Objective: To investigate the effects and safety of catgut embedding on alleviating insomnia. Methods: Totally 510 patients with insomnia were divided into 5 Chinese medicine(CM) syndrome types: Xin(Heart) and Pi(Sple...Objective: To investigate the effects and safety of catgut embedding on alleviating insomnia. Methods: Totally 510 patients with insomnia were divided into 5 Chinese medicine(CM) syndrome types: Xin(Heart) and Pi(Spleen) deficiency, yin deficiency with excess fire, Xin and gut qi deficiency, Wei(Stomach) disorder, and qi and blood deficiency, respectively. These 5 types of patients were randomly assigned to a catgut embedding group, an acupuncture group or a medication group(30 cases in Xin and Pi deficiency type, Wei disorder type, Xin and gut qi deficiency type, respectively;40 cases in yin deficiency with excess fire type and qi and blood deficiency type, respectively). In the catgut embedding group, patients were treated by implanting catgut into acupoints once every 10 days for a total of 30 days. In the acupuncture group, patients were treated with acupuncture once per day over 30 days(excluding weekends);and patients in the medication group took 1 mg Eurodin Tablet orally every night for 30 days. Pittsburgh Sleep Quality Index(PSQI) was evaluated before treatment, on 30 and 60 days after the first treatment, respectively. The International Unified Sleep Efficiency Value(IUSEV) was measured at 30 and 60 days. The safety was evaluated after treatment and adverse events were analyzed. Results: The objective PSQI scores including subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, daytime dysfunction, and total scores at 30 days were significantly improved compared with pre-treatment in the catgut embedding and acupuncture groups(P<0.01 or P<0.05). At 30 days, the PSQI scores in catgut embedding group were superior to the medication group in the patients with each type of insomnia, with the exception of sleep duration(P<0.01 or P<0.05). At 60 days, significant differences were found between the catgut embedding group and the medication group(P<0.01 for all indices). The IUSEV scores in the catgut embedding group were significantly higher than the acupuncture g展开更多
Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats.However,the underlying mechanisms are poorly understood.In this study,we used the rat middle cerebral artery occlusion model...Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats.However,the underlying mechanisms are poorly understood.In this study,we used the rat middle cerebral artery occlusion model of stroke.Three days after surgery,absorbable surgical catgut sutures were implanted at Dazhui（GV14）,Jizhong（GV6）,Houhui,Guanyuan（CV4）and Zhongwan（CV12）.The Zea Longa score was used to assess neurological function.The Modified Ashworth Scale was used to evaluate muscle tension.The 2,3,5-triphenyl-tetrazolium chloride assay was used to measure infarct volume.Immunohistochemical staining was performed for glutamate aspartate transporter（GLAST）and glial glutamate transporter-1（GLT-1）expression.Western blot assay was used to analyze the expression of GLAST and GLT-1.Reverse transcription and polymerase chain reaction were carried out to assess the expression of GLAST and GLT-1m RNAs.After catgut implantation at the acupoints,neurological function was substantially improved,muscle tension was decreased,and infarct volume was reduced in rats with spasticity after stroke.Furthermore,the expression of GLAST and GLT-1 m RNAs was increased on the injured（left）side.Our findings demonstrate that catgut implantation at acupoints alleviates spasticity after stroke,likely by increasing the expression of GLAST and GLT-1.展开更多
Objective:To explore the therapeutic effect of acupoint catgut embedding combined with gingerseparated moxibustion for sequelae of peripheral facial paralysis and whether surface electromyography(sEMG)can be an outcom...Objective:To explore the therapeutic effect of acupoint catgut embedding combined with gingerseparated moxibustion for sequelae of peripheral facial paralysis and whether surface electromyography(sEMG)can be an outcome to evaluate the effect of this disease.Methods:Thirty-five patients with sequelae of peripheral facial paralysis were treated with catgut embedding at the acupoints selected according to their individual symptoms and traditional Chinese medicine(TCM)differentiated syndromes.At the same time,the ginger-separated moxibustion was applied at Yifeng(翳风TE17)and Qianzheng(牵正EX-HN16)of the affected side.The catgut embedding was applied once every 15 days,one time of treatment is of one course,and a total of three courses were given.The moxibustion would be taken after 5 days of catgut embedding each time,once every other day,5 times as one course,a total of 3 courses are given.After treatment,the recovery of facial nerve functions was evaluated by House-Brackmann(H-B)facial nerve function evaluation grading system.Before and after treatment,the surface electromyography(sEMG)was used to detect the root-mean-square(RMS)of frontal muscles,cheek muscles,and orbicularis oris muscles to compare the RMS ratio of these muscles of affected side and healthy side.Results:After 3 courses of treatment,9 cases were cured,22 cases were effective,and 4 cases were ineffective.The total effective rate was 88.6%(31/35).After treatment,the RMS of frontal muscles,cheek muscles,and orbicularis oris muscles of the affected side were 31.56±4.25,34.13±4.28,and 7.46±1.53 respectively,significantly increased in comparing with 11.69±2.45,12.98±3.34,and 2.62±1.41 respectively before treatment(all P<0.05).After treatment,the RMS ratios of frontal muscles,cheek muscles,and orbicularis oris muscles of the affected side and healthy side were 0.73±0.09,0.71±0.11,and 0.68±0.08 respectively,greatly increased in comparing with 0.28±0.10,0.27±0.08,and 0.22±0.09 respectively before treatment(all P<0.05).Conclusion:Acupoint c展开更多
Objective To observe the clinical therapeutic effect of catgut embedding therapy for treatment of menopausal obesity. Methods Sixty-four cases of menopausal obesity patients were randomly divided into two groups, 32 c...Objective To observe the clinical therapeutic effect of catgut embedding therapy for treatment of menopausal obesity. Methods Sixty-four cases of menopausal obesity patients were randomly divided into two groups, 32 cases in each group. In control group, the diet control was employed. And based on it, in observation group, catgut embedding therapy was apphed at Zusanli （足三里 ST 36）, Sanyinjiao （三阴交 SP 6）, matched with other points in line with syndrome differentiation. Therapeutic effect evaluated by changes of weight, Body Mass Index （BMI）, waist circumference and Kupperman index before and after treatment was observed. Results The total effective rate for treating obesity and menopausal syndrome was 90.6% （29/32）, 87.5% （28/32） respectively in observation group, superior to those of 46.9% （15/32）, 40.6% （13/32） in control group （both P〈0.05）; weight, BMI, waist circumference and Kupperman index in both groups improved distinctively after treatment （all P〈0.05）, and changes were more significantly in observation group than those in control group （all P〈0.05）. Conclusion For treating menopausal obesity, catgut embedding therapy not only has a good therapeutic effect on weight loss, but also improves menopausal syndrome.展开更多
