目的观察中医情志疗法对三阴性乳腺癌患者术后恢复期的生存质量的影响。方法选择90例三阴性乳腺癌患者术后恢复期患者为研究对象,采用随机数字表法分为观察组和对照组,各45例。所有患者均参照NCCN指南进行乳腺癌基础治疗及常规护理干预...目的观察中医情志疗法对三阴性乳腺癌患者术后恢复期的生存质量的影响。方法选择90例三阴性乳腺癌患者术后恢复期患者为研究对象,采用随机数字表法分为观察组和对照组,各45例。所有患者均参照NCCN指南进行乳腺癌基础治疗及常规护理干预,观察组联合应用中医情志疗法。观察治疗前后抑郁评分变化,采用乳腺癌患者生命质量测定量表(Functional Assessment of Cancer Therapy-Breast,FACT-B)评估两组生存质量,并通过T细胞亚群检测CD4+百分比、CD8+百分比、CD4+/CD8+的数值。结果治疗后观察组CES-D评分、HAMD-17评分明显低于对照组(P<0.05);情感状况、功能状况、附加关注、总量表等生活质量评分均明显低于对照组(P<0.05);观察组CD4+百分比、CD4+/CD8+明显高于对照组,CD8+百分比明显低于对照(P<0.05)。结论中医情志疗法能有效缓解三阴性乳腺癌术后抑郁症状,改善免疫功能,提高患者整体生活质量。展开更多
The T cell co-stimulatory molecule OX40 and its cognate ligand OX40 L have attracted broad research interest as a therapeutic target in T cell-mediated diseases.Accumulating preclinical evidence highlights the therape...The T cell co-stimulatory molecule OX40 and its cognate ligand OX40 L have attracted broad research interest as a therapeutic target in T cell-mediated diseases.Accumulating preclinical evidence highlights the therapeutic efficacy of both agonist and blockade of the OX40-OX40 L interaction.Despite this progress,many questions about the immuno-modulator roles of OX40 on T cell function remain unanswered.In this review we summarize the impact of the OX40-OX40 L interaction on T cell subsets,including Th1,Th2,Th9,Th17,Th22,Treg,Tfh,and CD8+T cells,to gain a comprehensive understanding of anti-OX40 mAb-based therapies.The potential therapeutic application of the OX40-OX40 L interaction in autoimmunity diseases and cancer immunotherapy are further discussed;OX40-OX40 L blockade may ameliorate autoantigen-specific T cell responses and reduce immune activity in autoimmunity diseases.We also explore the rationale of targeting OX40-OX40 L interactions in cancer immunotherapy.Ligation of OX40 with targeted agonist anti-OX40 mAbs conveys activating signals to T cells.When combined with other therapeutic treatments,such as anti-PD-1 or anti-CTLA-4 blockade,cytokines,chemotherapy,or radiotherapy,the anti-tumor activity of agonist anti-OX40 treatment will be further enhanced.These data collectively suggest great potential for OX40-mediated therapies.展开更多
Background： Allogeneic blood transfusion-induced immunomodulation （TRIM） and its adverse effect on the prognosis of patients treated surgically for cancer remain complex and controversial. However, the potential ri...Background： Allogeneic blood transfusion-induced immunomodulation （TRIM） and its adverse effect on the prognosis of patients treated surgically for cancer remain complex and controversial. However, the potential risk associated with allogeneic blood transfusion has heightened interest in the use of autologous blood transfusion. In the present study, the serum concentrations of neopterin, interferon-gamma （IFN-γ）, T lymphocyte subsets （CD3^＋, CD4^＋, CD8^＋, CD4^＋/CD8^＋） and a possible association between these variables were investigated. The purpose was to further evaluate the effect of autologous versus allogeneic blood transfusion on immunological status in patients undergoing surgery for gastric cancer. Methods： Sixty ASA Ⅰ～Ⅱ（American Society of Anesthesiologists） patients undergoing elective radical resection for stomach cancer were randomly allocated to receive either allogeneic blood transfusion （n=30） or autologous blood transfusion （n=30）. Serum concentrations of the neopterin, IFN-γ and T lymphocyte subsets in the recipients were measured before induction of anesthesia, after operation, and on the 5th postoperative day. Results： Both two groups, serum neopterin, IFN-γ, percentages of T-cell subsets （CD3^＋, CD4^＋）, and CD4^＋/CD8^＋ ratio had significantly decreased after operation, but decreased more significantly in group H （receiving allogeneic blood transfusion） than those in group A （receiving autologous whole blood transfusion） （P〈0.05）. On the 5th postoperative day,serum neopterin, IFN-γ, CD3^＋, CD4^＋ T-cells, and CD4^＋/CD8^＋ ratio returned to the baseline values in group A. In contrast, the above remain decreasing in group H, where there were no significant relations between serum neopterin and IFN-γ. Conclusion：Perioperative surgical trauma and stress have an immunosuppressive impact on gastric cancer patients. Allogeneic blood transfusion exacerbates the impaired immune response. Autologous blood transfusion migh展开更多
文摘目的观察中医情志疗法对三阴性乳腺癌患者术后恢复期的生存质量的影响。方法选择90例三阴性乳腺癌患者术后恢复期患者为研究对象,采用随机数字表法分为观察组和对照组,各45例。所有患者均参照NCCN指南进行乳腺癌基础治疗及常规护理干预,观察组联合应用中医情志疗法。观察治疗前后抑郁评分变化,采用乳腺癌患者生命质量测定量表(Functional Assessment of Cancer Therapy-Breast,FACT-B)评估两组生存质量,并通过T细胞亚群检测CD4+百分比、CD8+百分比、CD4+/CD8+的数值。结果治疗后观察组CES-D评分、HAMD-17评分明显低于对照组(P<0.05);情感状况、功能状况、附加关注、总量表等生活质量评分均明显低于对照组(P<0.05);观察组CD4+百分比、CD4+/CD8+明显高于对照组,CD8+百分比明显低于对照(P<0.05)。结论中医情志疗法能有效缓解三阴性乳腺癌术后抑郁症状,改善免疫功能,提高患者整体生活质量。
基金supported by the National Mitural Science Foundation of China(Nos.81872824 and 81690261).
