目的:探讨糖尿病与非小细胞肺癌(non small cell lung cancer,NSCLC)临床病理因素的关系及对放射性肺炎发生率的影响。方法:回顾性分析2007年1月至2009年8月入住中南大学湘雅三医院肿瘤科的332例NSCLC患者的临床资料,将其分为糖尿病(dia...目的:探讨糖尿病与非小细胞肺癌(non small cell lung cancer,NSCLC)临床病理因素的关系及对放射性肺炎发生率的影响。方法:回顾性分析2007年1月至2009年8月入住中南大学湘雅三医院肿瘤科的332例NSCLC患者的临床资料,将其分为糖尿病(diabetesmellitus,DM)组(n=45)和非糖尿病(non-diabetesmellitus,NDM)组(n=287),比较两组间临床病理因素的差异;并将其中接受放射治疗的216例患者分为糖尿病放射组(DMR组,n=33)和非糖尿病放射组(NDMR组,n=183),比较两组放射性肺炎发生率的差异。结果:DM组与NDM组患者在体质量指数(bodymass index,BMI)、年龄、是否合并高血压方面差异均有统计学意义(P<0.05);两组在肿瘤病理类型、分化程度、TNM分期方面差异均无统计学意义(P>0.05)。接受放射治疗的DMR组和NDMR组患者照射面积差异无统计学意义(P>0.05),但放射性肺炎的发生率分别为42.42%和21.31%,差异有统计学意义(P<0.05);伴有糖尿病的NSCLC患者放射性肺炎的发病危险是非糖尿病组的2.721倍(95%CI为1.253～5.910)。结论:糖尿病为NSCLC患者发生放射性肺炎的易感因素。展开更多
AIM:To compare the clinical factors and tumor characteristics that predict survival in colorectal cancer(CRC)patients with different ethnicities in Xin Jiang area.METHODS:A total of 1421 histopathologically confirmed ...AIM:To compare the clinical factors and tumor characteristics that predict survival in colorectal cancer(CRC)patients with different ethnicities in Xin Jiang area.METHODS:A total of 1421 histopathologically confirmed sporadic CRC patients who were either Han/Chinese or Uyghur were identified and enrolled from a database of both diagnoses and operative procedures from Xin Jiang Tumor Hospital,which is affiliated to Xin Jiang Medical University between 2000 and 2007.Patients with family histories of CRC,hereditary nonpolyposis CRC,familial adenomatous polyposis,inflammatory bowel disease,carcinoid,squamous carcinoma or melanoma were excluded.The two ethnic groups were compared with regard to clinical features,tumor characteristics,disease stage,overall survival rate,diseasefree survival rate and cancer-specific survival rate.The factors predicting long-term survival were assessed via both univariate and multivariate analysis.RESULTS:Among the 1421 patients with CRC enrolled in this study,1210 patients were Han/Chinese(mean age,62.3±4.5 years;range,19-92 years),while 211patients were Uyghur(mean age,52.4±15.6 years;range,17-87 years).There were significant differences in proportions of gender,age,blood type,occupation and histopathological type between the Han/Chinese and Uyghur patients(P<0.05).The median overall,disease-free and cancer-specific survival time were 45,62and 65 mo for the Han/Chinese patients and 42,49 and61 mo for the Uyghur patients(P=0.000,P=0.005,P=0.007).The cumulative 5-year survival of the Uyghur patients was significantly worse than that of the Han patients(P=0.000).A multivariate analysis showed that age,ethnicity,histopathological type,differentiation,T(Infiltration depth),N(Lymph node metastasis),staging,postoperative metastasis and metastatic site(P<0.05)were found to be the prognostic factors.CONCLUSION:The Uyghur CRC patients are associated with significantly younger age,more aggressive histopathologic characteristics and have significantly worse prognosis than the Han/Chinese patient展开更多