Objective This review aimed to systematically evaluate the evidence on the effects of acupoint catgut embedding （ACE） therapy for patients with polycystic ovary syndrome （PCOS）. Methods Five databases （CBM, CNKI,...Objective This review aimed to systematically evaluate the evidence on the effects of acupoint catgut embedding （ACE） therapy for patients with polycystic ovary syndrome （PCOS）. Methods Five databases （CBM, CNKI, Wanfang Database, VlP Database, and PubMed） were searched to identify relevant studies published before June 2027. The outcomes were resumption of menstruation and serum levels of testosterone （T）. The methodological quality of the included studies was judged using the Cochrane risk of bias tool. The overall level of evidence was judged by the Grading of Recommendations Assessment, Development, and Evaluation （GRADE） criteria. Results Twenty- five randomized controlled trials were included. ACE therapy significantly lowered serum T levels, and patients receiving ACE treatment reported resumption of menstruation. However, these results should be interpreted with caution due to a high risk of randomization and blinding bias, and likely publication bias. The level of evidence for resumption of menstruation and serum T levels was assessed as ＂low＂ and ＂low＂, respectively, using GRADE. Conclusion The current evidence on ACE therapy for PCOS is insufficient to draw firm conclusions due to the poor methodological quality. Future well- designed trials are needed to validate the therapeutic efficacy, safety, and mechanisms of ACE in patients with PCOS.展开更多
Objective:To observe the clinical effect of acupoint catgut embedding combined with auricular plaster therapy in the treatment of children with vocal tic disorders.Methods:Catgut embedding was performed at the acupoin...Objective:To observe the clinical effect of acupoint catgut embedding combined with auricular plaster therapy in the treatment of children with vocal tic disorders.Methods:Catgut embedding was performed at the acupoints Bǎihuì(百会GV20),Shéntíng(神庭GV24),Dàzhuī(大椎GV14),Shēnzhù(身柱GV12),Fèishū(肺俞BL13),and Wèishū(胃俞BL21),and then auricular plaster sticking was applied to the acupoints Yānhòu(咽喉TG3),Fèi(肺CO14),Wèi(胃CO4),Jiāogǎn(交感AH6 a),Pízhìxià(皮质下AT4).Results:After treatment,the Yale Global Tic Severity Scale(YGTSS)scores of the patients were significantly reduced(P<0.05),5 cases were clinically cured,8 cases remarkably effective,12 cases effective,5 cases ineffective,and the total effective rate was 83.33%.Conclusion:Acupoint catgut embedding combined with auricular plaster therapy for vocal tic disorders was effective,being worthy of clinical popularization.展开更多
OBJECTIVE:To investigate the effects of acupoint catgut embedding for 3 weeks on lung tissue,blood immunoglobulin E(IgE)and interleutin-4(IL-4),brain tissue microglia x-42(OX-42)and toll-like receptor-2(TLR-2)in rats ...OBJECTIVE:To investigate the effects of acupoint catgut embedding for 3 weeks on lung tissue,blood immunoglobulin E(IgE)and interleutin-4(IL-4),brain tissue microglia x-42(OX-42)and toll-like receptor-2(TLR-2)in rats with allergic rhinitis of lung deficiency type.METHODS:Forty-five female Sprague-Dawley rats were randomly divided for two times.The first time,they were randomly divided into model group and blank group(Group C)according to 2∶1,and the second time,the model group were randomly divided into model control group(Group B)and intervention treatment group(Group A)according to 1∶1.15 in each group.For Group A and Group B,the lung deficiency model was made by"sulfur–moxa fumigation",and then the allergic rhinitis model was established by"ovalbumin(OVA)sensitization".Then catgut embedding was performed at acupoints in Group A and not in Group B.After 3 weeks,collect lung tissue samples for hematoxylin-eosin staining,then take blood to observe the concentration of IgE and IL-4,and finally take brain tissue to observe the results of OX-42 and TLR-2.RESULTS:IgE level(μg/m L)was(3.11±0.20)in the Group A,(4.19±0.44)in the Group B,and(2.29±0.30)in the Group C(all P<0.001).IL-4 level(pg/mL)was(14.2±0.7)in the Group A,(18.6±2.4)in the Group B,and(11.4±1.2)for the Group C(all P<0.001).The mean OD for OX-42 is(0.1728±0.0016)in the Group A,(0.1810±0.0046)in the Group B and(0.1674±0.0025)in the Group C(all P<0.001).CONCLUSION:Although 3 weeks of acupoint catgut embedding already showed obvious efficacy on rats with allergic rhinitis,the allergic reaction in the body still continued.To achieve further treatment,prolonging the catgut embedding time is necessary.展开更多
OBJECTIVE: To evaluate the clinical effectiveness and safety of acupoint catgut embedding and acupuncture on simple obesity by Meta-analysis. METHODS: Studies on clinical randomized controlled trials of acupoint catgu...OBJECTIVE: To evaluate the clinical effectiveness and safety of acupoint catgut embedding and acupuncture on simple obesity by Meta-analysis. METHODS: Studies on clinical randomized controlled trials of acupoint catgut embedding for simple obesity which were published from January 2015 to November 2020 were searched in Cochrane Central Register of Control Trials(Central), Pub Med, China Science and Technology Journal Database, China National Knowledge Infrastructure Database and Wanfang databases. And those that met the inclusion criteria were screened. Rev Man5.3 was used for Meta-analysis. The “Risk of Bias” tool was used to evaluate the quality of included studies. R studio software was used for the measurement of publication bias. RESULTS: A total of 33 studies were included for Metaanalysis, including 2685 patients with simple obesity. Meta-analysis results showed the comparison of effectiveness rate was relative risk(RR) = 1.12, 95%CI(1.08, 1.16), body mass index(BMI) was mean difference(MD) =-1.12, 95%CI(-2.09,-0.14), waist circumference was MD =-2.14, 95%CI(-4.22,-0.06), and body mass was MD =-2.36, 95%CI(-3.99,-0.73). On the basis of diet and exercise intervention, the effectiveness rate [RR = 1.12, 95%CI(1.05, 1.19)], BMI [MD =-0.88, 95%CI(-1.35,-0.40)], waist circumference [MD =-1.10, 95%CI(-4.27, 2.07)], and body mass [MD =-0.68, 95%CI(-2.90, 1.54)]. The risk of bias of included literatures was low. CONCLUSIONS: Acupoint catgut embedding therapy was slightly better than acupuncture therapy in most of the outcomes. Moreover, the treatment frequency of acupoint catgut embedding is less with larger stimulation intensity, which is more conducive to clinical promotion.展开更多