文摘The T cell co-stimulatory molecule OX40 and its cognate ligand OX40 L have attracted broad research interest as a therapeutic target in T cell-mediated diseases.Accumulating preclinical evidence highlights the therapeutic efficacy of both agonist and blockade of the OX40-OX40 L interaction.Despite this progress,many questions about the immuno-modulator roles of OX40 on T cell function remain unanswered.In this review we summarize the impact of the OX40-OX40 L interaction on T cell subsets,including Th1,Th2,Th9,Th17,Th22,Treg,Tfh,and CD8+T cells,to gain a comprehensive understanding of anti-OX40 mAb-based therapies.The potential therapeutic application of the OX40-OX40 L interaction in autoimmunity diseases and cancer immunotherapy are further discussed;OX40-OX40 L blockade may ameliorate autoantigen-specific T cell responses and reduce immune activity in autoimmunity diseases.We also explore the rationale of targeting OX40-OX40 L interactions in cancer immunotherapy.Ligation of OX40 with targeted agonist anti-OX40 mAbs conveys activating signals to T cells.When combined with other therapeutic treatments,such as anti-PD-1 or anti-CTLA-4 blockade,cytokines,chemotherapy,or radiotherapy,the anti-tumor activity of agonist anti-OX40 treatment will be further enhanced.These data collectively suggest great potential for OX40-mediated therapies.
基金Project supported by the Health Department of Zhejiang Province(No. 2004A040)the Education Department of Zhejiang Province (No. G20030486), China
文摘Background： Allogeneic blood transfusion-induced immunomodulation （TRIM） and its adverse effect on the prognosis of patients treated surgically for cancer remain complex and controversial. However, the potential risk associated with allogeneic blood transfusion has heightened interest in the use of autologous blood transfusion. In the present study, the serum concentrations of neopterin, interferon-gamma （IFN-γ）, T lymphocyte subsets （CD3^＋, CD4^＋, CD8^＋, CD4^＋/CD8^＋） and a possible association between these variables were investigated. The purpose was to further evaluate the effect of autologous versus allogeneic blood transfusion on immunological status in patients undergoing surgery for gastric cancer. Methods： Sixty ASA Ⅰ～Ⅱ（American Society of Anesthesiologists） patients undergoing elective radical resection for stomach cancer were randomly allocated to receive either allogeneic blood transfusion （n=30） or autologous blood transfusion （n=30）. Serum concentrations of the neopterin, IFN-γ and T lymphocyte subsets in the recipients were measured before induction of anesthesia, after operation, and on the 5th postoperative day. Results： Both two groups, serum neopterin, IFN-γ, percentages of T-cell subsets （CD3^＋, CD4^＋）, and CD4^＋/CD8^＋ ratio had significantly decreased after operation, but decreased more significantly in group H （receiving allogeneic blood transfusion） than those in group A （receiving autologous whole blood transfusion） （P〈0.05）. On the 5th postoperative day,serum neopterin, IFN-γ, CD3^＋, CD4^＋ T-cells, and CD4^＋/CD8^＋ ratio returned to the baseline values in group A. In contrast, the above remain decreasing in group H, where there were no significant relations between serum neopterin and IFN-γ. Conclusion：Perioperative surgical trauma and stress have an immunosuppressive impact on gastric cancer patients. Allogeneic blood transfusion exacerbates the impaired immune response. Autologous blood transfusion migh