AIM To evaluate the clinical and prognostic significance of preoperative and postoperative cytokeratin 19(CK19) and carcinoembryonic antigen(CEA) m RNA levels in peripheral blood of patients with gastric cardia cancer...AIM To evaluate the clinical and prognostic significance of preoperative and postoperative cytokeratin 19(CK19) and carcinoembryonic antigen(CEA) m RNA levels in peripheral blood of patients with gastric cardia cancer(GCC).METHODS We detected the preoperative and postoperative mR NA levels of CK19 and CEA in peripheral blood of 129 GCC patients by using reverse transcription-polymerase chain reaction and evaluated their clinical and prognostic significance by univariate Kaplan-Meier survival analysis and multivariate Cox proportional hazard analysis. A new prognostic model which stratified patients into three different risk groups was established based on the independent prognostic factors.RESULTS Elevated preoperative and postoperative CK19 and CEA mR NA levels in peripheral blood of GCC patients were associated with lymph node metastasis. Univariate analysis showed that tumor size, histological grade, depth of tumor invasion, lymph node metastasis, preoperative CK19 m RNA, and preoperative and postoperative CEA m RNA levels were correlated with the prognosis of GCC patients. The multivariate analysis showed that lymph node status(P = 0.018), preoperative CK19(P = 0.035) and CEA(P = 0.011) m RNA levels were independent prognostic factors for overall survival(OS). The 5-year OS rates for the low-, intermediate-, and high-risk groups were 48.3%, 22.6%, and 4.6%, respectively(P < 0.001).CONCLUSION Elevated preoperative CK19 and CEA mR NA levels may be regarded as promising biomarkers for predicting lymph node metastasis and poor prognosis in patients with GCC. This new prognostic model may help us identify the subpopulations of GCC patients with the highest risk.展开更多
目的:探讨三阴性乳腺癌(triple-negative breast cancer,TNBC)病人的临床病理特征、预后及其影响因素。方法:收集2010年9月至2015年9月收治的TNBC病人210例,并选取同期治疗的非TNBC病人70例作为对照,对其临床资料进行回顾性分析。结果:...目的:探讨三阴性乳腺癌(triple-negative breast cancer,TNBC)病人的临床病理特征、预后及其影响因素。方法:收集2010年9月至2015年9月收治的TNBC病人210例,并选取同期治疗的非TNBC病人70例作为对照,对其临床资料进行回顾性分析。结果:肿瘤大小与淋巴结转移有关,肿瘤长径越大,淋巴结转移率越高(P<0.01)。超声及钼靶检查对TNBC病理诊断的相符率比较,联合诊断相符率94.76%最高(P<0.01),超声诊断相符率84.76%次之(P<0.01),钼靶诊断相符率70.00%最低(P<0.01)。观察组病理组织学分级高于对照组(P<0.01)。预后分析表明,观察组复发率42.38%高于对照组28.57%,观察组生存率74.29%低于对照组85.71%(P<0.05)。肿瘤长径越大,生存率越低(P<0.01)。淋巴结阴性者存活率86.00%,高于淋巴结阳性者存活率65.45%(P<0.01)。结论:与非TNBC相比,TNBC肿瘤长径大、发病年龄低、病理组织学分级高,更易复发和转移,预后更差。超声和钼靶是TNBC辅助诊断的有效检查,二者联合诊断符合率更高。肿瘤长径较大和淋巴结阳性是TNBC死亡的危险因素。展开更多
目的:分析153例弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的临床病理特征及影响预后的相关因素。方法:收集2006年8月至2014年8月广西医科大学附属肿瘤医院收治的153例DLBCL患者的完整临床病理资料,分析和探讨该153例DLBC...目的:分析153例弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的临床病理特征及影响预后的相关因素。方法:收集2006年8月至2014年8月广西医科大学附属肿瘤医院收治的153例DLBCL患者的完整临床病理资料,分析和探讨该153例DLBCL患者的临床病理特征及影响预后的相关因素。结果:单因素分析结果发现,Ⅲ~Ⅳ期、乳酸脱氢酶(lactate dehydrogenase,LDH)升高、国际预后指数(international prognostic index,IPI)评分3~5分、CD10蛋白阳性表达均是影响预后的危险因素(P<0.05)。COX风险模型回归分析结果发现,LDH升高、IPI评分3~5分均是影响患者预后效果的独立因素(P<0.05)。结论:LDH升高、IPI 3~5分是影响患者预后的独立预后因素,CD10作为重要分子标志物,在评估DLBCL患者预后中具有一定的判断价值。展开更多
