The aim of this study is to compare the effects of single and combined oral administration of fresh aqueous extracts of Acalypha wilkesiana supplementation at 300 mg/ml and exercise training on some immuno indicator p...The aim of this study is to compare the effects of single and combined oral administration of fresh aqueous extracts of Acalypha wilkesiana supplementation at 300 mg/ml and exercise training on some immuno indicator parameters in Rats. The study was carried out in the College of Health Sciences, Department of Hematology, Igbinedion University, Okada between the Month of June and July, 2012. Following 30 days post-oral administration of extracts on (Group 2 and Group 3), exercise training on (Group 2 and Group 4) and No treated on Group 1, hematological parameters were determined using the sysmex®?Automated Hematological Analyzer, while CD4 and CD8 cells were estimated using Partec cyflow counter and serum IgG is determined using the ELISA Method. CD4 cells, CD8, and Total WBC count show a statistically significant increase while Hb concentration and IgG level show a statistically significant decrease in Group 2 and Group 4 (P < 0.05). Total WBC count shows a statistically significant increase against the control Group, while CD4 cell, CD8 cell count, Hb-concentration and IgG level show a statistically insignificant increase (P > 0.05), Table 2. Acalypha wilkesiana at a concentration of 300 mg/g/day seems to be immuno-protective in Rats. Single or combine effects of prolonged exercise and A. wilkesiana produce significant change in some immuno indicators parameters. However, the molecular mechanism behind their combined effect would require further investigation.展开更多
This paper focuses on the study and control of a non-linear mathematical epidemic model ( SSvihVELI ) based on a system of ordinary differential equation modeling the spread of tuberculosis infectious with HIV/AIDS co...This paper focuses on the study and control of a non-linear mathematical epidemic model ( SSvihVELI ) based on a system of ordinary differential equation modeling the spread of tuberculosis infectious with HIV/AIDS coinfection. Existence of both disease free equilibrium and endemic equilibrium is discussed. Reproduction number R0 is determined. Using Lyapunov-Lasalle methods, we analyze the stability of epidemic system around the equilibriums (disease free and endemic equilibrium). The global asymptotic stability of the disease free equilibrium whenever Rvac is proved, where R0 is the reproduction number. We prove also that when R0 is less than one, tuberculosis can be eradicated. Numerical simulations are conducted to approve analytic results. To achieve control of the disease, seeking to reduce the infectious group by the minimum vaccine coverage, a control problem is formulated. The Pontryagin’s maximum principle is used to characterize the optimal control. The optimality system is derived and solved numerically using the Runge Kutta fourth procedure.展开更多
This study investigated some immune system related parameters among post-menopausal women in Elele, River state, Nigeria. Forty-two individuals participated in this study and forty control subjects were established as...This study investigated some immune system related parameters among post-menopausal women in Elele, River state, Nigeria. Forty-two individuals participated in this study and forty control subjects were established as well. Blood was collected from the participants, and CD4 cells and total white blood cells count were analyzed using standard procedures. Result showed that test subjects and control values were 5.46 ± 1.64 × 109/L and 7.24 ± 1.47 × 109/L, respectively for total white blood cell and 1265.19 ± 458.56 cells/μl and 2159.53 ± 400.02 cells/μl respectively, for CD4 cells. There was significant difference (P < 0.001) among the test subject and control for both parameters. The results in the test subjects for both parameters were significantly lower compared to the control. The decline in immune system related parameters among the test subjects may predispose them at risk of multiple infections and other associated health conditions.展开更多
文摘The aim of this study is to compare the effects of single and combined oral administration of fresh aqueous extracts of Acalypha wilkesiana supplementation at 300 mg/ml and exercise training on some immuno indicator parameters in Rats. The study was carried out in the College of Health Sciences, Department of Hematology, Igbinedion University, Okada between the Month of June and July, 2012. Following 30 days post-oral administration of extracts on (Group 2 and Group 3), exercise training on (Group 2 and Group 4) and No treated on Group 1, hematological parameters were determined using the sysmex®?Automated Hematological Analyzer, while CD4 and CD8 cells were estimated using Partec cyflow counter and serum IgG is determined using the ELISA Method. CD4 cells, CD8, and Total WBC count show a statistically significant increase while Hb concentration and IgG level show a statistically significant decrease in Group 2 and Group 4 (P < 0.05). Total WBC count shows a statistically significant increase against the control Group, while CD4 cell, CD8 cell count, Hb-concentration and IgG level show a statistically insignificant increase (P > 0.05), Table 2. Acalypha wilkesiana at a concentration of 300 mg/g/day seems to be immuno-protective in Rats. Single or combine effects of prolonged exercise and A. wilkesiana produce significant change in some immuno indicators parameters. However, the molecular mechanism behind their combined effect would require further investigation.
文摘This paper focuses on the study and control of a non-linear mathematical epidemic model ( SSvihVELI ) based on a system of ordinary differential equation modeling the spread of tuberculosis infectious with HIV/AIDS coinfection. Existence of both disease free equilibrium and endemic equilibrium is discussed. Reproduction number R0 is determined. Using Lyapunov-Lasalle methods, we analyze the stability of epidemic system around the equilibriums (disease free and endemic equilibrium). The global asymptotic stability of the disease free equilibrium whenever Rvac is proved, where R0 is the reproduction number. We prove also that when R0 is less than one, tuberculosis can be eradicated. Numerical simulations are conducted to approve analytic results. To achieve control of the disease, seeking to reduce the infectious group by the minimum vaccine coverage, a control problem is formulated. The Pontryagin’s maximum principle is used to characterize the optimal control. The optimality system is derived and solved numerically using the Runge Kutta fourth procedure.
文摘This study investigated some immune system related parameters among post-menopausal women in Elele, River state, Nigeria. Forty-two individuals participated in this study and forty control subjects were established as well. Blood was collected from the participants, and CD4 cells and total white blood cells count were analyzed using standard procedures. Result showed that test subjects and control values were 5.46 ± 1.64 × 109/L and 7.24 ± 1.47 × 109/L, respectively for total white blood cell and 1265.19 ± 458.56 cells/μl and 2159.53 ± 400.02 cells/μl respectively, for CD4 cells. There was significant difference (P < 0.001) among the test subject and control for both parameters. The results in the test subjects for both parameters were significantly lower compared to the control. The decline in immune system related parameters among the test subjects may predispose them at risk of multiple infections and other associated health conditions.