Epilepsy is a very common worldwide neurological disorder that can affect a person’s quality of life at any age. People with epilepsy typically have recurrent seizures that can lead to injury or in some cases even de...Epilepsy is a very common worldwide neurological disorder that can affect a person’s quality of life at any age. People with epilepsy typically have recurrent seizures that can lead to injury or in some cases even death. Curing epilepsy requires risky surgery. If not, the patient may be subjected to a long drug treatment associated with lifestyle advice without guarantee of total recovery. However, regardless of the type of treatment performed, late treatment necessarily creates psychological instability in the patient. It is therefore important to be able to diagnose the disease as early as possible if we desire that the patient does not suffer from its consequences on their mental health. That is why the study aims to propose a model for detecting epilepsy in order to be able to identify it as early as possible, especially in newborns. The objective of the article is to propose a model for detecting epilepsy using data from electroencephalogram signals from 10 newborns. This model developed using the extra trees classifier technique offers the possibility of predicting epilepsy in infants with an accuracy of around 99.4%.展开更多
The automatic detection and identification of electroencephalogram waves play an important role in the prediction, diagnosis and treatment of epileptic seizures. In this study, a nonlinear dynamics index–approximate ...The automatic detection and identification of electroencephalogram waves play an important role in the prediction, diagnosis and treatment of epileptic seizures. In this study, a nonlinear dynamics index–approximate entropy and a support vector machine that has strong generalization ability were applied to classify electroencephalogram signals at epileptic interictal and ictal periods. Our aim was to verify whether approximate entropy waves can be effectively applied to the automatic real-time detection of epilepsy in the electroencephalogram, and to explore its generalization ability as a classifier trained using a nonlinear dynamics index. Four patients presenting with partial epileptic seizures were included in this study. They were all diagnosed with neocortex localized epilepsy and epileptic foci were clearly observed by electroencephalogram. The electroencephalogram data form the four involved patients were segmented and the characteristic values of each segment, that is, the approximate entropy, were extracted. The support vector machine classifier was constructed with the approximate entropy extracted from one epileptic case, and then electroencephalogram waves of the other three cases were classified, reaching a 93.33% accuracy rate. Our findings suggest that the use of approximate entropy allows the automatic real-time detection of electroencephalogram data in epileptic cases. The combination of approximate entropy and support vector machines shows good generalization ability for the classification of electroencephalogram signals for epilepsy.展开更多
Traditional Chinese herbal medicine (TCHM) has long been used to treat epilepsy. Although many clinical trials and animal studies have seemingly demonstrated its effect, the question of whether TCHM is efficacious in ...Traditional Chinese herbal medicine (TCHM) has long been used to treat epilepsy. Although many clinical trials and animal studies have seemingly demonstrated its effect, the question of whether TCHM is efficacious in epileptic patients has not been certified because of insufficient supportive evidence. This insufficient supportive evidence stems from the fact that most of the current studies regarding TCHM for epilepsy treatment are not designed according to the different seizure types and epileptic syndromes (STESs). Here, we explore the reasons why many studies have not considered the various STESs and explain how to treat epilepsy according to the pharmacological mechanism for different STESs and exploit the advantage of TCHM for epilepsy treatment. Then, we explain how we treat epilepsy using TCHM according to the different STESs and Bian Zheng Lun Zi.展开更多
Epilepsy is the most common neuropathology. Statistical studies related to the disease reported that 20% - 25% of epileptic patients with occurrence of seizures were even under treatment with drugs. This article prese...Epilepsy is the most common neuropathology. Statistical studies related to the disease reported that 20% - 25% of epileptic patients with occurrence of seizures were even under treatment with drugs. This article presents a strategy for improved detection of the neuropathology, based on electroencephalogram (EEG), using a classifier built with support vector machines (SVC). The SVC is designed based on feature extraction of higher order spectra of time series derived from the EEG applied to epileptic patients and control patients. As demonstrated in the study presented, the EEG time series are highly nonlinear and non-Gaussian, therefore, exhibit higher order spectra, which are extracted features that improve the accuracy in the performance of SVC. The results of this study suggest the development of highly accurate computational tools for the diagnosis of this dreaded neuropathology.展开更多
文摘Epilepsy is a very common worldwide neurological disorder that can affect a person’s quality of life at any age. People with epilepsy typically have recurrent seizures that can lead to injury or in some cases even death. Curing epilepsy requires risky surgery. If not, the patient may be subjected to a long drug treatment associated with lifestyle advice without guarantee of total recovery. However, regardless of the type of treatment performed, late treatment necessarily creates psychological instability in the patient. It is therefore important to be able to diagnose the disease as early as possible if we desire that the patient does not suffer from its consequences on their mental health. That is why the study aims to propose a model for detecting epilepsy in order to be able to identify it as early as possible, especially in newborns. The objective of the article is to propose a model for detecting epilepsy using data from electroencephalogram signals from 10 newborns. This model developed using the extra trees classifier technique offers the possibility of predicting epilepsy in infants with an accuracy of around 99.4%.
