AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences betwee...AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients.展开更多
AIM: To explore the associations of polymorphisms of lipopolysaccharide binding protein (LBP), cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR-4), interleukin-6 (IL-6) and tumor necrosis factor α (TNF...AIM: To explore the associations of polymorphisms of lipopolysaccharide binding protein (LBP), cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR-4), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) with the colorectal carcinoma (CRC) risk in Han Chinese. METHODS: Polymorphisms of LBP (rs1739654, rs223 2596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms (SNPs) between cases and controls were analyzed by unconditional logistic regression. RESULTS: GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk ofCRC [odds ratio (OR) = 1.51, 95% confidence interval (CI) 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 (OR= 1.69, 95% CI 1.20-2.36, P = 0.002). In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC (OR = 3.44, 95% CI 1.94-6.10, P = 0.000). CONCLUSION: This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.展开更多
目的:探讨定量采集分析舌象特征在非创伤性股骨头坏死中医辨证中的应用价值。方法:采用DS01-B舌面诊测信息采集仪采集分析273例非创伤性股骨头坏死患者的舌象信息,对所获得的舌象信息进行聚类分析,同时分析非创伤性股骨头坏死国际骨循...目的:探讨定量采集分析舌象特征在非创伤性股骨头坏死中医辨证中的应用价值。方法:采用DS01-B舌面诊测信息采集仪采集分析273例非创伤性股骨头坏死患者的舌象信息,对所获得的舌象信息进行聚类分析,同时分析非创伤性股骨头坏死国际骨循环研究会(Association Research Circulation Osseous,ARCO)分期与舌象特征的关系。结果:273例患者共涉及18项舌象信息,舌色以淡紫、暗红、淡红为主;舌形以胖、齿痕、裂纹为主;苔色以白、灰黑、黄白相兼为主;苔质以薄苔、腻苔为主。经聚类分析,最终将273例非创伤性股骨头坏死患者的舌象分为3类。第1类,舌胖、苔薄白;第2类,舌暗红或淡紫、苔黄白相间;第3类,舌淡红,有齿痕、裂纹,苔厚、腻或少苔、无苔,颜色灰黑。ARCOⅠ期患者舌色为淡紫、舌形为胖、苔色为灰黑、苔质少;ARCOⅡ、Ⅲ期患者舌色以暗红、淡紫、淡红为主,舌形以胖为主,苔色以白为主,苔质以薄苔为主;ARCOⅣ期患者舌色以暗红为主,舌形以胖、齿痕为主,苔色以黄白相兼、灰黑为主,苔质以薄苔为主。结论:通过舌面诊测信息采集仪定量采集分析的舌象信息可准确反映非创伤性股骨头坏死患者的舌象特征,可作为非创伤性股骨头坏死的中医辨证依据。展开更多
基金Supported by A research grant offered by Mashhad University of Medical Sciences, No. 85017
文摘AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients.
基金Supported by The Nationgal Natural Science Foundation of China,No.30571924
文摘AIM: To explore the associations of polymorphisms of lipopolysaccharide binding protein (LBP), cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR-4), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) with the colorectal carcinoma (CRC) risk in Han Chinese. METHODS: Polymorphisms of LBP (rs1739654, rs223 2596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms (SNPs) between cases and controls were analyzed by unconditional logistic regression. RESULTS: GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk ofCRC [odds ratio (OR) = 1.51, 95% confidence interval (CI) 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 (OR= 1.69, 95% CI 1.20-2.36, P = 0.002). In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC (OR = 3.44, 95% CI 1.94-6.10, P = 0.000). CONCLUSION: This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.
文摘目的:探讨定量采集分析舌象特征在非创伤性股骨头坏死中医辨证中的应用价值。方法:采用DS01-B舌面诊测信息采集仪采集分析273例非创伤性股骨头坏死患者的舌象信息,对所获得的舌象信息进行聚类分析,同时分析非创伤性股骨头坏死国际骨循环研究会(Association Research Circulation Osseous,ARCO)分期与舌象特征的关系。结果:273例患者共涉及18项舌象信息,舌色以淡紫、暗红、淡红为主;舌形以胖、齿痕、裂纹为主;苔色以白、灰黑、黄白相兼为主;苔质以薄苔、腻苔为主。经聚类分析,最终将273例非创伤性股骨头坏死患者的舌象分为3类。第1类,舌胖、苔薄白;第2类,舌暗红或淡紫、苔黄白相间;第3类,舌淡红,有齿痕、裂纹,苔厚、腻或少苔、无苔,颜色灰黑。ARCOⅠ期患者舌色为淡紫、舌形为胖、苔色为灰黑、苔质少;ARCOⅡ、Ⅲ期患者舌色以暗红、淡紫、淡红为主,舌形以胖为主,苔色以白为主,苔质以薄苔为主;ARCOⅣ期患者舌色以暗红为主,舌形以胖、齿痕为主,苔色以黄白相兼、灰黑为主,苔质以薄苔为主。结论:通过舌面诊测信息采集仪定量采集分析的舌象信息可准确反映非创伤性股骨头坏死患者的舌象特征,可作为非创伤性股骨头坏死的中医辨证依据。
