A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B（1a and 1b）, was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were sepa...A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B（1a and 1b）, was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were separated by chiral HPLC. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, including 2D NMR, X-ray crystallography, and electronic CD（ECD） calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.展开更多
Two new prenylated indole alkaloids,namely,dihydrocarneamide A（1） and iso-notoamide B（2）,were isolated from the marine-derived endophytic fungus Paecilomyces variotii EN-291.The structures of these metabolites wer...Two new prenylated indole alkaloids,namely,dihydrocarneamide A（1） and iso-notoamide B（2）,were isolated from the marine-derived endophytic fungus Paecilomyces variotii EN-291.The structures of these metabolites were determined based on comprehensive spectral analysis,together with chiral HPLC analysis of the acidic hydrolysates.Unlike other prenylated indole alkaloids such as asperparalines,notoamides,and versicolamides,compounds 1 and 2 are the rare examples of C-5 prenylation,forming the fused dimethyldihydropyran ring at C-5 and C-6 of the indole ring.The cytotoxic activity of the isolated compounds was evaluated.展开更多
A novel biscalixarene with two kinds of calix[4]arene derivative units connected by four bridging chains, was facilely＇ synthesized by ＂1 ＋ 1＂ condensation mode in high yield. The element analyses, ESI-MS, ^1H NMR...A novel biscalixarene with two kinds of calix[4]arene derivative units connected by four bridging chains, was facilely＇ synthesized by ＂1 ＋ 1＂ condensation mode in high yield. The element analyses, ESI-MS, ^1H NMR and ^1H-^1H COSY spectrum showed that the calix[4]arene units of compound 4 were in cone conformations and compound 4 possessed biscalixarene-tube structure. 2007 Fa Fu Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
基金Financial support from the National Natural Science Foundation of China(NNSFCNos.81373287 and 30825044)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University(PCSIRT,No.IRT1007)the National Science and Technology Project of China(Nos.2012ZX09301002-002 and 2011ZX0 9307-002-01)
文摘A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B（1a and 1b）, was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were separated by chiral HPLC. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, including 2D NMR, X-ray crystallography, and electronic CD（ECD） calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.
基金support from the Natural Science Foundation of China (No.31330009)the Ministry of Science and Technology of China (No.2010CB833802)
文摘Two new prenylated indole alkaloids,namely,dihydrocarneamide A（1） and iso-notoamide B（2）,were isolated from the marine-derived endophytic fungus Paecilomyces variotii EN-291.The structures of these metabolites were determined based on comprehensive spectral analysis,together with chiral HPLC analysis of the acidic hydrolysates.Unlike other prenylated indole alkaloids such as asperparalines,notoamides,and versicolamides,compounds 1 and 2 are the rare examples of C-5 prenylation,forming the fused dimethyldihydropyran ring at C-5 and C-6 of the indole ring.The cytotoxic activity of the isolated compounds was evaluated.
基金Financial support from the National Natural Science Foundation of China （No. 20402002）；Fujian Natural Science Foundation of China （No. 2006J0155）；Program for New Century Excellent Talents in University of Fujian Province were greatly acknowledged.
文摘A novel biscalixarene with two kinds of calix[4]arene derivative units connected by four bridging chains, was facilely＇ synthesized by ＂1 ＋ 1＂ condensation mode in high yield. The element analyses, ESI-MS, ^1H NMR and ^1H-^1H COSY spectrum showed that the calix[4]arene units of compound 4 were in cone conformations and compound 4 possessed biscalixarene-tube structure. 2007 Fa Fu Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