OBJECTIVE:To assess the efficacy of acupoint catgut embedding(ACE)for simple obesity in preclinical animal experiments.METHODS:We searched the following 14 electronic databases:PubM ed,Cochrane Library,EMBASE,Oriental...OBJECTIVE:To assess the efficacy of acupoint catgut embedding(ACE)for simple obesity in preclinical animal experiments.METHODS:We searched the following 14 electronic databases:PubM ed,Cochrane Library,EMBASE,Oriental Medicine Advanced Searching Integrated System,KoreaMed,Korean Studies Information Service System,Science-on,Research Information Sharing Service,Korea Citation Index,Korea Traditional Knowledge Portal,China Network Knowledge Infrastructure Database,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biology Medicine Database,from inception to November 2021 without language limitation.The assessment was performed according to the guidelines of Animal Research:Reporting of in vivo experiments;and Metaanalysis was performed using Reviewer Manager 5.4.1 software.RESULTS:Twenty-four studies involving 813 animals were selected.Meta-analysis showed that ACE was beneficial for weight control[n=40,MD=-50.63,95%CI(-57.59,-43.67),P<0.00001,I 2=0%]and reduced the Lee index[n=40,MD=-18.79,95%CI(-20.01,-17.57),P<0.00001,I 2=0%].However,when efficacy of ACE was compared with that of manual acupuncture,electroacupuncture,or oilistat therapy,statistical difference was not observed between the two groups.CONCLUSIONS:This systematic review suggests that ACE may be efficacious in treating obesity.Moreover,the analyses highlighted the necessity to perform welldesigned,higher-quality experiments.展开更多
OBJECTIVE:To explore the difference of catgut embedding effect between acupoints and non-acupoints in patients with abdominal obesity(AO).METHODS:In this multicenter,double-blind,randomized controlled trial,all subjec...OBJECTIVE:To explore the difference of catgut embedding effect between acupoints and non-acupoints in patients with abdominal obesity(AO).METHODS:In this multicenter,double-blind,randomized controlled trial,all subjects were randomly assigned into the acupoint catgut embedding(ACE)group and control group(catgut embedding at non-acupoints).With a 12-week actual intervention period and a 4-week period of follow-up.Waist circumference(WC),body weight,body mass index(BMI),hip circumference(HC)and appetite were applied and assessed at baseline and after 6,12 and 16 weeks.RESULTS:After the total intervention phase(12 weeks),the WC,body weight,BMI,HC and visual analogue scale scores of appetite,decreased significantly in the two groups as compared to the baseline(P<0.001).Meanwhile,after the 4-week follow-up,the indicators still decreased significantly in the ACE group(P<0.001).At 12 and 16 weeks,catgut embedding at acupoints showed significantly advantages to non-acupoints in WC and appetite(P<0.05).No serious adverse events were observed in ACE group and control group.CONCLUSIONS:Catgut embedding at acupoints and non-acupoints are all effective and safe for AO.ACE can effectively treat AO as expected and deliver lasting results.展开更多
Objective To compare the therapeutic effect of catgut embedding combined with diet plus exercise with that of diet plus exercise in treating simple obesity complicated with abnormal blood fat. Methods A prescription o...Objective To compare the therapeutic effect of catgut embedding combined with diet plus exercise with that of diet plus exercise in treating simple obesity complicated with abnormal blood fat. Methods A prescription of diet plus exercise was given to the patients in a control group, and catgut embedding was added to the prescription in a treatment group. It was given once every 15 days for the 1st three treatments, and once every month for the 2^nd three treatments. Six treatments constituted a therapeutic course. Body weight and blood fat were measured before and half a year since treatment. Results After treatment, BMI, TO, TG and LDL were very significantly improved in the treatment group （P〈0.01）, and BMI and TG were very significantly （P〈0.01） and TO and LDL were significantly （P〈0.05） improved in the control group. HDL was not obviously improved in both groups （P〉0.05）. The improvement of TO, TG and LDL in the treatment group was significantly more than that in the control group （P〈0.01）, but no difference in improvement of BMI and HDL was found between the two groups （P〉0.05）. Conclusion The therapy of diet plus exercise was effective in body weight reduction and lowering blood fat in patients with simple obesity complicated with abnormal blood fat, and catgut embedding used in combination was even better in lowering blood fat.展开更多
Objective To observe the clinical effect of acupoint catgut embedding combined with abdominal acupuncture for treatment of abdominal obesity under the theoretical guidance of regulating the three energizer.Methods One...Objective To observe the clinical effect of acupoint catgut embedding combined with abdominal acupuncture for treatment of abdominal obesity under the theoretical guidance of regulating the three energizer.Methods One hundred and twenty patients were randomly divided into acupoint catgut embedding group（group A）,abdominal acupuncture group（group B）,acupoint catgut embedding combined with abdominal acupuncture group（group C） and blank control group（group D） based on blocked random method,with 30 cases each;the first three groups based on the principle of regulating three energizer were respectively given acupoint catgut embedding at Zhongwan（中脘 CV12）,Tianshu（天枢 ST 25）,Yinjiao（阴交 CV 7）,Zhigou（支沟 TE 6）,Guanyuan（关元 CV 4）,Zusanli（足三里 ST 36） with catgut embedding once every 7 days,three times for each course of treatment,abdominal acupuncture once every3 days,seven times for each course of treatment.Results The therapeutic effect of each group after treatment was respectively 46.7%（14/30）,43.3%（13/30）,76.7%（23/30） and 26.7%（8/30）,with statistically significant difference.For comparison of waist circumference difference,there was no statistical significance between acupoint catgut embedding combined with abdominal acupuncture and acupoint catgut embedding group（P=0.54）,and for comparison of weight difference,there was statistical significance in terms of therapeutic effect between acupoint catgut embedding combined with abdominal acupuncture and A,B,D groups（4.49±0.59 vs 2.64±0.53,2.87±0.44,1.45±0.26,all P〈0.05）.Conclusion Acupoint catgut embedding combined with abdominal acupuncture had the best effect in terms of total effective rate for treatment of abdominal obesity,equivalent therapeutic effect to simple acupoint catgut embedding in terms of waist circumference reduction,and the best therapeutic effect in terms of weight reduction.展开更多
