This study examines the impact of the digital revolution on the job quality of workers with a specific focus on those at the lowest end of the spectrum in China's domestic labor market. Leveraging exogenous timing...This study examines the impact of the digital revolution on the job quality of workers with a specific focus on those at the lowest end of the spectrum in China's domestic labor market. Leveraging exogenous timing variations that result from the implementation of the Broadband China Program across different cities, it provides quasi-experimental evidence concerning the effects of the digital revolution on the job quality of lower class workers, particularly rural–urban migrant workers. Using data from China Migrants Dynamic Survey, this study reveals that migrants' comprehensive job quality index increased by 0.0138 (5.33 percent), and its component indices experienced positive effects after the Broadband China Program was implemented. This study also investigates heterogeneous policy treatment effects among workers with diverse demographic and occupational characteristics. Underlying mechanisms are considered, including positive macroeconomic shocks, increased social interactions, and Internet use. In particular, migrants' attitudes toward local settlement became more positive, suggesting that the positive effects of the digital revolution on livelihood lasted for some time. Taking China as an example, this study contributes valuable empirical evidence of how the digital revolution can affect lower class workers' employment or living conditions in a developing country. Related policy implications are also considered.展开更多
Infection by hepatitis C virus(HCV), a plus-stranded RNA virus that can cause cirrhosis and hepatocellular carcinoma, is one of the major health problems in the world. HCV infection is considered as a multistep comple...Infection by hepatitis C virus(HCV), a plus-stranded RNA virus that can cause cirrhosis and hepatocellular carcinoma, is one of the major health problems in the world. HCV infection is considered as a multistep complex process and correlated with abnormal metabolism of lipoprotein. In addition, virus attacks hepatocytes by the initial attaching viral envelop glycoprotein E1/E2 to receptors of lipoproteins on host cells. With the development of HCV model system, mechanisms of HCV cell entry through lipoprotein uptake and its receptor have been extensively studied in detail. Here we summarize recent knowledge about the role of lipoprotein receptors, scavenger receptor class B type Ⅰ and low-density lipoprotein receptor in the entry of HCV, providing a foundation of novel targeting therapeutic tools against HCV infection.展开更多
The Asian citrus psyllid,Diaphorina citri Kuwayama,is among the most im-portant pests of citrus.It is the main vector of the Huanglongbing(HLB)pathogen Can-didatus Liberibacter asiaticus(CLas),which causes severe loss...The Asian citrus psyllid,Diaphorina citri Kuwayama,is among the most im-portant pests of citrus.It is the main vector of the Huanglongbing(HLB)pathogen Can-didatus Liberibacter asiaticus(CLas),which causes severe losses in citrus crops.Control of D.citri is therefore of paramount importance to reduce the spread of HLB.In this re-gard,using RNA interference(RNAi)to silence target genes is a useful strategy to control psyllids.In this study,using RNAi,we examined the biological functions of the V-ATPase subunit E(V-ATP-E)gene of D.citri,including its effect on acquisition of CLas.The amino acid sequence of V-ATP-E from D.citri had high homology with proteins from other insects.V-ATP-E was expressed at all D.citri life stages analyzed,and the expres-sion level in mature adults was higher than that of teneral adults.Silencing of V-ATP-E resulted in a significant increase in mortality,reduced body weight,and induced cell apop-tosis of the D.citri midgut.The reduced expression of V-ATP-E was indicated to inhibit CLas passing through the midgut and into the hemolymph,leading to a majority of CLas being confined to the midgut.In addition,double-stranded RNA of D.citri V-ATP-E was safe to non-target parasitic wasps.These results suggest that V-ATP-E is an effective RNAi target that can be used in D.citri control to block CLas infection.展开更多
In this paper we discuss the reasons for our work towards establishing a new collaboration between Jefferson Lab （JLab） and the Institute of High Energy Physics （IHEP） in Beijing. We seek to combine experimentalis...In this paper we discuss the reasons for our work towards establishing a new collaboration between Jefferson Lab （JLab） and the Institute of High Energy Physics （IHEP） in Beijing. We seek to combine experimentalists and theorists into a dedicated group focused on better understanding the current and future data from JLab and from the Beijing Electron Positron Collider （BEPC）. Recent JLab results on the extraction of single- and double-polarization observables in both the lπ- and 2π-channel show their high sensitivity to small production amplitudes and therefore their importance for the extraction of resonance parameters. The Beijing Electron Spectrometer （BES） at the BEPC has collected high statistics data on J/ψ production. Its decay into baryon-antibaryon channels offers a unique and complementary way of probing nucleon resonances. The CEBAF Large Acceptance Spectrometer, CLAS, has access to N＊ form factors at high Q2 which is advantageous for the study of dynamical properties of nucleon resonances, while the low-background BES results will be able to provide guidance for the search for less-dominant excited states at JLab. Moreover, with the recently approved experimental proposal Nucleon Resonance Studies with CLAS12 and the high-quality data streaming from BES-Ⅲand CLAS, the time has come for forging a new Trans-Pacific collaboration of theorists and experimentalists on NSTAR physics.展开更多
