In eukaryotic cells, gene activity is not directly reflected by protein levels because mRNA processing, transport, stability, and translation are co- and post-transcriptionally regulated. These processes, collectively...In eukaryotic cells, gene activity is not directly reflected by protein levels because mRNA processing, transport, stability, and translation are co- and post-transcriptionally regulated. These processes, collectively known as the ribonome, are tightly controlled and carried out by a plethora of trans-acting RNA-binding proteins （RBPs） that bind to specific cis elements throughout the RNA sequence. Within the nervous system, the role of RBPs in brain function turns out to be essential due to the architectural complexity of neurons exemplified by a relatively small somal size and an extensive network of projections and connections, Thus far, RBPs have been shown to be indispensable for several aspects of neurogenesis, neurite outgrowth, synapse formation, and plasticity. Consequently, perturbation of their function is central in the etiology of an ever-growing spectrum of neurological diseases, including fragile X syndrome and the neurodegenerative disorders frontotemporal lobar degeneration and amyotrophic lateral sclerosis.展开更多
胞质聚腺苷酸化物结合蛋白（Cytoplasmic poly（A）denyla-tion element binding protein，CPEB）家族是一种序列特异性的RNA结合蛋白，最早发现于非洲爪蟾的卵母细胞中，调控非洲爪蟾卵母细胞发育过程中母源性mRNA的多聚腺苷酸化和翻...胞质聚腺苷酸化物结合蛋白（Cytoplasmic poly（A）denyla-tion element binding protein，CPEB）家族是一种序列特异性的RNA结合蛋白，最早发现于非洲爪蟾的卵母细胞中，调控非洲爪蟾卵母细胞发育过程中母源性mRNA的多聚腺苷酸化和翻译。随后的研究发现，CPEB蛋白与细胞周期、突触形成、学习和记忆等关系密切。展开更多
基金funded by grants from the Greek General Secretariat for Research and Development,Ministry of Education
文摘In eukaryotic cells, gene activity is not directly reflected by protein levels because mRNA processing, transport, stability, and translation are co- and post-transcriptionally regulated. These processes, collectively known as the ribonome, are tightly controlled and carried out by a plethora of trans-acting RNA-binding proteins （RBPs） that bind to specific cis elements throughout the RNA sequence. Within the nervous system, the role of RBPs in brain function turns out to be essential due to the architectural complexity of neurons exemplified by a relatively small somal size and an extensive network of projections and connections, Thus far, RBPs have been shown to be indispensable for several aspects of neurogenesis, neurite outgrowth, synapse formation, and plasticity. Consequently, perturbation of their function is central in the etiology of an ever-growing spectrum of neurological diseases, including fragile X syndrome and the neurodegenerative disorders frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
文摘胞质聚腺苷酸化物结合蛋白（Cytoplasmic poly（A）denyla-tion element binding protein，CPEB）家族是一种序列特异性的RNA结合蛋白，最早发现于非洲爪蟾的卵母细胞中，调控非洲爪蟾卵母细胞发育过程中母源性mRNA的多聚腺苷酸化和翻译。随后的研究发现，CPEB蛋白与细胞周期、突触形成、学习和记忆等关系密切。