基金financially supported by the National Natural Science Foundation of China,No.61263011,81000554Program in Sun Yat-sen University supported by Fundamental Research Funds for the Central Universities,No.11ykpy07+1 种基金Natural Science Foundation of Guangdong Province,No.S2011010005309Innovation Fund of Xinjiang Medical University,No.XJC201209
文摘The automatic detection and identification of electroencephalogram waves play an important role in the prediction, diagnosis and treatment of epileptic seizures. In this study, a nonlinear dynamics index–approximate entropy and a support vector machine that has strong generalization ability were applied to classify electroencephalogram signals at epileptic interictal and ictal periods. Our aim was to verify whether approximate entropy waves can be effectively applied to the automatic real-time detection of epilepsy in the electroencephalogram, and to explore its generalization ability as a classifier trained using a nonlinear dynamics index. Four patients presenting with partial epileptic seizures were included in this study. They were all diagnosed with neocortex localized epilepsy and epileptic foci were clearly observed by electroencephalogram. The electroencephalogram data form the four involved patients were segmented and the characteristic values of each segment, that is, the approximate entropy, were extracted. The support vector machine classifier was constructed with the approximate entropy extracted from one epileptic case, and then electroencephalogram waves of the other three cases were classified, reaching a 93.33% accuracy rate. Our findings suggest that the use of approximate entropy allows the automatic real-time detection of electroencephalogram data in epileptic cases. The combination of approximate entropy and support vector machines shows good generalization ability for the classification of electroencephalogram signals for epilepsy.
文摘Traditional Chinese herbal medicine (TCHM) has long been used to treat epilepsy. Although many clinical trials and animal studies have seemingly demonstrated its effect, the question of whether TCHM is efficacious in epileptic patients has not been certified because of insufficient supportive evidence. This insufficient supportive evidence stems from the fact that most of the current studies regarding TCHM for epilepsy treatment are not designed according to the different seizure types and epileptic syndromes (STESs). Here, we explore the reasons why many studies have not considered the various STESs and explain how to treat epilepsy according to the pharmacological mechanism for different STESs and exploit the advantage of TCHM for epilepsy treatment. Then, we explain how we treat epilepsy using TCHM according to the different STESs and Bian Zheng Lun Zi.
文摘Epilepsy is the most common neuropathology. Statistical studies related to the disease reported that 20% - 25% of epileptic patients with occurrence of seizures were even under treatment with drugs. This article presents a strategy for improved detection of the neuropathology, based on electroencephalogram (EEG), using a classifier built with support vector machines (SVC). The SVC is designed based on feature extraction of higher order spectra of time series derived from the EEG applied to epileptic patients and control patients. As demonstrated in the study presented, the EEG time series are highly nonlinear and non-Gaussian, therefore, exhibit higher order spectra, which are extracted features that improve the accuracy in the performance of SVC. The results of this study suggest the development of highly accurate computational tools for the diagnosis of this dreaded neuropathology.