AIM To assess cancer-testis antigens(CTAs) expression in gastric cancer patients and examined their associations with clinicopathological factors.METHODS Eighty-three gastric cancer patients were evaluated in this stu...AIM To assess cancer-testis antigens(CTAs) expression in gastric cancer patients and examined their associations with clinicopathological factors.METHODS Eighty-three gastric cancer patients were evaluated in this study. Gastric cancer specimens were evaluated for the gene expression of CTAs, Kitakyushu lung cancer antigen-1(KK-LC-1), melanoma antigen(MAGE)-A1, MAGE-A3 and New York esophageal cancer-1(NYESO-1), by reverse transcription PCR. Clinicopathological background information, such as gender, age, tumor size, macroscopic type, tumor histology, depth of invasion, lymph node metastasis, lymphatic invasion, venous invasion, and pathological stage, was obtained. Statistical comparisons between the expression of each CTA and each clinicopathological background were performed using the χ2 test. RESULTS The expression rates of KK-LC-1, MAGE-A1, MAGE-A3, and NY-ESO-1 were 79.5%, 32.5%, 39.8%, and 15.7%, respectively. In early stage gastric cancer specimens, the expression of KK-LC-1 was 79.4%, which is comparable to the 79.6% observed in advanced stage specimens. The expression of KK-LC-1 was not significantly associated with clinicopathological factors, while there were considerable differences in the expression rates of MAGE-A1 and MAGE-A3 with vs without lymphatic invasion(MAGE-A1, 39.3% vs 13.6%, P = 0.034; MAGE-A3, 47.5% vs 18.2%, P = 0.022) and/or vascular invasion(MAGE-A1, 41.5% vs 16.7%, P = 0.028; MAGE-A3, 49.1% vs 23.3%, P = 0.035) and, particularly, MAGE-A3, in patients with early vs advanced stage(36.5% vs 49.0%, P = 0.044), respectively. Patients expressing MAGE-A3 and NYESO-1 were older than those not expressing MAGE-A3 and NY-ESO-1(MAGE-A3, 73.7 ± 7.1 vs 67.4 ± 12.3, P = 0.009; NY-ESO-1, 75.5 ± 7.2 vs 68.8 ± 11.2, P = 0.042). CONCLUSION The KK-LC-1 expression rate was high even in patients with stage I cancer, suggesting that KK-LC-1 is a useful biomarker for early diagnosis of gastric cancer.展开更多
目的乳腺化生性癌(metaplastic breast carcinoma,MBC)是一种罕见异质性原发性乳腺癌,其激素受体表达低、预后差。本研究探讨MBC患者临床病理特点,分析其临床特征及预后影响因素。方法回顾性分析2012-08-01-2017-12-31郑州大学附属肿瘤...目的乳腺化生性癌(metaplastic breast carcinoma,MBC)是一种罕见异质性原发性乳腺癌,其激素受体表达低、预后差。本研究探讨MBC患者临床病理特点,分析其临床特征及预后影响因素。方法回顾性分析2012-08-01-2017-12-31郑州大学附属肿瘤医院乳腺科收治的32例MBC女性患者临床资料并随访,精确概率法比较不同病理类型的复发率;生存期分析采用Kaplan-Meier和Log-rank法检验;生存影响因素分析采用Cox回归。结果全组32例MBC患者,中位年龄49.5岁。随访时间9~76个月,中位40个月,6年无病生存率(disease-free survival,DFS)和总生存率(overall survival,OS)分别为58.6%和86.5%。9例患者复发,其中3例死亡。单因素分析显示,肿瘤大小(χ2=6.029,P=0.034)、淋巴结是否转移(χ2=4.661,P=0.015)以及接受放疗与否(χ2=3.521,P=0.044)是影响患者DFS的关联因素。Cox回归多因素分析显示,肿瘤大小(HR=9.604,95%CI:1.404~65.677,P=0.021)是DFS独立危险因素。结论 MBC常表现为雌激素受体、孕激素受体和人表皮生长因子受体2/neu表达缺失。手术是治疗MBC的主要方法,肿瘤小预后相对较好,术后建议化疗,具有放疗指征的患者应行术后放疗,但尚需扩大样本进行验证。展开更多
文摘AIM:To compare the clinical factors and tumor characteristics that predict survival in colorectal cancer(CRC)patients with different ethnicities in Xin Jiang area.METHODS:A total of 1421 histopathologically confirmed sporadic CRC patients who were either Han/Chinese or Uyghur were identified and enrolled from a database of both diagnoses and operative procedures from Xin Jiang Tumor Hospital,which is affiliated to Xin Jiang Medical University between 2000 and 2007.Patients with family histories of CRC,hereditary nonpolyposis CRC,familial adenomatous polyposis,inflammatory bowel disease,carcinoid,squamous carcinoma or melanoma were excluded.The two ethnic groups were compared with regard to clinical features,tumor