Objective: To explore the effect of catgut implantation at Baliao and Xingfu One Acupuncture point for patients with urinary incontinence secondary to spinal cord injury (SCI). Methods: Three SCI patients received cat...Objective: To explore the effect of catgut implantation at Baliao and Xingfu One Acupuncture point for patients with urinary incontinence secondary to spinal cord injury (SCI). Methods: Three SCI patients received catgut embedding at Baliao and Xingfu One Acupuncture point. The data of intermittent catheterization (IC) volume, intermittent catheterization frequency and the amount of using urine pad (urethral condom) were corrected. Results: Compared to the baseline data, IC volume increased and the leakage volume decreased. Conclusions: Catgut Implantation at Baliao and Xingfu One Acupuncture point is effective for patients with urinary incontinence secondary to incomplete SCI.展开更多
Acupoint catgut embedding therapy(ACET),filling the gaps of traditional Chinese medicine acupuncture treatment,has been widely used for the treatment of many diseases with significant effects.The aim of this paper is ...Acupoint catgut embedding therapy(ACET),filling the gaps of traditional Chinese medicine acupuncture treatment,has been widely used for the treatment of many diseases with significant effects.The aim of this paper is to obtain polyglycollide acid(PGA)fibers with higher performance at a lower cost,and ensure that PGA can meet the clinical requirements as well.PGA fibers with different diameters were spun as embedding materials.The mechanical performance,thermodynamic and biodegradable properties of PGA fibers were studied under different spinning process parameters,including spinning speed,drawing temperature and stretching ratio.The experimental results showed that the optimum spinning parameters were the spinning speed at 150 m/min,the drawing temperature of 45 ℃,and the stretching ratio of 4.0.The initial modulus of PGA fibers was 3.876 N/tex.The crystallization degree was 68% and the degradation performance was in consistent with treatment cycle of patients.展开更多
Objective： To observe the clinical efficacy of treatment with catgut implantation at acupoints on simple obesity. Methods： Following the theory of Chinese medicine （CM）, pattern identification （PI） and treatment...Objective： To observe the clinical efficacy of treatment with catgut implantation at acupoints on simple obesity. Methods： Following the theory of Chinese medicine （CM）, pattern identification （PI） and treatment was based on the patient＇s symptoms and signs. Patients were observed during three courses and one year following treatment through self-comparison before and after six or seven acupoints catgut implantation. Obesity was divided into five types based on PI： （1） Stomach （Wei） and Intestine excess-heat, （2） Spleen （Pi） deficiency and phlegm- wet stagnancy, （3） Liver （Gan）-qi stagnation, （4） Spleen-Kidney （Shen） yang deficiency, and （5） Liver-Kidney yin deficiency. Changes in the following measurements were recorded in 820 patients： body weight, body girth, skin- fold thickness, body mass index （BMI）, fat percentage （F%） and waist/hip ratio （WHR） and in the following blood values： leptin （LP）, insulin （INS）, blood lipids, fasting blood sugar （FBS）, and insulin sensitive index （ISI） before and after the treatment. Values were compared with those of healthy controls （normal group）. Results： Catgut implantation showed efficacy with all five types of obesity. Efficacy was greater in males than in females. There was no significant difference between the different types by Kruskal-Wallis H test, but the effect was best and of the highest number in patients with Stomach and Intestine excess-heat. Skin-fold thickness, body weight, waist circumference, F%, BMI, and WHR in all 820 cases decreased after treatment （at 90 days and one year）, with significant differences before and after treatment （P〈0.01）. Improved metabolism of blood lipids was also seen. Following treatment, LP, INS, and FBS decreased significantly （P〈0.01） and ISI increased significantly （P〈0.05）. Conclusion： Catgut implantation at acupoints provided effective and persistent results, convenience, safety, painlessness, and prolonged effect 展开更多
Objective： To assess the effectiveness and the possible adverse effects of catgut implantation at acupoints for allergic rhinitis （AR）. Methods： This systematic review was carried out in accordance with the Cochra...Objective： To assess the effectiveness and the possible adverse effects of catgut implantation at acupoints for allergic rhinitis （AR）. Methods： This systematic review was carried out in accordance with the Cochrane Handbook version 5.1.0 and the Preferred Reporting Items for Systematic Reviews and Meta- Analyses statement. Extensive literature searches were conducted in PubMed, Excerpta Medical Databases, the Cochrane Library, the China National Infrastructure, Wanfang Chinese Digital Periodical and Conference Database, and the Weipu Chinese Science and Technique Journals Database. The Chinese Clinical Trial Registry Center was also searched for ongoing trials up to September 2012. Randomized controlled trials （RCTs） or quasi-RCTs were included. Risk of bias assessment was performed using the Cochrane tool for assessing risk of bias. Results： Five RCTs with 285 participants were found from 49 relevant studies, but there was just one RCT which met the inclusion criteria for this review. The study showed that treatment of catgut implantation at acupoints could lead to a better alleviation of the signs and symptoms of AR than the crude herb moxibustion. No adverse events were reported in this study. Conclusions： Because of the methodological shortcoming and the risk of bias of the included trial catgut implantation was proved with only limited evidence for the treatment of AR. Robust RCTs with high quality and larger sample size in this field are hoped to be carried out in the future.展开更多
基金Supported by Zhejiang Province Science and Technology Hall(No.2011C33004)
