Abstract: Two new hetisine-type C20-diterpenoid alkaloids named spiraqine (1) and 6-hydroxylspiraqine (2), and four known alkaloids, namely spiredine (3), spiradine A (4), spiradine B (5), and spirasine V/VI (6), were...Abstract: Two new hetisine-type C20-diterpenoid alkaloids named spiraqine (1) and 6-hydroxylspiraqine (2), and four known alkaloids, namely spiredine (3), spiradine A (4), spiradine B (5), and spirasine V/VI (6), were isolated from Spiraea japonica L. f. var. fortunei(Planchon) Rehd. The structures of the alkaloids were elucidated using nuclear magnetic resonance analysis (1H-NMR, 13C-NMR, DEPT, HMQC, and HMBC) and mass spectrometry data.展开更多
A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder r...A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder reaction.展开更多
文摘Abstract: Two new hetisine-type C20-diterpenoid alkaloids named spiraqine (1) and 6-hydroxylspiraqine (2), and four known alkaloids, namely spiredine (3), spiradine A (4), spiradine B (5), and spirasine V/VI (6), were isolated from Spiraea japonica L. f. var. fortunei(Planchon) Rehd. The structures of the alkaloids were elucidated using nuclear magnetic resonance analysis (1H-NMR, 13C-NMR, DEPT, HMQC, and HMBC) and mass spectrometry data.
基金the financial support provided by the National Science Foundation of China(No.81273387)
文摘A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder reaction.