Agricultural environmental pollution emergencies have become a hot research topic because of the high incidence and influence depth.This paper introduces classification and features of agricultural environmental pollu...Agricultural environmental pollution emergencies have become a hot research topic because of the high incidence and influence depth.This paper introduces classification and features of agricultural environmental pollution emergencies:by pollutant type,it falls into organic pollution emergencies and inorganic pollution emergencies;by the approach of entering agricultural environment,it falls into water resource agricultural environmental pollution emergencies and non-water resource agricultural environmental pollution emergencies.Hazards of agricultural environmental pollution emergencies are analyzed from 4 perspectives:personal security,indirect loss,ecological environment and social stability.In view of the hazards,countermeasures are given to deal with the pollution emergencies as(i)establishing a risk evaluation mechanism for agricultural environment;(ii)enhancing the capacity of handling agricultural environmental pollution emergencies;(iii)introducing new management concepts for environmental emergencies,and cultivating keen emergency management consciousness.展开更多
Influence of the choice of the NN potential model governing the deuteron wave function on the observables for coherent π0-photoproduction on the deuteron near η-threshoM is investigated by using a three-body model ...Influence of the choice of the NN potential model governing the deuteron wave function on the observables for coherent π0-photoproduction on the deuteron near η-threshoM is investigated by using a three-body model for the intermediate ηN N system with separable two-body interactions. Results for unpolarized differential cross section and polarization observables are predicted. It is revealed that the choice of the NN potential model has a visible effect on the differential cross section and most of the polarization observables, especially in the photon energy range of 600-800 MeV and extreme backward pion angles. We find that the deviation among results obtained by using different deuteron wave functions is quite large. The use of the CD-Bonn NN potential for deuteron wave function doubles the differential cross section in this kinematic region. Compared with the experimental data from CLAS collaboration for differential cross section, sizeable discrepancies are found.展开更多
AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 virus.METHODS: This prospective study was c...AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 virus.METHODS: This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral therapy. Myeloid DCs were isolated from the peripheral blood of each subject using CD1c(BDCA1)+ DC isolation Kit. Monocytes from healthy donor were cultured with DC growth factors such as IL-4 and GM-CSF either in the presence or absence of hepatitis C virus(HCV) viral proteins followed by LPS stimulation. Phenotyping was done by flowcytometry and gene expression profiling was evaluated by real-time PCR.RESULTS: Non-responders [sustained virological response(SVR)-ve] to conventional antiviral therapy had significantly higher expression of genes associated with interferon responsive element such as IDO1 and PD-L1(6-fold) and negative regulators of JAK-STAT pathway such as SOCS(6-fold) as compared to responders(SVR+ve) to antiviral therapy. The downregulated genes in non-responders included factors involved in antigen processing and presentation mainly belonging to major histocompatibility complex(MHC) Class-Ⅱ family as HLA-DP, HLA-DQ(2-fold) and superoxide dismutase(2-fold). Cells grown in the presence of HCV viral proteins had genes downregulated for factors involved in innate response, interferon signaling, DC maturation and co-stimulatory signaling to T-cells, while the genes for cytokine signaling and Toll-like receptors(4-fold) were upregulated as compared to cells grown in absence of viral proteins.CONCLUSION: Underexpressed MHC class-Ⅱ genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs.展开更多
Nowadays,incorporating cooperative groups and group activities are very common in oral English classroom.By using group dy namics teachers can provide students with large blocks of time for authentic communication,whi...Nowadays,incorporating cooperative groups and group activities are very common in oral English classroom.By using group dy namics teachers can provide students with large blocks of time for authentic communication,while keeping the class focused in English.This paper discusses the importance of group dynamics in the oral English classroom and gives teachers some ideas about group dynamics in language classrooms.展开更多
基金This research was supported financially by the National Social Science Foundation of China(No.19BGL256).
