A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Mos...A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Most of the compounds display moderate to potent inhibitory activity.Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases.展开更多
A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis ...A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.展开更多
基金Supported by the Fund of Jilin University(China) Hi-Tech(Group) Co.Ltd
文摘A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Most of the compounds display moderate to potent inhibitory activity.Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases.
文摘A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by 1H NMR, 13C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.