文摘Objective: To investigate the effects and safety of catgut embedding on alleviating insomnia. Methods: Totally 510 patients with insomnia were divided into 5 Chinese medicine(CM) syndrome types: Xin(Heart) and Pi(Spleen) deficiency, yin deficiency with excess fire, Xin and gut qi deficiency, Wei(Stomach) disorder, and qi and blood deficiency, respectively. These 5 types of patients were randomly assigned to a catgut embedding group, an acupuncture group or a medication group(30 cases in Xin and Pi deficiency type, Wei disorder type, Xin and gut qi deficiency type, respectively;40 cases in yin deficiency with excess fire type and qi and blood deficiency type, respectively). In the catgut embedding group, patients were treated by implanting catgut into acupoints once every 10 days for a total of 30 days. In the acupuncture group, patients were treated with acupuncture once per day over 30 days(excluding weekends);and patients in the medication group took 1 mg Eurodin Tablet orally every night for 30 days. Pittsburgh Sleep Quality Index(PSQI) was evaluated before treatment, on 30 and 60 days after the first treatment, respectively. The International Unified Sleep Efficiency Value(IUSEV) was measured at 30 and 60 days. The safety was evaluated after treatment and adverse events were analyzed. Results: The objective PSQI scores including subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, daytime dysfunction, and total scores at 30 days were significantly improved compared with pre-treatment in the catgut embedding and acupuncture groups(P<0.01 or P<0.05). At 30 days, the PSQI scores in catgut embedding group were superior to the medication group in the patients with each type of insomnia, with the exception of sleep duration(P<0.01 or P<0.05). At 60 days, significant differences were found between the catgut embedding group and the medication group(P<0.01 for all indices). The IUSEV scores in the catgut embedding group were significantly higher than the acupuncture g
基金supported by the National Natural Science Foundation of China,No.14202225,&.81574042the Traditional Chinese Medicine Leading Talent Funding Projects of Henan Province of China,No.2000202a grant from the Special Research Project on the Construction of the National Traditional Chinese Medicine Clinical Research Base of the State Administration of Traditional Chinese Medicine of China,No.JDZX2015314
文摘Catgut implantation at acupoints has been shown to alleviate spasticity after stroke in rats.However,the underlying mechanisms are poorly understood.In this study,we used the rat middle cerebral artery occlusion model of stroke.Three days after surgery,absorbable surgical catgut sutures were implanted at Dazhui（GV14）,Jizhong（GV6）,Houhui,Guanyuan（CV4）and Zhongwan（CV12）.The Zea Longa score was used to assess neurological function.The Modified Ashworth Scale was used to evaluate muscle tension.The 2,3,5-triphenyl-tetrazolium chloride assay was used to measure infarct volume.Immunohistochemical staining was performed for glutamate aspartate transporter（GLAST）and glial glutamate transporter-1（GLT-1）expression.Western blot assay was used to analyze the expression of GLAST and GLT-1.Reverse transcription and polymerase chain reaction were carried out to assess the expression of GLAST and GLT-1m RNAs.After catgut implantation at the acupoints,neurological function was substantially improved,muscle tension was decreased,and infarct volume was reduced in rats with spasticity after stroke.Furthermore,the expression of GLAST and GLT-1 m RNAs was increased on the injured（left）side.Our findings demonstrate that catgut implantation at acupoints alleviates spasticity after stroke,likely by increasing the expression of GLAST and GLT-1.
文摘Objective:To explore the therapeutic effect of acupoint catgut embedding combined with gingerseparated moxibustion for sequelae of peripheral facial paralysis and whether surface electromyography(sEMG)can be an outcome to evaluate the effect of this disease.Methods:Thirty-five patients with sequelae of peripheral facial paralysis were treated with catgut embedding at the acupoints selected according to their individual symptoms and traditional Chinese medicine(TCM)differentiated syndromes.At the same time,the ginger-separated moxibustion was applied at Yifeng(翳风TE17)and Qianzheng(牵正EX-HN16)of the affected side.The catgut embedding was applied once every 15 days,one time of treatment is of one course,and a total of three courses were given.The moxibustion would be taken after 5 days of catgut embedding each time,once every other day,5 times as one course,a total of 3 courses are given.After treatment,the recovery of facial nerve functions was evaluated by House-Brackmann(H-B)facial nerve function evaluation grading system.Before and after treatment,the surface electromyography(sEMG)was used to detect the root-mean-square(RMS)of frontal muscles,cheek muscles,and orbicularis oris muscles to compare the RMS ratio of these muscles of affected side and healthy side.Results:After 3 courses of treatment,9 cases were cured,22 cases were effective,and 4 cases were ineffective.The total effective rate was 88.6%(31/35).After treatment,the RMS of frontal muscles,cheek muscles,and orbicularis oris muscles of the affected side were 31.56±4.25,34.13±4.28,and 7.46±1.53 respectively,significantly increased in comparing with 11.69±2.45,12.98±3.34,and 2.62±1.41 respectively before treatment(all P<0.05).After treatment,the RMS ratios of frontal muscles,cheek muscles,and orbicularis oris muscles of the affected side and healthy side were 0.73±0.09,0.71±0.11,and 0.68±0.08 respectively,greatly increased in comparing with 0.28±0.10,0.27±0.08,and 0.22±0.09 respectively before treatment(all P<0.05).Conclusion:Acupoint c
文摘Objective To observe the clinical therapeutic effect of catgut embedding therapy for treatment of menopausal obesity. Methods Sixty-four cases of menopausal obesity patients were randomly divided into two groups, 32 cases in each group. In control group, the diet control was employed. And based on it, in observation group, catgut embedding therapy was apphed at Zusanli （足三里 ST 36）, Sanyinjiao （三阴交 SP 6）, matched with other points in line with syndrome differentiation. Therapeutic effect evaluated by changes of weight, Body Mass Index （BMI）, waist circumference and Kupperman index before and after treatment was observed. Results The total effective rate for treating obesity and menopausal syndrome was 90.6% （29/32）, 87.5% （28/32） respectively in observation group, superior to those of 46.9% （15/32）, 40.6% （13/32） in control group （both P〈0.05）; weight, BMI, waist circumference and Kupperman index in both groups improved distinctively after treatment （all P〈0.05）, and changes were more significantly in observation group than those in control group （all P〈0.05）. Conclusion For treating menopausal obesity, catgut embedding therapy not only has a good therapeutic effect on weight loss, but also improves menopausal syndrome.