文摘This study examines the impact of the digital revolution on the job quality of workers with a specific focus on those at the lowest end of the spectrum in China's domestic labor market. Leveraging exogenous timing variations that result from the implementation of the Broadband China Program across different cities, it provides quasi-experimental evidence concerning the effects of the digital revolution on the job quality of lower class workers, particularly rural–urban migrant workers. Using data from China Migrants Dynamic Survey, this study reveals that migrants' comprehensive job quality index increased by 0.0138 (5.33 percent), and its component indices experienced positive effects after the Broadband China Program was implemented. This study also investigates heterogeneous policy treatment effects among workers with diverse demographic and occupational characteristics. Underlying mechanisms are considered, including positive macroeconomic shocks, increased social interactions, and Internet use. In particular, migrants' attitudes toward local settlement became more positive, suggesting that the positive effects of the digital revolution on livelihood lasted for some time. Taking China as an example, this study contributes valuable empirical evidence of how the digital revolution can affect lower class workers' employment or living conditions in a developing country. Related policy implications are also considered.
文摘我国企业在信息化进程中 ,成功实施的信息系统相对较少 ,多数系统以失败告终 ,其中缺乏一种比较系统全面的战略思想是重要原因。文章详细介绍了 CAL S的产生、发展及应用现状 ,并就其在信息化进程中的重要作用进行了分析 ,指出应该把 CAL S放到国防信息化和国民经济信息化的战略地位 ,刻不容缓地启动 CA LS工程。
基金Supported by The Ministry of Education,Culture,Sports,Science and Technology to Hitomi Imachi,Koji Murao,Japan,Nos.24591352,15K09415National Natural Science Foundation of China to Huanxiang Zhang,Nos.31371407 and 31071220
文摘Infection by hepatitis C virus(HCV), a plus-stranded RNA virus that can cause cirrhosis and hepatocellular carcinoma, is one of the major health problems in the world. HCV infection is considered as a multistep complex process and correlated with abnormal metabolism of lipoprotein. In addition, virus attacks hepatocytes by the initial attaching viral envelop glycoprotein E1/E2 to receptors of lipoproteins on host cells. With the development of HCV model system, mechanisms of HCV cell entry through lipoprotein uptake and its receptor have been extensively studied in detail. Here we summarize recent knowledge about the role of lipoprotein receptors, scavenger receptor class B type Ⅰ and low-density lipoprotein receptor in the entry of HCV, providing a foundation of novel targeting therapeutic tools against HCV infection.
基金supported by the National Joint Fund for Regional Innovation and Development(U22A20481)the Laboratory of Lingnan Modern Agriculture Project(NT2021003)the National High-Level Talent Special Support Plan(2020)to BLQ and China Postdoctoral Science Foundation(No.2022M711208)to CFG。
文摘The Asian citrus psyllid,Diaphorina citri Kuwayama,is among the most im-portant pests of citrus.It is the main vector of the Huanglongbing(HLB)pathogen Can-didatus Liberibacter asiaticus(CLas),which causes severe losses in citrus crops.Control of D.citri is therefore of paramount importance to reduce the spread of HLB.In this re-gard,using RNA interference(RNAi)to silence target genes is a useful strategy to control psyllids.In this study,using RNAi,we examined the biological functions of the V-ATPase subunit E(V-ATP-E)gene of D.citri,including its effect on acquisition of CLas.The amino acid sequence of V-ATP-E from D.citri had high homology with proteins from other insects.V-ATP-E was expressed at all D.citri life stages analyzed,and the expres-sion level in mature adults was higher than that of teneral adults.Silencing of V-ATP-E resulted in a significant increase in mortality,reduced body weight,and induced cell apop-tosis of the D.citri midgut.The reduced expression of V-ATP-E was indicated to inhibit CLas passing through the midgut and into the hemolymph,leading to a majority of CLas being confined to the midgut.In addition,double-stranded RNA of D.citri V-ATP-E was safe to non-target parasitic wasps.These results suggest that V-ATP-E is an effective RNAi target that can be used in D.citri control to block CLas infection.
