Chinese arsenic drugs have been applied in Chinese medicine for several centuries. Beginning from 1970s, arsenic containing drugs have been generally used for the treatment of malignant hematologic diseases including ...Chinese arsenic drugs have been applied in Chinese medicine for several centuries. Beginning from 1970s, arsenic containing drugs have been generally used for the treatment of malignant hematologic diseases including acute promyelocytic leukemia, myelodysplastic syndrome, and multiple myeloma. No matter what ingredients of arsenic drugs were applied, either arsenic trioxide, arsenic disulfide, or arsenic containing Chinese herbal compositions including Qinghuang Powder （青黄散） and Realgar-lndigo naturalis formula （复方黄黛片）, they all provided the distinct approaches for the management of malignant hematologic diseases, and good clinical efficacy was obtained with mild adverse reactions. Moreover, the mechanisms of action have been continuallv elucidated.展开更多
目的:系统评价中药组方联合美沙拉嗪或柳氮磺吡啶治疗溃疡性结肠炎患者的疗效及安全性。方法:在PubMed、Web of Science、中国知网、万方、维普数据库以"中药"、"溃疡性结肠炎"等为检索词,检索并筛选相关文献,以临...目的:系统评价中药组方联合美沙拉嗪或柳氮磺吡啶治疗溃疡性结肠炎患者的疗效及安全性。方法:在PubMed、Web of Science、中国知网、万方、维普数据库以"中药"、"溃疡性结肠炎"等为检索词,检索并筛选相关文献,以临床有效率及不良反应为结局指标,采用Revman 5.4进行Meta分析。结果:本次研究共检索文献2124篇,最终纳入117篇;Meta分析发现,美沙拉嗪联合中药组方口服(OR=3.49,95%CI[2.75,4.43])或灌肠(OR=4.42,95%CI[3.56,5.48])治疗均能提高临床有效率,且并未增加不良反应的发生风险(OR=0.55,95%CI[0.28,1.06];OR=0.39,95%CI[0.26,0.58]);柳氮磺吡啶联合中药组方口服(OR=5.95,95%CI[3.76,9.40])或灌肠(OR=3.75,95%CI[2.80,5.01])治疗同样可提高临床有效率,不良反应的风险并未因中药组方的使用而增加(OR=0.33,95%CI[0.05,2.07];OR=0.27,95%CI[0.01,5.66])。结论:在美沙拉嗪/柳氮磺吡啶的基础上联合中药组方口服或灌肠治疗能有效提高溃疡性结肠炎的治愈率,且并未增加不良反应的发生风险,但中药组方联合治疗溃疡性结肠炎仍需高质量的研究。展开更多
文摘Chinese arsenic drugs have been applied in Chinese medicine for several centuries. Beginning from 1970s, arsenic containing drugs have been generally used for the treatment of malignant hematologic diseases including acute promyelocytic leukemia, myelodysplastic syndrome, and multiple myeloma. No matter what ingredients of arsenic drugs were applied, either arsenic trioxide, arsenic disulfide, or arsenic containing Chinese herbal compositions including Qinghuang Powder （青黄散） and Realgar-lndigo naturalis formula （复方黄黛片）, they all provided the distinct approaches for the management of malignant hematologic diseases, and good clinical efficacy was obtained with mild adverse reactions. Moreover, the mechanisms of action have been continuallv elucidated.
文摘目的:系统评价中药组方联合美沙拉嗪或柳氮磺吡啶治疗溃疡性结肠炎患者的疗效及安全性。方法:在PubMed、Web of Science、中国知网、万方、维普数据库以"中药"、"溃疡性结肠炎"等为检索词,检索并筛选相关文献,以临床有效率及不良反应为结局指标,采用Revman 5.4进行Meta分析。结果:本次研究共检索文献2124篇,最终纳入117篇;Meta分析发现,美沙拉嗪联合中药组方口服(OR=3.49,95%CI[2.75,4.43])或灌肠(OR=4.42,95%CI[3.56,5.48])治疗均能提高临床有效率,且并未增加不良反应的发生风险(OR=0.55,95%CI[0.28,1.06];OR=0.39,95%CI[0.26,0.58]);柳氮磺吡啶联合中药组方口服(OR=5.95,95%CI[3.76,9.40])或灌肠(OR=3.75,95%CI[2.80,5.01])治疗同样可提高临床有效率,不良反应的风险并未因中药组方的使用而增加(OR=0.33,95%CI[0.05,2.07];OR=0.27,95%CI[0.01,5.66])。结论:在美沙拉嗪/柳氮磺吡啶的基础上联合中药组方口服或灌肠治疗能有效提高溃疡性结肠炎的治愈率,且并未增加不良反应的发生风险,但中药组方联合治疗溃疡性结肠炎仍需高质量的研究。
