临床麻醉信息系统(clinic anaesthesia information system,CAIS)应用于手术室、术后复苏室和加强治疗病房(ICU)。系统围绕手术的前期、中期、后期等各个阶段的业务进行智能化的管理。主要功能有术前访视提示和记录、术中体征及麻醉状...临床麻醉信息系统(clinic anaesthesia information system,CAIS)应用于手术室、术后复苏室和加强治疗病房(ICU)。系统围绕手术的前期、中期、后期等各个阶段的业务进行智能化的管理。主要功能有术前访视提示和记录、术中体征及麻醉状况自动采集和实时显示、基于专家知识的智能提示和警示、术后麻醉总结、自动计费、以及科室管理、知识总结等。该系统的应用将直接提高医疗工作质量和工作效率,改善医患关系。展开更多
We investigated the androgen receptor(AR) gene mutation profiles of Chinese patients exhibiting severe androgen insensitivity syndrome(AIS) phenotypes. The present study enrolled 28 patients with genetically diagnosed...We investigated the androgen receptor(AR) gene mutation profiles of Chinese patients exhibiting severe androgen insensitivity syndrome(AIS) phenotypes. The present study enrolled 28 patients with genetically diagnosed AIS, who presented with severe phenotypes(Prader grade 0–3). Patients and some family members were screened via amplification and sequencing of their AR exons 1–8, including the corresponding intronic flanking regions. Luteinizing(LH), follicle-stimulating(FSH), and testosterone(T) hormone levels were found to be slightly, but not significantly, higher in patients with complete androgen insensitivity syndrome(CAIS) than in patients with partial androgen insensitivity syndrome(PAIS)(P>0.05). We identified 24 different AR mutations, including 12 that were novel. Ten patients(cases 2, 3, 10, 28, 11, 12, 19, 20, 24, and 25) were found to carry five recurrent mutations(p.Y572 S, p.P914 S, p.S176 R, p.Y782 N, and p.R841H); of these, p.Y572 S, p.S176 R, and p.Y782 N were novel. Among the mutations identified in patients with CAIS, six(66.7%) were characterized as single-nucleotide missense mutations, and six(66.7%) were found to be located in the AR ligand-binding domain(LBD). Among the mutations identified in patients with PAIS, 15(93.8%) were found to be missense, and 11(68.8%) were found to be located in the LBD. Patients 10 and 28 were determined to harbor the same missense mutation(p.P914S), but were diagnosed with CAIS and PAIS, respectively.Sex hormone levels were slightly, but not significantly, elevated in patients with CAIS compared to those with PAIS. Missense mutations spanning AR exons 1–8 were the predominant form of identified mutations, and these were mostly located in the AR LBD. Approximately 50% of the identified mutations were novel, and have enriched the AR gene-mutation database. Patients harboring identical mutations were in some instances found to exhibit divergent phenotypes.展开更多
Isotope eff ects are pivotal in understanding silicate melt evaporation and planetary accretion processes.Based on the Hertz-Knudsen equation,the current theory often fails to predict observed isotope fractionations o...Isotope eff ects are pivotal in understanding silicate melt evaporation and planetary accretion processes.Based on the Hertz-Knudsen equation,the current theory often fails to predict observed isotope fractionations of laboratory experiments due to its oversimplified assumptions.Here,we point out that the Hertz-Knudsen-equation-based theory is incomplete for silicate melt evaporation cases and can only be used for situations where the vaporized species is identical to the one in the melt.We propose a new model designed for silicate melt evaporation under vacuum.Our model considers multiple steps including mass transfer,chemical reaction,and nucleation.Our derivations reveal a kinetic isotopic fractionation factor(KIFF orα)αour model=[m(^(1)species)/m(^(2)species)]^(0.5),where m(species)is the mass of the reactant of reaction/nucleation-limiting step or species of diffusion-limiting step and superscript 1 and 2 represent light and heavy isotopes,respectively.This model can eff ectively reproduce most reported KIFFs of laboratory experiments for various elements,i.e.,Mg,Si,K,Rb,Fe,Ca,and Ti.And,the KIFF-mixing model referring that an overall rate of evaporation can be determined by two steps jointly can account for the eff ects of low P_(H2)pressure,composition,and temperature.In addition,we find that chemical reactions,diffusion,and nucleation can control the overall rate of evaporation of silicate melts by using the fitting slope in ln(−ln f)versus ln(t).Notably,our model allows for the theoretical calculations of parameters like activation energy(E_(a)),providing a novel approach to studying compositional and environmental eff ects on evaporation processes,and shedding light on the formation and evolution of the proto-solar and Earth-Moon systems.展开更多
