳性31例,阴性为33例,灵敏度为93.75%,特异度为96.88%,阳性预测值为96.77%,阴性预测值为93.94%。高频彩色多普勒超声检验的曲线下面积(area under curve,AUC)值为0.906,95%CI(0.823~0.989);乳腺钼靶断层融合技术检验的AUC值为0.938,95%CI(0.868~0.992);两者联合检验的AUC值为0.969,95%CI(0.919~0.999)。结论采用高频彩色多普勒超声联合乳腺钼靶断层融合技术诊断早期乳腺癌患者的效果显著,较单独检验更具临床价值。