characteristics,disease stage,overall survival rate,diseasefree survival rate and cancer-specific survival rate.The factors predicting long-term survival were assessed via both univariate and multivariate analysis.RESULTS:Among the 1421 patients with CRC enrolled in this study,1210 patients were Han/Chinese(mean age,62.3±4.5 years;range,19-92 years),while 211patients were Uyghur(mean age,52.4±15.6 years;range,17-87 years).There were significant differences in proportions of gender,age,blood type,occupation and histopathological type between the Han/Chinese and Uyghur patients(P<0.05).The median overall,disease-free and cancer-specific survival time were 45,62and 65 mo for the Han/Chinese patients and 42,49 and61 mo for the Uyghur patients(P=0.000,P=0.005,P=0.007).The cumulative 5-year survival of the Uyghur patients was significantly worse than that of the Han patients(P=0.000).A multivariate analysis showed that age,ethnicity,histopathological type,differentiation,T(Infiltration depth),N(Lymph node metastasis),staging,postoperative metastasis and metastatic site(P<0.05)were found to be the prognostic factors.CONCLUSION:The Uyghur CRC patients are associated with significantly younger age,more aggressive histopathologic characteristics and have significantly worse prognosis than the Han/Chinese patient
基金Supported by the National Key Clinical Specialist Construction Programs of China,No.2013-544Science and Technology Development Fund of Tianjin Education Commission for Higher Education,No.20130121Science Foundation of Tianjin Medical University,No.2016KYZM03
文摘AIM To evaluate the clinical and prognostic significance of preoperative and postoperative cytokeratin 19(CK19) and carcinoembryonic antigen(CEA) m RNA levels in peripheral blood of patients with gastric cardia cancer(GCC).METHODS We detected the preoperative and postoperative mR NA levels of CK19 and CEA in peripheral blood of 129 GCC patients by using reverse transcription-polymerase chain reaction and evaluated their clinical and prognostic significance by univariate Kaplan-Meier survival analysis and multivariate Cox proportional hazard analysis. A new prognostic model which stratified patients into three different risk groups was established based on the independent prognostic factors.RESULTS Elevated preoperative and postoperative CK19 and CEA mR NA levels in peripheral blood of GCC patients were associated with lymph node metastasis. Univariate analysis showed that tumor size, histological grade, depth of tumor invasion, lymph node metastasis, preoperative CK19 m RNA, and preoperative and postoperative CEA m RNA levels were correlated with the prognosis of GCC patients. The multivariate analysis showed that lymph node status(P = 0.018), preoperative CK19(P = 0.035) and CEA(P = 0.011) m RNA levels were independent prognostic factors for overall survival(OS). The 5-year OS rates for the low-, intermediate-, and high-risk groups were 48.3%, 22.6%, and 4.6%, respectively(P < 0.001).CONCLUSION Elevated preoperative CK19 and CEA mR NA levels may be regarded as promising biomarkers for predicting lymph node metastasis and poor prognosis in patients with GCC. This new prognostic model may help us identify the subpopulations of GCC patients with the highest risk.