文摘Objective This review aimed to systematically evaluate the evidence on the effects of acupoint catgut embedding （ACE） therapy for patients with polycystic ovary syndrome （PCOS）. Methods Five databases （CBM, CNKI, Wanfang Database, VlP Database, and PubMed） were searched to identify relevant studies published before June 2027. The outcomes were resumption of menstruation and serum levels of testosterone （T）. The methodological quality of the included studies was judged using the Cochrane risk of bias tool. The overall level of evidence was judged by the Grading of Recommendations Assessment, Development, and Evaluation （GRADE） criteria. Results Twenty- five randomized controlled trials were included. ACE therapy significantly lowered serum T levels, and patients receiving ACE treatment reported resumption of menstruation. However, these results should be interpreted with caution due to a high risk of randomization and blinding bias, and likely publication bias. The level of evidence for resumption of menstruation and serum T levels was assessed as ＂low＂ and ＂low＂, respectively, using GRADE. Conclusion The current evidence on ACE therapy for PCOS is insufficient to draw firm conclusions due to the poor methodological quality. Future well- designed trials are needed to validate the therapeutic efficacy, safety, and mechanisms of ACE in patients with PCOS.
基金Guangdong Province Graduate Education Innovation Project:No.2017SFKC13。
文摘Objective:To observe the clinical effect of acupoint catgut embedding combined with auricular plaster therapy in the treatment of children with vocal tic disorders.Methods:Catgut embedding was performed at the acupoints Bǎihuì(百会GV20),Shéntíng(神庭GV24),Dàzhuī(大椎GV14),Shēnzhù(身柱GV12),Fèishū(肺俞BL13),and Wèishū(胃俞BL21),and then auricular plaster sticking was applied to the acupoints Yānhòu(咽喉TG3),Fèi(肺CO14),Wèi(胃CO4),Jiāogǎn(交感AH6 a),Pízhìxià(皮质下AT4).Results:After treatment,the Yale Global Tic Severity Scale(YGTSS)scores of the patients were significantly reduced(P<0.05),5 cases were clinically cured,8 cases remarkably effective,12 cases effective,5 cases ineffective,and the total effective rate was 83.33%.Conclusion:Acupoint catgut embedding combined with auricular plaster therapy for vocal tic disorders was effective,being worthy of clinical popularization.
基金General Program of the National Natural Science Foundation of China:Regulatory Mechanism of Acupoint Catgut Embedding via Axonal Reflex on Neurogenic Inflammation in Allergic Rhinitis(No.81273985)General Program of the National Natural Science Foundation of China:the Study on the Mechanism of Acupoint Catgut Embedding Therapy for Allergic Rhinitis Based on the Coupling of"Acupoint Nasal Mucosal Sensory Nerve Dendritic Cells"(No.81473523)National Science and Technology Support Program for the Twelfth Five-Year Plan:the Study on Clinical Effect and Operation Standard of Catgut Embedding at Acupoints in Treating Allergic Rhinitis(No.2015BA I04B00)。
文摘OBJECTIVE:To investigate the effects of acupoint catgut embedding for 3 weeks on lung tissue,blood immunoglobulin E(IgE)and interleutin-4(IL-4),brain tissue microglia x-42(OX-42)and toll-like receptor-2(TLR-2)in rats with allergic rhinitis of lung deficiency type.METHODS:Forty-five female Sprague-Dawley rats were randomly divided for two times.The first time,they were randomly divided into model group and blank group(Group C)according to 2∶1,and the second time,the model group were randomly divided into model control group(Group B)and intervention treatment group(Group A)according to 1∶1.15 in each group.For Group A and Group B,the lung deficiency model was made by"sulfur–moxa fumigation",and then the allergic rhinitis model was established by"ovalbumin(OVA)sensitization".Then catgut embedding was performed at acupoints in Group A and not in Group B.After 3 weeks,collect lung tissue samples for hematoxylin-eosin staining,then take blood to observe the concentration of IgE and IL-4,and finally take brain tissue to observe the results of OX-42 and TLR-2.RESULTS:IgE level(μg/m L)was(3.11±0.20)in the Group A,(4.19±0.44)in the Group B,and(2.29±0.30)in the Group C(all P<0.001).IL-4 level(pg/mL)was(14.2±0.7)in the Group A,(18.6±2.4)in the Group B,and(11.4±1.2)for the Group C(all P<0.001).The mean OD for OX-42 is(0.1728±0.0016)in the Group A,(0.1810±0.0046)in the Group B and(0.1674±0.0025)in the Group C(all P<0.001).CONCLUSION:Although 3 weeks of acupoint catgut embedding already showed obvious efficacy on rats with allergic rhinitis,the allergic reaction in the body still continued.To achieve further treatment,prolonging the catgut embedding time is necessary.
