目的:明确影响胰腺胶样癌(colloid carcinoma,CC)患者预后的危险因素,构建临床预后模型,对患者生存预后进行评估。方法:选取美国国家癌症研究所监测、流行病学和最终结果(Surveillance,Epidemiology,and End Results,SEER)数据库中510...目的:明确影响胰腺胶样癌(colloid carcinoma,CC)患者预后的危险因素,构建临床预后模型,对患者生存预后进行评估。方法:选取美国国家癌症研究所监测、流行病学和最终结果(Surveillance,Epidemiology,and End Results,SEER)数据库中510例患者,将其分为训练集和验证集,并根据训练集的临床变量构建预后模型,以预测CC患者在1、3、5年的癌症特异性生存率的概率值,而后用验证集验证训练集筛选出的变量及校准预测模型。结果:利用SEER数据库筛选CC患者预后的影响因素,包括肿瘤分级、检出淋巴结数量、是否手术、T分期、是否转移,并根据以上影响因素构建了临床预后模型。受试者特征曲线及曲线下面积值表明本预测模型具有较高的准确性。校正曲线显示模型预测的生存率与实际生存率相近。结论:本研究构建出CC患者的临床预后模型,并利用此模型对患者的生存预后进行了有效评估,填补了这种罕见肿瘤预后研究的空白,为临床医生评估CC患者预后提供了一项有力依据。展开更多
Background Colloid carcinomas of the pancreas have better prognosis than ordinary ductal adenocarcinoma, and preoperative distinction of colloid carcinoma from other pancreatic tumors is valuable for patient therapeut...Background Colloid carcinomas of the pancreas have better prognosis than ordinary ductal adenocarcinoma, and preoperative distinction of colloid carcinoma from other pancreatic tumors is valuable for patient therapeutic planning and prognosis assessment. However, data about CT features of colloid carcinoma are very limited. This study aimed to investigate the CT features of this tumor. Methods Institutional review board approval was obtained for this study. Seven patients with pathologically proven colloid carcinoma of the pancreas were included. Unenhanced and dynamic enhanced CT was performed in all the patients. CT features were analyzed retrospectively and correlations with pathological findings were evaluated. Results Mean age of the patients was 59.8 years （41-76 years）. Five tumors were located in the pancreatic head, and the other two in body and tail respectively. The maximum mean diameter of the tumors on axial scanning was 3.9 cm （3.0-6.7 cm）. Tumors were round （n=-5） and Iobular （n=2）. Tumors appeared slight hyp-attenuation on unenhanced CT, and peripheral and internal meshlike progressive delayed enhancement with great percent of cystic areas on enhanced CT. Calcification and gas in the tumor was seen in one patient whose duodenum was invaded by the tumor. Conclusions Colloid carcinomas of the pancreas appear as round or labular masses with great percent of cystic areas and slight hyp-attenuation on unenhanced CT and peripheral and internal meshlike progressive delayed enhancement on enhanced CT.展开更多
胰腺胶样癌（colloid carcinoma of the pancreas，CC）又称为胰腺黏液性非囊性癌，是指基质内黏液池中漂浮着散在成束、成条或单个肿瘤细胞，其中黏液区域占50％以上。CC是一种独特的浸润性肿瘤，我们初步探讨其病理学形态、相关蛋白...胰腺胶样癌（colloid carcinoma of the pancreas，CC）又称为胰腺黏液性非囊性癌，是指基质内黏液池中漂浮着散在成束、成条或单个肿瘤细胞，其中黏液区域占50％以上。CC是一种独特的浸润性肿瘤，我们初步探讨其病理学形态、相关蛋白表达及与生物学行为的关系，并将结果报告如下。展开更多
文摘目的:明确影响胰腺胶样癌(colloid carcinoma,CC)患者预后的危险因素,构建临床预后模型,对患者生存预后进行评估。方法:选取美国国家癌症研究所监测、流行病学和最终结果(Surveillance,Epidemiology,and End Results,SEER)数据库中510例患者,将其分为训练集和验证集,并根据训练集的临床变量构建预后模型,以预测CC患者在1、3、5年的癌症特异性生存率的概率值,而后用验证集验证训练集筛选出的变量及校准预测模型。结果:利用SEER数据库筛选CC患者预后的影响因素,包括肿瘤分级、检出淋巴结数量、是否手术、T分期、是否转移,并根据以上影响因素构建了临床预后模型。受试者特征曲线及曲线下面积值表明本预测模型具有较高的准确性。校正曲线显示模型预测的生存率与实际生存率相近。结论:本研究构建出CC患者的临床预后模型,并利用此模型对患者的生存预后进行了有效评估,填补了这种罕见肿瘤预后研究的空白,为临床医生评估CC患者预后提供了一项有力依据。
文摘Background Colloid carcinomas of the pancreas have better prognosis than ordinary ductal adenocarcinoma, and preoperative distinction of colloid carcinoma from other pancreatic tumors is valuable for patient therapeutic planning and prognosis assessment. However, data about CT features of colloid carcinoma are very limited. This study aimed to investigate the CT features of this tumor. Methods Institutional review board approval was obtained for this study. Seven patients with pathologically proven colloid carcinoma of the pancreas were included. Unenhanced and dynamic enhanced CT was performed in all the patients. CT features were analyzed retrospectively and correlations with pathological findings were evaluated. Results Mean age of the patients was 59.8 years （41-76 years）. Five tumors were located in the pancreatic head, and the other two in body and tail respectively. The maximum mean diameter of the tumors on axial scanning was 3.9 cm （3.0-6.7 cm）. Tumors were round （n=-5） and Iobular （n=2）. Tumors appeared slight hyp-attenuation on unenhanced CT, and peripheral and internal meshlike progressive delayed enhancement with great percent of cystic areas on enhanced CT. Calcification and gas in the tumor was seen in one patient whose duodenum was invaded by the tumor. Conclusions Colloid carcinomas of the pancreas appear as round or labular masses with great percent of cystic areas and slight hyp-attenuation on unenhanced CT and peripheral and internal meshlike progressive delayed enhancement on enhanced CT.
文摘胰腺胶样癌（colloid carcinoma of the pancreas，CC）又称为胰腺黏液性非囊性癌，是指基质内黏液池中漂浮着散在成束、成条或单个肿瘤细胞，其中黏液区域占50％以上。CC是一种独特的浸润性肿瘤，我们初步探讨其病理学形态、相关蛋白表达及与生物学行为的关系，并将结果报告如下。