文摘In this paper we discuss the reasons for our work towards establishing a new collaboration between Jefferson Lab （JLab） and the Institute of High Energy Physics （IHEP） in Beijing. We seek to combine experimentalists and theorists into a dedicated group focused on better understanding the current and future data from JLab and from the Beijing Electron Positron Collider （BEPC）. Recent JLab results on the extraction of single- and double-polarization observables in both the lπ- and 2π-channel show their high sensitivity to small production amplitudes and therefore their importance for the extraction of resonance parameters. The Beijing Electron Spectrometer （BES） at the BEPC has collected high statistics data on J/ψ production. Its decay into baryon-antibaryon channels offers a unique and complementary way of probing nucleon resonances. The CEBAF Large Acceptance Spectrometer, CLAS, has access to N＊ form factors at high Q2 which is advantageous for the study of dynamical properties of nucleon resonances, while the low-background BES results will be able to provide guidance for the search for less-dominant excited states at JLab. Moreover, with the recently approved experimental proposal Nucleon Resonance Studies with CLAS12 and the high-quality data streaming from BES-Ⅲand CLAS, the time has come for forging a new Trans-Pacific collaboration of theorists and experimentalists on NSTAR physics.
基金Supported by Humanities and Social Science Fund of Henan Provincial Department of Education(2013-QN-027)Doctoral Fund of Henan Polytechnic University(B2012-008)
文摘Agricultural environmental pollution emergencies have become a hot research topic because of the high incidence and influence depth.This paper introduces classification and features of agricultural environmental pollution emergencies:by pollutant type,it falls into organic pollution emergencies and inorganic pollution emergencies;by the approach of entering agricultural environment,it falls into water resource agricultural environmental pollution emergencies and non-water resource agricultural environmental pollution emergencies.Hazards of agricultural environmental pollution emergencies are analyzed from 4 perspectives:personal security,indirect loss,ecological environment and social stability.In view of the hazards,countermeasures are given to deal with the pollution emergencies as(i)establishing a risk evaluation mechanism for agricultural environment;(ii)enhancing the capacity of handling agricultural environmental pollution emergencies;(iii)introducing new management concepts for environmental emergencies,and cultivating keen emergency management consciousness.
文摘Influence of the choice of the NN potential model governing the deuteron wave function on the observables for coherent π0-photoproduction on the deuteron near η-threshoM is investigated by using a three-body model for the intermediate ηN N system with separable two-body interactions. Results for unpolarized differential cross section and polarization observables are predicted. It is revealed that the choice of the NN potential model has a visible effect on the differential cross section and most of the polarization observables, especially in the photon energy range of 600-800 MeV and extreme backward pion angles. We find that the deviation among results obtained by using different deuteron wave functions is quite large. The use of the CD-Bonn NN potential for deuteron wave function doubles the differential cross section in this kinematic region. Compared with the experimental data from CLAS collaboration for differential cross section, sizeable discrepancies are found.
基金Supported by Council of Scientific and Industrial Research,No.27(0262)12/EMR-II
文摘AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 virus.METHODS: This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral therapy. Myeloid DCs were isolated from the peripheral blood of each subject using CD1c(BDCA1)+ DC isolation Kit. Monocytes from healthy donor were cultured with DC growth factors such as IL-4 and GM-CSF either in the presence or absence of hepatitis C virus(HCV) viral proteins followed by LPS stimulation. Phenotyping was done by flowcytometry and gene expression profiling was evaluated by real-time PCR.RESULTS: Non-responders [sustained virological response(SVR)-ve] to conventional antiviral therapy had significantly higher expression of genes associated with interferon responsive element such as IDO1 and PD-L1(6-fold) and negative regulators of JAK-STAT pathway such as SOCS(6-fold) as compared to responders(SVR+ve) to antiviral therapy. The downregulated genes in non-responders included factors involved in antigen processing and presentation mainly belonging to major histocompatibility complex(MHC) Class-Ⅱ family as HLA-DP, HLA-DQ(2-fold) and superoxide dismutase(2-fold). Cells grown in the presence of HCV viral proteins had genes downregulated for factors involved in innate response, interferon signaling, DC maturation and co-stimulatory signaling to T-cells, while the genes for cytokine signaling and Toll-like receptors(4-fold) were upregulated as compared to cells grown in absence of viral proteins.CONCLUSION: Underexpressed MHC class-Ⅱ genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs.
文摘Nowadays,incorporating cooperative groups and group activities are very common in oral English classroom.By using group dy namics teachers can provide students with large blocks of time for authentic communication,while keeping the class focused in English.This paper discusses the importance of group dynamics in the oral English classroom and gives teachers some ideas about group dynamics in language classrooms.