基金Supported by National Administration of Traditional Chinese Medicine Project:Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No. ZYYCXTD-C-202006)。
文摘OBJECTIVE: To evaluate the clinical effectiveness and safety of acupoint catgut embedding and acupuncture on simple obesity by Meta-analysis. METHODS: Studies on clinical randomized controlled trials of acupoint catgut embedding for simple obesity which were published from January 2015 to November 2020 were searched in Cochrane Central Register of Control Trials(Central), Pub Med, China Science and Technology Journal Database, China National Knowledge Infrastructure Database and Wanfang databases. And those that met the inclusion criteria were screened. Rev Man5.3 was used for Meta-analysis. The “Risk of Bias” tool was used to evaluate the quality of included studies. R studio software was used for the measurement of publication bias. RESULTS: A total of 33 studies were included for Metaanalysis, including 2685 patients with simple obesity. Meta-analysis results showed the comparison of effectiveness rate was relative risk(RR) = 1.12, 95%CI(1.08, 1.16), body mass index(BMI) was mean difference(MD) =-1.12, 95%CI(-2.09,-0.14), waist circumference was MD =-2.14, 95%CI(-4.22,-0.06), and body mass was MD =-2.36, 95%CI(-3.99,-0.73). On the basis of diet and exercise intervention, the effectiveness rate [RR = 1.12, 95%CI(1.05, 1.19)], BMI [MD =-0.88, 95%CI(-1.35,-0.40)], waist circumference [MD =-1.10, 95%CI(-4.27, 2.07)], and body mass [MD =-0.68, 95%CI(-2.90, 1.54)]. The risk of bias of included literatures was low. CONCLUSIONS: Acupoint catgut embedding therapy was slightly better than acupuncture therapy in most of the outcomes. Moreover, the treatment frequency of acupoint catgut embedding is less with larger stimulation intensity, which is more conducive to clinical promotion.
基金the Korea Institute of Oriental Medicine(Grant No.KSN1823211 and KSN20234115)。
文摘OBJECTIVE:To assess the efficacy of acupoint catgut embedding(ACE)for simple obesity in preclinical animal experiments.METHODS:We searched the following 14 electronic databases:PubM ed,Cochrane Library,EMBASE,Oriental Medicine Advanced Searching Integrated System,KoreaMed,Korean Studies Information Service System,Science-on,Research Information Sharing Service,Korea Citation Index,Korea Traditional Knowledge Portal,China Network Knowledge Infrastructure Database,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biology Medicine Database,from inception to November 2021 without language limitation.The assessment was performed according to the guidelines of Animal Research:Reporting of in vivo experiments;and Metaanalysis was performed using Reviewer Manager 5.4.1 software.RESULTS:Twenty-four studies involving 813 animals were selected.Meta-analysis showed that ACE was beneficial for weight control[n=40,MD=-50.63,95%CI(-57.59,-43.67),P<0.00001,I 2=0%]and reduced the Lee index[n=40,MD=-18.79,95%CI(-20.01,-17.57),P<0.00001,I 2=0%].However,when efficacy of ACE was compared with that of manual acupuncture,electroacupuncture,or oilistat therapy,statistical difference was not observed between the two groups.CONCLUSIONS:This systematic review suggests that ACE may be efficacious in treating obesity.Moreover,the analyses highlighted the necessity to perform welldesigned,higher-quality experiments.
基金Yunnan Expert Workstation-Liang Fanrong Station:Study and Transformation of Classical Syndrome Differentiation System on Acupuncture and Moxibustion(No.202305AF150072)Yunnan Province Ten-thousand Plan:Youth Special-Guo Taipin(No.YNWR-QNBJ-2019-257)+2 种基金Yunnan Provincial Science Project:Study on the Bidirectional Regulation Mechanism of Central Network of ShuMu Catgut Embedding in Abdominal Obesity of Stomach Heat-Spleen Deficiency Type Which based on Multimodal Technique(No.2017FF117-011)Study on the Central Mechanism of Synergistic Potentiation of Shu-Mu Catgut Embedding in Abdominal Obesity(No.2019FF002-021)Study on the Brain Network Mechanism of Shu-Mu Catgut Embedding in Abdominal Obesity which based on Multi-Modal Technique(No.202101AZ070001-096)。
文摘OBJECTIVE:To explore the difference of catgut embedding effect between acupoints and non-acupoints in patients with abdominal obesity(AO).METHODS:In this multicenter,double-blind,randomized controlled trial,all subjects were randomly assigned into the acupoint catgut embedding(ACE)group and control group(catgut embedding at non-acupoints).With a 12-week actual intervention period and a 4-week period of follow-up.Waist circumference(WC),body weight,body mass index(BMI),hip circumference(HC)and appetite were applied and assessed at baseline and after 6,12 and 16 weeks.RESULTS:After the total intervention phase(12 weeks),the WC,body weight,BMI,HC and visual analogue scale scores of appetite,decreased significantly in the two groups as compared to the baseline(P<0.001).Meanwhile,after the 4-week follow-up,the indicators still decreased significantly in the ACE group(P<0.001).At 12 and 16 weeks,catgut embedding at acupoints showed significantly advantages to non-acupoints in WC and appetite(P<0.05).No serious adverse events were observed in ACE group and control group.CONCLUSIONS:Catgut embedding at acupoints and non-acupoints are all effective and safe for AO.ACE can effectively treat AO as expected and deliver lasting results.
文摘Objective To compare the therapeutic effect of catgut embedding combined with diet plus exercise with that of diet plus exercise in treating simple obesity complicated with abnormal blood fat. Methods A prescription of diet plus exercise was given to the patients in a control group, and catgut embedding was added to the prescription in a treatment group. It was given once every 15 days for the 1st three treatments, and once every month for the 2^nd three treatments. Six treatments constituted a therapeutic course. Body weight and blood fat were measured before and half a year since treatment. Results After treatment, BMI, TO, TG and LDL were very significantly improved in the treatment group （P〈0.01）, and BMI and TG were very significantly （P〈0.01） and TO and LDL were significantly （P〈0.05） improved in the control group. HDL was not obviously improved in both groups （P〉0.05）. The improvement of TO, TG and LDL in the treatment group was significantly more than that in the control group （P〈0.01）, but no difference in improvement of BMI and HDL was found between the two groups （P〉0.05）. Conclusion The therapy of diet plus exercise was effective in body weight reduction and lowering blood fat in patients with simple obesity complicated with abnormal blood fat, and catgut embedding used in combination was even better in lowering blood fat.
