目的研究华蟾素注射液辅助治疗前列腺癌的临床疗效。方法收集2015年1月—2017年2月襄阳市中心医院(湖北文理学院附属医院)肿瘤科收治的前列腺癌患者110例,随机分为对照组和治疗组,每组各55例。对照组患者给予相应的放化疗治疗。治疗组...目的研究华蟾素注射液辅助治疗前列腺癌的临床疗效。方法收集2015年1月—2017年2月襄阳市中心医院(湖北文理学院附属医院)肿瘤科收治的前列腺癌患者110例,随机分为对照组和治疗组,每组各55例。对照组患者给予相应的放化疗治疗。治疗组在放化疗开始时即静脉滴注华蟾素注射液,10~20 m L稀释于5%葡萄糖注射液250 m L中,连续用药6 d,停药1 d。连续用药3周为1个疗程,共治疗4个疗程。观察两组的临床疗效,比较两组治疗前后血清前列腺特异抗原(PSA)水平和毒副反应。结果治疗后,对照组客观缓解率(ORR)是69.09%,临床获益率(CBR)是85.45%;治疗组ORR是89.09%,CBR是96.36%,两组ORR、CBR比较差异有统计学意义(P<0.05)。治疗后,两组患者血清PSA水平均显著降低,同组治疗前后差异有统计学意义(P<0.05);治疗后,治疗组血清PSA水平显著低于对照组,两组比较差异有统计学意义(P<0.05)。治疗组患者白细胞减少、恶心呕吐的发生率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论华蟾素注射液辅助治疗前列腺癌临床疗效确切,能显著降低血清PSA水平,减少患者白细胞降低和恶心呕吐的发生率,具有一定的临床推广应用价值。展开更多
To investigate the clinical efficacy of adjuvant chemotherapy of cinobufacin injection in the treatment of senior patients with colorectal cancer and its influence on serum tumor markers and immune function,from Novem...To investigate the clinical efficacy of adjuvant chemotherapy of cinobufacin injection in the treatment of senior patients with colorectal cancer and its influence on serum tumor markers and immune function,from November 2018 to November 2019,84 senior colorectal cancer patients in author's hospital were al randomly divided into control group and observation group,42 cases in each group,and the control group was treated with routine chemotherapy,the observation group was treated with routine chemotherapy and intravenous injection of cinobufacin,the two groups were all treated for 4 cycles,then the short-term efficacy,serum tumor markers[carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 724(CA724),carcinoembryonic antigen(CEA)]and immune function indexes(CD3+,CD4+,CD4+/CD8+),as well as the unward reaction of chemotherapy were compared between the two groups before and after treatment.As results,Short-term efficacy:the total effective rate of observation group was significantly higher than that of control group(78.57%vs 47.62%,P<0.05).Tumor markers:after treatment,the levels of CA19-9,CA724 and CEA in the two groups were significantly lower than those before treatment(P<0.05).Compared between the two groups,the levels of each index in observation group were lower(P<0.05).Immune function after treatment the levels of CD3+,CD4+,CD4+/CD8+in observation group were significantly higher than those before treatment while the levels of CD3+,CD4+,CD4+/CD8+in control group were significantly lower(P<0.05).After treatment,the above each index in observation group were higher than those in control group(P<0.05).Untoward reaction:the incidence of leukopenia,thrombocytopenia,gastrointestinal response,fatigue and myelosuppresion in observation group were significantly lower than those in control group(P<0.05).The results show that cinobufacin injection in the adjuvant treatment of senior patients with colorectal cancer can improve the shortterm efficacy of chemotherapy,reduce the untoward reaction,and reduce the serum levels展开更多
文摘目的研究华蟾素注射液辅助治疗前列腺癌的临床疗效。方法收集2015年1月—2017年2月襄阳市中心医院(湖北文理学院附属医院)肿瘤科收治的前列腺癌患者110例,随机分为对照组和治疗组,每组各55例。对照组患者给予相应的放化疗治疗。治疗组在放化疗开始时即静脉滴注华蟾素注射液,10~20 m L稀释于5%葡萄糖注射液250 m L中,连续用药6 d,停药1 d。连续用药3周为1个疗程,共治疗4个疗程。观察两组的临床疗效,比较两组治疗前后血清前列腺特异抗原(PSA)水平和毒副反应。结果治疗后,对照组客观缓解率(ORR)是69.09%,临床获益率(CBR)是85.45%;治疗组ORR是89.09%,CBR是96.36%,两组ORR、CBR比较差异有统计学意义(P<0.05)。治疗后,两组患者血清PSA水平均显著降低,同组治疗前后差异有统计学意义(P<0.05);治疗后,治疗组血清PSA水平显著低于对照组,两组比较差异有统计学意义(P<0.05)。治疗组患者白细胞减少、恶心呕吐的发生率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论华蟾素注射液辅助治疗前列腺癌临床疗效确切,能显著降低血清PSA水平,减少患者白细胞降低和恶心呕吐的发生率,具有一定的临床推广应用价值。
文摘To investigate the clinical efficacy of adjuvant chemotherapy of cinobufacin injection in the treatment of senior patients with colorectal cancer and its influence on serum tumor markers and immune function,from November 2018 to November 2019,84 senior colorectal cancer patients in author's hospital were al randomly divided into control group and observation group,42 cases in each group,and the control group was treated with routine chemotherapy,the observation group was treated with routine chemotherapy and intravenous injection of cinobufacin,the two groups were all treated for 4 cycles,then the short-term efficacy,serum tumor markers[carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 724(CA724),carcinoembryonic antigen(CEA)]and immune function indexes(CD3+,CD4+,CD4+/CD8+),as well as the unward reaction of chemotherapy were compared between the two groups before and after treatment.As results,Short-term efficacy:the total effective rate of observation group was significantly higher than that of control group(78.57%vs 47.62%,P<0.05).Tumor markers:after treatment,the levels of CA19-9,CA724 and CEA in the two groups were significantly lower than those before treatment(P<0.05).Compared between the two groups,the levels of each index in observation group were lower(P<0.05).Immune function after treatment the levels of CD3+,CD4+,CD4+/CD8+in observation group were significantly higher than those before treatment while the levels of CD3+,CD4+,CD4+/CD8+in control group were significantly lower(P<0.05).After treatment,the above each index in observation group were higher than those in control group(P<0.05).Untoward reaction:the incidence of leukopenia,thrombocytopenia,gastrointestinal response,fatigue and myelosuppresion in observation group were significantly lower than those in control group(P<0.05).The results show that cinobufacin injection in the adjuvant treatment of senior patients with colorectal cancer can improve the shortterm efficacy of chemotherapy,reduce the untoward reaction,and reduce the serum levels