Purpose: This study examines quality of life and psychological distress in individuals with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKHS) and Complete Androgen Insensitivity Syndrome (CAIS), two syndromes belon...Purpose: This study examines quality of life and psychological distress in individuals with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKHS) and Complete Androgen Insensitivity Syndrome (CAIS), two syndromes belonging to the field of “disorders of sex development”. Methods: Fifty women with MRKHS and eleven individuals with CAIS participated. The German versions of the World Health Organization Quality of Life Questionnaire (short version, WHOQOL-Bref), the Brief Symptom Inventory (BSI), and the Patient Health Questionnaire (PHQ-D) were used as standardized instruments to measure quality of life and psychopathology. Additional questions concerning demographic variables and suicidality were included. Results: In both patient samples examined, general quality of life reported was in the average range (CAIS: mean z-score = ﹣0.43, SD = 1.05;MRKHS: mean z-score = ﹣0.11, SD = 1.06). The standardized instrument assessment revealed increased psychological distress (proportion of clinical cases according to the BSI: CAIS: 54.5%;MRKHS: 55.1%). A correlation between psychological distress and time span from first suspicion to diagnosis was found in women with MRKHS (Spearman’s rho = 0.35, p = 0.018). Conclusions: The results illustrate the importance of individualised and thorough diagnostics when dealing with patients with MRKHS or CAIS. Psychological distress might be an issue for these individuals and therefore should be considered in treatment and counselling.展开更多
We report the petrology and oxygen isotopic composition,using a Cameca Nano SIMS 50L ion microprobe,of a plagioclase-olivine inclusion,C#1,found in the Ningqiang carbonaceous chondrite.In addition to major phases(plag...We report the petrology and oxygen isotopic composition,using a Cameca Nano SIMS 50L ion microprobe,of a plagioclase-olivine inclusion,C#1,found in the Ningqiang carbonaceous chondrite.In addition to major phases(plagioclase,spinel and olivine),C#1 is also surrounded by a pyroxene rim(64 vol%Ca-rich and 36 vol%Ca-poor pyroxenes).On a three-isotope oxygen diagram,δ^(17)O vs.δ^(18)O,the compositions of individual minerals analyzed in C#1 fall along the carbonaceous chondrite anhydrous mineral line(CCAM),and oxygen isotopic compositions in C#1 show significant variability in δ^(18)O and δ^(17)O.The oxygen isotopic compositions of the pyroxene rim minerals are similar to those of the other host minerals,which suggests that the rim likely formed from the same melting process as the host.The rim is considered to have formed as a result of interaction between an ^(16)O-poor gas and a melt.Some spinel grains are typically ^(16)O-rich and likely of relict origin,which is similar to ^(16)O-rich Ca-,Al-rich inclusions,which are probably a precursor of C#1.The inclusion then likely melted in an ^(16)O-poor region where chondrules form,accompanied by oxygen isotope exchange with an ^(16)O-poor gas.Some anorthite,pyroxene and spinel might have undergone fluid-assisted thermal metamorphism on the Ningqiang chondrite parent body.The oxygen isotope data and evolution of the C#1 plagioclase-olivine inclusion are similar with those of Al-chondrules in chondrites.展开更多
文摘临床麻醉信息系统(clinic anaesthesia information system,CAIS)应用于手术室、术后复苏室和加强治疗病房(ICU)。系统围绕手术的前期、中期、后期等各个阶段的业务进行智能化的管理。主要功能有术前访视提示和记录、术中体征及麻醉状况自动采集和实时显示、基于专家知识的智能提示和警示、术后麻醉总结、自动计费、以及科室管理、知识总结等。该系统的应用将直接提高医疗工作质量和工作效率,改善医患关系。
基金supported by the Public Health Project for Residents in Beijing (Z151100003915103)the National Key Research and Development Program of China (2016YFC0901505)
文摘We investigated the androgen receptor(AR) gene mutation profiles of Chinese patients exhibiting severe androgen insensitivity syndrome(AIS) phenotypes. The present study enrolled 28 patients with genetically diagnosed AIS, who presented with severe phenotypes(Prader grade 0–3). Patients and some family members were screened via amplification and sequencing of their AR exons 1–8, including the corresponding intronic flanking regions. Luteinizing(LH), follicle-stimulating(FSH), and testosterone(T) hormone levels were found to be slightly, but not significantly, higher in patients with complete androgen insensitivity syndrome(CAIS) than in patients with partial androgen insensitivity syndrome(PAIS)(P>0.05). We identified 24 different AR mutations, including 12 that were novel. Ten patients(cases 2, 3, 10, 28, 11, 12, 19, 20, 24, and 25) were found to carry five recurrent mutations(p.Y572 S, p.P914 S, p.S176 R, p.Y782 N, and p.R841H); of these, p.Y572 S, p.S176 R, and p.Y782 N were novel. Among the mutations identified in patients with CAIS, six(66.7%) were characterized as single-nucleotide missense mutations, and six(66.7%) were found to be located in the AR ligand-binding domain(LBD). Among the mutations identified in patients with PAIS, 15(93.8%) were found to be missense, and 11(68.8%) were found to be located in the LBD. Patients 10 and 28 were determined to harbor the same missense mutation(p.P914S), but were diagnosed with CAIS and PAIS, respectively.Sex hormone levels were slightly, but not significantly, elevated in patients with CAIS compared to those with PAIS. Missense mutations spanning AR exons 1–8 were the predominant form of identified mutations, and these were mostly located in the AR LBD. Approximately 50% of the identified mutations were novel, and have enriched the AR gene-mutation database. Patients harboring identical mutations were in some instances found to exhibit divergent phenotypes.