文摘Objective To observe the clinical effect of acupoint catgut embedding combined with abdominal acupuncture for treatment of abdominal obesity under the theoretical guidance of regulating the three energizer.Methods One hundred and twenty patients were randomly divided into acupoint catgut embedding group（group A）,abdominal acupuncture group（group B）,acupoint catgut embedding combined with abdominal acupuncture group（group C） and blank control group（group D） based on blocked random method,with 30 cases each;the first three groups based on the principle of regulating three energizer were respectively given acupoint catgut embedding at Zhongwan（中脘 CV12）,Tianshu（天枢 ST 25）,Yinjiao（阴交 CV 7）,Zhigou（支沟 TE 6）,Guanyuan（关元 CV 4）,Zusanli（足三里 ST 36） with catgut embedding once every 7 days,three times for each course of treatment,abdominal acupuncture once every3 days,seven times for each course of treatment.Results The therapeutic effect of each group after treatment was respectively 46.7%（14/30）,43.3%（13/30）,76.7%（23/30） and 26.7%（8/30）,with statistically significant difference.For comparison of waist circumference difference,there was no statistical significance between acupoint catgut embedding combined with abdominal acupuncture and acupoint catgut embedding group（P=0.54）,and for comparison of weight difference,there was statistical significance in terms of therapeutic effect between acupoint catgut embedding combined with abdominal acupuncture and A,B,D groups（4.49±0.59 vs 2.64±0.53,2.87±0.44,1.45±0.26,all P〈0.05）.Conclusion Acupoint catgut embedding combined with abdominal acupuncture had the best effect in terms of total effective rate for treatment of abdominal obesity,equivalent therapeutic effect to simple acupoint catgut embedding in terms of waist circumference reduction,and the best therapeutic effect in terms of weight reduction.
文摘Objective: To explore the effect of catgut implantation at Baliao and Xingfu One Acupuncture point for patients with urinary incontinence secondary to spinal cord injury (SCI). Methods: Three SCI patients received catgut embedding at Baliao and Xingfu One Acupuncture point. The data of intermittent catheterization (IC) volume, intermittent catheterization frequency and the amount of using urine pad (urethral condom) were corrected. Results: Compared to the baseline data, IC volume increased and the leakage volume decreased. Conclusions: Catgut Implantation at Baliao and Xingfu One Acupuncture point is effective for patients with urinary incontinence secondary to incomplete SCI.
基金“111 Project” Biomedical Textile Materials Science and Technology,China(No.B07024)
文摘Acupoint catgut embedding therapy(ACET),filling the gaps of traditional Chinese medicine acupuncture treatment,has been widely used for the treatment of many diseases with significant effects.The aim of this paper is to obtain polyglycollide acid(PGA)fibers with higher performance at a lower cost,and ensure that PGA can meet the clinical requirements as well.PGA fibers with different diameters were spun as embedding materials.The mechanical performance,thermodynamic and biodegradable properties of PGA fibers were studied under different spinning process parameters,including spinning speed,drawing temperature and stretching ratio.The experimental results showed that the optimum spinning parameters were the spinning speed at 150 m/min,the drawing temperature of 45 ℃,and the stretching ratio of 4.0.The initial modulus of PGA fibers was 3.876 N/tex.The crystallization degree was 68% and the degradation performance was in consistent with treatment cycle of patients.
基金Supported by Science Research Projects of Colleges and Universities of Liaoning Provincial Committee of Education(No.05L121)
文摘Objective： To observe the clinical efficacy of treatment with catgut implantation at acupoints on simple obesity. Methods： Following the theory of Chinese medicine （CM）, pattern identification （PI） and treatment was based on the patient＇s symptoms and signs. Patients were observed during three courses and one year following treatment through self-comparison before and after six or seven acupoints catgut implantation. Obesity was divided into five types based on PI： （1） Stomach （Wei） and Intestine excess-heat, （2） Spleen （Pi） deficiency and phlegm- wet stagnancy, （3） Liver （Gan）-qi stagnation, （4） Spleen-Kidney （Shen） yang deficiency, and （5） Liver-Kidney yin deficiency. Changes in the following measurements were recorded in 820 patients： body weight, body girth, skin- fold thickness, body mass index （BMI）, fat percentage （F%） and waist/hip ratio （WHR） and in the following blood values： leptin （LP）, insulin （INS）, blood lipids, fasting blood sugar （FBS）, and insulin sensitive index （ISI） before and after the treatment. Values were compared with those of healthy controls （normal group）. Results： Catgut implantation showed efficacy with all five types of obesity. Efficacy was greater in males than in females. There was no significant difference between the different types by Kruskal-Wallis H test, but the effect was best and of the highest number in patients with Stomach and Intestine excess-heat. Skin-fold thickness, body weight, waist circumference, F%, BMI, and WHR in all 820 cases decreased after treatment （at 90 days and one year）, with significant differences before and after treatment （P〈0.01）. Improved metabolism of blood lipids was also seen. Following treatment, LP, INS, and FBS decreased significantly （P〈0.01） and ISI increased significantly （P〈0.05）. Conclusion： Catgut implantation at acupoints provided effective and persistent results, convenience, safety, painlessness, and prolonged effect
基金Supported by the National Natural Science Foundation of China(No.81273985)International Scientific and Technological Cooperation and Exchange Projects of Science and Technology Department of Sichuan Province(No.2013HH0021)
文摘Objective： To assess the effectiveness and the possible adverse effects of catgut implantation at acupoints for allergic rhinitis （AR）. Methods： This systematic review was carried out in accordance with the Cochrane Handbook version 5.1.0 and the Preferred Reporting Items for Systematic Reviews and Meta- Analyses statement. Extensive literature searches were conducted in PubMed, Excerpta Medical Databases, the Cochrane Library, the China National Infrastructure, Wanfang Chinese Digital Periodical and Conference Database, and the Weipu Chinese Science and Technique Journals Database. The Chinese Clinical Trial Registry Center was also searched for ongoing trials up to September 2012. Randomized controlled trials （RCTs） or quasi-RCTs were included. Risk of bias assessment was performed using the Cochrane tool for assessing risk of bias. Results： Five RCTs with 285 participants were found from 49 relevant studies, but there was just one RCT which met the inclusion criteria for this review. The study showed that treatment of catgut implantation at acupoints could lead to a better alleviation of the signs and symptoms of AR than the crude herb moxibustion. No adverse events were reported in this study. Conclusions： Because of the methodological shortcoming and the risk of bias of the included trial catgut implantation was proved with only limited evidence for the treatment of AR. Robust RCTs with high quality and larger sample size in this field are hoped to be carried out in the future.