文摘目的:探讨三阴性乳腺癌(triple-negative breast cancer,TNBC)病人的临床病理特征、预后及其影响因素。方法:收集2010年9月至2015年9月收治的TNBC病人210例,并选取同期治疗的非TNBC病人70例作为对照,对其临床资料进行回顾性分析。结果:肿瘤大小与淋巴结转移有关,肿瘤长径越大,淋巴结转移率越高(P<0.01)。超声及钼靶检查对TNBC病理诊断的相符率比较,联合诊断相符率94.76%最高(P<0.01),超声诊断相符率84.76%次之(P<0.01),钼靶诊断相符率70.00%最低(P<0.01)。观察组病理组织学分级高于对照组(P<0.01)。预后分析表明,观察组复发率42.38%高于对照组28.57%,观察组生存率74.29%低于对照组85.71%(P<0.05)。肿瘤长径越大,生存率越低(P<0.01)。淋巴结阴性者存活率86.00%,高于淋巴结阳性者存活率65.45%(P<0.01)。结论:与非TNBC相比,TNBC肿瘤长径大、发病年龄低、病理组织学分级高,更易复发和转移,预后更差。超声和钼靶是TNBC辅助诊断的有效检查,二者联合诊断符合率更高。肿瘤长径较大和淋巴结阳性是TNBC死亡的危险因素。
文摘目的:分析153例弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的临床病理特征及影响预后的相关因素。方法:收集2006年8月至2014年8月广西医科大学附属肿瘤医院收治的153例DLBCL患者的完整临床病理资料,分析和探讨该153例DLBCL患者的临床病理特征及影响预后的相关因素。结果:单因素分析结果发现,Ⅲ~Ⅳ期、乳酸脱氢酶(lactate dehydrogenase,LDH)升高、国际预后指数(international prognostic index,IPI)评分3~5分、CD10蛋白阳性表达均是影响预后的危险因素(P<0.05)。COX风险模型回归分析结果发现,LDH升高、IPI评分3~5分均是影响患者预后效果的独立因素(P<0.05)。结论:LDH升高、IPI 3~5分是影响患者预后的独立预后因素,CD10作为重要分子标志物,在评估DLBCL患者预后中具有一定的判断价值。
基金Supported by Grant-in-Aid for research by Kitasato University Medical Center,No.H25-0006 and the JSPS,KAKENHI,No.26670609 to Futawatari Nthe JSPS,KAKENHI,No.21700510 and No.17K16578,Takeda Science Foundation and Kitasato University Research Grant for Young Researchers to Fukuyama T
文摘AIM To assess cancer-testis antigens(CTAs) expression in gastric cancer patients and examined their associations with clinicopathological factors.METHODS Eighty-three gastric cancer patients were evaluated in this study. Gastric cancer specimens were evaluated for the gene expression of CTAs, Kitakyushu lung cancer antigen-1(KK-LC-1), melanoma antigen(MAGE)-A1, MAGE-A3 and New York esophageal cancer-1(NYESO-1), by reverse transcription PCR. Clinicopathological background information, such as gender, age, tumor size, macroscopic type, tumor histology, depth of invasion, lymph node metastasis, lymphatic invasion, venous invasion, and pathological stage, was obtained. Statistical comparisons between the expression of each CTA and each clinicopathological background were performed using the χ2 test. RESULTS The expression rates of KK-LC-1, MAGE-A1, MAGE-A3, and NY-ESO-1 were 79.5%, 32.5%, 39.8%, and 15.7%, respectively. In early stage gastric cancer specimens, the expression of KK-LC-1 was 79.4%, which is comparable to the 79.6% observed in advanced stage specimens. The expression of KK-LC-1 was not significantly associated with clinicopathological factors, while there were considerable differences in the expression rates of MAGE-A1 and MAGE-A3 with vs without lymphatic invasion(MAGE-A1, 39.3% vs 13.6%, P = 0.034; MAGE-A3, 47.5% vs 18.2%, P = 0.022) and/or vascular invasion(MAGE-A1, 41.5% vs 16.7%, P = 0.028; MAGE-A3, 49.1% vs 23.3%, P = 0.035) and, particularly, MAGE-A3, in patients with early vs advanced stage(36.5% vs 49.0%, P = 0.044), respectively. Patients expressing MAGE-A3 and NYESO-1 were older than those not expressing MAGE-A3 and NY-ESO-1(MAGE-A3, 73.7 ± 7.1 vs 67.4 ± 12.3, P = 0.009; NY-ESO-1, 75.5 ± 7.2 vs 68.8 ± 11.2, P = 0.042). CONCLUSION The KK-LC-1 expression rate was high even in patients with stage I cancer, suggesting that KK-LC-1 is a useful biomarker for early diagnosis of gastric cancer.