基金supported by Chinese NSF project(42,130,114)the strategic priority research program(B)of CAS(XDB41000000)the pre-research Project on Civil Aerospace Technologies No.D020202 funded by Chinese National Space Administration(CNSA)and Guizhou Provincial 2021 Science and Technology Subsidies(No.GZ2021SIG).
文摘Isotope eff ects are pivotal in understanding silicate melt evaporation and planetary accretion processes.Based on the Hertz-Knudsen equation,the current theory often fails to predict observed isotope fractionations of laboratory experiments due to its oversimplified assumptions.Here,we point out that the Hertz-Knudsen-equation-based theory is incomplete for silicate melt evaporation cases and can only be used for situations where the vaporized species is identical to the one in the melt.We propose a new model designed for silicate melt evaporation under vacuum.Our model considers multiple steps including mass transfer,chemical reaction,and nucleation.Our derivations reveal a kinetic isotopic fractionation factor(KIFF orα)αour model=[m(^(1)species)/m(^(2)species)]^(0.5),where m(species)is the mass of the reactant of reaction/nucleation-limiting step or species of diffusion-limiting step and superscript 1 and 2 represent light and heavy isotopes,respectively.This model can eff ectively reproduce most reported KIFFs of laboratory experiments for various elements,i.e.,Mg,Si,K,Rb,Fe,Ca,and Ti.And,the KIFF-mixing model referring that an overall rate of evaporation can be determined by two steps jointly can account for the eff ects of low P_(H2)pressure,composition,and temperature.In addition,we find that chemical reactions,diffusion,and nucleation can control the overall rate of evaporation of silicate melts by using the fitting slope in ln(−ln f)versus ln(t).Notably,our model allows for the theoretical calculations of parameters like activation energy(E_(a)),providing a novel approach to studying compositional and environmental eff ects on evaporation processes,and shedding light on the formation and evolution of the proto-solar and Earth-Moon systems.
文摘Purpose: This study examines quality of life and psychological distress in individuals with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKHS) and Complete Androgen Insensitivity Syndrome (CAIS), two syndromes belonging to the field of “disorders of sex development”. Methods: Fifty women with MRKHS and eleven individuals with CAIS participated. The German versions of the World Health Organization Quality of Life Questionnaire (short version, WHOQOL-Bref), the Brief Symptom Inventory (BSI), and the Patient Health Questionnaire (PHQ-D) were used as standardized instruments to measure quality of life and psychopathology. Additional questions concerning demographic variables and suicidality were included. Results: In both patient samples examined, general quality of life reported was in the average range (CAIS: mean z-score = ﹣0.43, SD = 1.05;MRKHS: mean z-score = ﹣0.11, SD = 1.06). The standardized instrument assessment revealed increased psychological distress (proportion of clinical cases according to the BSI: CAIS: 54.5%;MRKHS: 55.1%). A correlation between psychological distress and time span from first suspicion to diagnosis was found in women with MRKHS (Spearman’s rho = 0.35, p = 0.018). Conclusions: The results illustrate the importance of individualised and thorough diagnostics when dealing with patients with MRKHS or CAIS. Psychological distress might be an issue for these individuals and therefore should be considered in treatment and counselling.
基金supported by the Natural Science Foundation of China(Grant Nos.41673070,41103032,41503062)the Hunan Provincial Natural Science Foundation of China(Grant No.2021JJ30242)the Scientific Research Fund of Hunan Provincial Education Department(Grant No.18A204)。
文摘We report the petrology and oxygen isotopic composition,using a Cameca Nano SIMS 50L ion microprobe,of a plagioclase-olivine inclusion,C#1,found in the Ningqiang carbonaceous chondrite.In addition to major phases(plagioclase,spinel and olivine),C#1 is also surrounded by a pyroxene rim(64 vol%Ca-rich and 36 vol%Ca-poor pyroxenes).On a three-isotope oxygen diagram,δ^(17)O vs.δ^(18)O,the compositions of individual minerals analyzed in C#1 fall along the carbonaceous chondrite anhydrous mineral line(CCAM),and oxygen isotopic compositions in C#1 show significant variability in δ^(18)O and δ^(17)O.The oxygen isotopic compositions of the pyroxene rim minerals are similar to those of the other host minerals,which suggests that the rim likely formed from the same melting process as the host.The rim is considered to have formed as a result of interaction between an ^(16)O-poor gas and a melt.Some spinel grains are typically ^(16)O-rich and likely of relict origin,which is similar to ^(16)O-rich Ca-,Al-rich inclusions,which are probably a precursor of C#1.The inclusion then likely melted in an ^(16)O-poor region where chondrules form,accompanied by oxygen isotope exchange with an ^(16)O-poor gas.Some anorthite,pyroxene and spinel might have undergone fluid-assisted thermal metamorphism on the Ningqiang chondrite parent body.The oxygen isotope data and evolution of the C#1 plagioclase-olivine inclusion are similar with those of Al-chondrules in chondrites.
